AI ASSISTANT
Ask DrugCentral
Explore drug information in your own words.
Type a question in the search bar above to get started. Each question is answered independently.
AI can make mistakes. Verify answers against the original sources before relying on them.
cinchophen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quinoline derivatives | 3101 | 132-60-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
| S (Water solubility) | 0.16 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BA (Bioavailability) | 87.21 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 0.047 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 3.105 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 65.917 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 4.753 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 1.100 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 1.910 | % | High | 1 |
| herg | hERG pIC50 | 4.029 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 4.966 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 2.965 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 0.540 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPK9,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1 | 44 | |||
| kinase-selectivity-class | ACVR2A,ACVR2B,AXL,BRAF,CDK9,DYRK1B,ERBB2,GRK2,MAP2K6,MAPK7,PRKDC,SIK2,STK33,TTK | 14 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 4.477 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 5.433 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 4.980 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.601 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | Moderate | 0.65 | |
| pppb | Pig plasma protein binding (% unbound) | 2.090 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 9.141 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 77.130 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 0.790 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 946.237 | uM | High | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | M04AC02 | MUSCULO-SKELETAL SYSTEM ANTIGOUT PREPARATIONS ANTIGOUT PREPARATIONS Preparations with no effect on uric acid metabolism |
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D000779 | Anesthetics, Local |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018689 | Sensory System Agents |
Related Drugs by ATC class:
M04AC Preparations with no effect on uric acid metabolism 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Gout | indication | 90560007 | DOID:13189 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.35 | acidic |
| pKa2 | 4.7 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Enzyme | Kd | 3.90 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07280 | KEGG_DRUG |
| C0008793 | UMLSCUI |
| CHEBI:114195 | CHEBI |
| CHEMBL348000 | ChEMBL_ID |
| DB13551 | DRUGBANK_ID |
| C084834 | MESH_SUPPLEMENTAL_RECORD_UI |
| 8593 | PUBCHEM_CID |
| 1332 | INN_ID |
| 39Y533Z02M | UNII |
| 61709008 | SNOMEDCT_US |
| D003992 | MESH_DESCRIPTOR_UI |
| 39Y533Z02M | INXIGHT DRUGS |
Pharmaceutical products:
None