fosfestrol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
estrogens 3248 522-40-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fosfestrol
  • diethyldihydroxystilbene diphosphate
  • diethylstilbesterol bisphosphate
  • diethylstilbesterol diphosphate
  • diethylstilbestrol diphosphate
  • diethylstilbestryl bisphosphate
  • diethylstilbestryl diphosphate
  • phosphestrol
  • stilbestrol diphosphate
  • stilphostrol
Rx of prostatic carcinoma; RN given refers to parent cpd with unspecified isomeric designation; structure
  • Molecular weight: 428.31
  • Formula: C18H22O8P2
  • CLOGP: 1
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 4
  • TPSA: 133.52
  • ALOGS: -4.32
  • ROTB: 8
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.25 g O
0.25 g P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA BAYER PHARMS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L02AA04 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ENDOCRINE THERAPY
HORMONES AND RELATED AGENTS
Estrogens
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.91 acidic
pKa2 1.51 acidic
pKa3 5.96 acidic
pKa4 6.56 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Estrogen receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4017428 VUID
N0000179139 NUI
D00946 KEGG_DRUG
4017428 VANDF
C0060692 UMLSCUI
CHEBI:4532 CHEBI
CHEMBL1200598 ChEMBL_ID
C004955 MESH_SUPPLEMENTAL_RECORD_UI
3032325 PUBCHEM_CID
1824 INN_ID
A0E0NMA80F UNII
225040 RXNORM
1755 MMSL
4592 MMSL
001276 NDDF
395979004 SNOMEDCT_US

Pharmaceutical products:

None