polyestradiol phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
estrogens	3482	28014-46-2

Description:

Molecule

Description

Synonyms:

polyestradiol phosphate
estradurin
polyestrol phosphate

polymeric phosphoric acid ester of estradiol

Molecular weight:
Formula: H3O3P(C18H23O5P)n
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
6	mg	P

ADMET properties:

Property	Value	Reference
S (Water solubility)	0.01 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
April 17, 1957	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L02AA02	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ENDOCRINE THERAPY HORMONES AND RELATED AGENTS Estrogens
FDA CS	M0447348	Estradiol Congeners
FDA MoA	N0000000100	Estrogen Receptor Agonists
MeSH PA	D004967	Estrogens
MeSH PA	D006728	Hormones
FDA EPC	N0000175825	Estrogen
CHEBI has role	CHEBI:50114	estrogens
CHEBI has role	CHEBI:62872	quinoline oxidase inhibitors
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:83056	Daphnia magna metabolites
CHEBI has role	CHEBI:176497	geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Estrogen receptor	Nuclear hormone receptor	P03372	ESR1_HUMAN	AGONIST				CHEMBL	CHEMBL

External reference:

ID	Source
4018486	VUID
N0000179213	NUI
D07434	KEGG_DRUG
4017609	VANDF
4018486	VANDF
4021205	VANDF
C0071554	UMLSCUI
CHEBI:16469	CHEBI
EST	PDB_CHEM_ID
CHEMBL1201477	ChEMBL_ID
DB09369	DRUGBANK_ID
C008958	MESH_SUPPLEMENTAL_RECORD_UI
4009	INN_ID
P14877CDX2	UNII
DB00783	DRUGBANK_ID
34120	RXNORM
4684	MMSL
6157	MMSL
73244	MMSL
8602	MMSL
d00537	MMSL
001265	NDDF
001268	NDDF
126084009	SNOMEDCT_US
126172005	SNOMEDCT_US
12839006	SNOMEDCT_US
C0014912	UMLSCUI
406	INN_ID
68579	PUBCHEM_CID
5757	PUBCHEM_CID
D004958	MESH_DESCRIPTOR_UI

Pharmaceutical products:

None