cefteram 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 3076 82547-58-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cefteram
  • cefterame
  • ceftetrame
  • Molecular weight: 479.49
  • Formula: C16H17N9O5S2
  • CLOGP: 0.18
  • LIPINSKI: 1
  • HAC: 14
  • HDO: 3
  • TPSA: 190.81
  • ALOGS: -3.09
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.774 Moderate 0.78
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.153 Moderate 0.78
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 1.153 10^-6 cm/s Moderate 0.78
dh-clint Dog hepatocyte intrinsic clearance 1.959 uL/min/10^6 cells Moderate 0.78
dppb Dog plasma protein binding (% unbound) 61.040 % Moderate 0.78
fcs-ppb Fetal calf serum protein binding (% unbound) 46.670 % Moderate 0.78
herg hERG pIC50 4.185 pIC50 Moderate 0.78
hh-clint Human hepatocyte intrinsic clearance 1.400 uL/min/10^6 cells Moderate 0.78
hlm-clint Human liver microsomal intrinsic clearance 3.811 uL/min/mg protein Moderate 0.78
hppb Human plasma protein binding (% unbound) 35.940 % Moderate 0.78
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PDK1,PDK2,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TTK 46
kinase-selectivity-class AXL,DYRK1B,EIF2AK3,GRK2,MAP2K6,MAP3K14,MAPK7,STK33,TEK,TTK 10
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 9.506 Moderate 0.78
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.355 Moderate 0.78
mh-clint Mouse hepatocyte intrinsic clearance 3.388 Moderate 0.78
mppb Mouse plasma protein binding (% unbound) 56.190 Moderate 0.78
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.936 Moderate 0.78
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 45.350 % Moderate 0.78
rat-kpuu-brain Rat brain Kpuu 0.007 % Moderate 0.78
rh-clint Rat hepatocyte intrinsic clearance 1.390 uL/min/10^6 cells Moderate 0.78
rh-fuinc Rat hepatocyte fraction unbound in incubation 90.780 % Moderate 0.78
rppb Rat plasma protein binding (% unbound) 34.830 % Moderate 0.78
solubility-dd Solubility at pH 7.4 in DMSO 926.830 uM Moderate 0.78

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DD18 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Third-generation cephalosporins
CHEBI has role CHEBI:33282 antibacterial agent

Related Drugs by ATC class:

J01DD Third-generation cephalosporins 17 drugs
cefcapenecefdinircefditoren pivoxilcefetametcefiximecefmenoximecefodizimecefoperazonecefotaximecefpiramidecefpodoxime proxetilcefsulodin show all 17 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.95 acidic
pKa2 13.31 acidic
pKa3 3.1 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07655 KEGG_DRUG
C0108946 UMLSCUI
CHEBI:135776 CHEBI
CHEMBL2105953 ChEMBL_ID
C049493 MESH_SUPPLEMENTAL_RECORD_UI
11051 IUPHAR_LIGAND_ID
5947 INN_ID
74CQ4Q3N63 UNII
6537431 PUBCHEM_CID
008157 NDDF

Pharmaceutical products:

None