benziodarone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antiarrhythmics | 321 | 68-90-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
minor descriptor (75-89); on-line & INDEX MEDICUS search BENZOFURANS (68-89) & IODOBENZOATES (74)
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.25 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
| S (Water solubility) | 0.01 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01DX04 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Other vasodilators used in cardiac diseases |
| ATC | C01DX54 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Other vasodilators used in cardiac diseases |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D006074 | Gout Suppressants |
| MeSH PA | D014528 | Uricosuric Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.81 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Baculoviral IAP repeat-containing protein 5 | Unclassified | Kd | 5.10 | CHEMBL | |||||
| Eyes absent homolog 3 | Enzyme | IC50 | 5.47 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01833 | KEGG_DRUG |
| C0053185 | UMLSCUI |
| CHEBI:135814 | CHEBI |
| PJO | PDB_CHEM_ID |
| CHEMBL232201 | ChEMBL_ID |
| DB13277 | DRUGBANK_ID |
| C058702 | MESH_SUPPLEMENTAL_RECORD_UI |
| 984 | INN_ID |
| 75CL65GTYR | UNII |
| 6237 | PUBCHEM_CID |
Pharmaceutical products:
None