benzarone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiarrhythmics 317 1477-19-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzarone
  • benzaron
antihemorrhagic agent; structure
  • Molecular weight: 266.30
  • Formula: C17H14O3
  • CLOGP: 4.64
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 50.44
  • ALOGS: -4.05
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.02 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.12 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 22 member 12 Transporter IC50 5.55 CHEMBL
Eyes absent homolog 3 Enzyme IC50 4.77 CHEMBL
Eyes absent homolog 3 Enzyme IC50 4.72 CHEMBL

External reference:

IDSource
18923 RXNORM
C0053152 UMLSCUI
CHEBI:34559 CHEBI
CHEMBL1474963 ChEMBL_ID
C004528 MESH_SUPPLEMENTAL_RECORD_UI
255968 PUBCHEM_CID
1426 INN_ID
23ZW4BG89C UNII

Pharmaceutical products:

None