ornithine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3401 | 70-26-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:62868 | hepatoprotective agents |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:84735 | algal metabolites |
| CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:83056 | Daphnia magna metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Female Facial Hirsutism | indication | ||
| Eruption of skin | contraindication | 271807003 | DOID:0050486 |
| Skin irritation | contraindication | 367466007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.85 | acidic |
| pKa2 | 10.19 | Basic |
| pKa3 | 9.23 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| G-protein coupled receptor family C group 6 member A | GPCR | AGONIST | EC50 | 4 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| N0000006781 | NUI |
| D08302 | KEGG_DRUG |
| 4020565 | VANDF |
| C0029277 | UMLSCUI |
| CHEBI:18257 | CHEBI |
| ORN | PDB_CHEM_ID |
| CHEMBL446143 | ChEMBL_ID |
| 6262 | PUBCHEM_CID |
| DB00129 | DRUGBANK_ID |
| D009952 | MESH_DESCRIPTOR_UI |
| 6167 | INN_ID |
| 725 | IUPHAR_LIGAND_ID |
| E524N2IXA3 | UNII |
| 314709 | RXNORM |
| 003541 | NDDF |
| 8514004 | SNOMEDCT_US |
Pharmaceutical products:
None