choline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3097 62-49-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • choline chloride
  • choline
  • vitamin J
  • bilineurine
  • choline ion
  • choline bitartrate
A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
  • Molecular weight: 104.17
  • Formula: C5H14NO
  • CLOGP: -4.36
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -1.59
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000963 Antimetabolites
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents
MeSH PA D008082 Lipotropic Agents
MeSH PA D018697 Nootropic Agents
CHEBI has role CHEBI:25512 neurotransmitters
CHEBI has role CHEBI:33284 nutrients
CHEBI has role CHEBI:50904 alergeno
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:83056 Daphnia magna metabolites
CHEBI has role CHEBI:82655 animal growth promotants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Insomnia indication 193462001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholine receptor subunit delta Ion channel Ki 4.38 CHEMBL
High affinity choline transporter 1 Transporter IC50 5.80 CHEMBL
Neuronal acetylcholine receptor; alpha2/beta2 Ion channel Ki 4.74 CHEMBL
Neuronal acetylcholine receptor; alpha3/beta2 Ion channel Ki 4.43 CHEMBL
Neuronal acetylcholine receptor; alpha3/beta4 Ion channel Ki 4.32 CHEMBL
Neuronal acetylcholine receptor; alpha4/beta2 Ion channel Ki 4.43 CHEMBL
Neuronal acetylcholine receptor; alpha4/beta4 Ion channel Ki 4.47 CHEMBL
Creatine transporter Transporter Ki 4.38 CHEMBL

External reference:

IDSource
N91BDP6H0X UNII
4020078 VUID
N0000178902 NUI
D07690 KEGG_DRUG
67-48-1 SECONDARY_CAS_RN
87-67-2 SECONDARY_CAS_RN
4017687 VANDF
4017699 VANDF
4020077 VANDF
4020078 VANDF
C0008405 UMLSCUI
CHEBI:15354 CHEBI
CHT PDB_CHEM_ID
CHEMBL920 ChEMBL_ID
305 PUBCHEM_CID
DB00122 DRUGBANK_ID
CHEMBL282468 ChEMBL_ID
CHEMBL2105935 ChEMBL_ID
D002794 MESH_DESCRIPTOR_UI
4551 IUPHAR_LIGAND_ID
1425426 RXNORM
4436 MMSL
4437 MMSL
4875 MMSL
4880 MMSL
NOCODE MMSL
d03064 MMSL
d03159 MMSL
002058 NDDF
002059 NDDF
005105 NDDF
111156002 SNOMEDCT_US
387030006 SNOMEDCT_US
427976002 SNOMEDCT_US
65123005 SNOMEDCT_US
442 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NESTABSPrenatal Multi-vitamin/Mineral Supplement HUMAN PRESCRIPTION DRUG LABEL 15 50967-219 TABLET, FILM COATED 55 mg ORAL unapproved drug other 8 sections
Prenatrix HUMAN PRESCRIPTION DRUG LABEL 20 59088-166 TABLET 55 mg ORAL unapproved drug other 13 sections
Prenatryl HUMAN PRESCRIPTION DRUG LABEL 20 59088-169 TABLET 55 mg ORAL unapproved drug other 13 sections
Prometa HUMAN PRESCRIPTION DRUG LABEL 20 59088-172 TABLET 55 mg ORAL unapproved drug other 13 sections
Pretrate HUMAN PRESCRIPTION DRUG LABEL 20 59088-178 TABLET 55 mg ORAL unapproved drug other 13 sections
Lipovite HUMAN PRESCRIPTION DRUG LABEL 13 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections