eburnamonine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3170 474-00-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cervoxan
  • eburnamonine monohydrochloride
  • eburnamonine phosphate
  • eburnamonine
  • (+)-Eburnamonine
  • (+)-Vincamone
  • (+)-cis-Eburnamonine
  • d-Eburnamonine
  • Molecular weight: 294.40
  • Formula: C19H22N2O
  • CLOGP: 4.03
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 25.24
  • ALOGS: -3.23
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.88 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ALLOSTERIC MODULATOR Kd 5.20 IUPHAR
Muscarinic acetylcholine receptor M1 GPCR ALLOSTERIC MODULATOR Kd 5.10 IUPHAR
Muscarinic acetylcholine receptor M4 GPCR ALLOSTERIC MODULATOR Kd 4.60 IUPHAR
Muscarinic acetylcholine receptor M2 GPCR ALLOSTERIC MODULATOR Kd 4.20 IUPHAR

External reference:

IDSource
010904 NDDF
CHEBI:4740 CHEBI
NPD9S131ZU UNII
71203 PUBCHEM_CID
C016422 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None