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sodium tetradecyl sulfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3550 | 139-88-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 58 | |||
| kinase-selectivity-class | AXL,GRK2,MAP2K6,TEK,ZAP70 | 5 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 13, 1946 | FDA | ELKINS SINN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C05BB04 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Sclerosing agents for local injection |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D012597 | Sclerosing Solutions |
| MeSH PA | D013501 | Surface-Active Agents |
| CHEBI has role | CHEBI:27780 | detergent |
| CHEBI has role | CHEBI:63923 | sclerotherapy agent |
Related Drugs by ATC class:
C05BB Sclerosing agents for local injection 4 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Venous varices | indication | 128060009 | DOID:799 |
| Incompetence of any valvular structure | contraindication | 10337008 | |
| Infection of skin AND/OR subcutaneous tissue | contraindication | 19824006 | |
| Peripheral venous insufficiency | contraindication | 20696009 | DOID:10128 |
| Acute tuberculosis | contraindication | 25629007 | |
| Thrombophlebitis migrans | contraindication | 31268005 | DOID:14392 |
| Infectious disease | contraindication | 40733004 | |
| Thromboangiitis obliterans | contraindication | 52403007 | DOID:12918 |
| Thrombophlebitis | contraindication | 64156001 | DOID:3875 |
| Arteriosclerotic vascular disease | contraindication | 72092001 | |
| Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
| Neoplasm | contraindication | 108369006 | |
| Bed-ridden | contraindication | 160685001 | |
| Disease of blood AND/OR blood-forming organ | contraindication | 191124002 | DOID:74 |
| Sepsis syndrome | contraindication | 238150007 | |
| Diabetic - poor control | contraindication | 268519009 | |
| Exacerbation of asthma | contraindication | 281239006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 0.02 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D06882 | KEGG_DRUG |
| 300-52-7 | SECONDARY_CAS_RN |
| 4019068 | VANDF |
| CHEBI:75273 | CHEBI |
| CHEMBL1200354 | ChEMBL_ID |
| CHEMBL1201345 | ChEMBL_ID |
| 130 | INN_ID |
| DB00464 | DRUGBANK_ID |
| Q1SUG5KBD6 | UNII |
| DB11328 | DRUGBANK_ID |
| 1370424 | RXNORM |
| 1154 | MMSL |
| 1445 | MMSL |
| 5497 | MMSL |
| d01383 | MMSL |
| 002554 | NDDF |
| 387320008 | SNOMEDCT_US |
| 57616006 | SNOMEDCT_US |
| C0037556 | UMLSCUI |
| D012981 | MESH_DESCRIPTOR_UI |
| 23665772 | PUBCHEM_CID |
| Q1SUG5KBD6 | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Sodium Tetradecyl Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24201-201 | INJECTION, SOLUTION | 30 mg | INTRAVENOUS | ANDA | 19 sections |
| Sotradecol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4525 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | ANDA | 20 sections |
| Sotradecol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4529 | INJECTION, SOLUTION | 30 mg | INTRAVENOUS | ANDA | 20 sections |
| SODIUM TETRADECYL SULFATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51662-1562 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | ANDA | 17 sections |
| (SOTRADECOL) SODIUM TETRADECYL SULFATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51662-1563 | INJECTION, SOLUTION | 30 mg | INTRAVENOUS | ANDA | 18 sections |
| Sotradecol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67457-162 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | ANDA | 20 sections |
| Sotradecol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67457-163 | INJECTION, SOLUTION | 30 mg | INTRAVENOUS | ANDA | 20 sections |