octopamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
dopaminergic agents dopamine derivatives used as cardiac stimulant/antihypertensives/diuretics	3396	104-14-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: octopamine DL-Octopamine norden norphen norsympathol norsympatol norsynephrine racemic octopamine p-Hydroxyphenylethanolamine p-Octopamine octopamine hydrochloride octopamine HCl	An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates. Molecular weight: 153.18 Formula: C8H11NO2 CLOGP: -0.39 LIPINSKI: 0 HAC: 3 HDO: 3 TPSA: 66.48 ALOGS: -0.95 ROTB: 2

Molecule

Description

Molfile Inchi Smiles

Synonyms:

octopamine
DL-Octopamine
norden
norphen
norsympathol
norsympatol
norsynephrine
racemic octopamine
p-Hydroxyphenylethanolamine
p-Octopamine
octopamine hydrochloride
octopamine HCl

An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.

Molecular weight: 153.18
Formula: C8H11NO2
CLOGP: -0.39
LIPINSKI: 0
HAC: 3
HDO: 3
TPSA: 66.48
ALOGS: -0.95
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C01CA18	CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Adrenergic and dopaminergic agents
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D000322	Adrenergic Agonists
MeSH PA	D000316	Adrenergic alpha-Agonists
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D014662	Vasoconstrictor Agents
CHEBI has role	CHEBI:25512	neurotransmitters

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.66	acidic
pKa2	13.67	acidic
pKa3	8.86	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
5-hydroxytryptamine receptor 3A	Ion channel	P46098	5HT3A_HUMAN		EC50	7.62	CHEMBL
Trace amine-associated receptor 1	GPCR	Q96RJ0	TAAR1_HUMAN	AGONIST	EC50	5.80	IUPHAR
Trace amine-associated receptor 1	GPCR		TAAR1_RAT	AGONIST	EC50	5.90	IUPHAR
Trace amine-associated receptor 1	GPCR		TAAR1_MOUSE	AGONIST	EC50	5.80	IUPHAR
TyR1	GPCR		H9TVJ1_9NEOP		EC50	6.01	CHEMBL

External reference:

ID	Source
N0000166811	NUI
D00178	KEGG_DRUG
C0028403	UMLSCUI
CHEBI:141486	CHEBI
CHEMBL53929	ChEMBL_ID
DB13251	DRUGBANK_ID
D009655	MESH_DESCRIPTOR_UI
4581	PUBCHEM_CID
3653	INN_ID
2149	IUPHAR_LIGAND_ID
770-05-8	SECONDARY_CAS_RN
14O50WS8JD	UNII
1311141	RXNORM
96261002	SNOMEDCT_US
CHEMBL1367565	ChEMBL_ID

Pharmaceutical products:

None