ruboxistaurin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3533 169939-94-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ruboxistaurin mesilate monohydrate
  • ruboxistaurin mesilate
  • ruboxistaurin mesylate
  • ruboxistaurin
inhibits protein kinase C beta
  • Molecular weight: 468.56
  • Formula: C28H28N4O3
  • CLOGP: 4.32
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 68.50
  • ALOGS: -3.99
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D004791 Enzyme Inhibitors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.35 acidic
pKa2 8.95 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Receptor-type tyrosine-protein kinase FLT3 Kinase Kd 6.89 CHEMBL
Epidermal growth factor receptor Kinase Kd 5.29 CHEMBL
Protein kinase C theta type Kinase Kd 8.60 CHEMBL
SRSF protein kinase 1 Kinase Kd 5.92 CHEMBL
Serine/threonine-protein kinase RIO3 Kinase Kd 6.19 CHEMBL
Ribosomal protein S6 kinase alpha-6 Kinase Kd 5.64 CHEMBL
Ribosomal protein S6 kinase alpha-1 Kinase Kd 6.40 CHEMBL
Cyclin-G-associated kinase Kinase Kd 5.96 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 5 Kinase Kd 5.96 CHEMBL
Homeodomain-interacting protein kinase 3 Kinase Kd 7.11 CHEMBL
Cyclin-dependent kinase-like 5 Kinase Kd 5.39 CHEMBL
Homeodomain-interacting protein kinase 2 Kinase Kd 6.85 CHEMBL
Serine/threonine-protein kinase pim-3 Kinase Kd 7.92 CHEMBL
NUAK family SNF1-like kinase 1 Kinase Kd 5.74 CHEMBL
Protein kinase C iota type Kinase Kd 5.85 CHEMBL
Serine/threonine-protein kinase TBK1 Kinase Kd 6.01 CHEMBL
Serine/threonine-protein kinase ICK Kinase Kd 6.62 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 1 Kinase Kd 5.59 CHEMBL
cAMP-dependent protein kinase catalytic subunit alpha Kinase Kd 5.27 CHEMBL
Mitogen-activated protein kinase 15 Kinase Kd 7.06 CHEMBL
MAP kinase-interacting serine/threonine-protein kinase 1 Kinase Kd 5.15 CHEMBL
Serine/threonine-protein kinase Sgk3 Kinase Kd 5.85 CHEMBL
Protein kinase C gamma type Kinase IC50 6.52 CHEMBL
Dual specificity protein kinase CLK2 Kinase Kd 6.38 CHEMBL
G protein-coupled receptor kinase 7 Kinase Kd 6.51 CHEMBL
Homeodomain-interacting protein kinase 1 Kinase Kd 6.64 CHEMBL
Dual specificity protein kinase CLK1 Kinase Kd 6.04 CHEMBL
Serine/threonine-protein kinase 10 Kinase Kd 6.55 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit gamma Kinase Kd 5.11 CHEMBL
Serine/threonine-protein kinase PLK4 Kinase Kd 6.43 CHEMBL
AP2-associated protein kinase 1 Kinase Kd 6.05 CHEMBL
Serine/threonine-protein kinase MARK2 Kinase Kd 5.64 CHEMBL
Protein kinase C epsilon type Kinase Kd 7.96 CHEMBL
Tyrosine-protein kinase JAK3 Kinase Kd 6.38 CHEMBL
Casein kinase II subunit alpha' Kinase Kd 5.47 CHEMBL
Ribosomal protein S6 kinase alpha-5 Kinase Kd 5.89 CHEMBL
Serine/threonine-protein kinase pim-1 Kinase Kd 7.30 CHEMBL
Serine/threonine-protein kinase N2 Kinase Kd 5.82 CHEMBL
Serine/threonine-protein kinase TAO1 Kinase Kd 5.74 CHEMBL
Tyrosine-protein kinase HCK Kinase Kd 5.55 CHEMBL
Aurora kinase C Kinase Kd 5.52 CHEMBL
Platelet-derived growth factor receptor beta Kinase Kd 5.15 CHEMBL
Fibroblast growth factor receptor 1 Kinase Kd 5.29 CHEMBL
Citron Rho-interacting kinase Kinase Kd 5.85 CHEMBL
Ribosomal protein S6 kinase alpha-3 Kinase Kd 5.66 CHEMBL
Myosin light chain kinase, smooth muscle Kinase Kd 6.54 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 5 Kinase Kd 5.08 CHEMBL
Misshapen-like kinase 1 Kinase Kd 6.51 CHEMBL
Leucine-rich repeat serine/threonine-protein kinase 2 Kinase Kd 5.01 CHEMBL
Mast/stem cell growth factor receptor Kit Kinase Kd 6.42 CHEMBL
BMP-2-inducible protein kinase Kinase Kd 6.37 CHEMBL
Serine/threonine-protein kinase pim-2 Kinase Kd 6.89 CHEMBL
TRAF2 and NCK-interacting protein kinase Kinase Kd 5.24 CHEMBL
Calcium/calmodulin-dependent protein kinase kinase 2 Kinase Kd 5.96 CHEMBL
Ribosomal protein S6 kinase alpha-4 Kinase Kd 5.21 CHEMBL
STE20-like serine/threonine-protein kinase Kinase Kd 6.40 CHEMBL
Dual specificity protein kinase CLK4 Kinase Kd 5.72 CHEMBL
Death-associated protein kinase 2 Kinase Kd 5.59 CHEMBL
Serine/threonine-protein kinase 4 Kinase Kd 6.66 CHEMBL
Calcium/calmodulin-dependent protein kinase kinase 1 Kinase Kd 5.82 CHEMBL
Serine/threonine-protein kinase 3 Kinase Kd 6.02 CHEMBL
Calcium/calmodulin-dependent protein kinase type 1D Kinase Kd 5.59 CHEMBL
Serine/threonine-protein kinase TAO2 Kinase Kd 5.41 CHEMBL
Ribosomal protein S6 kinase alpha-2 Kinase Kd 6.55 CHEMBL
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Kinase Kd 5.57 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 3 Kinase Kd 5.08 CHEMBL
Cyclin-dependent kinase 16 Kinase Kd 5.59 CHEMBL
Casein kinase II subunit alpha Kinase Kd 5.44 CHEMBL
RAC-gamma serine/threonine-protein kinase Kinase Kd 5.85 CHEMBL
RAC-beta serine/threonine-protein kinase Kinase Kd 5.06 CHEMBL
Serine/threonine-protein kinase STK11 Kinase Kd 5.23 CHEMBL
Rhodopsin kinase Kinase Kd 6.10 CHEMBL
CaM kinase II Kinase IC50 5.21 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit alpha Kinase Kd 5.35 CHEMBL
G protein-coupled receptor kinase 4 Kinase Kd 6.23 CHEMBL
Mitogen-activated protein kinase kinase kinase 2 Kinase Kd 6.15 CHEMBL
Serine/threonine-protein kinase LATS2 Kinase Kd 6.19 CHEMBL
Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Kd 5.27 CHEMBL
Serine/threonine-protein kinase PRP4 homolog Kinase Kd 5.80 CHEMBL
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma Kinase Kd 6.29 CHEMBL
Proto-oncogene tyrosine-protein kinase ROS Kinase Kd 5.24 CHEMBL
Serine/threonine-protein kinase TAO3 Kinase Kd 7.01 CHEMBL
Cyclin-dependent kinase 7 Kinase Kd 5.77 CHEMBL
Death-associated protein kinase 1 Kinase Kd 6.01 CHEMBL
Protein kinase C delta type Kinase Kd 8.44 CHEMBL
Death-associated protein kinase 3 Kinase Kd 5.89 CHEMBL
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Kinase Kd 6.60 CHEMBL
Myotonin-protein kinase Kinase Kd 6.55 CHEMBL
Serine/threonine-protein kinase LATS1 Kinase Kd 5.59 CHEMBL
Tyrosine-protein kinase Lck Kinase Kd 5.89 CHEMBL
Mitogen-activated protein kinase kinase kinase 9 Kinase Kd 5.85 CHEMBL
Mitogen-activated protein kinase kinase kinase 19 Kinase Kd 7.32 CHEMBL
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Kinase Kd 6.08 CHEMBL
3-phosphoinositide-dependent protein kinase 1 Kinase Kd 6.15 CHEMBL
Serine/threonine-protein kinase D2 Kinase Kd 6.05 CHEMBL
NUAK family SNF1-like kinase 2 Kinase Kd 6.49 CHEMBL
SRSF protein kinase 2 Kinase Kd 5.96 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 4 Kinase Kd 6.03 CHEMBL
Serine/threonine-protein kinase tousled-like 1 Kinase Kd 5.68 CHEMBL
SRSF protein kinase 3 Kinase Kd 5.80 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 6 Kinase Kd 5.41 CHEMBL
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Kinase Kd 6.16 CHEMBL
Mitogen-activated protein kinase kinase kinase 3 Kinase Kd 6.77 CHEMBL
Serine/threonine-protein kinase RIO1 Kinase Kd 6.09 CHEMBL
Cyclin-dependent kinase 4 Kinase Kd 6.55 CHEMBL
Ribosomal protein S6 kinase beta-1 Kinase Kd 6.68 CHEMBL
Serine/threonine-protein kinase Chk2 Kinase Kd 5.43 CHEMBL
Serine/threonine-protein kinase 33 Kinase Kd 5.59 CHEMBL
Glycogen synthase kinase-3 beta Kinase Kd 5.59 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit delta Kinase Kd 5.34 CHEMBL
Serine/threonine-protein kinase Chk1 Kinase Kd 6.27 CHEMBL
cGMP-dependent protein kinase 2 Kinase Kd 5.51 CHEMBL
cAMP-dependent protein kinase catalytic subunit beta Kinase Kd 5.49 CHEMBL
Protein kinase C eta type Kinase Kd 5.74 CHEMBL
Serine/threonine-protein kinase N1 Kinase Kd 6.46 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 2 Kinase Kd 6.54 CHEMBL
Protein kinase C beta type Kinase IC50 8.33 CHEMBL
Protein kinase C alpha type Kinase IC50 6.44 CHEMBL
Serine/threonine-protein kinase 3 Kinase Kd 7.05 CHEMBL
Protein kinase C (PKC) Kinase IC50 6.49 CHEMBL

External reference:

IDSource
6V860VW8AO UNII
192050-59-2 SECONDARY_CAS_RN
8108 INN_ID
4025269 VANDF
CHEMBL91829 ChEMBL_ID
DB11829 DRUGBANK_ID
153999 PUBCHEM_CID
5263 IUPHAR_LIGAND_ID
C099154 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None