DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
fospropofol 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
insecticides, anthelminthics, pesticides etc., phosphorous derivatives
3249
258516-89-1
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
fospropofol sodium
fospropofol
fospropofol disodium
lusedra
Molecular weight: 288.28
Formula: C13H21O5P
CLOGP: 1.73
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 75.99
ALOGS: -2.98
ROTB: 6
Status: OFM
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)
1
Bocci G, Oprea TI, Benet LZ
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Approvals:
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Date
Agency
Company
Orphan
Dec. 12, 2008
FDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D002492
Central Nervous System Depressants
MeSH PA
D006993
Hypnotics and Sedatives
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Sedation as Adjunct to Anesthesia
indication
Apnea
contraindication
1023001
Hypovolemia
contraindication
28560003
Low blood pressure
contraindication
45007003
Decreased respiratory function
contraindication
80954004
Myocardial dysfunction
contraindication
233928007
Hypoxia
contraindication
389086002
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
2.39
acidic
pKa2
7.44
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
GABA-A receptor
Ion channel
O14764
P14867
P18505
P18507
P28472
P31644
P34903
P47869
P47870
P48169
Q16445
Q8N1C3
Q99928
GBRD_HUMAN
GBRA1_HUMAN
GBRB1_HUMAN
GBRG2_HUMAN
GBRB3_HUMAN
GBRA5_HUMAN
GBRA3_HUMAN
GBRA2_HUMAN
GBRB2_HUMAN
GBRA4_HUMAN
GBRA6_HUMAN
GBRG1_HUMAN
GBRG3_HUMAN
POSITIVE ALLOSTERIC MODULATOR
DRUG LABEL
DRUG LABEL
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External reference:
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ID
Source
013314
NDDF
013315
NDDF
159531
MMSL
258516-87-9
SECONDARY_CAS_RN
26076
MMSL
3038498
PUBCHEM_CID
4028230
VUID
4028230
VANDF
4028231
VANDF
714706007
SNOMEDCT_US
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Pharmaceutical products:
None
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Structure 🔎
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L1000
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fospropofol