neridronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| calcium metabolism regulator, pharmaceutical aid | 3377 | 79778-41-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
used for therapy of Paget's disease of bone & malignant hypercalcaemia
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Humoral hypercalcemia of malignancy | indication | 47709007 | |
| Osteoporosis | indication | 64859006 | DOID:11476 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.56 | acidic |
| pKa2 | 5.63 | acidic |
| pKa3 | 6.61 | acidic |
| pKa4 | 10.9 | acidic |
| pKa5 | 12.94 | acidic |
| pKa6 | 10.27 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Farnesyl pyrophosphate synthase | Enzyme | Ki | 7.20 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C1882065 | UMLSCUI |
| CHEBI:135145 | CHEBI |
| NRD | PDB_CHEM_ID |
| CHEMBL55214 | ChEMBL_ID |
| DB11620 | DRUGBANK_ID |
| C053389 | MESH_SUPPLEMENTAL_RECORD_UI |
| 71237 | PUBCHEM_CID |
| 6463 | INN_ID |
| 8U27U3RIN4 | UNII |
Pharmaceutical products:
None