saralasin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3542 | 34273-10-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | PROCTER AND GAMBLE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D047228 | Angiotensin II Type 1 Receptor Blockers |
| MeSH PA | D057911 | Angiotensin Receptor Antagonists |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.75 | acidic |
| pKa2 | 9.65 | acidic |
| pKa3 | 13.51 | acidic |
| pKa4 | 13.6 | acidic |
| pKa5 | 10.75 | Basic |
| pKa6 | 8.5 | Basic |
| pKa7 | 6.3 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor | GPCR | ANTAGONIST | Ki | 9.77 | CHEMBL | CHEMBL | |||
| Type-2 angiotensin II receptor | GPCR | Ki | 9.82 | CHEMBL | |||||
| Type-1B angiotensin II receptor | GPCR | IC50 | 8.62 | CHEMBL | |||||
| Type-2 angiotensin II receptor | GPCR | ANTAGONIST | IC50 | 9 | IUPHAR | ||||
| Angiotensin II receptor (AT-1) type-1 | GPCR | IC50 | 8.77 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D04126 | KEGG_DRUG |
| 39698-78-7 | SECONDARY_CAS_RN |
| C0036193 | UMLSCUI |
| CHEBI:135894 | CHEBI |
| CHEMBL938 | ChEMBL_ID |
| CHEMBL1200670 | ChEMBL_ID |
| D012504 | MESH_DESCRIPTOR_UI |
| DB06763 | DRUGBANK_ID |
| 598 | IUPHAR_LIGAND_ID |
| 3484 | INN_ID |
| H2AFV2HE66 | UNII |
| 6324663 | PUBCHEM_CID |
| 7830 | RXNORM |
| 000667 | NDDF |
| 004525 | NDDF |
Pharmaceutical products:
None