ornithine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3401 70-26-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ornithine
  • L-Ornithine
  • (S)-2,5-Diaminopentanoic acid
  • (S)-Ornithine
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
  • Molecular weight: 132.16
  • Formula: C5H12N2O2
  • CLOGP: -2.85
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 89.34
  • ALOGS: 0.11
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.254 High 0.86
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.541 High 0.86
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.843 10^-6 cm/s High 0.86
dh-clint Dog hepatocyte intrinsic clearance 1.500 uL/min/10^6 cells High 0.86
dppb Dog plasma protein binding (% unbound) 91.570 % High 0.86
fcs-ppb Fetal calf serum protein binding (% unbound) 39.840 % High 0.86
herg hERG pIC50 5.319 pIC50 High 0.86
hh-clint Human hepatocyte intrinsic clearance 1.172 uL/min/10^6 cells High 0.86
hlm-clint Human liver microsomal intrinsic clearance 8.954 uL/min/mg protein High 0.86
hppb Human plasma protein binding (% unbound) 93.160 % High 0.86
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,IKBKB,ITK,JAK3,KDR,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK1,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,ZAP70 40
kinase-selectivity-class AXL,CAMK2D,CDK4,CDK9,CHUK,EIF2AK3,GRK2,MAP2K6,MAPK7,STK33,SYK,TEK,TGFBR1 13
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 3.006 High 0.86
mh-clint Mouse hepatocyte intrinsic clearance 1.770 High 0.86
mppb Mouse plasma protein binding (% unbound) 97.130 High 0.86
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.135 High 0.86
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 95.580 % High 0.86
rh-clint Rat hepatocyte intrinsic clearance 4.305 uL/min/10^6 cells High 0.86
rh-fuinc Rat hepatocyte fraction unbound in incubation 76.270 % High 0.86
rppb Rat plasma protein binding (% unbound) 98.560 % High 0.86
solubility-dd Solubility at pH 7.4 in DMSO 425.598 uM High 0.86

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:84735 algal metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:83056 <em>Daphnia magna</em> metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Female Facial Hirsutism indication
Eruption of skin contraindication 271807003 DOID:0050486
Skin irritation contraindication 367466007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.85 acidic
pKa2 10.19 Basic
pKa3 9.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
G-protein coupled receptor family C group 6 member A GPCR AGONIST EC50 4 IUPHAR

External reference:

IDSource
N0000006781 NUI
D08302 KEGG_DRUG
4020565 VANDF
C0029277 UMLSCUI
CHEBI:18257 CHEBI
ORN PDB_CHEM_ID
CHEMBL446143 ChEMBL_ID
6262 PUBCHEM_CID
DB00129 DRUGBANK_ID
D009952 MESH_DESCRIPTOR_UI
6167 INN_ID
E524N2IXA3 UNII
314709 RXNORM
003541 NDDF
725 IUPHAR_LIGAND_ID
8514004 SNOMEDCT_US
E524N2IXA3 INXIGHT DRUGS

Pharmaceutical products:

None