fospropofol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
insecticides, anthelminthics, pesticides etc., phosphorous derivatives 3249 258516-89-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fospropofol sodium
  • fospropofol
  • fospropofol disodium
  • lusedra
  • Molecular weight: 288.28
  • Formula: C13H21O5P
  • CLOGP: 1.73
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.99
  • ALOGS: -2.98
  • ROTB: 6
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 59
kinase-selectivity-class AXL,BRAF,CDK9,DDR1,EPHB4,FLT3,GRK2,MAP2K6,MAP3K1,MAPK7,STK33,SYK,TEK,ZAP70 14
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Dec. 12, 2008 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sedation as Adjunct to Anesthesia indication
Apnea contraindication 1023001
Hypovolemia contraindication 28560003
Low blood pressure contraindication 45007003
Decreased respiratory function contraindication 80954004
Myocardial dysfunction contraindication 233928007
Hypoxia contraindication 389086002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.39 acidic
pKa2 7.44 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-A receptor Ion channel POSITIVE ALLOSTERIC MODULATOR DRUG LABEL DRUG LABEL

External reference:

IDSource
4028230 VUID
N0000177942 NUI
D04257 KEGG_DRUG
4028230 VANDF
4028231 VANDF
C2370726 UMLSCUI
CHEBI:135193 CHEBI
CHEMBL1201766 ChEMBL_ID
CHEMBL2021422 ChEMBL_ID
DB06716 DRUGBANK_ID
C472965 MESH_SUPPLEMENTAL_RECORD_UI
3038498 PUBCHEM_CID
7475 IUPHAR_LIGAND_ID
8696 INN_ID
258516-87-9 SECONDARY_CAS_RN
LZ257RZP7K UNII
813021 RXNORM
159531 MMSL
26076 MMSL
d07370 MMSL
013314 NDDF
013315 NDDF
714706007 SNOMEDCT_US
764594003 SNOMEDCT_US
A1LZU PDB_CHEM_ID

Pharmaceutical products:

None