desonide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
steroids for topical use, acetal derivatives	3135	638-94-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: desonide budesonide acetonide prednacinolone	A nonfluorinated corticosteroid anti-inflammatory agent used topically for DERMATOSES. Molecular weight: 416.51 Formula: C24H32O6 CLOGP: 2.37 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 93.06 ALOGS: -3.85 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

desonide
budesonide acetonide
prednacinolone

A nonfluorinated corticosteroid anti-inflammatory agent used topically for DERMATOSES.

Molecular weight: 416.51
Formula: C24H32O6
CLOGP: 2.37
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 93.06
ALOGS: -3.85
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 4, 1972	FDA	PERRIGO NEW YORK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	1119.94	25.29	280	4808	24096	63459838
Drug ineffective	244.55	25.29	352	4736	1044413	62439521
Chronic sinusitis	226.88	25.29	70	5018	12773	63471161
Paraesthesia oral	195.21	25.29	69	5019	19187	63464747
Procedural pain	187.57	25.29	69	5019	21500	63462434
Dermatitis atopic	154.93	25.29	49	5039	9675	63474259
Psoriasis	125.21	25.29	81	5007	86876	63397058
Vaginal flatulence	102.94	25.29	28	5060	3265	63480669
Dyspepsia	97.50	25.29	74	5014	102122	63381812
Proctitis	93.24	25.29	29	5059	5412	63478522
Therapeutic product effect incomplete	88.43	25.29	76	5012	124980	63358954
Radiculopathy	80.18	25.29	29	5059	8582	63475352
Female genital tract fistula	80.02	25.29	28	5060	7531	63476403
Vaginal discharge	78.31	25.29	29	5059	9169	63474765
Weight decreased	53.12	25.29	86	5002	276712	63207222
Oral candidiasis	53.07	25.29	29	5059	22769	63461165
Frequent bowel movements	52.81	25.29	29	5059	22993	63460941
Colitis ulcerative	52.08	25.29	30	5058	26061	63457873
Rectal haemorrhage	43.39	25.29	34	5054	48996	63434938
Cutaneous T-cell lymphoma	39.72	25.29	11	5077	1369	63482565
Nausea	39.20	25.29	153	4935	854318	62629616
Skin exfoliation	38.37	25.29	30	5058	43072	63440862
Infusion related reaction	37.49	25.29	69	5019	245452	63238482
Dry skin	36.96	25.29	33	5055	56854	63427080
Erythema	36.95	25.29	57	5031	175694	63308240
Haematochezia	34.66	25.29	31	5057	53513	63430421
Eczema	32.09	25.29	24	5064	32267	63451667
Colitis	31.22	25.29	28	5060	48500	63435434
Malaise	28.16	25.29	85	5003	415869	63068065
Iridoschisis	27.71	25.29	4	5084	14	63483920
Pyrexia	25.41	25.29	89	4999	470389	63013545

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Psoriasis	123.44	23.54	57	2234	38755	34915885
Dermatitis atopic	90.81	23.54	27	2264	5320	34949320
Dry skin	39.69	23.54	25	2266	31262	34923378
Drug ineffective	34.32	23.54	85	2206	456666	34497974
Pruritus	32.37	23.54	43	2248	141938	34812702
Product dose omission issue	31.60	23.54	39	2252	119672	34834968
Skin exfoliation	30.05	23.54	20	2271	27412	34927228
Hepatic lesion	27.43	23.54	10	2281	3702	34950938
Ocular hyperaemia	24.86	23.54	13	2278	11439	34943201

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	236.24	22.01	68	5502	11228	79727590
Chronic sinusitis	226.67	22.01	68	5502	12958	79725860
Paraesthesia oral	196.44	22.01	68	5502	20403	79718415
Procedural pain	188.45	22.01	68	5502	23016	79715802
Psoriasis	151.49	22.01	88	5482	89499	79649319
Dermatitis atopic	147.26	22.01	46	5524	10010	79728808
Vaginal flatulence	108.55	22.01	27	5543	2548	79736270
Dyspepsia	100.21	22.01	73	5497	108614	79630204
Therapeutic product effect incomplete	89.24	22.01	76	5494	141569	79597249
Female genital tract fistula	86.06	22.01	27	5543	5948	79732870
Vaginal discharge	84.13	22.01	28	5542	7435	79731383
Proctitis	84.10	22.01	27	5543	6405	79732413
Radiculopathy	75.73	22.01	27	5543	8797	79730021
Weight decreased	57.81	22.01	95	5475	355103	79383715
Oral candidiasis	52.36	22.01	30	5540	29598	79709220
Frequent bowel movements	49.78	22.01	29	5541	29510	79709308
Dry skin	47.97	22.01	39	5531	67956	79670862
Colitis ulcerative	47.94	22.01	30	5540	34712	79704106
Infusion related reaction	46.37	22.01	68	5502	230169	79508649
Cutaneous T-cell lymphoma	42.22	22.01	13	5557	2690	79736128
Rectal haemorrhage	42.07	22.01	38	5532	76262	79662556
Pruritus	39.72	22.01	86	5484	394562	79344256
Drug ineffective	36.32	22.01	160	5410	1080753	78658065
Pyrexia	32.95	22.01	113	5457	678596	79060222
Nausea	32.34	22.01	142	5428	957054	78781764
Product dose omission issue	32.11	22.01	60	5510	247477	79491341
Skin exfoliation	31.47	22.01	28	5542	55072	79683746
Pain	31.43	22.01	114	5456	703688	79035130
Malaise	29.61	22.01	88	5482	489781	79249037
Iridoschisis	28.26	22.01	4	5566	14	79738804
Application site pain	27.86	22.01	11	5559	4736	79734082
Erythema	27.56	22.01	53	5517	223237	79515581
Haematochezia	27.11	22.01	32	5538	87613	79651205
Eczema	25.84	22.01	22	5548	40796	79698022
Dry eye	25.65	22.01	21	5549	36910	79701908
Off label use	25.03	22.01	127	5443	907088	78831730
Colitis	24.74	22.01	28	5542	73279	79665539

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D07AB08	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II)
ATC	D07BB02	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, moderately potent, combinations with antiseptics
ATC	S01BA11	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
MeSH PA	D000893	Anti-Inflammatory Agents
CHEBI has role	CHEBI:35472	anti-inflammatory drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Otitis externa	indication	3135009
Atopic dermatitis	indication	24079001	DOID:3310
Crohn's disease	indication	34000006
Contact dermatitis	indication	40275004	DOID:2773
Seborrheic dermatitis	indication	50563003	DOID:8741
Lichen simplex chronicus	indication	53891004
Allergic rhinitis	indication	61582004
Granuloma annulare	indication	65508009	DOID:3777
Pruritus ani	indication	90446007
Asthma	indication	195967001	DOID:2841
Discoid lupus erythematosus	indication	200938002
Plaque psoriasis	indication	200965009
Scalp psoriasis	indication	238608008
Pruritus of genital organs	indication	267802000
Eruption of skin	indication	271807003	DOID:0050486
Primary cutaneous T-cell lymphoma	indication	400122007
Asthma management	indication	406162001
Crohn's disease in remission	indication	426549001
Allergic Rhinitis Prevention	indication
Chronic Non-Allergic Rhinitis	indication
Severe chronic obstructive pulmonary disease	off-label use	313299006
Otitis Externa Eczema	off-label use
Otitis Externa Seborrhea	off-label use
Infection by Strongyloides	contraindication	1214006	DOID:10955
Mycosis	contraindication	3218000	DOID:1564
Ocular hypertension	contraindication	4210003	DOID:9282
Gastritis	contraindication	4556007	DOID:4029
Inactive tuberculosis	contraindication	11999007
Epistaxis	contraindication	12441001
Peptic ulcer	contraindication	13200003	DOID:750
Hypercholesterolemia	contraindication	13644009
Measles	contraindication	14189004	DOID:8622
Disease caused by parasite	contraindication	17322007
Cirrhosis of liver	contraindication	19943007	DOID:5082
Arginase deficiency	contraindication	23501004	DOID:9278
Glaucoma	contraindication	23986001	DOID:1686
Acute tuberculosis	contraindication	25629007
Viral disease	contraindication	34014006	DOID:934
Immunosuppression	contraindication	38013005
Hypertensive disorder	contraindication	38341003	DOID:10763
Infectious disease	contraindication	40733004
Hypothyroidism	contraindication	40930008	DOID:1459
Hypokalemia	contraindication	43339004
Hypercortisolism	contraindication	47270006
Chronic heart failure	contraindication	48447003
Cerebral malaria	contraindication	53622003	DOID:14069
Tuberculosis	contraindication	56717001
Perforation of tympanic membrane	contraindication	60442001
Congenital hyperammonemia, type I	contraindication	62522004
Osteoporosis	contraindication	64859006	DOID:11476
Psychotic disorder	contraindication	69322001
Diabetes mellitus	contraindication	73211009	DOID:9351
Hypopituitarism	contraindication	74728003	DOID:9406
Perforation of nasal septum	contraindication	80142000
Hyperglycemia	contraindication	80394007	DOID:4195
Ornithine Carbamyltransferase Deficiency	contraindication	80908008	DOID:9271
Open-angle glaucoma	contraindication	84494001	DOID:1067
Bacterial infectious disease	contraindication	87628006
Muscle atrophy	contraindication	88092000	DOID:767
Herpes simplex	contraindication	88594005	DOID:8566
Operation on nose	contraindication	88733004
Bilateral cataracts	contraindication	95722004
Seizure disorder	contraindication	128613002
Disorder of muscle	contraindication	129565002	DOID:423
Pulmonary tuberculosis	contraindication	154283005	DOID:2957
Ophthalmic herpes simplex	contraindication	186542001
Anastomosis of intestine	contraindication	235407009
Disease of liver	contraindication	235856003	DOID:409
Telangiectasia disorder	contraindication	247479008
Edema	contraindication	267038008
Pathological fracture	contraindication	268029009
Diverticulitis of gastrointestinal tract	contraindication	271366000
Cerebral trauma	contraindication	275382005
Varicella-zoster virus infection	contraindication	309465005
Osteopenia	contraindication	312894000
Adrenal cortical hypofunction	contraindication	386584007	DOID:10493
Avascular necrosis of bone	contraindication	397758007	DOID:10159
Citrullinemia	contraindication	398680004	DOID:9273
Atrophoderma	contraindication	399979006
Peripheral vascular disease	contraindication	400047006
Traumatic rupture of tendon	contraindication	415749005
Exposure to varicella	contraindication	444453009
Nasal Candidiasis	contraindication
Untreated Fungal Infection	contraindication
Uncontrolled Bacterial Infections	contraindication
Nasal Septal Ulcers	contraindication
Nasal Trauma	contraindication
Arginosuccinate Lyase Deficiency	contraindication
Oropharyngeal Candidiasis	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.78	acidic
pKa2	12.78	acidic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
0.05%	VERDESO	ALMIRALL	N021978	Sept. 19, 2006	RX	AEROSOL, FOAM	TOPICAL	8962000	Aug. 31, 2025	TREATMENT OF ATOPIC DERMATITIS
0.05%	VERDESO	ALMIRALL	N021978	Sept. 19, 2006	RX	AEROSOL, FOAM	TOPICAL	9492384	Aug. 31, 2025	TREATMENT OF ATOPIC DERMATITIS
0.05%	VERDESO	ALMIRALL	N021978	Sept. 19, 2006	RX	AEROSOL, FOAM	TOPICAL	8460641	Aug. 13, 2027	TREATMENT OF ATOPIC DERMATITIS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST				CHEMBL	CHEMBL

External reference:

ID	Source
4018267	VUID
N0000146597	NUI
D03696	KEGG_DRUG
4018267	VANDF
C0011705	UMLSCUI
CHEBI:204734	CHEBI
CHEMBL1201109	ChEMBL_ID
D003898	MESH_DESCRIPTOR_UI
DB01260	DRUGBANK_ID
5311066	PUBCHEM_CID
7066	IUPHAR_LIGAND_ID
2889	INN_ID
J280872D1O	UNII
3254	RXNORM
1093	MMSL
4550	MMSL
002199	NDDF
412363005	SNOMEDCT_US
52215008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0115-1517	LOTION	0.50 mg	TOPICAL	ANDA	17 sections
desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0309	OINTMENT	0.50 mg	TOPICAL	ANDA	17 sections
desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0310	LOTION	0.50 mg	TOPICAL	ANDA	19 sections
DesOwen	HUMAN PRESCRIPTION DRUG LABEL	1	0299-5765	LOTION	0.50 mg	TOPICAL	ANDA	18 sections
DesOwen	HUMAN PRESCRIPTION DRUG LABEL	1	0299-5770	CREAM	0.50 mg	TOPICAL	NDA	18 sections
LoKara	HUMAN PRESCRIPTION DRUG LABEL	1	0462-0392	LOTION	0.50 mg	TOPICAL	ANDA	18 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0472-0803	LOTION	0.50 mg	TOPICAL	ANDA	19 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0472-0804	CREAM	0.50 mg	TOPICAL	NDA authorized generic	19 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0661	CREAM	0.50 mg	TOPICAL	ANDA	18 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0661	CREAM	0.50 mg	TOPICAL	ANDA	18 sections
DESONATE	HUMAN PRESCRIPTION DRUG LABEL	1	10922-828	GEL	0.50 mg	TOPICAL	NDA	24 sections
Verdeso	HUMAN PRESCRIPTION DRUG LABEL	1	16110-111	AEROSOL, FOAM	0.50 mg	TOPICAL	NDA	26 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	16714-729	CREAM	0.50 mg	TOPICAL	ANDA	21 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	16714-729	CREAM	0.50 mg	TOPICAL	ANDA	21 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	16714-828	OINTMENT	0.50 mg	TOPICAL	ANDA	20 sections
DESONIDE	HUMAN PRESCRIPTION DRUG LABEL	1	21695-944	CREAM	0.50 mg	TOPICAL	ANDA	21 sections
Desonide Ointment, 0.05%	HUMAN PRESCRIPTION DRUG LABEL	1	21922-004	OINTMENT	0.50 mg	TOPICAL	ANDA	18 sections
DESONIDE	HUMAN PRESCRIPTION DRUG LABEL	1	24470-920	GEL	0.50 mg	TOPICAL	ANDA	20 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	42254-142	CREAM	0.50 mg	TOPICAL	NDA	20 sections
DESRX	HUMAN PRESCRIPTION DRUG LABEL	1	44118-710	GEL	0.50 mg	TOPICAL	ANDA	20 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	45802-422	CREAM	0.50 mg	TOPICAL	NDA	20 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	45802-422	CREAM	0.50 mg	TOPICAL	NDA	20 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	45802-423	OINTMENT	0.50 mg	TOPICAL	NDA	20 sections
DESONATE	HUMAN PRESCRIPTION DRUG LABEL	1	50222-504	GEL	0.50 mg	TOPICAL	NDA	24 sections
DESONATE	HUMAN PRESCRIPTION DRUG LABEL	1	50419-828	GEL	0.50 mg	TOPICAL	NDA	24 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	50436-3300	CREAM	0.50 mg	TOPICAL	ANDA	18 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	51672-1280	CREAM	0.50 mg	TOPICAL	ANDA	21 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	51672-1280	CREAM	0.50 mg	TOPICAL	ANDA	21 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	51672-1281	OINTMENT	0.50 mg	TOPICAL	ANDA	21 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	51672-1281	OINTMENT	0.50 mg	TOPICAL	ANDA	21 sections