zolpidem Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| hypnotics/sedatives, zolpidem derivatives | 2870 | 82626-48-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 10 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 23 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.47 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 72 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.54 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 4.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.70 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 16, 1992 | FDA | SANOFI AVENTIS US |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 1695.82 | 9.42 | 2073 | 157094 | 136128 | 53053771 |
| Drug abuse | 914.54 | 9.42 | 1051 | 158116 | 64475 | 53125424 |
| Intentional overdose | 683.78 | 9.42 | 920 | 158247 | 66285 | 53123614 |
| Toxicity to various agents | 626.31 | 9.42 | 1748 | 157419 | 217850 | 52972049 |
| Somnambulism | 535.71 | 9.42 | 280 | 158887 | 5122 | 53184777 |
| Drug dependence | 531.24 | 9.42 | 470 | 158697 | 21002 | 53168897 |
| Suicide attempt | 516.46 | 9.42 | 746 | 158421 | 57422 | 53132477 |
| Rheumatoid arthritis | 476.43 | 9.42 | 172 | 158995 | 314359 | 52875540 |
| Amnesia | 400.74 | 9.42 | 580 | 158587 | 44708 | 53145191 |
| Sopor | 332.95 | 9.42 | 361 | 158806 | 20723 | 53169176 |
| Overdose | 308.71 | 9.42 | 860 | 158307 | 106876 | 53083023 |
| Contraindicated product administered | 307.73 | 9.42 | 26 | 159141 | 135603 | 53054296 |
| Intentional self-injury | 305.31 | 9.42 | 377 | 158790 | 24907 | 53164992 |
| Drug intolerance | 299.77 | 9.42 | 119 | 159048 | 205374 | 52984525 |
| Synovitis | 264.31 | 9.42 | 14 | 159153 | 107879 | 53082020 |
| Joint swelling | 257.89 | 9.42 | 194 | 158973 | 234444 | 52955455 |
| Coma | 253.77 | 9.42 | 566 | 158601 | 61217 | 53128682 |
| Treatment failure | 244.23 | 9.42 | 44 | 159123 | 128359 | 53061540 |
| Infusion related reaction | 231.20 | 9.42 | 88 | 159079 | 155869 | 53034030 |
| Drug ineffective | 228.93 | 9.42 | 1467 | 157700 | 815778 | 52374121 |
| Hand deformity | 228.72 | 9.42 | 5 | 159162 | 84844 | 53105055 |
| Insomnia | 224.83 | 9.42 | 1128 | 158039 | 185944 | 53003955 |
| Abnormal sleep-related event | 224.35 | 9.42 | 85 | 159082 | 684 | 53189215 |
| Anxiety | 217.62 | 9.42 | 1159 | 158008 | 195545 | 52994354 |
| Systemic lupus erythematosus | 215.97 | 9.42 | 54 | 159113 | 125360 | 53064539 |
| Intentional product misuse | 204.50 | 9.42 | 454 | 158713 | 48938 | 53140961 |
| Cardio-respiratory arrest | 188.25 | 9.42 | 489 | 158678 | 58269 | 53131630 |
| Poisoning deliberate | 186.68 | 9.42 | 176 | 158991 | 8537 | 53181362 |
| Somnolence | 186.60 | 9.42 | 990 | 158177 | 166744 | 53023155 |
| Arthropathy | 182.73 | 9.42 | 97 | 159070 | 141356 | 53048543 |
| Drug withdrawal syndrome | 180.02 | 9.42 | 310 | 158857 | 27712 | 53162187 |
| Off label use | 176.78 | 9.42 | 767 | 158400 | 471445 | 52718454 |
| Glossodynia | 173.01 | 9.42 | 43 | 159124 | 100248 | 53089651 |
| Respiratory arrest | 160.44 | 9.42 | 327 | 158840 | 33213 | 53156686 |
| Sleep-related eating disorder | 159.80 | 9.42 | 67 | 159100 | 721 | 53189178 |
| Maternal exposure during pregnancy | 159.24 | 9.42 | 138 | 159029 | 155501 | 53034398 |
| Depression | 157.80 | 9.42 | 1010 | 158157 | 182042 | 53007857 |
| Poisoning | 152.08 | 9.42 | 197 | 158970 | 13653 | 53176246 |
| Peripheral swelling | 149.56 | 9.42 | 240 | 158927 | 205868 | 52984031 |
| Lower respiratory tract infection | 143.95 | 9.42 | 46 | 159121 | 90935 | 53098964 |
| Hypersensitivity | 140.34 | 9.42 | 259 | 158908 | 210406 | 52979493 |
| Suicidal ideation | 130.05 | 9.42 | 437 | 158730 | 60074 | 53129825 |
| Pericarditis | 127.00 | 9.42 | 20 | 159147 | 64386 | 53125513 |
| Alopecia | 126.02 | 9.42 | 325 | 158842 | 234258 | 52955641 |
| Swelling | 121.11 | 9.42 | 242 | 158925 | 190863 | 52999036 |
| Mydriasis | 121.09 | 9.42 | 159 | 159008 | 11167 | 53178732 |
| Wound | 120.85 | 9.42 | 61 | 159106 | 91496 | 53098403 |
| Fall | 119.86 | 9.42 | 1612 | 157555 | 356828 | 52833071 |
| Abdominal discomfort | 110.66 | 9.42 | 317 | 158850 | 220745 | 52969154 |
| Abnormal behaviour | 109.12 | 9.42 | 217 | 158950 | 21649 | 53168250 |
| Loss of consciousness | 108.90 | 9.42 | 647 | 158520 | 113565 | 53076334 |
| Arthralgia | 105.98 | 9.42 | 823 | 158344 | 438960 | 52750939 |
| Withdrawal syndrome | 102.95 | 9.42 | 197 | 158970 | 19104 | 53170795 |
| Road traffic accident | 102.03 | 9.42 | 232 | 158935 | 25399 | 53164500 |
| Impaired driving ability | 101.97 | 9.42 | 92 | 159075 | 4215 | 53185684 |
| Infection | 99.18 | 9.42 | 230 | 158937 | 171975 | 53017924 |
| Rash | 97.49 | 9.42 | 857 | 158310 | 445334 | 52744565 |
| Therapeutic product effect decreased | 93.28 | 9.42 | 144 | 159023 | 125511 | 53064388 |
| Restlessness | 91.20 | 9.42 | 235 | 158932 | 27852 | 53162047 |
| Drug hypersensitivity | 89.41 | 9.42 | 447 | 158720 | 264795 | 52925104 |
| Nasopharyngitis | 88.18 | 9.42 | 287 | 158880 | 192008 | 52997891 |
| Miosis | 85.45 | 9.42 | 105 | 159062 | 6897 | 53183002 |
| Confusional state | 84.20 | 9.42 | 918 | 158249 | 193303 | 52996596 |
| Drug use disorder | 82.66 | 9.42 | 72 | 159095 | 3147 | 53186752 |
| Duodenal ulcer perforation | 81.83 | 9.42 | 6 | 159161 | 35177 | 53154722 |
| Agitation | 81.50 | 9.42 | 369 | 158798 | 58257 | 53131642 |
| Exposure via ingestion | 79.97 | 9.42 | 71 | 159096 | 3184 | 53186715 |
| Disorientation | 79.95 | 9.42 | 279 | 158888 | 39080 | 53150819 |
| Product use issue | 77.51 | 9.42 | 190 | 158977 | 139394 | 53050505 |
| Homicide | 75.46 | 9.42 | 32 | 159135 | 355 | 53189544 |
| Helicobacter infection | 75.08 | 9.42 | 13 | 159154 | 39056 | 53150843 |
| Musculoskeletal stiffness | 72.43 | 9.42 | 163 | 159004 | 123205 | 53066694 |
| Cardiac arrest | 71.66 | 9.42 | 502 | 158665 | 93165 | 53096734 |
| Hepatic enzyme increased | 68.33 | 9.42 | 174 | 158993 | 126021 | 53063878 |
| Therapeutic product effect incomplete | 68.28 | 9.42 | 105 | 159062 | 91679 | 53098220 |
| Delirium | 66.21 | 9.42 | 272 | 158895 | 41157 | 53148742 |
| Product substitution issue | 64.69 | 9.42 | 145 | 159022 | 15721 | 53174178 |
| Mental status changes | 62.60 | 9.42 | 259 | 158908 | 39312 | 53150587 |
| Drug abuser | 62.45 | 9.42 | 61 | 159106 | 3092 | 53186807 |
| Discomfort | 59.48 | 9.42 | 122 | 159045 | 95350 | 53094549 |
| Folliculitis | 57.85 | 9.42 | 12 | 159155 | 31697 | 53158202 |
| Bradypnoea | 56.54 | 9.42 | 59 | 159108 | 3238 | 53186661 |
| Bradyphrenia | 56.12 | 9.42 | 84 | 159083 | 6666 | 53183233 |
| Disturbance in attention | 55.14 | 9.42 | 226 | 158941 | 34157 | 53155742 |
| Sleep disorder due to general medical condition, insomnia type | 54.28 | 9.42 | 5 | 159162 | 24344 | 53165555 |
| Blister | 54.00 | 9.42 | 95 | 159072 | 78658 | 53111241 |
| Sleep talking | 53.04 | 9.42 | 35 | 159132 | 1001 | 53188898 |
| Affect lability | 52.86 | 9.42 | 98 | 159069 | 9277 | 53180622 |
| Muscle injury | 52.81 | 9.42 | 12 | 159155 | 29754 | 53160145 |
| Product use in unapproved indication | 51.84 | 9.42 | 167 | 159000 | 112122 | 53077777 |
| Exposure during pregnancy | 50.75 | 9.42 | 196 | 158971 | 124664 | 53065235 |
| Hallucination | 50.63 | 9.42 | 304 | 158863 | 53534 | 53136365 |
| Prescription form tampering | 50.13 | 9.42 | 29 | 159138 | 652 | 53189247 |
| Akathisia | 50.10 | 9.42 | 91 | 159076 | 8480 | 53181419 |
| Substance abuse | 49.45 | 9.42 | 64 | 159103 | 4430 | 53185469 |
| Pain | 48.06 | 9.42 | 1363 | 157804 | 587035 | 52602864 |
| Myocardial depression | 47.88 | 9.42 | 25 | 159142 | 456 | 53189443 |
| Dependence | 47.30 | 9.42 | 44 | 159123 | 2097 | 53187802 |
| Tremor | 47.13 | 9.42 | 578 | 158589 | 125158 | 53064741 |
| Mental disorder | 47.10 | 9.42 | 170 | 158997 | 24206 | 53165693 |
| Hallucination, visual | 45.87 | 9.42 | 142 | 159025 | 18690 | 53171209 |
| Tachycardia | 45.69 | 9.42 | 509 | 158658 | 107703 | 53082196 |
| Immobilisation prolonged | 45.45 | 9.42 | 15 | 159152 | 76 | 53189823 |
| Altered state of consciousness | 45.30 | 9.42 | 170 | 158997 | 24666 | 53165233 |
| Alcohol abuse | 42.89 | 9.42 | 41 | 159126 | 2023 | 53187876 |
| Psychomotor skills impaired | 42.80 | 9.42 | 43 | 159124 | 2256 | 53187643 |
| Decorticate posture | 42.51 | 9.42 | 21 | 159146 | 339 | 53189560 |
| Ill-defined disorder | 42.38 | 9.42 | 51 | 159116 | 49393 | 53140506 |
| Cough | 41.11 | 9.42 | 530 | 158637 | 256363 | 52933536 |
| Condition aggravated | 39.83 | 9.42 | 635 | 158532 | 296499 | 52893400 |
| Premature delivery | 38.19 | 9.42 | 15 | 159152 | 26089 | 53163810 |
| Victim of sexual abuse | 37.09 | 9.42 | 22 | 159145 | 519 | 53189380 |
| Listless | 37.02 | 9.42 | 42 | 159125 | 2534 | 53187365 |
| Depressed level of consciousness | 36.63 | 9.42 | 283 | 158884 | 54145 | 53135754 |
| Logorrhoea | 36.52 | 9.42 | 41 | 159126 | 2445 | 53187454 |
| Drug detoxification | 36.40 | 9.42 | 16 | 159151 | 195 | 53189704 |
| Anaphylactic reaction | 35.92 | 9.42 | 75 | 159092 | 58251 | 53131648 |
| Persistent genital arousal disorder | 35.87 | 9.42 | 18 | 159149 | 301 | 53189598 |
| Drug withdrawal convulsions | 35.86 | 9.42 | 31 | 159136 | 1341 | 53188558 |
| Drug tolerance | 35.85 | 9.42 | 54 | 159113 | 4309 | 53185590 |
| Dissociative disorder | 35.55 | 9.42 | 16 | 159151 | 207 | 53189692 |
| Illusion | 34.95 | 9.42 | 28 | 159139 | 1088 | 53188811 |
| Device expulsion | 34.85 | 9.42 | 23 | 159144 | 29790 | 53160109 |
| Memory impairment | 34.11 | 9.42 | 395 | 158772 | 84362 | 53105537 |
| Aggression | 33.78 | 9.42 | 149 | 159018 | 23254 | 53166645 |
| High risk sexual behaviour | 33.72 | 9.42 | 7 | 159160 | 0 | 53189899 |
| Red blood cell sedimentation rate increased | 33.68 | 9.42 | 21 | 159146 | 28036 | 53161863 |
| Accidental overdose | 33.51 | 9.42 | 140 | 159027 | 21339 | 53168560 |
| Victim of chemical submission | 32.68 | 9.42 | 16 | 159151 | 253 | 53189646 |
| Irritability | 32.50 | 9.42 | 180 | 158987 | 30773 | 53159126 |
| Anterograde amnesia | 31.81 | 9.42 | 19 | 159148 | 454 | 53189445 |
| Pruritus | 31.78 | 9.42 | 652 | 158515 | 293180 | 52896719 |
| Dysarthria | 31.34 | 9.42 | 218 | 158949 | 40350 | 53149549 |
| Chemical submission | 30.31 | 9.42 | 14 | 159153 | 193 | 53189706 |
| Parasomnia | 30.18 | 9.42 | 18 | 159149 | 429 | 53189470 |
| Gastrointestinal disorder | 30.07 | 9.42 | 152 | 159015 | 89852 | 53100047 |
| Hypokalaemia | 30.04 | 9.42 | 429 | 158738 | 96088 | 53093811 |
| Intentional product use issue | 29.96 | 9.42 | 113 | 159054 | 72381 | 53117518 |
| Tardive dyskinesia | 29.87 | 9.42 | 71 | 159096 | 7999 | 53181900 |
| Respiratory depression | 29.75 | 9.42 | 95 | 159072 | 12711 | 53177188 |
| Hip arthroplasty | 29.32 | 9.42 | 24 | 159143 | 27838 | 53162061 |
| Mania | 28.63 | 9.42 | 89 | 159078 | 11740 | 53178159 |
| Impaired healing | 28.58 | 9.42 | 97 | 159070 | 64108 | 53125791 |
| Panic attack | 28.41 | 9.42 | 133 | 159034 | 21285 | 53168614 |
| Dyspnoea | 28.40 | 9.42 | 1445 | 157722 | 584787 | 52605112 |
| Nightmare | 27.92 | 9.42 | 116 | 159051 | 17635 | 53172264 |
| Blood pressure fluctuation | 27.91 | 9.42 | 39 | 159128 | 35431 | 53154468 |
| Wheezing | 27.46 | 9.42 | 101 | 159066 | 65174 | 53124725 |
| Neutropenia | 27.10 | 9.42 | 324 | 158843 | 158861 | 53031038 |
| Vertigo | 27.03 | 9.42 | 271 | 158896 | 55810 | 53134089 |
| Urinary retention | 26.92 | 9.42 | 161 | 159006 | 28305 | 53161594 |
| Injury | 26.88 | 9.42 | 251 | 158916 | 50720 | 53139179 |
| Drug resistance | 26.78 | 9.42 | 13 | 159154 | 19949 | 53169950 |
| Initial insomnia | 26.73 | 9.42 | 52 | 159115 | 5103 | 53184796 |
| Unresponsive to stimuli | 26.64 | 9.42 | 181 | 158986 | 33245 | 53156654 |
| Arthritis | 26.63 | 9.42 | 152 | 159015 | 87146 | 53102753 |
| Coma scale abnormal | 26.57 | 9.42 | 52 | 159115 | 5126 | 53184773 |
| Urticaria | 26.54 | 9.42 | 268 | 158899 | 135617 | 53054282 |
| Blood pressure systolic increased | 26.38 | 9.42 | 40 | 159127 | 35137 | 53154762 |
| Head injury | 26.31 | 9.42 | 149 | 159018 | 25684 | 53164215 |
| Parkinsonism hyperpyrexia syndrome | 26.03 | 9.42 | 13 | 159154 | 215 | 53189684 |
| Drop attacks | 26.02 | 9.42 | 20 | 159147 | 731 | 53189168 |
| Hyponatraemia | 25.98 | 9.42 | 462 | 158705 | 108145 | 53081754 |
| Obstructive airways disorder | 25.52 | 9.42 | 10 | 159157 | 17419 | 53172480 |
| Prescription drug used without a prescription | 25.36 | 9.42 | 29 | 159138 | 1765 | 53188134 |
| Hallucination, auditory | 25.25 | 9.42 | 85 | 159082 | 11688 | 53178211 |
| Multiple sclerosis relapse | 25.24 | 9.42 | 224 | 158943 | 44629 | 53145270 |
| Drug screen positive | 25.07 | 9.42 | 43 | 159124 | 3829 | 53186070 |
| Behaviour disorder | 25.04 | 9.42 | 34 | 159133 | 2466 | 53187433 |
| COVID-19 | 23.94 | 9.42 | 46 | 159121 | 36842 | 53153057 |
| Asthma | 23.81 | 9.42 | 209 | 158958 | 108763 | 53081136 |
| Mobility decreased | 23.70 | 9.42 | 132 | 159035 | 76139 | 53113760 |
| Erythema | 23.21 | 9.42 | 329 | 158838 | 156640 | 53033259 |
| Electrocardiogram QT prolonged | 23.19 | 9.42 | 264 | 158903 | 56139 | 53133760 |
| Rhabdomyolysis | 23.01 | 9.42 | 216 | 158951 | 43707 | 53146192 |
| Hangover | 22.93 | 9.42 | 25 | 159142 | 1443 | 53188456 |
| Incoherent | 22.86 | 9.42 | 46 | 159121 | 4626 | 53185273 |
| Euphoric mood | 22.65 | 9.42 | 45 | 159122 | 4484 | 53185415 |
| Pyrexia | 22.64 | 9.42 | 978 | 158189 | 402215 | 52787684 |
| Bulimia nervosa | 22.16 | 9.42 | 16 | 159151 | 531 | 53189368 |
| Renal impairment | 21.84 | 9.42 | 152 | 159015 | 83166 | 53106733 |
| Psychomotor retardation | 21.74 | 9.42 | 39 | 159128 | 3599 | 53186300 |
| Dehydration | 21.72 | 9.42 | 657 | 158510 | 167753 | 53022146 |
| C-reactive protein increased | 21.36 | 9.42 | 117 | 159050 | 67769 | 53122130 |
| Sinusitis | 21.31 | 9.42 | 364 | 158803 | 168200 | 53021699 |
| Psychotic disorder | 21.22 | 9.42 | 135 | 159032 | 24250 | 53165649 |
| Emotional distress | 21.17 | 9.42 | 167 | 159000 | 32150 | 53157749 |
| Psychomotor hyperactivity | 20.87 | 9.42 | 72 | 159095 | 10024 | 53179875 |
| Administration site discomfort | 20.75 | 9.42 | 9 | 159158 | 106 | 53189793 |
| Rheumatoid nodule | 20.61 | 9.42 | 5 | 159162 | 11859 | 53178040 |
| Apathy | 20.54 | 9.42 | 63 | 159104 | 8249 | 53181650 |
| Crying | 20.47 | 9.42 | 125 | 159042 | 22137 | 53167762 |
| Drug interaction | 20.39 | 9.42 | 824 | 158343 | 218505 | 52971394 |
| Imprisonment | 20.07 | 9.42 | 11 | 159156 | 222 | 53189677 |
| Live birth | 19.91 | 9.42 | 10 | 159157 | 15049 | 53174850 |
| Generalised tonic-clonic seizure | 19.61 | 9.42 | 150 | 159017 | 28608 | 53161291 |
| Hypotension | 19.52 | 9.42 | 936 | 158231 | 253140 | 52936759 |
| Parkinsonism | 19.27 | 9.42 | 65 | 159102 | 8948 | 53180951 |
| Major depression | 19.24 | 9.42 | 58 | 159109 | 7524 | 53182375 |
| Fatigue | 18.85 | 9.42 | 1901 | 157266 | 728605 | 52461294 |
| Tracheal atresia | 18.76 | 9.42 | 6 | 159161 | 27 | 53189872 |
| Ventricular hypokinesia | 18.75 | 9.42 | 41 | 159126 | 4371 | 53185528 |
| Amnestic disorder | 18.70 | 9.42 | 12 | 159155 | 327 | 53189572 |
| Coagulation factor V level decreased | 18.41 | 9.42 | 12 | 159155 | 336 | 53189563 |
| Foreign body | 18.41 | 9.42 | 27 | 159140 | 2104 | 53187795 |
| Femoral neck fracture | 18.40 | 9.42 | 61 | 159106 | 8322 | 53181577 |
| Sinus tachycardia | 18.40 | 9.42 | 127 | 159040 | 23445 | 53166454 |
| Stomatitis | 17.78 | 9.42 | 197 | 158970 | 97961 | 53091938 |
| Derailment | 17.70 | 9.42 | 7 | 159160 | 64 | 53189835 |
| Feeling drunk | 17.63 | 9.42 | 38 | 159129 | 4011 | 53185888 |
| Knee arthroplasty | 17.60 | 9.42 | 47 | 159120 | 33522 | 53156377 |
| Inappropriate schedule of product administration | 17.08 | 9.42 | 142 | 159025 | 74736 | 53115163 |
| Herpes zoster | 17.05 | 9.42 | 140 | 159027 | 73879 | 53116020 |
| Psoriatic arthropathy | 16.89 | 9.42 | 80 | 159087 | 48110 | 53141789 |
| Diplopia | 16.88 | 9.42 | 113 | 159054 | 20652 | 53169247 |
| Syncope | 16.68 | 9.42 | 445 | 158722 | 111548 | 53078351 |
| Anger | 16.48 | 9.42 | 77 | 159090 | 12313 | 53177586 |
| Abnormal dreams | 16.46 | 9.42 | 69 | 159098 | 10532 | 53179367 |
| Panic disorder | 16.30 | 9.42 | 29 | 159138 | 2659 | 53187240 |
| Reduced facial expression | 16.29 | 9.42 | 23 | 159144 | 1731 | 53188168 |
| Alcohol use | 16.24 | 9.42 | 25 | 159142 | 2033 | 53187866 |
| Protrusion tongue | 16.18 | 9.42 | 11 | 159156 | 331 | 53189568 |
| Pneumonia aspiration | 16.17 | 9.42 | 165 | 159002 | 34136 | 53155763 |
| Carotid artery thrombosis | 15.89 | 9.42 | 19 | 159148 | 1213 | 53188686 |
| Cytomegalovirus infection | 15.86 | 9.42 | 21 | 159146 | 19518 | 53170381 |
| Inappropriate antidiuretic hormone secretion | 15.73 | 9.42 | 87 | 159080 | 14864 | 53175035 |
| Prothrombin time shortened | 15.59 | 9.42 | 23 | 159144 | 1801 | 53188098 |
| Legal problem | 15.54 | 9.42 | 5 | 159162 | 23 | 53189876 |
| Product complaint | 15.45 | 9.42 | 75 | 159092 | 12182 | 53177717 |
| Autonomic nervous system imbalance | 15.44 | 9.42 | 28 | 159139 | 2606 | 53187293 |
| Vision blurred | 15.40 | 9.42 | 349 | 158818 | 85255 | 53104644 |
| Laryngeal pain | 15.37 | 9.42 | 39 | 159128 | 4577 | 53185322 |
| Bone erosion | 15.36 | 9.42 | 7 | 159160 | 11145 | 53178754 |
| Loss of proprioception | 15.29 | 9.42 | 11 | 159156 | 363 | 53189536 |
| Cholecystitis chronic | 15.20 | 9.42 | 67 | 159100 | 10451 | 53179448 |
| Productive cough | 15.11 | 9.42 | 103 | 159064 | 56626 | 53133273 |
| Pneumonia | 15.10 | 9.42 | 1029 | 158138 | 406140 | 52783759 |
| Inflammation | 15.09 | 9.42 | 104 | 159063 | 57032 | 53132867 |
| Pulmonary vasculitis | 15.06 | 9.42 | 6 | 159161 | 56 | 53189843 |
| Mucosal inflammation | 15.01 | 9.42 | 71 | 159096 | 42713 | 53147186 |
| Blood pressure diastolic decreased | 14.75 | 9.42 | 17 | 159150 | 16786 | 53173113 |
| Adjustment disorder | 14.67 | 9.42 | 23 | 159144 | 1900 | 53187999 |
| Aortic valve calcification | 14.46 | 9.42 | 11 | 159156 | 396 | 53189503 |
| Incomplete spinal fusion | 14.45 | 9.42 | 3 | 159164 | 0 | 53189899 |
| Serotonin syndrome | 14.41 | 9.42 | 131 | 159036 | 26275 | 53163624 |
| Facial nerve disorder | 14.33 | 9.42 | 13 | 159154 | 600 | 53189299 |
| Cognitive disorder | 14.31 | 9.42 | 200 | 158967 | 44578 | 53145321 |
| Extrapyramidal disorder | 14.30 | 9.42 | 74 | 159093 | 12328 | 53177571 |
| Bladder sphincter atony | 14.19 | 9.42 | 8 | 159159 | 171 | 53189728 |
| Analgesic drug level above therapeutic | 13.94 | 9.42 | 8 | 159159 | 177 | 53189722 |
| Joint range of motion decreased | 13.87 | 9.42 | 20 | 159147 | 17936 | 53171963 |
| General physical health deterioration | 13.86 | 9.42 | 333 | 158834 | 146609 | 53043290 |
| Personality disorder | 13.86 | 9.42 | 35 | 159132 | 4096 | 53185803 |
| Grip strength decreased | 13.82 | 9.42 | 9 | 159158 | 11740 | 53178159 |
| Poor sucking reflex | 13.78 | 9.42 | 8 | 159159 | 181 | 53189718 |
| Persecutory delusion | 13.77 | 9.42 | 27 | 159140 | 2665 | 53187234 |
| Frostbite | 13.76 | 9.42 | 4 | 159163 | 12 | 53189887 |
| Hypothermia | 13.75 | 9.42 | 76 | 159091 | 12980 | 53176919 |
| Terminal insomnia | 13.64 | 9.42 | 13 | 159154 | 639 | 53189260 |
| Inadequate analgesia | 13.57 | 9.42 | 28 | 159139 | 2867 | 53187032 |
| Mood swings | 13.52 | 9.42 | 94 | 159073 | 17392 | 53172507 |
| Disinhibition | 13.48 | 9.42 | 15 | 159152 | 886 | 53189013 |
| Self-injurious ideation | 13.45 | 9.42 | 25 | 159142 | 2371 | 53187528 |
| Decreased interest | 13.44 | 9.42 | 30 | 159137 | 3243 | 53186656 |
| Spinal rod insertion | 13.30 | 9.42 | 4 | 159163 | 14 | 53189885 |
| Genitourinary symptom | 13.24 | 9.42 | 6 | 159161 | 79 | 53189820 |
| Accidental poisoning | 13.23 | 9.42 | 13 | 159154 | 664 | 53189235 |
| Hepatotoxicity | 13.18 | 9.42 | 41 | 159126 | 27839 | 53162060 |
| Hypokinesia | 13.17 | 9.42 | 75 | 159092 | 12952 | 53176947 |
| Therapy non-responder | 13.17 | 9.42 | 89 | 159078 | 49031 | 53140868 |
| Neonatal behavioural syndrome | 13.12 | 9.42 | 5 | 159162 | 41 | 53189858 |
| Injection site reaction | 13.09 | 9.42 | 94 | 159073 | 51072 | 53138827 |
| Multiple injuries | 13.06 | 9.42 | 22 | 159145 | 1931 | 53187968 |
| Occupational dermatitis | 13.01 | 9.42 | 5 | 159162 | 42 | 53189857 |
| Peripheral paralysis | 12.97 | 9.42 | 6 | 159161 | 83 | 53189816 |
| Neurotoxicity | 12.97 | 9.42 | 16 | 159151 | 15333 | 53174566 |
| Angioedema | 12.97 | 9.42 | 73 | 159094 | 42003 | 53147896 |
| Sleep disorder | 12.87 | 9.42 | 247 | 158920 | 58623 | 53131276 |
| Hyperhidrosis | 12.84 | 9.42 | 379 | 158788 | 96414 | 53093485 |
| Compulsive shopping | 12.78 | 9.42 | 14 | 159153 | 812 | 53189087 |
| Brain contusion | 12.78 | 9.42 | 12 | 159155 | 579 | 53189320 |
| Irritable bowel syndrome | 12.75 | 9.42 | 77 | 159090 | 43555 | 53146344 |
| No adverse event | 12.72 | 9.42 | 67 | 159100 | 39198 | 53150701 |
| Feeling abnormal | 12.72 | 9.42 | 509 | 158658 | 134792 | 53055107 |
| Blastocystis infection | 12.69 | 9.42 | 4 | 159163 | 17 | 53189882 |
| Victim of child abuse | 12.69 | 9.42 | 4 | 159163 | 17 | 53189882 |
| Sleep terror | 12.59 | 9.42 | 14 | 159153 | 826 | 53189073 |
| Seizure | 12.59 | 9.42 | 489 | 158678 | 129020 | 53060879 |
| Drug tolerance increased | 12.56 | 9.42 | 8 | 159159 | 215 | 53189684 |
| Death | 12.55 | 9.42 | 907 | 158260 | 356325 | 52833574 |
| Periventricular leukomalacia | 12.54 | 9.42 | 6 | 159161 | 90 | 53189809 |
| Accidental exposure to product | 12.52 | 9.42 | 33 | 159134 | 23641 | 53166258 |
| Intravascular haemolysis | 12.51 | 9.42 | 9 | 159158 | 297 | 53189602 |
| Peptic ulcer | 12.47 | 9.42 | 34 | 159133 | 4166 | 53185733 |
| Septic shock | 12.45 | 9.42 | 122 | 159045 | 62107 | 53127792 |
| Blood pressure systolic abnormal | 12.42 | 9.42 | 3 | 159164 | 7136 | 53182763 |
| Benzodiazepine drug level | 12.38 | 9.42 | 3 | 159164 | 3 | 53189896 |
| Suicidal behaviour | 12.30 | 9.42 | 25 | 159142 | 2533 | 53187366 |
| Blepharospasm | 12.29 | 9.42 | 26 | 159141 | 2710 | 53187189 |
| Theft | 12.25 | 9.42 | 6 | 159161 | 95 | 53189804 |
| Haemophagocytic lymphohistiocytosis | 12.18 | 9.42 | 6 | 159161 | 9131 | 53180768 |
| Mood altered | 12.12 | 9.42 | 77 | 159090 | 13824 | 53176075 |
| Speech disorder | 12.12 | 9.42 | 174 | 158993 | 39007 | 53150892 |
| Drug diversion | 12.07 | 9.42 | 14 | 159153 | 865 | 53189034 |
| Social anxiety disorder | 12.02 | 9.42 | 10 | 159157 | 410 | 53189489 |
| Crime | 12.00 | 9.42 | 4 | 159163 | 21 | 53189878 |
| Diarrhoea | 11.98 | 9.42 | 1660 | 157507 | 623886 | 52566013 |
| Diabetic ketoacidosis | 11.93 | 9.42 | 26 | 159141 | 19889 | 53170010 |
| Dysphagia | 11.90 | 9.42 | 333 | 158834 | 84064 | 53105835 |
| Gun shot wound | 11.71 | 9.42 | 6 | 159161 | 105 | 53189794 |
| Transplant rejection | 11.64 | 9.42 | 8 | 159159 | 10143 | 53179756 |
| Urinary hesitation | 11.60 | 9.42 | 22 | 159145 | 2119 | 53187780 |
| Toxic epidermal necrolysis | 11.59 | 9.42 | 34 | 159133 | 23516 | 53166383 |
| Fibrocystic breast disease | 11.54 | 9.42 | 16 | 159151 | 1184 | 53188715 |
| Left ventricular hypertrophy | 11.46 | 9.42 | 38 | 159129 | 5185 | 53184714 |
| Self-medication | 11.46 | 9.42 | 24 | 159143 | 2484 | 53187415 |
| Automatism | 11.37 | 9.42 | 5 | 159162 | 61 | 53189838 |
| Drug dependence, antepartum | 11.29 | 9.42 | 4 | 159163 | 26 | 53189873 |
| Myelosuppression | 11.24 | 9.42 | 13 | 159154 | 12815 | 53177084 |
| Balance disorder | 11.22 | 9.42 | 292 | 158875 | 72915 | 53116984 |
| Alcohol poisoning | 11.12 | 9.42 | 20 | 159147 | 1849 | 53188050 |
| Bronchopulmonary aspergillosis | 11.09 | 9.42 | 6 | 159161 | 8659 | 53181240 |
| Tension | 11.08 | 9.42 | 28 | 159139 | 3278 | 53186621 |
| Bone scan abnormal | 11.01 | 9.42 | 9 | 159158 | 360 | 53189539 |
| Waxy flexibility | 11.00 | 9.42 | 6 | 159161 | 120 | 53189779 |
| Anal incontinence | 10.99 | 9.42 | 70 | 159097 | 12577 | 53177322 |
| Dysuria | 10.97 | 9.42 | 139 | 159028 | 30314 | 53159585 |
| Vertigo CNS origin | 10.92 | 9.42 | 4 | 159163 | 29 | 53189870 |
| Type 2 diabetes mellitus | 10.85 | 9.42 | 53 | 159114 | 31617 | 53158282 |
| Foetal exposure during pregnancy | 10.82 | 9.42 | 60 | 159107 | 34655 | 53155244 |
| Enthesopathy | 10.82 | 9.42 | 3 | 159164 | 6508 | 53183391 |
| Peritoneal perforation | 10.82 | 9.42 | 6 | 159161 | 124 | 53189775 |
| Liver injury | 10.81 | 9.42 | 32 | 159135 | 22071 | 53167828 |
| Bradycardia | 10.77 | 9.42 | 283 | 158884 | 70773 | 53119126 |
| Muscle tone disorder | 10.74 | 9.42 | 6 | 159161 | 126 | 53189773 |
| Restless legs syndrome | 10.73 | 9.42 | 88 | 159079 | 17135 | 53172764 |
| Eustachian tube disorder | 10.69 | 9.42 | 5 | 159162 | 71 | 53189828 |
| Mouth ulceration | 10.68 | 9.42 | 48 | 159119 | 29278 | 53160621 |
| Multiple sclerosis | 10.67 | 9.42 | 126 | 159041 | 27027 | 53162872 |
| Panniculitis | 10.62 | 9.42 | 5 | 159162 | 7809 | 53182090 |
| Respiratory disorder | 10.59 | 9.42 | 59 | 159108 | 34038 | 53155861 |
| Dermatitis allergic | 10.59 | 9.42 | 15 | 159152 | 13553 | 53176346 |
| Asthenia | 10.53 | 9.42 | 1175 | 157992 | 342415 | 52847484 |
| Haemangioma congenital | 10.48 | 9.42 | 10 | 159157 | 492 | 53189407 |
| Nasal congestion | 10.43 | 9.42 | 105 | 159062 | 53182 | 53136717 |
| Middle insomnia | 10.40 | 9.42 | 61 | 159106 | 10647 | 53179252 |
| Adverse drug reaction | 10.36 | 9.42 | 106 | 159061 | 53519 | 53136380 |
| Neurologic neglect syndrome | 10.31 | 9.42 | 15 | 159152 | 1160 | 53188739 |
| Immunodeficiency | 10.30 | 9.42 | 18 | 159149 | 14949 | 53174950 |
| Deep vein thrombosis | 10.29 | 9.42 | 322 | 158845 | 82591 | 53107308 |
| Respiratory acidosis | 10.25 | 9.42 | 42 | 159125 | 6346 | 53183553 |
| Prothrombin time prolonged | 10.23 | 9.42 | 57 | 159110 | 9765 | 53180134 |
| Eating disorder | 10.22 | 9.42 | 83 | 159084 | 16114 | 53173785 |
| Dysphoria | 10.07 | 9.42 | 37 | 159130 | 5312 | 53184587 |
| Psychotic behaviour | 10.07 | 9.42 | 11 | 159156 | 636 | 53189263 |
| Respiratory dyskinesia | 10.07 | 9.42 | 4 | 159163 | 37 | 53189862 |
| Trance | 10.07 | 9.42 | 4 | 159163 | 37 | 53189862 |
| Thirst | 10.04 | 9.42 | 64 | 159103 | 11502 | 53178397 |
| Poor venous access | 10.00 | 9.42 | 9 | 159158 | 9966 | 53179933 |
| Blood potassium decreased | 9.98 | 9.42 | 173 | 158994 | 40287 | 53149612 |
| Dreamy state | 9.98 | 9.42 | 4 | 159163 | 38 | 53189861 |
| Tuberculosis | 9.94 | 9.42 | 11 | 159156 | 11060 | 53178839 |
| Lethargy | 9.92 | 9.42 | 220 | 158947 | 53540 | 53136359 |
| Secretion discharge | 9.92 | 9.42 | 10 | 159157 | 10496 | 53179403 |
| Spondylolisthesis | 9.85 | 9.42 | 27 | 159140 | 3318 | 53186581 |
| Apallic syndrome | 9.85 | 9.42 | 11 | 159156 | 652 | 53189247 |
| Acute kidney injury | 9.83 | 9.42 | 639 | 158528 | 253229 | 52936670 |
| Spleen congestion | 9.81 | 9.42 | 6 | 159161 | 150 | 53189749 |
| Eye movement disorder | 9.75 | 9.42 | 35 | 159132 | 4970 | 53184929 |
| Emotional poverty | 9.72 | 9.42 | 8 | 159159 | 323 | 53189576 |
| Pulmonary fibrosis | 9.72 | 9.42 | 38 | 159129 | 24097 | 53165802 |
| Proteinuria | 9.70 | 9.42 | 25 | 159142 | 18043 | 53171856 |
| Sensory loss | 9.70 | 9.42 | 48 | 159119 | 7857 | 53182042 |
| Coordination abnormal | 9.69 | 9.42 | 65 | 159102 | 11886 | 53178013 |
| Sedation | 9.67 | 9.42 | 133 | 159034 | 29542 | 53160357 |
| Bipolar disorder | 9.66 | 9.42 | 47 | 159120 | 7639 | 53182260 |
| Oophorectomy bilateral | 9.63 | 9.42 | 4 | 159163 | 42 | 53189857 |
| Device difficult to use | 9.62 | 9.42 | 10 | 159157 | 10349 | 53179550 |
| Therapeutic response unexpected | 9.59 | 9.42 | 86 | 159081 | 17184 | 53172715 |
| Communication disorder | 9.49 | 9.42 | 22 | 159145 | 2439 | 53187460 |
| Labelled drug-food interaction issue | 9.47 | 9.42 | 3 | 159164 | 13 | 53189886 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 869.89 | 10.13 | 1188 | 91350 | 91329 | 32329659 |
| Somnambulism | 651.99 | 10.13 | 270 | 92268 | 2962 | 32418026 |
| Drug abuse | 418.00 | 10.13 | 788 | 91750 | 79455 | 32341533 |
| Drug dependence | 413.95 | 10.13 | 417 | 92121 | 23067 | 32397921 |
| Intentional overdose | 351.07 | 10.13 | 508 | 92030 | 41093 | 32379895 |
| Amnesia | 286.77 | 10.13 | 355 | 92183 | 24681 | 32396307 |
| Suicide attempt | 247.08 | 10.13 | 413 | 92125 | 37831 | 32383157 |
| Toxicity to various agents | 242.75 | 10.13 | 1076 | 91462 | 176965 | 32244023 |
| Insomnia | 235.17 | 10.13 | 723 | 91815 | 99625 | 32321363 |
| Intentional self-injury | 185.30 | 10.13 | 213 | 92325 | 13687 | 32407301 |
| Road traffic accident | 159.43 | 10.13 | 221 | 92317 | 17160 | 32403828 |
| Off label use | 138.25 | 10.13 | 431 | 92107 | 305889 | 32115099 |
| Abnormal sleep-related event | 136.86 | 10.13 | 52 | 92486 | 445 | 32420543 |
| Sopor | 135.12 | 10.13 | 167 | 92371 | 11582 | 32409406 |
| Poisoning | 132.20 | 10.13 | 161 | 92377 | 10997 | 32409991 |
| Somnolence | 124.62 | 10.13 | 605 | 91933 | 103192 | 32317796 |
| Overdose | 124.20 | 10.13 | 534 | 92004 | 86543 | 32334445 |
| Respiratory arrest | 121.60 | 10.13 | 260 | 92278 | 28648 | 32392340 |
| Sleep-related eating disorder | 119.90 | 10.13 | 43 | 92495 | 307 | 32420681 |
| Drug withdrawal syndrome | 107.97 | 10.13 | 201 | 92337 | 20030 | 32400958 |
| Abnormal behaviour | 104.44 | 10.13 | 232 | 92306 | 26234 | 32394754 |
| Impaired driving ability | 101.29 | 10.13 | 72 | 92466 | 2447 | 32418541 |
| Parasomnia | 99.97 | 10.13 | 39 | 92499 | 361 | 32420627 |
| Delirium | 95.31 | 10.13 | 309 | 92229 | 43737 | 32377251 |
| Confusional state | 94.58 | 10.13 | 714 | 91824 | 142401 | 32278587 |
| Suicidal ideation | 91.45 | 10.13 | 277 | 92261 | 37806 | 32383182 |
| Anxiety | 77.47 | 10.13 | 503 | 92035 | 95502 | 32325486 |
| Homicide | 74.98 | 10.13 | 42 | 92496 | 931 | 32420057 |
| Coma | 73.19 | 10.13 | 277 | 92261 | 42335 | 32378653 |
| Depression | 71.99 | 10.13 | 498 | 92040 | 96562 | 32324426 |
| Cardio-respiratory arrest | 66.13 | 10.13 | 325 | 92213 | 55664 | 32365324 |
| Withdrawal syndrome | 65.37 | 10.13 | 121 | 92417 | 12001 | 32408987 |
| Automatism | 65.14 | 10.13 | 20 | 92518 | 81 | 32420907 |
| Poisoning deliberate | 64.43 | 10.13 | 85 | 92453 | 6290 | 32414698 |
| Bradyphrenia | 61.78 | 10.13 | 71 | 92467 | 4558 | 32416430 |
| Intentional product misuse | 61.62 | 10.13 | 234 | 92304 | 35817 | 32385171 |
| Product use in unapproved indication | 61.13 | 10.13 | 96 | 92442 | 87108 | 32333880 |
| Disorientation | 57.16 | 10.13 | 217 | 92321 | 33208 | 32387780 |
| Suicidal behaviour | 56.74 | 10.13 | 41 | 92497 | 1430 | 32419558 |
| Gun shot wound | 54.29 | 10.13 | 36 | 92502 | 1090 | 32419898 |
| Rheumatoid arthritis | 52.17 | 10.13 | 31 | 92507 | 44513 | 32376475 |
| Aggression | 51.12 | 10.13 | 235 | 92303 | 39154 | 32381834 |
| Drug use disorder | 50.81 | 10.13 | 57 | 92481 | 3564 | 32417424 |
| Drug abuser | 48.95 | 10.13 | 60 | 92478 | 4124 | 32416864 |
| Drug ineffective | 48.91 | 10.13 | 783 | 91755 | 382694 | 32038294 |
| Prescription form tampering | 44.64 | 10.13 | 25 | 92513 | 554 | 32420434 |
| Fall | 43.48 | 10.13 | 792 | 91746 | 195409 | 32225579 |
| Drug tolerance | 42.30 | 10.13 | 42 | 92496 | 2279 | 32418709 |
| Agitation | 41.41 | 10.13 | 292 | 92246 | 56944 | 32364044 |
| Anterograde amnesia | 41.40 | 10.13 | 17 | 92521 | 182 | 32420806 |
| Restlessness | 38.86 | 10.13 | 157 | 92381 | 24724 | 32396264 |
| Altered state of consciousness | 38.59 | 10.13 | 144 | 92394 | 21853 | 32399135 |
| Asthma | 37.51 | 10.13 | 42 | 92496 | 44023 | 32376965 |
| Sleep disorder | 37.25 | 10.13 | 163 | 92375 | 26589 | 32394399 |
| Nightmare | 36.64 | 10.13 | 101 | 92437 | 13065 | 32407923 |
| Antidepressant drug level above therapeutic | 36.01 | 10.13 | 15 | 92523 | 167 | 32420821 |
| Dependence | 35.35 | 10.13 | 29 | 92509 | 1224 | 32419764 |
| Legal problem | 35.31 | 10.13 | 15 | 92523 | 176 | 32420812 |
| Mania | 35.28 | 10.13 | 82 | 92456 | 9550 | 32411438 |
| Irritability | 34.93 | 10.13 | 151 | 92387 | 24503 | 32396485 |
| Conduction disorder | 34.41 | 10.13 | 35 | 92503 | 1955 | 32419033 |
| Acute kidney injury | 34.14 | 10.13 | 609 | 91929 | 292859 | 32128129 |
| Cytomegalovirus infection | 33.86 | 10.13 | 15 | 92523 | 25449 | 32395539 |
| Angioedema | 33.82 | 10.13 | 32 | 92506 | 36257 | 32384731 |
| Death | 33.60 | 10.13 | 831 | 91707 | 381686 | 32039302 |
| Memory impairment | 33.16 | 10.13 | 213 | 92325 | 40266 | 32380722 |
| Therapeutic product effect incomplete | 32.43 | 10.13 | 42 | 92496 | 41299 | 32379689 |
| Hallucination | 31.61 | 10.13 | 257 | 92281 | 52362 | 32368626 |
| Thinking abnormal | 31.33 | 10.13 | 57 | 92481 | 5578 | 32415410 |
| Exposure via ingestion | 31.20 | 10.13 | 36 | 92502 | 2321 | 32418667 |
| Initial insomnia | 31.11 | 10.13 | 41 | 92497 | 3031 | 32417957 |
| Persistent depressive disorder | 30.72 | 10.13 | 16 | 92522 | 305 | 32420683 |
| Analgesic drug level above therapeutic | 30.61 | 10.13 | 15 | 92523 | 250 | 32420738 |
| Drug intolerance | 30.05 | 10.13 | 61 | 92477 | 50174 | 32370814 |
| Joint swelling | 29.96 | 10.13 | 64 | 92474 | 51671 | 32369317 |
| Loss of consciousness | 29.71 | 10.13 | 363 | 92175 | 82344 | 32338644 |
| Oedematous pancreatitis | 29.71 | 10.13 | 18 | 92520 | 464 | 32420524 |
| Self-medication | 29.25 | 10.13 | 35 | 92503 | 2346 | 32418642 |
| Multiple organ dysfunction syndrome | 28.13 | 10.13 | 103 | 92435 | 69751 | 32351237 |
| Febrile neutropenia | 27.59 | 10.13 | 213 | 92325 | 119353 | 32301635 |
| Sepsis | 27.56 | 10.13 | 304 | 92234 | 158530 | 32262458 |
| Treatment failure | 27.53 | 10.13 | 43 | 92495 | 39120 | 32381868 |
| Dissociative disorder | 27.40 | 10.13 | 13 | 92525 | 201 | 32420787 |
| Hypokinesia | 26.97 | 10.13 | 68 | 92470 | 8337 | 32412651 |
| Personality change | 26.65 | 10.13 | 50 | 92488 | 5009 | 32415979 |
| Incoherent | 26.12 | 10.13 | 46 | 92492 | 4388 | 32416600 |
| General physical health deterioration | 25.81 | 10.13 | 207 | 92331 | 115052 | 32305936 |
| Poor quality sleep | 25.58 | 10.13 | 65 | 92473 | 8009 | 32412979 |
| Circadian rhythm sleep disorder | 25.23 | 10.13 | 16 | 92522 | 448 | 32420540 |
| Pyrexia | 25.18 | 10.13 | 706 | 91832 | 319262 | 32101726 |
| Septic shock | 25.05 | 10.13 | 106 | 92432 | 68883 | 32352105 |
| Lower respiratory tract infection | 24.74 | 10.13 | 28 | 92510 | 29215 | 32391773 |
| Paranoia | 24.46 | 10.13 | 77 | 92461 | 10722 | 32410266 |
| Miosis | 24.44 | 10.13 | 67 | 92471 | 8637 | 32412351 |
| Cardiac arrest | 24.39 | 10.13 | 399 | 92139 | 96377 | 32324611 |
| Infection | 23.99 | 10.13 | 142 | 92396 | 84573 | 32336415 |
| Theft | 23.71 | 10.13 | 13 | 92525 | 276 | 32420712 |
| Logorrhoea | 23.61 | 10.13 | 32 | 92506 | 2430 | 32418558 |
| Neutropenia | 23.14 | 10.13 | 276 | 92262 | 141899 | 32279089 |
| Dyspnoea | 23.13 | 10.13 | 821 | 91717 | 361224 | 32059764 |
| Visceral congestion | 22.97 | 10.13 | 16 | 92522 | 526 | 32420462 |
| Labelled drug-food interaction medication error | 22.95 | 10.13 | 8 | 92530 | 52 | 32420936 |
| Thermophobia | 22.64 | 10.13 | 9 | 92529 | 88 | 32420900 |
| Disturbance in attention | 22.63 | 10.13 | 130 | 92408 | 23623 | 32397365 |
| Abnormal dreams | 22.17 | 10.13 | 64 | 92474 | 8500 | 32412488 |
| Erythema | 22.12 | 10.13 | 142 | 92396 | 82963 | 32338025 |
| Bradypnoea | 21.88 | 10.13 | 31 | 92507 | 2455 | 32418533 |
| Panic attack | 21.87 | 10.13 | 67 | 92471 | 9194 | 32411794 |
| Depressed level of consciousness | 21.63 | 10.13 | 194 | 92344 | 40653 | 32380335 |
| Cardiac failure | 21.28 | 10.13 | 163 | 92375 | 91510 | 32329478 |
| Drug withdrawal convulsions | 20.96 | 10.13 | 21 | 92517 | 1152 | 32419836 |
| Acute stress disorder | 20.83 | 10.13 | 10 | 92528 | 159 | 32420829 |
| Myelosuppression | 20.77 | 10.13 | 4 | 92534 | 11672 | 32409316 |
| Akathisia | 20.66 | 10.13 | 55 | 92483 | 6970 | 32414018 |
| Sleep apnoea syndrome | 20.64 | 10.13 | 107 | 92431 | 18707 | 32402281 |
| Anger | 20.11 | 10.13 | 77 | 92461 | 11827 | 32409161 |
| Victim of chemical submission | 19.89 | 10.13 | 7 | 92531 | 47 | 32420941 |
| Infusion related reaction | 19.86 | 10.13 | 65 | 92473 | 45534 | 32375454 |
| Hallucination, visual | 19.81 | 10.13 | 99 | 92439 | 17060 | 32403928 |
| Reduced facial expression | 19.56 | 10.13 | 18 | 92520 | 888 | 32420100 |
| Distributive shock | 19.40 | 10.13 | 18 | 92520 | 897 | 32420091 |
| Alcohol interaction | 19.35 | 10.13 | 28 | 92510 | 2261 | 32418727 |
| Mental status changes | 18.75 | 10.13 | 179 | 92359 | 38158 | 32382830 |
| Intentional product use issue | 18.50 | 10.13 | 60 | 92478 | 42151 | 32378837 |
| Tachyphrenia | 18.49 | 10.13 | 20 | 92518 | 1200 | 32419788 |
| Stress at work | 18.20 | 10.13 | 9 | 92529 | 153 | 32420835 |
| Drug screen positive | 17.65 | 10.13 | 38 | 92500 | 4203 | 32416785 |
| Impatience | 17.54 | 10.13 | 11 | 92527 | 302 | 32420686 |
| Major depression | 17.41 | 10.13 | 39 | 92499 | 4432 | 32416556 |
| Perseveration | 17.26 | 10.13 | 8 | 92530 | 117 | 32420871 |
| Pruritus | 17.24 | 10.13 | 260 | 92278 | 128442 | 32292546 |
| Renal impairment | 17.16 | 10.13 | 173 | 92365 | 91799 | 32329189 |
| Peripheral swelling | 17.07 | 10.13 | 119 | 92419 | 68226 | 32352762 |
| Synovitis | 16.85 | 10.13 | 5 | 92533 | 10873 | 32410115 |
| Asphyxia | 16.62 | 10.13 | 44 | 92494 | 5556 | 32415432 |
| Transplant rejection | 16.61 | 10.13 | 4 | 92534 | 9995 | 32410993 |
| COVID-19 | 16.60 | 10.13 | 42 | 92496 | 31973 | 32389015 |
| Loss of personal independence in daily activities | 16.55 | 10.13 | 32 | 92506 | 26801 | 32394187 |
| Rectal haemorrhage | 16.54 | 10.13 | 53 | 92485 | 37370 | 32383618 |
| Victim of homicide | 16.45 | 10.13 | 8 | 92530 | 131 | 32420857 |
| Oral discharge | 16.18 | 10.13 | 8 | 92530 | 136 | 32420852 |
| Cough | 16.10 | 10.13 | 288 | 92250 | 138529 | 32282459 |
| Libido decreased | 16.01 | 10.13 | 39 | 92499 | 4679 | 32416309 |
| Brachial plexus injury | 15.98 | 10.13 | 7 | 92531 | 89 | 32420899 |
| Apallic syndrome | 15.93 | 10.13 | 10 | 92528 | 275 | 32420713 |
| Drug diversion | 15.80 | 10.13 | 16 | 92522 | 889 | 32420099 |
| Sexual abuse | 15.72 | 10.13 | 8 | 92530 | 145 | 32420843 |
| Condition aggravated | 15.61 | 10.13 | 331 | 92207 | 155330 | 32265658 |
| Euphoric mood | 15.45 | 10.13 | 41 | 92497 | 5186 | 32415802 |
| Drug resistance | 15.40 | 10.13 | 26 | 92512 | 22939 | 32398049 |
| Galactorrhoea | 15.26 | 10.13 | 11 | 92527 | 382 | 32420606 |
| Skin laceration | 15.22 | 10.13 | 71 | 92467 | 11895 | 32409093 |
| Adrenocorticotropic hormone deficiency | 15.15 | 10.13 | 13 | 92525 | 584 | 32420404 |
| Hallucination, auditory | 15.12 | 10.13 | 64 | 92474 | 10286 | 32410702 |
| Nervousness | 15.12 | 10.13 | 73 | 92465 | 12406 | 32408582 |
| Sleep talking | 14.82 | 10.13 | 12 | 92526 | 497 | 32420491 |
| Pulmonary fibrosis | 14.64 | 10.13 | 16 | 92522 | 16958 | 32404030 |
| Neurotoxicity | 14.38 | 10.13 | 13 | 92525 | 15057 | 32405931 |
| Dysarthria | 14.29 | 10.13 | 151 | 92387 | 33050 | 32387938 |
| Acute myocardial infarction | 14.28 | 10.13 | 95 | 92443 | 55054 | 32365934 |
| Tubulointerstitial nephritis | 14.23 | 10.13 | 21 | 92517 | 19556 | 32401432 |
| Amimia | 14.20 | 10.13 | 4 | 92534 | 11 | 32420977 |
| Coagulation factor VII level decreased | 14.16 | 10.13 | 7 | 92531 | 119 | 32420869 |
| Product dose omission issue | 14.15 | 10.13 | 206 | 92332 | 102369 | 32318619 |
| Pneumothorax traumatic | 13.79 | 10.13 | 6 | 92532 | 75 | 32420913 |
| Sciatic nerve neuropathy | 13.65 | 10.13 | 6 | 92532 | 77 | 32420911 |
| Aspergillus infection | 13.62 | 10.13 | 8 | 92530 | 11566 | 32409422 |
| Dry mouth | 13.52 | 10.13 | 116 | 92422 | 24003 | 32396985 |
| Psychomotor skills impaired | 13.51 | 10.13 | 25 | 92513 | 2478 | 32418510 |
| Leukopenia | 13.44 | 10.13 | 108 | 92430 | 60014 | 32360974 |
| C-reactive protein increased | 13.41 | 10.13 | 81 | 92457 | 48021 | 32372967 |
| Psychomotor hyperactivity | 13.29 | 10.13 | 56 | 92482 | 8983 | 32412005 |
| Hangover | 13.24 | 10.13 | 16 | 92522 | 1083 | 32419905 |
| Disinhibition | 13.24 | 10.13 | 26 | 92512 | 2694 | 32418294 |
| Toxic epidermal necrolysis | 13.19 | 10.13 | 24 | 92514 | 20569 | 32400419 |
| Respiratory failure | 13.18 | 10.13 | 220 | 92318 | 106962 | 32314026 |
| Differentiation syndrome | 13.12 | 10.13 | 17 | 92521 | 1236 | 32419752 |
| Heart rate decreased | 13.11 | 10.13 | 33 | 92505 | 25167 | 32395821 |
| Drug tolerance increased | 13.09 | 10.13 | 11 | 92527 | 480 | 32420508 |
| Victim of crime | 13.09 | 10.13 | 10 | 92528 | 380 | 32420608 |
| Electrocardiogram J wave | 13.07 | 10.13 | 4 | 92534 | 16 | 32420972 |
| Psychotic disorder | 13.05 | 10.13 | 111 | 92427 | 22909 | 32398079 |
| Hypogonadism | 12.98 | 10.13 | 20 | 92518 | 1707 | 32419281 |
| Ataxia | 12.97 | 10.13 | 71 | 92467 | 12670 | 32408318 |
| Hyperlipidaemia | 12.90 | 10.13 | 78 | 92460 | 14433 | 32406555 |
| Inappropriate antidiuretic hormone secretion | 12.81 | 10.13 | 68 | 92470 | 11995 | 32408993 |
| Psoriasis | 12.68 | 10.13 | 78 | 92460 | 46045 | 32374943 |
| Imprisonment | 12.67 | 10.13 | 11 | 92527 | 502 | 32420486 |
| Alcohol use | 12.61 | 10.13 | 29 | 92509 | 3354 | 32417634 |
| Slow speech | 12.48 | 10.13 | 15 | 92523 | 1010 | 32419978 |
| Sciatic nerve injury | 12.35 | 10.13 | 6 | 92532 | 98 | 32420890 |
| Hypersensitivity | 12.34 | 10.13 | 105 | 92433 | 57653 | 32363335 |
| Grandiosity | 12.21 | 10.13 | 9 | 92529 | 324 | 32420664 |
| Drowning | 12.19 | 10.13 | 10 | 92528 | 422 | 32420566 |
| Congenital hydrocephalus | 12.08 | 10.13 | 6 | 92532 | 103 | 32420885 |
| Neutropenic sepsis | 12.06 | 10.13 | 11 | 92527 | 12688 | 32408300 |
| Bradykinesia | 12.04 | 10.13 | 33 | 92505 | 4253 | 32416735 |
| Family stress | 11.96 | 10.13 | 7 | 92531 | 169 | 32420819 |
| Hospitalisation | 11.87 | 10.13 | 86 | 92452 | 48885 | 32372103 |
| Mucosal inflammation | 11.75 | 10.13 | 52 | 92486 | 33382 | 32387606 |
| Accidental poisoning | 11.73 | 10.13 | 11 | 92527 | 556 | 32420432 |
| Mental disorder due to a general medical condition | 11.67 | 10.13 | 7 | 92531 | 177 | 32420811 |
| Thrombocytopenia | 11.67 | 10.13 | 327 | 92211 | 147972 | 32273016 |
| Feeling abnormal | 11.66 | 10.13 | 239 | 92299 | 60184 | 32360804 |
| Drug withdrawal syndrome neonatal | 11.61 | 10.13 | 29 | 92509 | 3535 | 32417453 |
| Urticaria | 11.59 | 10.13 | 111 | 92427 | 59503 | 32361485 |
| Blood pressure fluctuation | 11.57 | 10.13 | 25 | 92513 | 20110 | 32400878 |
| Diarrhoea | 11.57 | 10.13 | 888 | 91650 | 363914 | 32057074 |
| Myocardial infarction | 11.52 | 10.13 | 271 | 92267 | 125405 | 32295583 |
| Epstein-Barr virus infection | 11.46 | 10.13 | 3 | 92535 | 7087 | 32413901 |
| Cholestasis | 11.45 | 10.13 | 39 | 92499 | 26994 | 32393994 |
| Blood pressure increased | 11.43 | 10.13 | 158 | 92380 | 79196 | 32341792 |
| Wheezing | 11.41 | 10.13 | 60 | 92478 | 36814 | 32384174 |
| Spigelian hernia | 11.32 | 10.13 | 3 | 92535 | 6 | 32420982 |
| Bronchiectasis | 11.23 | 10.13 | 3 | 92535 | 6989 | 32413999 |
| Anaphylactic reaction | 11.17 | 10.13 | 46 | 92492 | 30126 | 32390862 |
| Coprolalia | 11.10 | 10.13 | 4 | 92534 | 29 | 32420959 |
| Poor feeding infant | 11.08 | 10.13 | 10 | 92528 | 481 | 32420507 |
| Amnestic disorder | 11.07 | 10.13 | 7 | 92531 | 195 | 32420793 |
| Neutrophil count increased | 11.03 | 10.13 | 18 | 92520 | 16096 | 32404892 |
| Pilonidal cyst congenital | 10.98 | 10.13 | 4 | 92534 | 30 | 32420958 |
| Substance-induced mood disorder | 10.98 | 10.13 | 5 | 92533 | 70 | 32420918 |
| Urinary hesitation | 10.94 | 10.13 | 22 | 92516 | 2319 | 32418669 |
| Bone marrow failure | 10.85 | 10.13 | 47 | 92491 | 30357 | 32390631 |
| Renal injury | 10.80 | 10.13 | 11 | 92527 | 12044 | 32408944 |
| Hyperhidrosis | 10.77 | 10.13 | 272 | 92266 | 70896 | 32350092 |
| Lactic acidosis | 10.70 | 10.13 | 54 | 92484 | 33482 | 32387506 |
| Thrombotic microangiopathy | 10.54 | 10.13 | 7 | 92531 | 9475 | 32411513 |
| Staring | 10.54 | 10.13 | 17 | 92521 | 1509 | 32419479 |
| Product substitution issue | 10.52 | 10.13 | 58 | 92480 | 10378 | 32410610 |
| Labile hypertension | 10.50 | 10.13 | 5 | 92533 | 78 | 32420910 |
| Rash | 10.46 | 10.13 | 488 | 92050 | 208845 | 32212143 |
| Drug half-life reduced | 10.46 | 10.13 | 3 | 92535 | 9 | 32420979 |
| Lethargy | 10.38 | 10.13 | 170 | 92368 | 41058 | 32379930 |
| Labelled drug-drug interaction medication error | 10.37 | 10.13 | 12 | 92526 | 12401 | 32408587 |
| Tuberculosis | 10.32 | 10.13 | 6 | 92532 | 8723 | 32412265 |
| Scar pain | 10.22 | 10.13 | 5 | 92533 | 83 | 32420905 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05CF02 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Benzodiazepine related drugs |
| FDA CS | M0018233 | Pyridines |
| FDA MoA | N0000000196 | GABA A Agonists |
| FDA Chemical/Ingredient | N0000007570 | Pyridines |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018682 | GABA Agents |
| MeSH PA | D018755 | GABA Agonists |
| MeSH PA | D058785 | GABA-A Receptor Agonists |
| MeSH PA | D006993 | Hypnotics and Sedatives |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D000068776 | Sleep Aids, Pharmaceutical |
| CHEBI has role | CHEBI:35488 | CNS depressants |
| CHEBI has role | CHEBI:35717 | sedatives |
| CHEBI has role | CHEBI:51373 | gamma-aminobutyric acid receptor agonists |
| FDA PE | N0000175728 | Central Nervous System Depression |
| FDA EPC | N0000175759 | gamma-Aminobutyric Acid-ergic Agonist |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Initial insomnia | indication | 59050008 | |
| Insomnia | indication | 193462001 | |
| Cognitive impairment following traumatic brain injury | off-label use | 127295002 | |
| Arousal post traumatic brain injury | off-label use | 127295002 | |
| Suicidal thoughts | contraindication | 6471006 | |
| Hallucinations | contraindication | 7011001 | |
| Asthenia | contraindication | 13791008 | |
| Alcohol intoxication | contraindication | 25702006 | |
| Depressive disorder | contraindication | 35489007 | |
| Aggressive behavior | contraindication | 61372001 | |
| Substance abuse | contraindication | 66214007 | |
| Sleep apnea | contraindication | 73430006 | DOID:0050847 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Sleep automatism | contraindication | 247962006 | |
| Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
| Impaired cognition | contraindication | 386806002 | |
| Memory impairment | contraindication | 386807006 | |
| Attention deficit hyperactivity disorder | contraindication | 406506008 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.73 | Basic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7682628 | Feb. 16, 2025 | METHOD FOR TREATING INSOMNIA |
| 3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7682628 | Feb. 16, 2025 | METHOD FOR TREATING INSOMNIA |
| 10MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9597281 | April 6, 2027 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 5MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9597281 | April 6, 2027 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7658945 | April 15, 2027 | METHOD FOR TREATING INSOMNIA |
| 3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7658945 | April 15, 2027 | METHOD FOR TREATING INSOMNIA |
| 1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 8242131 | Aug. 20, 2029 | METHOD OF TREATING MIDDLE-OF-THE-NIGHT INSOMNIA |
| 3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 8242131 | Aug. 20, 2029 | METHOD OF TREATING MIDDLE-OF-THE-NIGHT INSOMNIA |
| 10MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9265720 | Feb. 25, 2031 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 5MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9265720 | Feb. 25, 2031 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 5MG/SPRAY | ZOLPIMIST | AYTU | N022196 | Dec. 19, 2008 | RX | SPRAY, METERED | ORAL | 8236285 | Aug. 7, 2032 | TREATMENT OF TRANSIENT INSOMNIA |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-1 | Ion channel | ALLOSTERIC MODULATOR | Ki | 7.68 | IUPHAR | IUPHAR | |||
| GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 6.70 | WOMBAT-PK | CHEMBL | |||
| GABA-A receptor alpha-2/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.81 | WOMBAT-PK | CHEMBL | |||
| GABA-A receptor alpha-3/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.42 | WOMBAT-PK | CHEMBL | |||
| GABA-A receptor alpha-1/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 7.57 | WOMBAT-PK | CHEMBL | |||
| GABA A receptor alpha-3/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.16 | WOMBAT-PK | CHEMBL | |||
| Gamma-aminobutyric acid receptor subunit alpha-2 | Ion channel | Ki | 6.39 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-3 | Ion channel | Ki | 6.01 | CHEMBL | |||||
| Multidrug resistance protein 1 | Transporter | Km | 3.70 | WOMBAT-PK | |||||
| Gamma-aminobutyric acid receptor subunit alpha-2 | Ion channel | Ki | 6.12 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-5 | Ion channel | Ki | 7.46 | CHEMBL | |||||
| GABA A receptor alpha-6/beta-2/gamma-2 | Ion channel | Ki | 6.01 | CHEMBL | |||||
| GABA-A receptor; alpha-1/beta-2/gamma-2 | Ion channel | Ki | 7.72 | CHEMBL | |||||
| GABA A receptor alpha-2/beta-2/gamma-2 | Ion channel | Ki | 6.81 | CHEMBL | |||||
| CAAX prenyl protease 2 | Enzyme | AC50 | 4.77 | CHEMBL | |||||
| GABA-A receptor; anion channel | Ion channel | Ki | 7.60 | CHEMBL | |||||
| GABA A receptor alpha-3/beta-2/gamma-2 | Ion channel | Ki | 6.42 | CHEMBL | |||||
| Translocator protein | Membrane receptor | IC50 | 5.33 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-1 | Ion channel | Ki | 7.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00706 | KEGG_DRUG |
| 99294-93-6 | SECONDARY_CAS_RN |
| 4020811 | VANDF |
| 4023596 | VANDF |
| C0078839 | UMLSCUI |
| CHEBI:10125 | CHEBI |
| CHEMBL911 | ChEMBL_ID |
| CHEMBL3989820 | ChEMBL_ID |
| DB00425 | DRUGBANK_ID |
| CHEMBL1723343 | ChEMBL_ID |
| D000077334 | MESH_DESCRIPTOR_UI |
| 5732 | PUBCHEM_CID |
| 4348 | IUPHAR_LIGAND_ID |
| 5741 | INN_ID |
| 7K383OQI23 | UNII |
| 131725 | RXNORM |
| 109404 | MMSL |
| 343 | MMSL |
| 5713 | MMSL |
| d00910 | MMSL |
| 004146 | NDDF |
| 004147 | NDDF |
| 387569009 | SNOMEDCT_US |
| 395928005 | SNOMEDCT_US |
| 96231005 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5401 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 33 sections |
| Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5421 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 33 sections |
| Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5501 | TABLET, COATED | 6.25 mg | ORAL | NDA | 33 sections |
| Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5521 | TABLET, COATED | 12.50 mg | ORAL | NDA | 33 sections |
| Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6010 | TABLET | 10 mg | ORAL | NDA | 33 sections |
| Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6050 | TABLET | 5 mg | ORAL | NDA | 33 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0086 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0087 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0073 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 30 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0074 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 30 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8225 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 32 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8226 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 32 sections |
| Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5315 | TABLET, EXTENDED RELEASE | 6.25 mg | ORAL | ANDA | 32 sections |
| Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5316 | TABLET, EXTENDED RELEASE | 12.50 mg | ORAL | ANDA | 32 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5317 | TABLET, COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5318 | TABLET, COATED | 10 mg | ORAL | ANDA | 31 sections |
| ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6082 | TABLET | 5 mg | ORAL | ANDA | 31 sections |
| ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6083 | TABLET | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1702 | TABLET, FILM COATED, EXTENDED RELEASE | 6.25 mg | ORAL | NDA AUTHORIZED GENERIC | 33 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1703 | TABLET, FILM COATED, EXTENDED RELEASE | 12.50 mg | ORAL | NDA AUTHORIZED GENERIC | 33 sections |
| Zolpidem TartrateExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-116 | TABLET, FILM COATED, EXTENDED RELEASE | 12.50 mg | ORAL | ANDA | 32 sections |
| Zolpidem TartrateExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-117 | TABLET, FILM COATED, EXTENDED RELEASE | 6.25 mg | ORAL | ANDA | 32 sections |
| ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-040 | TABLET | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-539 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-540 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-548 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
| ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-943 | TABLET | 5 mg | ORAL | ANDA | 14 sections |
| ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-944 | TABLET | 10 mg | ORAL | ANDA | 14 sections |
| ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-007 | TABLET | 5 mg | ORAL | ANDA | 31 sections |
| ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-008 | TABLET | 10 mg | ORAL | ANDA | 31 sections |