beclometasone dipropionate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prednisone and prednisolone derivatives	294	5534-09-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: rhinocort beclometasone dipropionate beclomethasone dipropionate beclomethasone dipropionate monohydrate	An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA. Molecular weight: 521.05 Formula: C28H37ClO7 CLOGP: 4.26 LIPINSKI: 1 HAC: 7 HDO: 1 TPSA: 106.97 ALOGS: -5.40 ROTB: 8 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

rhinocort
beclometasone dipropionate
beclomethasone dipropionate
beclomethasone dipropionate monohydrate

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

Molecular weight: 521.05
Formula: C28H37ClO7
CLOGP: 4.26
LIPINSKI: 1
HAC: 7
HDO: 1
TPSA: 106.97
ALOGS: -5.40
ROTB: 8

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.40	mg	N
0.80	mg	Inhal.aerosol
0.80	mg	Inhal.powder
1.50	mg	Inhal.solution

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.05 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	0.29 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	36 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.13 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	0.50 hours	Lombardo F, Berellini G, Obach RS
S (Water solubility)	0.00 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
May 12, 1976	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	433.20	12.69	382	25553	127179	63335908
Wheezing	208.75	12.69	225	25710	95370	63367717
Bacterial disease carrier	141.15	12.69	42	25893	1289	63461798
Bronchial secretion retention	129.27	12.69	47	25888	2726	63460361
Bronchospasm	128.73	12.69	83	25852	17197	63445890
Superinfection	113.44	12.69	42	25893	2565	63460522
Aggression	112.28	12.69	86	25849	23412	63439675
Dyspnoea	109.12	12.69	545	25390	660768	62802319
Nightmare	104.56	12.69	76	25859	19118	63443969
Drug ineffective	99.74	12.69	172	25763	1044593	62418494
Depressed mood	93.63	12.69	98	25837	40093	63422994
Sleep disorder due to a general medical condition	79.75	12.69	54	25881	12134	63450953
Chest discomfort	79.65	12.69	153	25782	109816	63353271
Cough	76.59	12.69	278	25657	292465	63170622
Swelling face	69.31	12.69	106	25829	63369	63399718
Nonspecific reaction	68.10	12.69	28	25907	2264	63460823
Lip swelling	67.49	12.69	73	25862	30990	63432097
Contraindicated product administered	66.87	12.69	6	25929	217642	63245445
Rheumatoid arthritis	63.85	12.69	13	25922	253806	63209281
Illness	62.33	12.69	88	25847	48971	63414116
Sinus operation	61.58	12.69	27	25908	2559	63460528
Scoliosis	61.49	12.69	39	25896	7849	63455238
Treatment failure	59.78	12.69	6	25929	199037	63264050
Arthropathy	59.11	12.69	12	25923	234780	63228307
Swollen tongue	57.47	12.69	71	25864	34729	63428358
Off label use	53.77	12.69	123	25812	674339	62788748
Infusion related reaction	53.26	12.69	17	25918	245504	63217583
Palpitations	51.07	12.69	130	25805	112640	63350447
Toxicity to various agents	47.14	12.69	21	25914	247229	63215858
Myalgia	46.90	12.69	149	25786	146380	63316707
Transient ischaemic attack	43.98	12.69	65	25870	37688	63425399
Asthmatic crisis	43.40	12.69	19	25916	1794	63461293
Separation anxiety disorder	43.35	12.69	8	25927	24	63463063
Glossodynia	43.26	12.69	10	25925	178866	63284221
Malaise	43.11	12.69	304	25631	415650	63047437
Anxiety	42.69	12.69	189	25746	217352	63245735
Atelectasis	42.37	12.69	48	25887	21435	63441652
Blood electrolytes abnormal	42.18	12.69	16	25919	1045	63462042
Pericarditis	42.14	12.69	3	25932	131576	63331511
Sputum discoloured	41.94	12.69	42	25893	16305	63446782
Death	41.87	12.69	55	25880	374326	63088761
Throat tightness	41.45	12.69	51	25884	24836	63438251
Rib fracture	38.76	12.69	47	25888	22550	63440537
Genital pain	38.31	12.69	12	25923	439	63462648
Systemic lupus erythematosus	37.89	12.69	19	25916	208899	63254188
Vascular device infection	37.66	12.69	28	25907	7284	63455803
Eosinophilia	36.88	12.69	46	25889	22710	63440377
Impaired quality of life	36.44	12.69	36	25899	13747	63449340
Abdominal discomfort	36.01	12.69	47	25888	320838	63142249
Hepatic enzyme increased	35.80	12.69	19	25916	202309	63260778
Flashback	34.39	12.69	9	25926	170	63462917
Squamous cell carcinoma of the oral cavity	33.76	12.69	10	25925	302	63462785
Middle insomnia	33.38	12.69	33	25902	12610	63450477
Infective pulmonary exacerbation of cystic fibrosis	33.04	12.69	28	25907	8789	63454298
Productive cough	33.01	12.69	77	25858	63131	63399956
Therapeutic product effect decreased	32.93	12.69	19	25916	193168	63269919
Limb injury	32.79	12.69	46	25889	25431	63437656
Periorbital swelling	32.06	12.69	18	25917	2900	63460187
Breast conserving surgery	31.79	12.69	13	25922	1036	63462051
Angioplasty	31.42	12.69	14	25921	1378	63461709
Oropharyngeal pain	31.05	12.69	97	25838	94390	63368697
Eosinophilic granulomatosis with polyangiitis	31.03	12.69	16	25919	2176	63460911
Alopecia	30.66	12.69	57	25878	337479	63125608
Bronchitis	30.36	12.69	116	25819	124819	63338268
Genital ulceration	30.15	12.69	11	25924	644	63462443
Miller Fisher syndrome	29.33	12.69	7	25928	89	63462998
Gastric mucosa erythema	29.33	12.69	9	25926	307	63462780
Abdominal rigidity	29.30	12.69	15	25920	2009	63461078
Discomfort	29.19	12.69	16	25919	167358	63295729
Anaphylactic reaction	28.67	12.69	75	25860	66025	63397062
Sinusitis	28.49	12.69	174	25761	226479	63236608
Sinus disorder	28.20	12.69	42	25893	24511	63438576
Hiccups	27.93	12.69	15	25920	2216	63460871
Musculoskeletal stiffness	27.63	12.69	21	25914	184597	63278490
Obstructive airways disorder	27.58	12.69	38	25897	20661	63442426
Helicobacter infection	27.32	12.69	3	25932	92782	63370305
Rhinovirus infection	27.11	12.69	19	25916	4510	63458577
Drug monitoring procedure not performed	27.05	12.69	10	25925	608	63462479
Peripheral vascular disorder	26.46	12.69	21	25914	6014	63457073
Arterial spasm	26.46	12.69	6	25929	60	63463027
Nail infection	26.20	12.69	15	25920	2508	63460579
Onychophagia	25.54	12.69	6	25929	71	63463016
Dizziness	25.51	12.69	278	25657	429647	63033440
Duodenal ulcer perforation	25.22	12.69	3	25932	87206	63375881
Dysmetropsia	25.02	12.69	6	25929	78	63463009
Essential tremor	24.74	12.69	11	25924	1077	63462010
Differential white blood cell count abnormal	24.71	12.69	10	25925	776	63462311
Choking	24.64	12.69	25	25910	9854	63453233
Crying	24.09	12.69	38	25897	23305	63439782
Paraesthesia oral	23.65	12.69	34	25901	19222	63443865
Forced expiratory volume decreased	23.32	12.69	18	25917	4950	63458137
Pharyngeal swelling	23.30	12.69	20	25915	6384	63456703
Hyponatraemia	23.27	12.69	99	25836	111801	63351286
Joint swelling	22.72	12.69	64	25871	327602	63135485
Rash macular	22.69	12.69	37	25898	23327	63439760
Eye movement disorder	22.51	12.69	18	25917	5210	63457877
Butterfly rash	22.42	12.69	12	25923	1761	63461326
Dermatitis allergic	21.99	12.69	29	25906	15119	63447968
Stomatitis	21.77	12.69	15	25920	138710	63324377
Anger	21.51	12.69	26	25909	12430	63450657
Food poisoning	21.06	12.69	16	25919	4300	63458787
Maternal exposure during pregnancy	21.01	12.69	36	25899	220026	63243061
Poor peripheral circulation	20.76	12.69	15	25920	3734	63459353
Secretion discharge	20.26	12.69	25	25910	12206	63450881
Pregnancy with implant contraceptive	20.25	12.69	13	25922	2670	63460417
Status asthmaticus	20.11	12.69	9	25926	895	63462192
Treatment noncompliance	20.06	12.69	46	25889	37279	63425808
Personality change	19.91	12.69	19	25916	6954	63456133
Idiopathic orbital inflammation	19.80	12.69	6	25929	196	63462891
Drug abuse	19.77	12.69	3	25932	72515	63390572
Mobility decreased	19.14	12.69	13	25922	121146	63341941
Lacrimation increased	19.13	12.69	32	25903	20599	63442488
Malignant neoplasm progression	19.04	12.69	5	25930	82116	63380971
Gastroenteritis aeromonas	18.79	12.69	4	25931	29	63463058
Gingival swelling	18.57	12.69	15	25920	4403	63458684
Mood altered	18.06	12.69	26	25909	14717	63448370
Blood cholesterol increased	17.88	12.69	8	25927	94024	63369063
Impaired healing	17.58	12.69	10	25925	102532	63360555
Tongue pruritus	17.45	12.69	7	25928	531	63462556
Hyperkinesia	17.35	12.69	10	25925	1694	63461393
Intentional product use issue	17.34	12.69	16	25919	127876	63335211
Oral mucosal blistering	17.09	12.69	16	25919	5717	63457370
Pubic pain	17.07	12.69	5	25930	145	63462942
Brain contusion	16.88	12.69	7	25928	578	63462509
Hallucination	16.84	12.69	55	25880	54762	63408325
Pulmonary congestion	16.13	12.69	27	25908	17391	63445696
Irritability	15.88	12.69	38	25897	31656	63431431
Nasal discomfort	15.58	12.69	14	25921	4746	63458341
Respiration abnormal	15.57	12.69	16	25919	6401	63456686
Acute myocardial infarction	15.54	12.69	38	25897	32086	63431001
Angioedema	15.53	12.69	49	25886	47916	63415171
Emotional disorder	15.52	12.69	23	25912	13356	63449731
Sleep terror	15.48	12.69	11	25924	2669	63460418
Platelet count decreased	15.19	12.69	15	25920	116107	63346980
Therapy non-responder	15.16	12.69	6	25929	75895	63387192
Antipsychotic drug level increased	15.16	12.69	12	25923	3423	63459664
Fungal infection	15.13	12.69	41	25894	36833	63426254
Tendonitis	15.05	12.69	28	25907	19587	63443500
Pulmonary oedema	15.04	12.69	53	25882	54820	63408267
Facial pain	15.00	12.69	20	25915	10541	63452546
Oral mucosa erosion	14.94	12.69	8	25927	1175	63461912
Heart rate increased	14.91	12.69	77	25858	94161	63368926
Psychomotor hyperactivity	14.85	12.69	20	25915	10643	63452444
Arthralgia	14.85	12.69	155	25780	569555	62893532
Derealisation	14.78	12.69	8	25927	1200	63461887
Reperfusion arrhythmia	14.68	12.69	5	25930	239	63462848
Bladder irritation	14.62	12.69	5	25930	242	63462845
Necrosis ischaemic	14.30	12.69	7	25928	853	63462234
Crepitations	14.24	12.69	17	25918	8023	63455064
Pneumonia streptococcal	14.23	12.69	9	25926	1802	63461285
Urticaria	14.19	12.69	116	25819	165686	63297401
Fall	14.18	12.69	232	25703	392102	63070985
Influenza	13.98	12.69	84	25851	108638	63354449
Therapeutic product effect incomplete	13.84	12.69	93	25842	124963	63338124
Product dosage form issue	13.83	12.69	3	25932	24	63463063
Cytomegalovirus enteritis	13.82	12.69	5	25930	286	63462801
Drug intolerance	13.80	12.69	72	25863	308589	63154498
Disease progression	13.72	12.69	18	25917	122740	63340347
Eosinophil count abnormal	13.55	12.69	6	25929	582	63462505
Urinary incontinence	13.54	12.69	36	25899	31978	63431109
Anaemia	13.37	12.69	68	25867	293362	63169725
Abnormal behaviour	13.32	12.69	28	25907	21398	63441689
Product use issue	13.20	12.69	46	25889	220474	63242613
Dermatitis atopic	13.18	12.69	18	25917	9706	63453381
Skin exfoliation	13.01	12.69	43	25892	43059	63420028
Gingival discomfort	12.82	12.69	5	25930	352	63462735
Migraine	12.75	12.69	79	25856	103267	63359820
Urinary retention	12.74	12.69	34	25901	30267	63432820

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	326.57	13.44	209	14249	42447	34900026
Wheezing	143.01	13.44	126	14332	41276	34901197
Dyspnoea	85.47	13.44	344	14114	376438	34566035
Nightmare	71.12	13.44	54	14404	14337	34928136
Anger	70.97	13.44	50	14408	11834	34930639
Lip swelling	63.73	13.44	53	14405	16027	34926446
Ballismus	54.95	13.44	12	14446	98	34942375
Sleep terror	51.06	13.44	23	14435	2295	34940178
Lower respiratory tract infection	49.19	13.44	63	14395	31574	34910899
Abnormal behaviour	49.07	13.44	56	14402	24913	34917560
Swollen tongue	47.48	13.44	43	14415	14562	34927911
Blood immunoglobulin E increased	45.94	13.44	22	14436	2524	34939949
Pharyngeal oedema	42.16	13.44	28	14430	6019	34936454
Infective pulmonary exacerbation of cystic fibrosis	39.18	13.44	28	14430	6773	34935700
Malaise	35.91	13.44	162	14296	185663	34756810
Nasal disorder	35.82	13.44	17	14441	1911	34940562
Attention-seeking behaviour	34.23	13.44	7	14451	40	34942433
Acquired macroglossia	32.44	13.44	6	14452	18	34942455
Cough	30.57	13.44	133	14325	150007	34792466
Neuropsychiatric symptoms	30.03	13.44	12	14446	890	34941583
Chest discomfort	29.67	13.44	68	14390	54462	34888011
Toxicity to various agents	29.25	13.44	24	14434	200338	34742135
Crepitations	27.75	13.44	17	14441	3179	34939294
Drug abuse	27.73	13.44	4	14454	99092	34843381
Chorea	27.35	13.44	12	14446	1125	34941348
Central obesity	26.97	13.44	10	14448	605	34941868
Dyspnoea at rest	24.95	13.44	17	14441	3811	34938662
Gastric ulcer perforation	24.81	13.44	11	14447	1057	34941416
Neonatal hyponatraemia	24.67	13.44	6	14452	82	34942391
Anosmia	24.18	13.44	17	14441	4007	34938466
Daydreaming	24.17	13.44	9	14449	551	34941922
Sputum discoloured	23.45	13.44	22	14436	7790	34934683
Nasal discomfort	23.24	13.44	12	14446	1616	34940857
Crying	22.55	13.44	19	14439	5843	34936630
Death	22.35	13.44	87	14371	397962	34544511
Depressed mood	21.82	13.44	33	14425	19284	34923189
Completed suicide	21.34	13.44	7	14451	98161	34844312
Paraesthesia oral	21.28	13.44	16	14442	4181	34938292
Neuropsychiatric syndrome	21.16	13.44	5	14453	60	34942413
Spleen congestion	21.02	13.44	7	14451	308	34942165
Gastrointestinal tract irritation	20.96	13.44	7	14451	311	34942162
Cervicogenic headache	20.94	13.44	4	14454	15	34942458
Micturition urgency	20.79	13.44	19	14439	6506	34935967
Tic	20.61	13.44	12	14446	2046	34940427
Platelet count decreased	20.56	13.44	12	14446	119705	34822768
Productive cough	20.39	13.44	47	14411	37766	34904707
Off label use	20.31	13.44	97	14361	419427	34523046
Mood altered	19.16	13.44	21	14437	8931	34933542
Mesothelioma	18.66	13.44	7	14451	438	34942035
Graft versus host disease in gastrointestinal tract	18.58	13.44	14	14444	3669	34938804
Suicidal ideation	18.36	13.44	47	14411	40341	34902132
Irritability	18.35	13.44	35	14423	24655	34917818
Chronic obstructive pulmonary disease	18.31	13.44	53	14405	48865	34893608
Locked-in syndrome	17.91	13.44	6	14452	269	34942204
Mood swings	17.72	13.44	19	14439	7882	34934591
Sinusitis	17.61	13.44	47	14411	41355	34901118
Bronchomalacia	17.53	13.44	5	14453	130	34942343
Nasal septum perforation	17.49	13.44	5	14453	131	34942342
Convulsive threshold lowered	17.37	13.44	7	14451	531	34941942
Self-injurious ideation	17.34	13.44	10	14448	1674	34940799
Eye swelling	17.28	13.44	21	14437	9974	34932499
Reading disorder	17.27	13.44	7	14451	539	34941934
Multifocal motor neuropathy	17.24	13.44	4	14454	44	34942429
Impaired quality of life	16.73	13.44	16	14442	5802	34936671
Oral pain	15.94	13.44	21	14437	10806	34931667
Thrombocytopenia	15.94	13.44	25	14433	156222	34786251
Disease progression	15.68	13.44	13	14445	108064	34834409
Palpitations	15.62	13.44	44	14414	39942	34902531
Pruritus	15.41	13.44	106	14352	141875	34800598
Apnoeic attack	15.35	13.44	6	14452	420	34942053
Benign prostatic hyperplasia	15.30	13.44	24	14434	14471	34928002
Headache	15.28	13.44	138	14320	200497	34741976
Renal failure	15.20	13.44	19	14439	130538	34811935
Antibody test abnormal	15.17	13.44	5	14453	213	34942260
Ocular discomfort	15.16	13.44	10	14448	2124	34940349
Infarction	15.09	13.44	11	14447	2742	34939731
Aortic dissection	15.04	13.44	11	14447	2757	34939716
Renal aplasia	14.99	13.44	7	14451	759	34941714
Tryptase increased	14.76	13.44	5	14453	232	34942241
Slow speech	14.73	13.44	8	14450	1194	34941279
Weaning failure	14.68	13.44	5	14453	236	34942237
Ejaculation failure	14.62	13.44	7	14451	802	34941671
Pharyngeal swelling	14.59	13.44	10	14448	2262	34940211
Eosinophilia	14.58	13.44	33	14425	26189	34916284
Angioedema	14.47	13.44	41	14417	37333	34905140
Neonatal seizure	14.37	13.44	6	14452	498	34941975
Testicular mass	14.17	13.44	4	14454	100	34942373
Nasal inflammation	14.03	13.44	5	14453	270	34942203
Urticaria	14.02	13.44	57	14401	62320	34880153
Violence-related symptom	14.01	13.44	6	14452	530	34941943
Abdominal symptom	13.96	13.44	6	14452	535	34941938
Sleep talking	13.95	13.44	6	14452	536	34941937
Rash papular	13.71	13.44	19	14439	10259	34932214
Hepatic cancer	13.68	13.44	17	14441	8258	34934215
Ageusia	13.66	13.44	19	14439	10289	34932184
Forced expiratory volume decreased	13.61	13.44	11	14447	3192	34939281
Obsessive-compulsive disorder	13.59	13.44	14	14444	5550	34936923
Malignant neoplasm progression	13.52	13.44	10	14448	88036	34854437
Sleep disorder	13.50	13.44	36	14422	31652	34910821

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	601.05	11.72	486	34292	134609	79575001
Wheezing	303.87	11.72	311	34467	116353	79593257
Nightmare	189.56	11.72	126	34652	25735	79683875
Dyspnoea	166.27	11.72	775	34003	856250	78853360
Bacterial disease carrier	136.38	11.72	43	34735	1503	79708107
Lip swelling	130.54	11.72	122	34656	40789	79668821
Depressed mood	122	11.72	127	34651	48353	79661257
Bronchospasm	111.41	11.72	90	34688	24769	79684841
Bronchial secretion retention	108.42	11.72	47	34731	4057	79705553
Swollen tongue	104.40	11.72	110	34668	42460	79667150
Drug ineffective	94.23	11.72	208	34570	1080705	78628905
Chest discomfort	88.81	11.72	190	34588	137854	79571756
Aggression	88.26	11.72	110	34668	50848	79658762
Superinfection	85.23	11.72	42	34736	4860	79704750
Completed suicide	84.03	11.72	6	34772	245761	79463849
Anger	80.88	11.72	64	34714	17098	79692512
Toxicity to various agents	77.21	11.72	44	34734	421496	79288114
Swelling face	74.73	11.72	121	34657	71091	79638519
Sinus operation	70.26	11.72	30	34748	2495	79707115
Malaise	70.15	11.72	408	34370	489461	79220149
Sleep disorder due to a general medical condition	68.91	11.72	54	34724	14223	79695387
Palpitations	67.75	11.72	162	34616	126448	79583162
Infective pulmonary exacerbation of cystic fibrosis	67.26	11.72	51	34727	12800	79696810
Cough	66.46	11.72	326	34452	366463	79343147
Off label use	65.43	11.72	192	34586	907023	78802587
Scoliosis	63.62	11.72	40	34738	7424	79702186
Abnormal behaviour	62.07	11.72	78	34700	36343	79673267
Sputum discoloured	62.07	11.72	61	34717	21682	79687928
Illness	61.49	11.72	88	34690	46423	79663187
Nonspecific reaction	60.42	11.72	27	34751	2505	79707105
Myalgia	58.44	11.72	196	34582	185445	79524165
Sleep terror	56.80	11.72	31	34747	4427	79705183
Death	55.13	11.72	102	34676	566412	79143198
Rheumatoid arthritis	52.72	11.72	13	34765	208457	79501153
Infusion related reaction	51.57	11.72	18	34760	230219	79479391
Treatment failure	50.88	11.72	7	34771	170479	79539131
Synovitis	50.60	11.72	4	34774	150730	79558880
Separation anxiety disorder	48.18	11.72	9	34769	27	79709583
Contraindicated product administered	48.13	11.72	6	34772	157532	79552078
Drug abuse	47.80	11.72	7	34771	162684	79546926
Anxiety	45.75	11.72	222	34556	248290	79461320
Pharyngeal oedema	45.24	11.72	45	34733	16227	79693383
Eosinophilia	44.80	11.72	75	34703	45270	79664340
Impaired quality of life	44.15	11.72	42	34736	14344	79695266
Crying	43.55	11.72	52	34726	22991	79686619
Ballismus	42.12	11.72	12	34766	294	79709316
Productive cough	40.90	11.72	107	34671	88224	79621386
Asthmatic crisis	40.36	11.72	19	34759	1987	79707623
Crepitations	40.15	11.72	34	34744	9983	79699627
Dizziness	39.88	11.72	377	34401	526064	79183546
Arthropathy	39.39	11.72	14	34764	177097	79532513
Transient ischaemic attack	39.13	11.72	77	34701	52618	79656992
Paraesthesia oral	38.36	11.72	46	34732	20425	79689185
Genital pain	37.80	11.72	14	34764	800	79708810
Irritability	36.64	11.72	65	34713	41079	79668531
Hepatic enzyme increased	36.44	11.72	17	34761	182593	79527017
Throat tightness	35.71	11.72	52	34726	27855	79681755
Mood altered	34.92	11.72	41	34737	17806	79691804
Breast conserving surgery	34.54	11.72	13	34765	777	79708833
Periorbital swelling	33.78	11.72	19	34759	2877	79706733
Pharyngeal swelling	32.59	11.72	27	34751	7692	79701918
Attention-seeking behaviour	32.56	11.72	8	34770	108	79709502
Obstructive airways disorder	32.37	11.72	53	34725	31406	79678204
Oropharyngeal pain	32.23	11.72	113	34665	109240	79600370
Eosinophilic granulomatosis with polyangiitis	32.16	11.72	20	34758	3640	79705970
Essential tremor	32.13	11.72	15	34763	1540	79708070
Blood electrolytes abnormal	31.93	11.72	16	34762	1918	79707692
Middle insomnia	31.58	11.72	37	34741	16032	79693578
Mood swings	31.39	11.72	41	34737	19839	79689771
Rib fracture	31.38	11.72	49	34729	27898	79681712
Choking	30.96	11.72	32	34746	12069	79697541
Genital ulceration	30.38	11.72	13	34765	1087	79708523
Forced expiratory volume decreased	30.25	11.72	26	34752	7788	79701822
Rash macular	30.16	11.72	49	34729	28850	79680760
Atelectasis	30.07	11.72	52	34726	32205	79677405
Malignant neoplasm progression	29.81	11.72	11	34767	135979	79573631
Angioplasty	29.55	11.72	15	34763	1848	79707762
Pericarditis	29.45	11.72	5	34773	104231	79605379
Thrombocytopenia	28.27	11.72	45	34733	265214	79444396
Angioedema	28.21	11.72	85	34693	75950	79633660
Platelet count decreased	28.18	11.72	26	34752	194638	79514972
Limb injury	28.05	11.72	48	34730	29480	79680130
Squamous cell carcinoma of the oral cavity	27.94	11.72	10	34768	518	79709092
Blood immunoglobulin E increased	27.85	11.72	22	34756	5860	79703750
Vascular device infection	27.79	11.72	28	34750	10248	79699362
Antipsychotic drug level increased	27.60	11.72	22	34756	5935	79703675
Dermatitis allergic	26.49	11.72	36	34742	18094	79691516
Nail infection	25.99	11.72	15	34763	2384	79707226
Gingival swelling	25.69	11.72	19	34759	4590	79705020
Hallucination	25.61	11.72	89	34689	85656	79623954
Disease progression	25.09	11.72	26	34752	184336	79525274
Anaphylactic reaction	25.07	11.72	87	34691	83656	79625954
Abdominal rigidity	24.95	11.72	16	34762	3072	79706538
Poor peripheral circulation	24.72	11.72	17	34761	3666	79705944
Pregnancy with implant contraceptive	23.90	11.72	13	34765	1843	79707767
Peripheral vascular disorder	23.80	11.72	23	34755	8007	79701603
Dysmetropsia	23.77	11.72	6	34772	91	79709519
Anaemia	23.48	11.72	107	34671	444908	79264702
Micturition urgency	23.02	11.72	28	34750	12613	79696997
Tic	22.96	11.72	15	34763	2971	79706639
Food poisoning	22.93	11.72	18	34760	4751	79704859
Urticaria	22.47	11.72	148	34630	185053	79524557
Psychomotor hyperactivity	22.44	11.72	32	34746	16817	79692793
Musculoskeletal stiffness	22.36	11.72	26	34752	174982	79534628
Bleeding time prolonged	22.34	11.72	11	34767	1270	79708340
Rhinovirus infection	22.12	11.72	22	34756	7931	79701679
Nasal disorder	22.06	11.72	16	34762	3753	79705857
Febrile neutropenia	22.05	11.72	42	34736	230957	79478653
Sinus disorder	21.98	11.72	37	34741	22427	79687183
Drug monitoring procedure not performed	21.66	11.72	10	34768	1001	79708609
Miller Fisher syndrome	21.61	11.72	7	34771	267	79709343
Intentional product use issue	21.21	11.72	21	34757	152091	79557519
Disturbance in attention	20.96	11.72	59	34719	50742	79658868
Flashback	20.90	11.72	7	34771	297	79709313
Arterial spasm	20.65	11.72	6	34772	158	79709452
Systemic lupus erythematosus	20.26	11.72	14	34764	121135	79588475
Anosmia	20.17	11.72	22	34756	8822	79700788
Somnambulism	20.07	11.72	18	34760	5703	79703907
Suicidal ideation	20.05	11.72	76	34702	76264	79633346
Glossodynia	20.03	11.72	10	34768	103327	79606283
Ejaculation failure	19.65	11.72	7	34771	358	79709252
Butterfly rash	19.44	11.72	11	34767	1685	79707925
Liver function test abnormal	19.31	11.72	67	34711	64408	79645202
Daydreaming	19.28	11.72	9	34769	924	79708686
Hyponatraemia	19.13	11.72	138	34640	177710	79531900
Central obesity	19.05	11.72	11	34767	1750	79707860
Upper gastrointestinal haemorrhage	19.02	11.72	50	34728	41330	79668280
Dermatitis bullous	18.89	11.72	27	34751	14218	79695392
Acquired macroglossia	18.78	11.72	6	34772	219	79709391
Renal failure	18.78	11.72	37	34741	200931	79508679
Emotional disorder	18.68	11.72	27	34751	14360	79695250
Gastroenteritis aeromonas	18.52	11.72	4	34774	29	79709581
Neuropsychiatric symptoms	18.47	11.72	10	34768	1405	79708205
Graft versus host disease in gastrointestinal tract	18.45	11.72	18	34760	6338	79703272
Oral pain	18.42	11.72	42	34736	31756	79677854
Helicobacter infection	18.30	11.72	4	34774	69700	79639910
Chorea	18.24	11.72	12	34766	2405	79707205
Therapeutic product effect decreased	18.21	11.72	27	34751	163836	79545774
Pulmonary congestion	18.21	11.72	38	34740	27062	79682548
Adverse drug reaction	18.19	11.72	67	34711	66325	79643285
Spleen congestion	18.16	11.72	7	34771	447	79709163
Idiopathic orbital inflammation	17.90	11.72	6	34772	255	79709355
Muscle spasms	17.89	11.72	134	34644	174596	79535014
Secretion discharge	17.79	11.72	27	34751	14995	79694615
Nasal discharge discolouration	17.78	11.72	12	34766	2509	79707101
Neuropsychiatric syndrome	17.69	11.72	5	34773	119	79709491
Cervicogenic headache	17.66	11.72	4	34774	37	79709573
Heart rate increased	17.48	11.72	101	34677	120623	79588987
Encephalopathy	17.42	11.72	4	34774	67393	79642217
Differential white blood cell count abnormal	17.37	11.72	11	34767	2066	79707544
Blood pressure fluctuation	17.33	11.72	4	34774	67141	79642469
Joint swelling	17.32	11.72	66	34712	288580	79421030
Multifocal motor neuropathy	17.03	11.72	4	34774	44	79709566
Pain	16.99	11.72	211	34567	703591	79006019
Syncope	16.91	11.72	135	34643	179314	79530296
Eye movement disorder	16.67	11.72	19	34759	7992	79701618
Product administered to patient of inappropriate age	16.63	11.72	16	34762	5537	79704073
Lactic acidosis	16.62	11.72	5	34773	70354	79639256
Tongue pruritus	16.61	11.72	7	34771	563	79709047
White blood cell count decreased	16.46	11.72	36	34742	188252	79521358
Bronchitis	16.20	11.72	105	34673	130539	79579071
Headache	16.20	11.72	386	34392	653386	79056224
Migraine	15.95	11.72	78	34700	87415	79622195
Reading disorder	15.70	11.72	8	34770	994	79708616
Pubic pain	15.61	11.72	5	34773	184	79709426
Stomatitis	15.52	11.72	25	34753	146732	79562878
Status asthmaticus	15.46	11.72	8	34770	1026	79708584
Skin exfoliation	15.42	11.72	56	34722	55044	79654566
Urinary incontinence	15.42	11.72	46	34732	40863	79668747
Treatment noncompliance	15.38	11.72	54	34724	52214	79657396
Gastrointestinal tract irritation	15.37	11.72	7	34771	679	79708931
Therapeutic product effect incomplete	15.28	11.72	110	34668	141535	79568075
Testicular mass	15.15	11.72	4	34774	73	79709537
Oral mucosal blistering	15.04	11.72	16	34762	6235	79703375
Impaired healing	14.83	11.72	10	34768	87645	79621965
Overdose	14.68	11.72	37	34741	184169	79525441
Gastric ulcer perforation	14.67	11.72	10	34768	2125	79707485
Infection	14.67	11.72	55	34723	241657	79467953
Suicide attempt	14.66	11.72	9	34769	82923	79626687
Personality change	14.56	11.72	20	34758	10150	79699460
Nasal congestion	14.50	11.72	69	34709	76483	79633127
Tendonitis	14.39	11.72	32	34746	23798	79685812
Eye swelling	14.28	11.72	34	34744	26434	79683176
Blood creatinine increased	14.09	11.72	29	34749	155028	79554582
Cardio-respiratory arrest	13.99	11.72	16	34762	108494	79601116
Benign prostatic hyperplasia	13.94	11.72	21	34757	11591	79698019
Bladder irritation	13.83	11.72	5	34773	267	79709343
Nasal septum ulceration	13.75	11.72	3	34775	23	79709587
Bronchomalacia	13.74	11.72	5	34773	272	79709338
Mouth swelling	13.71	11.72	15	34763	6036	79703574
Discomfort	13.66	11.72	21	34757	125596	79584014
Duodenal ulcer perforation	13.46	11.72	6	34772	66205	79643405
Intentional product misuse	13.42	11.72	13	34765	95152	79614458
Reperfusion arrhythmia	13.35	11.72	5	34773	295	79709315
Hypovolaemia	13.31	11.72	26	34752	17665	79691945
Skin fragility	13.27	11.72	7	34771	934	79708676
Convulsive threshold lowered	13.23	11.72	7	34771	940	79708670
Ageusia	13.19	11.72	25	34753	16607	79693003
Poor quality sleep	13.15	11.72	30	34748	22692	79686918
Growth retardation	13.11	11.72	9	34769	1934	79707676
Oral mucosa erosion	13.10	11.72	9	34769	1938	79707672
Dyspnoea at rest	13.02	11.72	16	34762	7286	79702324
Neutropenia	12.98	11.72	73	34705	287637	79421973
Pulmonary oedema	12.88	11.72	74	34704	88180	79621430
Fibromyalgia	12.81	11.72	6	34772	64334	79645276
Abdominal discomfort	12.78	11.72	61	34717	250666	79458944
Abnormal weight gain	12.76	11.72	10	34768	2634	79706976
Vaginal discharge	12.74	11.72	16	34762	7447	79702163
Sleep disorder	12.61	11.72	72	34706	85605	79624005
Beta haemolytic streptococcal infection	12.50	11.72	9	34769	2088	79707522
Mouth ulceration	12.47	11.72	41	34737	38353	79671257
Contusion	12.46	11.72	109	34669	148667	79560943
Pneumonia streptococcal	12.43	11.72	10	34768	2735	79706875
Platelet count increased	12.32	11.72	29	34749	22377	79687233
Necrosis ischaemic	12.30	11.72	7	34771	1083	79708527
Lacrimation increased	12.26	11.72	29	34749	22448	79687162
Sputum retention	12.26	11.72	7	34771	1090	79708520
Respiration abnormal	12.20	11.72	16	34762	7772	79701838
Gastric mucosa erythema	12.04	11.72	5	34773	388	79709222
Derealisation	11.99	11.72	8	34770	1641	79707969
Inflammatory myofibroblastic tumour	11.96	11.72	4	34774	169	79709441
Violence-related symptom	11.93	11.72	6	34772	725	79708885
Pancytopenia	11.92	11.72	35	34743	165710	79543900
Self-injurious ideation	11.89	11.72	11	34767	3627	79705983
Locked-in syndrome	11.87	11.72	6	34772	733	79708877
Myositis	11.87	11.72	26	34752	19142	79690468
Fatigue	11.84	11.72	312	34466	929415	78780195
Hiccups	11.84	11.72	18	34760	10013	79699597
Dermatitis atopic	11.81	11.72	18	34760	10038	79699572
Eosinophil count abnormal	11.78	11.72	6	34772	745	79708865
Hypotension	11.77	11.72	129	34649	440188	79269422
Coma	11.76	11.72	16	34762	100633	79608977

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A07EA07	ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally
ATC	D07AC15	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III)
ATC	D07CC04	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, potent, combinations with antibiotics
ATC	R01AD01	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids
ATC	R03AK08	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC	R03AK13	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC	R03AL09	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC	R03BA01	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:49167	anti-asthmatic drugs
CHEBI has role	CHEBI:38070	antiarrhythmic agent
CHEBI has role	CHEBI:50266	Prodrugs
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D005938	Glucocorticoids
MeSH PA	D006728	Hormones
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D018373	Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Vasomotor rhinitis	indication	8229003	DOID:4730
Nasal polyp	indication	52756005
Allergic rhinitis	indication	61582004
Rhinitis	indication	70076002	DOID:4483
Asthma	indication	195967001	DOID:2841
Asthma management	indication	406162001
Severe chronic obstructive pulmonary disease	off-label use	313299006
Mycosis	contraindication	3218000	DOID:1564
Ocular hypertension	contraindication	4210003	DOID:9282
Inactive tuberculosis	contraindication	11999007
Epistaxis	contraindication	12441001
Measles	contraindication	14189004	DOID:8622
Disease caused by parasite	contraindication	17322007
Glaucoma	contraindication	23986001	DOID:1686
Acute tuberculosis	contraindication	25629007
Perforation of nasal septum	contraindication	80142000
Bacterial infectious disease	contraindication	87628006
Mycobacteriosis	contraindication	88415009
Operation on nose	contraindication	88733004
Bilateral cataracts	contraindication	95722004
Ophthalmic herpes simplex	contraindication	186542001
Disease of liver	contraindication	235856003	DOID:409
Varicella-zoster virus infection	contraindication	309465005
Adrenal cortical hypofunction	contraindication	386584007	DOID:10493
Exposure to varicella	contraindication	444453009
Nasal Trauma	contraindication
Nasal Candidiasis	contraindication
Nasal Septal Ulcers	contraindication
Uncontrolled Bacterial Infections	contraindication
Untreated Fungal Infection	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.01	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST	Ki	8.43	DRUG MATRIX	CHEMBL
Interleukin-5	Cytokine	P05113	IL5_HUMAN		IC50	4.57	CHEMBL
Mineralocorticoid receptor	Nuclear hormone receptor	P08235	MCR_HUMAN		EC50	8.32	CHEMBL
Matrix metalloproteinase-9	Enzyme	P14780	MMP9_HUMAN		IC50	5.70	CHEMBL
Probable G-protein coupled receptor 97	GPCR	Q86Y34	AGRG3_HUMAN	AGONIST	EC50	8.50	IUPHAR
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN		IC50	7.55	CHEMBL
Androgen receptor	Transcription factor		ANDR_RAT		Ki	5.96	CHEMBL
Progesterone receptor	Transcription factor		Q690N0_BOVIN		Ki	7.57	CHEMBL
Glucocorticoid receptor	Transcription factor		GCR_RAT		IC50	8.54	CHEMBL
Interleukin-5	Unclassified		IL5_MOUSE		IC50	4.58	CHEMBL
Interleukin-5 receptor subunit alpha	Unclassified		IL5RA_MOUSE		IC50	4.58	CHEMBL

External reference:

ID	Source
D00689	KEGG_DRUG
77011-63-3	SECONDARY_CAS_RN
1347	RXNORM
C0004906	UMLSCUI
CHEBI:3002	CHEBI
CHEBI:3001	CHEBI
CHEMBL1200500	ChEMBL_ID
CHEMBL1370	ChEMBL_ID
DB00394	DRUGBANK_ID
5894	IUPHAR_LIGAND_ID
21700	PUBCHEM_CID
1167	MMSL
4249	MMSL
71834	MMSL
8263	MMSL
d00760	MMSL
116574000	SNOMEDCT_US
116575004	SNOMEDCT_US
1389007	SNOMEDCT_US
426017007	SNOMEDCT_US
D019819	MESH_DESCRIPTOR_UI
D001507	MESH_DESCRIPTOR_UI
C0004905	UMLSCUI
4018793	VANDF
4019625	VANDF
2307	INN_ID
4419-39-0	SECONDARY_CAS_RN
20469	PUBCHEM_CID
7059	IUPHAR_LIGAND_ID
5B307S63B2	UNII
KGZ1SLC28Z	UNII
002179	NDDF
004947	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
BECONASEAQ	HUMAN PRESCRIPTION DRUG LABEL	1	0173-0388	SPRAY, SUSPENSION	42 ug	NASAL	NDA	20 sections
BECONASEAQ	HUMAN PRESCRIPTION DRUG LABEL	1	0173-0388	SPRAY, SUSPENSION	42 ug	NASAL	NDA	20 sections
BECONASEAQ	HUMAN PRESCRIPTION DRUG LABEL	1	0173-0388	SPRAY, SUSPENSION	42 ug	NASAL	NDA	20 sections
BECONASE AQ	HUMAN PRESCRIPTION DRUG LABEL	1	16590-030	SPRAY, SUSPENSION	42 ug	NASAL	NDA	13 sections
QVAR	HUMAN PRESCRIPTION DRUG LABEL	1	16590-860	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	26 sections
QVAR	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1342	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	28 sections
QVAR	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3033	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	28 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3459	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	16 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	50090-5031	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	50090-5032	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	53002-2436	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	53002-2436	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	53002-3477	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	53002-3477	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5857	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	14 sections
QVAR	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5858	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	14 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-302	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-302	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-302	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-302	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-304	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-304	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-304	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-304	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-406	AEROSOL, METERED	40 ug	NASAL	NDA	27 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-406	AEROSOL, METERED	40 ug	NASAL	NDA	27 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-406	AEROSOL, METERED	40 ug	NASAL	NDA	27 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-410	AEROSOL, METERED	80 ug	NASAL	NDA	27 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-410	AEROSOL, METERED	80 ug	NASAL	NDA	27 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-410	AEROSOL, METERED	80 ug	NASAL	NDA	27 sections