ibufenac 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibufenac derivatives 3293 1553-60-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ibufenac
  • 4-Isobutylphenylacetic acid
  • dytransin
  • ibunac
  • isodilan
used in the treatment of rheumatism; also possesses antipyretic properties; minor descriptor (75-84); on-line & Index Medicus search PHENYLACETATES (75-84); RN given refers to parent cpd
  • Molecular weight: 192.26
  • Formula: C12H16O2
  • CLOGP: 3.37
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -3.47
  • ROTB: 4

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35544 cyclooxygenase inhibitors
CHEBI has role CHEBI:50908 agente hepatotoxico

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.4 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme IC50 5.26 CHEMBL

External reference:

IDSource
D01963 KEGG_DRUG
C0063266 UMLSCUI
CHEBI:76158 CHEBI
CHEMBL341812 ChEMBL_ID
15250 PUBCHEM_CID
1649 INN_ID
C100118 MESH_SUPPLEMENTAL_RECORD_UI
5V4WIX44VI UNII

Pharmaceutical products:

None