eseridine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
acetylcholinesterase inhibitors 3186 25573-43-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • eseridine tartrate
  • eseridine salicylate
  • eserine oxide salicylate
  • eseridine
  • geneserine
  • eserine aminoxide
  • eserine oxide
  • physostigmine aminoxide
  • Molecular weight: 291.35
  • Formula: C15H21N3O3
  • CLOGP: 2.06
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 54.04
  • ALOGS: -2.30
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Indigestion indication 162031009

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.89 acidic
pKa2 7.96 Basic
pKa3 6.48 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholinesterase Enzyme IC50 6.82 CHEMBL
Cholinesterase Enzyme IC50 7.92 CHEMBL
Acetylcholinesterase Enzyme IC50 5.76 CHEMBL

External reference:

IDSource
D07914 KEGG_DRUG
5995-96-0 SECONDARY_CAS_RN
C0637914 UMLSCUI
CHEBI:4855 CHEBI
CHEMBL123248 ChEMBL_ID
CHEMBL539874 ChEMBL_ID
65719 PUBCHEM_CID
C060406 MESH_SUPPLEMENTAL_RECORD_UI
5758 INN_ID
LW9S78L4M8 UNII
005663 NDDF
005664 NDDF
768343004 SNOMEDCT_US

Pharmaceutical products:

None