oxedrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| sympathomimetics | 3577 | 94-07-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.20 | g | O |
| 0.20 | g | P |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01CA08 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Adrenergic and dopaminergic agents |
| ATC | S01GA06 | SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Sympathomimetics used as decongestants |
| ATC | S01GA56 | SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Sympathomimetics used as decongestants |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D000316 | Adrenergic alpha-Agonists |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D014663 | Nasal Decongestants |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D019141 | Respiratory System Agents |
| MeSH PA | D013566 | Sympathomimetics |
| MeSH PA | D014662 | Vasoconstrictor Agents |
| CHEBI has role | CHEBI:35569 | alpha-adrenergic agonists |
| CHEBI has role | CHEBI:76924 | plant metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Nasal discharge | indication | 64531003 | |
| Nasal congestion | indication | 68235000 | |
| Eustachian Tube Congestion | indication | ||
| Priapism | off-label use | 6273006 | DOID:9286 |
| Low blood pressure | off-label use | 45007003 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Ventricular tachycardia | contraindication | 25569003 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Acute hepatitis | contraindication | 37871000 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Chronic heart failure | contraindication | 48447003 | |
| Bradycardia | contraindication | 48867003 | |
| Acidosis | contraindication | 51387008 | |
| Heart disease | contraindication | 56265001 | DOID:114 |
| Arterial thrombosis | contraindication | 65198009 | |
| Arteriosclerotic vascular disease | contraindication | 72092001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Partial atrioventricular block | contraindication | 195039008 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Arterial aneurysm | contraindication | 233981004 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Hypoxia | contraindication | 389086002 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Disorder of coronary artery | contraindication | 414024009 | |
| Hypertensive urgency | contraindication | 443482000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.17 | acidic |
| pKa2 | 9.11 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 4.20 | CHEMBL | |||||
| Neuromedin-U receptor 2 | GPCR | EC50 | 5.18 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| PEG5DP7434 | UNII |
| N0000166809 | NUI |
| D07148 | KEGG_DRUG |
| 5985-28-4 | SECONDARY_CAS_RN |
| 16589-24-5 | SECONDARY_CAS_RN |
| C0795712 | UMLSCUI |
| CHEBI:29081 | CHEBI |
| CHEMBL33720 | ChEMBL_ID |
| 7172 | PUBCHEM_CID |
| DB09203 | DRUGBANK_ID |
| D013578 | MESH_DESCRIPTOR_UI |
| 10288 | RXNORM |
| 005725 | NDDF |
| 419339003 | SNOMEDCT_US |
| 420192008 | SNOMEDCT_US |
Pharmaceutical products:
None