octopamine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
dopaminergic agents dopamine derivatives used as cardiac stimulant/antihypertensives/diuretics 3396 104-14-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • octopamine
  • DL-Octopamine
  • norden
  • norphen
  • norsympathol
  • norsympatol
  • norsynephrine
  • racemic octopamine
  • p-Hydroxyphenylethanolamine
  • p-Octopamine
  • octopamine hydrochloride
  • octopamine HCl
An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.
  • Molecular weight: 153.18
  • Formula: C8H11NO2
  • CLOGP: -0.39
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 66.48
  • ALOGS: -0.95
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CA18 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014662 Vasoconstrictor Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.66 acidic
pKa2 13.67 acidic
pKa3 8.86 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 3A Ion channel EC50 7.62 CHEMBL
Trace amine-associated receptor 1 GPCR AGONIST EC50 5.80 IUPHAR
TyR1 GPCR EC50 6.01 CHEMBL
Trace amine-associated receptor 1 GPCR AGONIST EC50 5.90 IUPHAR
Trace amine-associated receptor 1 GPCR AGONIST EC50 5.80 IUPHAR

External reference:

IDSource
N0000166811 NUI
C0028403 UMLSCUI
D00178 KEGG_DRUG
14O50WS8JD UNII
3653 INN_ID
770-05-8 SECONDARY_CAS_RN
96261002 SNOMEDCT_US
1311141 RXNORM
4581 PUBCHEM_CID
CHEBI:17134 CHEBI
CHEMBL53929 ChEMBL_ID
CHEMBL1367565 ChEMBL_ID
D009655 MESH_DESCRIPTOR_UI
DB13251 DRUGBANK_ID
2149 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Viatrexx-Neuro 3 HUMAN PRESCRIPTION DRUG LABEL 15 73069-373 INJECTION 201 [kp_C] INTRAVENOUS unapproved drug other 11 sections