rapacuronium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
neuromuscular blocking agents with rigid structure 3520 156137-99-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Org-9487
  • Org 9487
  • Org9487
  • rapacuronium bromide
  • raplon
  • rapacuronium
a nondepolarizing neuromuscular blocking agent with a rapid onset of action acts by competing for cholinergic receptors at the motor end plate
  • Molecular weight: 597.90
  • Formula: C37H61N2O4
  • CLOGP: 5.64
  • LIPINSKI: 2
  • HAC: 6
  • HDO: 0
  • TPSA: 55.84
  • ALOGS: -8.13
  • ROTB: 9

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 18, 1999 FDA ORGANON USA INC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D009465 Neuromuscular Agents
MeSH PA D009466 Neuromuscular Blocking Agents
MeSH PA D003473 Neuromuscular Nondepolarizing Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Muscle relaxation, function indication 11977004
General anesthesia indication 50697003
Skeletal Muscle Relaxation for Endotracheal Intubation indication
Skeletal Muscle Relaxation for Endotracheal Intubation in C-Section indication
Eaton-Lambert syndrome contraindication 56989000 DOID:0050214
Myasthenia gravis contraindication 91637004 DOID:437
Disease of liver contraindication 235856003 DOID:409

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscle-type nicotinic acetylcholine receptor Ion channel ANTAGONIST CHEMBL SCIENTIFIC LITERATURE

External reference:

IDSource
4021207 VUID
N0000148653 NUI
D05703 KEGG_DRUG
465499-11-0 SECONDARY_CAS_RN
4021206 VANDF
4021207 VANDF
C0219598 UMLSCUI
CHEBI:135845 CHEBI
CHEMBL1200549 ChEMBL_ID
CHEMBL1201352 ChEMBL_ID
DB04834 DRUGBANK_ID
C082938 MESH_SUPPLEMENTAL_RECORD_UI
7635 INN_ID
GG1LBM463S UNII
5311398 PUBCHEM_CID
228530 RXNORM
31315 MMSL
8291 MMSL
d04450 MMSL
007881 NDDF
013422 NDDF
116106006 SNOMEDCT_US
763001001 SNOMEDCT_US
764600006 SNOMEDCT_US

Pharmaceutical products:

None