hydroquinone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3282 123-31-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • 1,4-Benzenediol
  • hydroquinone
  • benzene-1,4-diol
  • idrochinone
skin depigmentation agent
  • Molecular weight: 110.11
  • Formula: C6H6O2
  • CLOGP: 0.81
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -0.06
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 18, 2002 FDA GALDERMA LABS LP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Squamous cell carcinoma of skin 199.60 36.53 35 403 5143 50599543
Skin atrophy 112.86 36.53 21 417 4224 50600462
Neoplasm skin 89.13 36.53 14 424 1026 50603660
Ochronosis 63.80 36.53 7 431 26 50604660
Product use in unapproved indication 47.46 36.53 22 416 115797 50488889

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Squamous cell carcinoma of skin 185.23 42.41 35 335 11841 64486521
Skin atrophy 118.49 42.41 21 349 4899 64493463
Neoplasm skin 92.96 42.41 14 356 1183 64497179
Ochronosis 85.05 42.41 9 361 37 64498325
Product use in unapproved indication 47.34 42.41 22 348 176596 64321766

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AX11 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
MeSH PA D000975 Antioxidants
MeSH PA D009153 Mutagens
MeSH PA D009676 Noxae
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
FDA MoA N0000175850 Melanin Synthesis Inhibitors
FDA PE N0000175851 Depigmenting Activity
FDA EPC N0000175854 Melanin Synthesis Inhibitor
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:50903 carcinogen
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76967 human xenobiotic metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:85046 skin lightening agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Discoloration of skin indication 3253007
Chloasma indication 36209000
Facial Hyperpigmentation indication
Sunburn contraindication 23346002
Eczema contraindication 43116000
Telangiectasia disorder contraindication 247479008
Pregnancy, function contraindication 289908002
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.26 acidic
pKa2 11.59 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme Ki 7.05 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 4.97 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 4.97 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.49 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.11 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 4.85 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 4.90 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.09 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 4.38 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 4.13 CHEMBL
Acetylcholinesterase Enzyme Ki 8.91 CHEMBL
Polyphenol oxidase 2 Enzyme IC50 5.01 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 4.97 CHEMBL
Carbonic anhydrase Enzyme Ki 5.23 CHEMBL

External reference:

IDSource
XV74C1N1AE UNII
4018886 VUID
N0000147180 NUI
D00073 KEGG_DRUG
4018886 VANDF
C0020306 UMLSCUI
CHEBI:17594 CHEBI
HQE PDB_CHEM_ID
CHEMBL537 ChEMBL_ID
785 PUBCHEM_CID
DB09526 DRUGBANK_ID
C031927 MESH_SUPPLEMENTAL_RECORD_UI
5509 RXNORM
1507 MMSL
4849 MMSL
002019 NDDF
387422001 SNOMEDCT_US
74583006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Differin Dark Spot Correcting Serum HUMAN OTC DRUG LABEL 1 0299-4608 SOLUTION 2 g TOPICAL OTC monograph not final 9 sections
TRI-LUMA HUMAN PRESCRIPTION DRUG LABEL 3 0299-5950 CREAM 40 mg TOPICAL NDA 24 sections
TRI-LUMA HUMAN PRESCRIPTION DRUG LABEL 3 0299-5950 CREAM 40 mg TOPICAL NDA 24 sections
hydroquinone HUMAN PRESCRIPTION DRUG LABEL 1 10135-724 CREAM 40 mg TOPICAL unapproved drug other 19 sections
Proactiv Advanced Dark Spot Correcting Serum HUMAN OTC DRUG LABEL 1 11410-045 LIQUID 20 mg TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
Proactiv Advanced Dark Spot Correcting Serum HUMAN OTC DRUG LABEL 1 11410-045 LIQUID 20 mg TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
Skin LighteningRodan Fields HUMAN OTC DRUG LABEL 1 14222-1615 LIQUID 2 mL TOPICAL OTC monograph not final 8 sections
Skin Beautifying Milk HUMAN OTC DRUG LABEL 1 16708-001 CREAM 0.02 g TOPICAL OTC monograph not final 11 sections
Medicated Fade Creme with Sunscreen HUMAN OTC DRUG LABEL 2 16708-002 CREAM 0.02 g TOPICAL OTC monograph not final 10 sections
Advanced Lightning HUMAN OTC DRUG LABEL 2 24623-042 CREAM 0.02 g TOPICAL OTC MONOGRAPH NOT FINAL 11 sections
Hydroquinone cream HUMAN PRESCRIPTION DRUG LABEL 1 24689-101 CREAM 40 mg TOPICAL unapproved drug other 11 sections
Hydroquinone HUMAN PRESCRIPTION DRUG LABEL 1 24979-141 CREAM 40 mg TOPICAL Unapproved drug other 21 sections
hydroquinone time release HUMAN PRESCRIPTION DRUG LABEL 1 24979-144 CREAM 40 mg TOPICAL Unapproved drug other 21 sections
Hydro-Q HUMAN PRESCRIPTION DRUG LABEL 1 30815-0040 GEL 40 mg TOPICAL UNAPPROVED DRUG OTHER 17 sections
HYDROQUINONE 4% HUMAN PRESCRIPTION DRUG LABEL 1 42192-151 CREAM 40 mg TOPICAL unapproved drug other 21 sections
Hydroquinone HUMAN PRESCRIPTION DRUG LABEL 1 42582-700 CREAM 40 mg TOPICAL UNAPPROVED DRUG OTHER 22 sections
MELAMIN Skin Bleaching and Correcting HUMAN PRESCRIPTION DRUG LABEL 1 42851-030 CREAM 0.04 g TOPICAL UNAPPROVED DRUG OTHER 9 sections
MELAMIX Skin Lightener and Blending HUMAN PRESCRIPTION DRUG LABEL 1 42851-031 CREAM 0.04 g TOPICAL UNAPPROVED DRUG OTHER 13 sections
MELAMIN Skin Bleaching and Correcting Hydroquinone HUMAN PRESCRIPTION DRUG LABEL 1 42851-032 CREAM 0.04 g TOPICAL UNAPPROVED DRUG OTHER 10 sections
MELAMIX Skin Lightener and Blending HUMAN PRESCRIPTION DRUG LABEL 1 42851-033 CREAM 0.04 g TOPICAL UNAPPROVED DRUG OTHER 7 sections
ZO MEDICAL MELAMIN-C Skin Bleaching and Correcting with Vitamin C Hydroquinone HUMAN PRESCRIPTION DRUG LABEL 1 42851-034 CREAM 0.04 g TOPICAL Export only 18 sections
ZO Skin Health Pigment Control plus Brightening Creme Hydroquinone plus Vitamin C HUMAN PRESCRIPTION DRUG LABEL 1 42851-035 EMULSION 0.04 mg TOPICAL UNAPPROVED DRUG OTHER 5 sections
ZO Skin Health Pigment Control plus Brightening Creme Hydroquinone plus Vitamin C HUMAN PRESCRIPTION DRUG LABEL 1 42851-035 EMULSION 0.04 mg TOPICAL UNAPPROVED DRUG OTHER 5 sections
ZO Skin Health Pigment Control plus Blending Creme Hydroquinone HUMAN PRESCRIPTION DRUG LABEL 1 42851-036 EMULSION 0.04 g TOPICAL UNAPPROVED DRUG OTHER 5 sections
ZO Skin Health Pigment Control plus Blending Creme Hydroquinone HUMAN PRESCRIPTION DRUG LABEL 1 42851-036 EMULSION 0.04 g TOPICAL UNAPPROVED DRUG OTHER 5 sections
ZO Skin Health Pigment Control Creme Hydroquinone HUMAN PRESCRIPTION DRUG LABEL 1 42851-037 EMULSION 40 mg TOPICAL Unapproved drug other 5 sections
ZO Skin Health Pigment Control Creme Hydroquinone HUMAN PRESCRIPTION DRUG LABEL 1 42851-037 EMULSION 40 mg TOPICAL Unapproved drug other 5 sections
ZO Skin Health Pigment Control Creme Hydroquinone HUMAN OTC DRUG LABEL 1 42851-038 LOTION 20 mg TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
ZO Skin Health Pigment Control Creme Hydroquinone HUMAN OTC DRUG LABEL 1 42851-038 LOTION 20 mg TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
ZO Skin Health Pigment Control Plus Blending Creme Hydroquinone HUMAN OTC DRUG LABEL 1 42851-039 LOTION 20 mg TOPICAL OTC MONOGRAPH NOT FINAL 13 sections