phosphocreatine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3464 67-07-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phosphocreatine
  • N-Phosphorocreatine
  • N-Phosphorylcreatine
  • phosphorylcreatine
  • fosfocreatine
An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1996)
  • Molecular weight: 211.11
  • Formula: C4H10N3O5P
  • CLOGP: -1.73
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 5
  • TPSA: 133.95
  • ALOGS: -1.78
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01EB06 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
OTHER CARDIAC PREPARATIONS
Other cardiac preparations
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.09 acidic
pKa2 2.62 acidic
pKa3 5.14 acidic
pKa4 11.41 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C0031634 UMLSCUI
CHEBI:17287 CHEBI
CHEMBL1204644 ChEMBL_ID
DB13191 DRUGBANK_ID
D010725 MESH_DESCRIPTOR_UI
020IUV4N33 UNII
9548602 PUBCHEM_CID

Pharmaceutical products:

None