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rutoside 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3535 | 153-18-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT3,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,CHUK,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MAPKAPK2,MAPKAPK5,MTOR,NTRK1,NTRK2,PDK1,PDK2,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 66 | |||
| kinase-selectivity-class | ACVRL1,AXL,CDK4,CDK9,CHUK,GRK2,MAP2K6,MAP3K14,PDK1,PIK3CD,TGFBR1,ZAP70 | 12 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C05CA01 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES CAPILLARY STABILIZING AGENTS Bioflavonoids |
| ATC | C05CA51 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES CAPILLARY STABILIZING AGENTS Bioflavonoids |
| CHEBI has role | CHEBI:22586 | antioxidant |
| CHEBI has role | CHEBI:25212 | metabolite |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:50249 | anticoagulant |
Related Drugs by ATC class:
C05CA Bioflavonoids 4 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ascorbic acid deficiency | indication | 76169001 | |
| Methemoglobinemia | off-label use | 38959009 | DOID:10783 |
| Primary hyperoxaluria | contraindication | 17901006 | DOID:2977 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Hb SS disease | contraindication | 127040003 | DOID:10923 |
| Hemochromatosis | contraindication | 399187006 | DOID:2352 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.66 | acidic |
| pKa2 | 8.12 | acidic |
| pKa3 | 9.13 | acidic |
| pKa4 | 11.35 | acidic |
| pKa5 | 12.8 | acidic |
| pKa6 | 13.49 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | GPCR | Ki | 5.03 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M5 | GPCR | Ki | 7.45 | PDSP | |||||
| Alpha-2C adrenergic receptor | GPCR | Ki | 5.02 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 7.92 | CHEMBL | |||||
| Xanthine dehydrogenase/oxidase | Enzyme | IC50 | 4.28 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | IC50 | 5.41 | CHEMBL | |||||
| Beta-secretase 1 | Enzyme | IC50 | 8.42 | CHEMBL | |||||
| Cystic fibrosis transmembrane conductance regulator | Ion channel | Kd | 4.18 | CHEMBL | |||||
| Bifunctional epoxide hydrolase 2 | Enzyme | IC50 | 4.61 | CHEMBL | |||||
| Lysine-specific histone demethylase 1A | Enzyme | IC50 | 5.67 | CHEMBL | |||||
| Neuromedin-U receptor 2 | GPCR | EC50 | 5.92 | CHEMBL | |||||
| High mobility group protein B1 | Nuclear other | Kd | 6.58 | CHEMBL | |||||
| Aldose reductase | Enzyme | IC50 | 4.89 | CHEMBL | |||||
| Polyphenol oxidase 2 | Enzyme | IC50 | 4.16 | CHEMBL | |||||
| Serum albumin | Secreted | IC50 | 4.38 | CHEMBL | |||||
| Neuraminidase | Enzyme | Ki | 4.47 | CHEMBL | |||||
| Sialidase | Enzyme | IC50 | 4.51 | CHEMBL | |||||
| Neuraminidase | Enzyme | IC50 | 4.02 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018980 | VUID |
| N0000147257 | NUI |
| D08499 | KEGG_DRUG |
| 4018980 | VANDF |
| C0035976 | UMLSCUI |
| CHEBI:28527 | CHEBI |
| RUT | PDB_CHEM_ID |
| CHEMBL226335 | ChEMBL_ID |
| DB01698 | DRUGBANK_ID |
| C404204 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5280805 | PUBCHEM_CID |
| 9500 | RXNORM |
| 136910 | MMSL |
| NOCODE | MMSL |
| 001034 | NDDF |
| 126145002 | SNOMEDCT_US |
| 68077006 | SNOMEDCT_US |
| D012431 | MESH_DESCRIPTOR_UI |
| 2213 | INN_ID |
| 5G06TVY3R7 | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| St. Paul Brands Verestor | HUMAN OTC DRUG LABEL | 7 | 13411-861 | CAPSULE | 25 mg | ORAL | unapproved drug other | 8 sections |
| JBA Verestor Mega Fiber Powder | HUMAN OTC DRUG LABEL | 8 | 13411-862 | POWDER | 25 mg | ORAL | unapproved drug other | 6 sections |
| Bruselix Bruising | HUMAN PRESCRIPTION DRUG LABEL | 8 | 59088-003 | TABLET | 50 mg | ORAL | unapproved drug other | 10 sections |
| JinXianLian Hepato-Enzyme Regulating Agent | HUMAN OTC DRUG LABEL | 4 | 87650-002 | EXTRACT | 255 mg | ORAL | unapproved drug other | 11 sections |