DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
abarelix ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
gonadotropin-releasing-hormone (GnRH) inhibitors, peptides
35
183552-38-7
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
abarelix
plenaxis
PPI-149
R3827
Molecular weight: 1416.09
Formula: C72H95ClN14O14
CLOGP: 0.47
LIPINSKI: 3
HAC: 28
HDO: 13
TPSA: 424.98
ALOGS: -5.58
ROTB: 38
Drug dosage:
Dose
Unit
Route
3.60
mg
P
ADMET properties:
Show
10
25
50
100
entries
Search:
Property
Value
Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)
0.03 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Showing 1 to 1 of 1 entries
Previous
1
Next
Approvals:
Show
10
25
50
100
entries
Search:
Date
Agency
Company
Orphan
Nov. 25, 2003
FDA
SPECIALITY EUROPEAN
Showing 1 to 1 of 1 entries
Previous
1
Next
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
Show
10
25
50
100
entries
Search:
Source
Code
Description
ATC
L02BX01
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ENDOCRINE THERAPY
HORMONE ANTAGONISTS AND RELATED AGENTS
Other hormone antagonists and related agents
CHEBI has role
CHEBI:35610
antineoplastic agents
CHEBI has role
CHEBI:49020
hormone antagonists
MeSH PA
D006727
Hormone Antagonists
Showing 1 to 4 of 4 entries
Previous
1
Next
Drug Use
| Suggest Off label Use Form|
|View source of the data|
Show
10
25
50
100
entries
Search:
Disease
Relation
SNOMED_ID
DOID
Ischemic priapism
indication
441575009
Prolonged QT interval
contraindication
111975006
Liver function tests abnormal
contraindication
166603001
Pregnancy, function
contraindication
289908002
Breastfeeding (mother)
contraindication
413712001
Obesity
contraindication
414916001
DOID:9970
Showing 1 to 6 of 6 entries
Previous
1
Next
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
Show
10
25
50
100
entries
Search:
Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
9.32
acidic
pKa2
12.48
acidic
pKa3
12.52
acidic
pKa4
13.01
acidic
pKa5
13.47
acidic
pKa6
13.53
acidic
pKa7
9.93
Basic
pKa8
5.35
Basic
Showing 1 to 8 of 8 entries
Previous
1
Next
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
Show
10
25
50
100
entries
Search:
Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Gonadotropin-releasing hormone receptor
GPCR
P30968
GNRHR_HUMAN
ANTAGONIST
Ki
9.49
IUPHAR
CHEMBL
Showing 1 to 1 of 1 entries
Previous
1
Next
External reference:
Show
10
25
50
100
entries
Search:
ID
Source
008459
NDDF
1188
IUPHAR_LIGAND_ID
16131215
PUBCHEM_CID
17679
MMSL
301739
RXNORM
4021410
VUID
4021410
VANDF
407128008
SNOMEDCT_US
407129000
SNOMEDCT_US
47872
MMSL
Showing 1 to 10 of 20 entries
Previous
1
2
Next
Pharmaceutical products:
None
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
abarelix