Stem definition | Drug id | CAS RN |
---|---|---|
hypnotics/sedatives, zolpidem derivatives | 2870 | 82626-48-0 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 23 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.47 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 72 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.54 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 4.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.70 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 16, 1992 | FDA | SANOFI AVENTIS US |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 828.33 | 9.56 | 1381 | 138261 | 130508 | 50334974 |
Intentional overdose | 520.15 | 9.56 | 746 | 138896 | 61758 | 50403724 |
Drug abuse | 519.75 | 9.56 | 729 | 138913 | 59117 | 50406365 |
Somnambulism | 494.78 | 9.56 | 251 | 139391 | 4673 | 50460809 |
Drug dependence | 397.22 | 9.56 | 372 | 139270 | 19387 | 50446095 |
Amnesia | 377.58 | 9.56 | 522 | 139120 | 41738 | 50423744 |
Suicide attempt | 359.82 | 9.56 | 568 | 139074 | 51164 | 50414318 |
Contraindicated product administered | 350.29 | 9.56 | 14 | 139628 | 148944 | 50316538 |
Drug intolerance | 314.94 | 9.56 | 106 | 139536 | 218998 | 50246484 |
Synovitis | 283.45 | 9.56 | 14 | 139628 | 123851 | 50341631 |
Drug ineffective | 262.58 | 9.56 | 1269 | 138373 | 818064 | 49647418 |
Treatment failure | 261.78 | 9.56 | 35 | 139607 | 137602 | 50327880 |
Intentional self-injury | 256.93 | 9.56 | 318 | 139324 | 22794 | 50442688 |
Joint swelling | 256.69 | 9.56 | 182 | 139460 | 245104 | 50220378 |
Hand deformity | 251.69 | 9.56 | 5 | 139637 | 100194 | 50365288 |
Sopor | 244.63 | 9.56 | 288 | 139354 | 19591 | 50445891 |
Systemic lupus erythematosus | 240.14 | 9.56 | 48 | 139594 | 140574 | 50324908 |
Infusion related reaction | 238.44 | 9.56 | 85 | 139557 | 169472 | 50296010 |
Anxiety | 235.93 | 9.56 | 1043 | 138599 | 176563 | 50288919 |
Abnormal sleep-related event | 215.25 | 9.56 | 79 | 139563 | 629 | 50464853 |
Arthropathy | 204.21 | 9.56 | 90 | 139552 | 157816 | 50307666 |
Rheumatoid arthritis | 201.88 | 9.56 | 158 | 139484 | 202392 | 50263090 |
Glossodynia | 200.35 | 9.56 | 38 | 139604 | 115531 | 50349951 |
Overdose | 198.37 | 9.56 | 666 | 138976 | 99061 | 50366421 |
Off label use | 193.17 | 9.56 | 668 | 138974 | 473758 | 49991724 |
Intentional product misuse | 187.71 | 9.56 | 405 | 139237 | 46329 | 50419153 |
Depression | 187.69 | 9.56 | 928 | 138714 | 164495 | 50300987 |
Peripheral swelling | 160.95 | 9.56 | 199 | 139443 | 205737 | 50259745 |
Alopecia | 154.35 | 9.56 | 275 | 139367 | 244772 | 50220710 |
Maternal exposure during pregnancy | 151.26 | 9.56 | 131 | 139511 | 159647 | 50305835 |
Toxicity to various agents | 150.03 | 9.56 | 1052 | 138590 | 211447 | 50254035 |
Pericarditis | 149.58 | 9.56 | 20 | 139622 | 78669 | 50386813 |
Poisoning | 146.20 | 9.56 | 176 | 139466 | 12253 | 50453229 |
Wound | 143.67 | 9.56 | 56 | 139586 | 105738 | 50359744 |
Somnolence | 142.66 | 9.56 | 821 | 138821 | 154164 | 50311318 |
Lower respiratory tract infection | 142.05 | 9.56 | 43 | 139599 | 95158 | 50370324 |
Poisoning deliberate | 138.33 | 9.56 | 138 | 139504 | 7774 | 50457708 |
Hypersensitivity | 137.70 | 9.56 | 239 | 139403 | 214922 | 50250560 |
Drug withdrawal syndrome | 134.03 | 9.56 | 245 | 139397 | 24836 | 50440646 |
Swelling | 133.26 | 9.56 | 218 | 139424 | 200654 | 50264828 |
Abdominal discomfort | 126.08 | 9.56 | 283 | 139359 | 231358 | 50234124 |
Coma | 124.87 | 9.56 | 393 | 139249 | 56486 | 50408996 |
Respiratory arrest | 119.26 | 9.56 | 259 | 139383 | 29750 | 50435732 |
Suicidal ideation | 117.31 | 9.56 | 378 | 139264 | 55007 | 50410475 |
Cardio-respiratory arrest | 112.51 | 9.56 | 366 | 139276 | 53526 | 50411956 |
Fall | 111.07 | 9.56 | 1411 | 138231 | 333521 | 50131961 |
Road traffic accident | 104.66 | 9.56 | 217 | 139425 | 24135 | 50441347 |
Therapeutic product effect decreased | 104.62 | 9.56 | 133 | 139509 | 135917 | 50329565 |
Impaired driving ability | 104.42 | 9.56 | 87 | 139555 | 3874 | 50461608 |
Rash | 104.34 | 9.56 | 743 | 138899 | 436728 | 50028754 |
Abnormal behaviour | 102.48 | 9.56 | 190 | 139452 | 19468 | 50446014 |
Sleep-related eating disorder | 100.78 | 9.56 | 47 | 139595 | 721 | 50464761 |
Infection | 100.14 | 9.56 | 204 | 139438 | 172750 | 50292732 |
Product use issue | 97.43 | 9.56 | 164 | 139478 | 149311 | 50316171 |
Helicobacter infection | 93.58 | 9.56 | 13 | 139629 | 49689 | 50415793 |
Loss of consciousness | 90.89 | 9.56 | 545 | 139097 | 103808 | 50361674 |
Arthralgia | 90.62 | 9.56 | 775 | 138867 | 437927 | 50027555 |
Insomnia | 86.33 | 9.56 | 798 | 138844 | 174067 | 50291415 |
Hepatic enzyme increased | 84.76 | 9.56 | 156 | 139486 | 137224 | 50328258 |
Musculoskeletal stiffness | 78.28 | 9.56 | 147 | 139495 | 128334 | 50337148 |
Discomfort | 78.18 | 9.56 | 111 | 139531 | 108269 | 50357213 |
Drug hypersensitivity | 77.25 | 9.56 | 393 | 139249 | 250617 | 50214865 |
Restlessness | 75.80 | 9.56 | 195 | 139447 | 24978 | 50440504 |
Disorientation | 74.96 | 9.56 | 242 | 139400 | 35242 | 50430240 |
Withdrawal syndrome | 74.71 | 9.56 | 156 | 139486 | 17434 | 50448048 |
Nasopharyngitis | 73.98 | 9.56 | 278 | 139364 | 192649 | 50272833 |
Mydriasis | 72.87 | 9.56 | 116 | 139526 | 10511 | 50454971 |
Mental status changes | 72.70 | 9.56 | 243 | 139399 | 36029 | 50429453 |
Therapeutic product effect incomplete | 71.86 | 9.56 | 88 | 139554 | 91427 | 50374055 |
Folliculitis | 69.88 | 9.56 | 12 | 139630 | 39213 | 50426269 |
Product substitution issue | 68.48 | 9.56 | 132 | 139510 | 13925 | 50451557 |
Hallucination | 67.94 | 9.56 | 282 | 139360 | 46375 | 50419107 |
Sleep disorder due to general medical condition, insomnia type | 67.53 | 9.56 | 5 | 139637 | 31442 | 50434040 |
Agitation | 66.57 | 9.56 | 308 | 139334 | 53076 | 50412406 |
Blister | 66.16 | 9.56 | 83 | 139559 | 85335 | 50380147 |
Drug use disorder | 65.91 | 9.56 | 60 | 139582 | 3012 | 50462470 |
Muscle injury | 64.71 | 9.56 | 12 | 139630 | 37099 | 50428383 |
Drug abuser | 62.17 | 9.56 | 56 | 139586 | 2772 | 50462710 |
Delirium | 58.90 | 9.56 | 235 | 139407 | 37957 | 50427525 |
Dependence | 57.52 | 9.56 | 45 | 139597 | 1830 | 50463652 |
Immobilisation prolonged | 56.62 | 9.56 | 18 | 139624 | 87 | 50465395 |
Affect lability | 55.99 | 9.56 | 94 | 139548 | 8904 | 50456578 |
Bradyphrenia | 53.41 | 9.56 | 75 | 139567 | 6077 | 50459405 |
Product use in unapproved indication | 52.53 | 9.56 | 155 | 139487 | 115664 | 50349818 |
Sleep talking | 51.13 | 9.56 | 32 | 139610 | 904 | 50464578 |
Tremor | 50.56 | 9.56 | 512 | 139130 | 114391 | 50351091 |
Miosis | 50.49 | 9.56 | 74 | 139568 | 6236 | 50459246 |
Confusional state | 50.34 | 9.56 | 756 | 138886 | 185172 | 50280310 |
Substance abuse | 47.85 | 9.56 | 58 | 139584 | 4066 | 50461416 |
Cardiac arrest | 47.05 | 9.56 | 393 | 139249 | 83258 | 50382224 |
Hyponatraemia | 47.01 | 9.56 | 438 | 139204 | 95701 | 50369781 |
Mental disorder | 46.46 | 9.56 | 150 | 139492 | 21841 | 50443641 |
Ill-defined disorder | 45.65 | 9.56 | 50 | 139592 | 54604 | 50410878 |
Drug withdrawal convulsions | 44.84 | 9.56 | 34 | 139608 | 1319 | 50464163 |
Exposure during pregnancy | 44.03 | 9.56 | 178 | 139464 | 120837 | 50344645 |
Condition aggravated | 42.85 | 9.56 | 570 | 139072 | 296488 | 50168994 |
Intentional product use issue | 41.74 | 9.56 | 94 | 139548 | 76824 | 50388658 |
Listless | 40.52 | 9.56 | 41 | 139601 | 2349 | 50463133 |
Urinary retention | 40.26 | 9.56 | 161 | 139481 | 26029 | 50439453 |
Psychomotor skills impaired | 39.82 | 9.56 | 38 | 139604 | 2026 | 50463456 |
Pain | 39.11 | 9.56 | 1259 | 138383 | 577644 | 49887838 |
Parkinsonism | 38.20 | 9.56 | 79 | 139563 | 8768 | 50456714 |
Altered state of consciousness | 38.04 | 9.56 | 140 | 139502 | 21770 | 50443712 |
Bradypnoea | 36.92 | 9.56 | 44 | 139598 | 3030 | 50462452 |
Dysarthria | 36.89 | 9.56 | 202 | 139440 | 37201 | 50428281 |
Disturbance in attention | 36.73 | 9.56 | 177 | 139465 | 31009 | 50434473 |
Dissociative disorder | 36.61 | 9.56 | 16 | 139626 | 209 | 50465273 |
Impaired healing | 36.48 | 9.56 | 87 | 139555 | 69699 | 50395783 |
Tardive dyskinesia | 36.25 | 9.56 | 69 | 139573 | 7210 | 50458272 |
Depressed level of consciousness | 35.84 | 9.56 | 256 | 139386 | 51697 | 50413785 |
Exposure via ingestion | 35.12 | 9.56 | 41 | 139601 | 2762 | 50462720 |
Gastrointestinal disorder | 34.94 | 9.56 | 138 | 139504 | 94318 | 50371164 |
Emotional distress | 34.71 | 9.56 | 164 | 139478 | 28499 | 50436983 |
High risk sexual behaviour | 34.27 | 9.56 | 7 | 139635 | 0 | 50465482 |
Hallucination, visual | 34.03 | 9.56 | 112 | 139530 | 16470 | 50449012 |
Logorrhoea | 32.52 | 9.56 | 36 | 139606 | 2288 | 50463194 |
Hip arthroplasty | 32.51 | 9.56 | 22 | 139620 | 30407 | 50435075 |
Drug screen positive | 31.83 | 9.56 | 43 | 139599 | 3359 | 50462123 |
Red blood cell sedimentation rate increased | 31.79 | 9.56 | 21 | 139621 | 29395 | 50436087 |
Premature delivery | 31.33 | 9.56 | 13 | 139629 | 23650 | 50441832 |
Initial insomnia | 31.24 | 9.56 | 53 | 139589 | 5062 | 50460420 |
Panic attack | 30.61 | 9.56 | 120 | 139522 | 19222 | 50446260 |
Injury | 30.30 | 9.56 | 235 | 139407 | 48690 | 50416792 |
Memory impairment | 29.95 | 9.56 | 343 | 139299 | 79017 | 50386465 |
Carotid artery thrombosis | 29.69 | 9.56 | 28 | 139614 | 1471 | 50464011 |
Akathisia | 29.30 | 9.56 | 68 | 139574 | 8161 | 50457321 |
Tachycardia | 29.07 | 9.56 | 411 | 139231 | 99352 | 50366130 |
Homicide | 28.97 | 9.56 | 16 | 139626 | 356 | 50465126 |
Victim of sexual abuse | 28.93 | 9.56 | 18 | 139624 | 503 | 50464979 |
Drug detoxification | 28.74 | 9.56 | 12 | 139630 | 139 | 50465343 |
Persistent genital arousal disorder | 28.73 | 9.56 | 14 | 139628 | 238 | 50465244 |
Blood pressure fluctuation | 28.58 | 9.56 | 34 | 139608 | 35789 | 50429693 |
Hallucination, auditory | 28.16 | 9.56 | 79 | 139563 | 10649 | 50454833 |
Dehydration | 28.02 | 9.56 | 583 | 139059 | 151866 | 50313616 |
Syncope | 27.91 | 9.56 | 419 | 139223 | 102583 | 50362899 |
Cough | 27.88 | 9.56 | 483 | 139159 | 240781 | 50224701 |
Bulimia nervosa | 27.63 | 9.56 | 16 | 139626 | 391 | 50465091 |
Hypokalaemia | 27.47 | 9.56 | 367 | 139275 | 87625 | 50377857 |
Head injury | 27.33 | 9.56 | 135 | 139507 | 23885 | 50441597 |
Illusion | 27.24 | 9.56 | 22 | 139620 | 937 | 50464545 |
Multiple drug therapy | 27.10 | 9.56 | 30 | 139612 | 1907 | 50463575 |
Device expulsion | 26.79 | 9.56 | 24 | 139618 | 28798 | 50436684 |
Urticaria | 26.57 | 9.56 | 229 | 139413 | 129332 | 50336150 |
Nightmare | 26.44 | 9.56 | 101 | 139541 | 15985 | 50449497 |
Pruritus | 25.75 | 9.56 | 591 | 139051 | 282977 | 50182505 |
Anaphylactic reaction | 25.48 | 9.56 | 71 | 139571 | 53984 | 50411498 |
Live birth | 25.21 | 9.56 | 7 | 139635 | 16401 | 50449081 |
Prescription drug used without a prescription | 24.95 | 9.56 | 27 | 139615 | 1673 | 50463809 |
Blood pressure systolic increased | 24.86 | 9.56 | 37 | 139605 | 35412 | 50430070 |
Drug tolerance | 24.57 | 9.56 | 47 | 139595 | 4929 | 50460553 |
Irritability | 24.42 | 9.56 | 148 | 139494 | 28278 | 50437204 |
Adverse drug reaction | 24.24 | 9.56 | 75 | 139567 | 55147 | 50410335 |
Alcohol abuse | 24.14 | 9.56 | 28 | 139614 | 1873 | 50463609 |
Stomatitis | 24.09 | 9.56 | 172 | 139470 | 101172 | 50364310 |
Personality disorder | 24.06 | 9.56 | 43 | 139599 | 4281 | 50461201 |
Rhabdomyolysis | 23.36 | 9.56 | 186 | 139456 | 38841 | 50426641 |
Neutropenia | 23.12 | 9.56 | 279 | 139363 | 147686 | 50317796 |
Neurologic neglect syndrome | 22.89 | 9.56 | 24 | 139618 | 1434 | 50464048 |
Drug resistance | 22.72 | 9.56 | 12 | 139630 | 18977 | 50446505 |
Incoherent | 22.19 | 9.56 | 41 | 139601 | 4189 | 50461293 |
Behaviour disorder | 22.14 | 9.56 | 30 | 139612 | 2350 | 50463132 |
Fatigue | 22.12 | 9.56 | 1668 | 137974 | 705933 | 49759549 |
Imprisonment | 21.71 | 9.56 | 11 | 139631 | 204 | 50465278 |
Abnormal dreams | 21.68 | 9.56 | 66 | 139576 | 9311 | 50456171 |
Hyperhidrosis | 21.65 | 9.56 | 357 | 139285 | 89069 | 50376413 |
COVID-19 | 21.47 | 9.56 | 62 | 139580 | 46600 | 50418882 |
Cholecystitis chronic | 21.38 | 9.56 | 67 | 139575 | 9602 | 50455880 |
Vertigo | 21.37 | 9.56 | 228 | 139414 | 51604 | 50413878 |
Dyspnoea | 21.27 | 9.56 | 1266 | 138376 | 546342 | 49919140 |
Apathy | 21.22 | 9.56 | 57 | 139585 | 7491 | 50457991 |
Multiple sclerosis | 21.10 | 9.56 | 112 | 139530 | 20381 | 50445101 |
Arthritis | 20.70 | 9.56 | 147 | 139495 | 86574 | 50378908 |
C-reactive protein increased | 20.44 | 9.56 | 104 | 139538 | 66370 | 50399112 |
Irritable bowel syndrome | 20.42 | 9.56 | 73 | 139569 | 51368 | 50414114 |
Rheumatoid nodule | 20.40 | 9.56 | 5 | 139637 | 12730 | 50452752 |
Hangover | 20.28 | 9.56 | 22 | 139620 | 1367 | 50464115 |
Foreign body | 20.12 | 9.56 | 26 | 139616 | 1945 | 50463537 |
Obstructive airways disorder | 20.08 | 9.56 | 9 | 139633 | 15643 | 50449839 |
Mania | 20.01 | 9.56 | 71 | 139571 | 10845 | 50454637 |
Laryngeal pain | 19.92 | 9.56 | 39 | 139603 | 4160 | 50461322 |
Product complaint | 19.68 | 9.56 | 73 | 139569 | 11393 | 50454089 |
Adjustment disorder | 19.63 | 9.56 | 26 | 139616 | 1993 | 50463489 |
Reduced facial expression | 19.45 | 9.56 | 23 | 139619 | 1571 | 50463911 |
Eating disorder | 19.27 | 9.56 | 89 | 139553 | 15320 | 50450162 |
Wheezing | 19.12 | 9.56 | 97 | 139545 | 61950 | 50403532 |
Diplopia | 18.98 | 9.56 | 104 | 139538 | 19156 | 50446326 |
Tension | 18.73 | 9.56 | 30 | 139612 | 2732 | 50462750 |
Feeling drunk | 18.65 | 9.56 | 35 | 139607 | 3618 | 50461864 |
Deep vein thrombosis | 18.62 | 9.56 | 295 | 139347 | 73009 | 50392473 |
Anger | 18.49 | 9.56 | 71 | 139571 | 11262 | 50454220 |
Knee arthroplasty | 18.48 | 9.56 | 45 | 139597 | 35801 | 50429681 |
Peptic ulcer | 18.46 | 9.56 | 36 | 139606 | 3830 | 50461652 |
Panic disorder | 18.42 | 9.56 | 27 | 139615 | 2276 | 50463206 |
Psychomotor hyperactivity | 18.35 | 9.56 | 62 | 139580 | 9239 | 50456243 |
Sinus tachycardia | 18.23 | 9.56 | 111 | 139531 | 21243 | 50444239 |
Multiple sclerosis relapse | 18.19 | 9.56 | 190 | 139452 | 42774 | 50422708 |
Inflammation | 18.09 | 9.56 | 88 | 139554 | 56824 | 50408658 |
Psoriatic arthropathy | 17.84 | 9.56 | 68 | 139574 | 46964 | 50418518 |
Unresponsive to stimuli | 17.84 | 9.56 | 145 | 139497 | 30464 | 50435018 |
Dysuria | 17.69 | 9.56 | 137 | 139505 | 28367 | 50437115 |
Inadequate analgesia | 17.64 | 9.56 | 28 | 139614 | 2530 | 50462952 |
Sinusitis | 17.64 | 9.56 | 348 | 139294 | 170210 | 50295272 |
Death | 17.51 | 9.56 | 727 | 138915 | 324652 | 50140830 |
Anterograde amnesia | 17.49 | 9.56 | 13 | 139629 | 489 | 50464993 |
Major depression | 17.39 | 9.56 | 50 | 139592 | 6834 | 50458648 |
Crying | 17.35 | 9.56 | 106 | 139536 | 20310 | 50445172 |
Vision blurred | 17.24 | 9.56 | 309 | 139333 | 78338 | 50387144 |
Dysphagia | 17.14 | 9.56 | 305 | 139337 | 77213 | 50388269 |
Alcohol use | 16.84 | 9.56 | 24 | 139618 | 1971 | 50463511 |
Loss of proprioception | 16.73 | 9.56 | 11 | 139631 | 339 | 50465143 |
Femoral neck fracture | 16.65 | 9.56 | 52 | 139590 | 7438 | 50458044 |
Mucosal inflammation | 16.58 | 9.56 | 56 | 139586 | 40086 | 50425396 |
Psychotic disorder | 16.53 | 9.56 | 110 | 139532 | 21702 | 50443780 |
Facial nerve disorder | 16.52 | 9.56 | 13 | 139629 | 533 | 50464949 |
Aggression | 16.31 | 9.56 | 107 | 139535 | 21009 | 50444473 |
Legal problem | 16.29 | 9.56 | 5 | 139637 | 21 | 50465461 |
Mobility decreased | 16.07 | 9.56 | 142 | 139500 | 79806 | 50385676 |
Hiatus hernia | 16.07 | 9.56 | 96 | 139546 | 18248 | 50447234 |
Asthenia | 15.84 | 9.56 | 1052 | 138590 | 317990 | 50147492 |
General physical health deterioration | 15.84 | 9.56 | 287 | 139355 | 142147 | 50323335 |
Feeling abnormal | 15.83 | 9.56 | 456 | 139186 | 125036 | 50340446 |
Decreased interest | 15.80 | 9.56 | 29 | 139613 | 2947 | 50462535 |
Coagulation factor V level decreased | 15.74 | 9.56 | 10 | 139632 | 290 | 50465192 |
Pulmonary vasculitis | 15.71 | 9.56 | 6 | 139636 | 54 | 50465428 |
Grip strength decreased | 15.50 | 9.56 | 7 | 139635 | 12114 | 50453368 |
Prothrombin time shortened | 15.49 | 9.56 | 21 | 139621 | 1646 | 50463836 |
Serotonin syndrome | 15.46 | 9.56 | 119 | 139523 | 24594 | 50440888 |
Liver injury | 15.43 | 9.56 | 28 | 139614 | 24778 | 50440704 |
Accidental poisoning | 15.41 | 9.56 | 13 | 139629 | 589 | 50464893 |
Erythema | 15.36 | 9.56 | 298 | 139344 | 146116 | 50319366 |
Compulsive shopping | 15.36 | 9.56 | 14 | 139628 | 704 | 50464778 |
Accidental exposure to product | 15.28 | 9.56 | 25 | 139617 | 23032 | 50442450 |
Sleep terror | 15.27 | 9.56 | 14 | 139628 | 709 | 50464773 |
Tracheal atresia | 15.27 | 9.56 | 5 | 139637 | 27 | 50465455 |
Drug tolerance increased | 15.22 | 9.56 | 9 | 139633 | 229 | 50465253 |
Thirst | 15.20 | 9.56 | 64 | 139578 | 10586 | 50454896 |
Protrusion tongue | 15.15 | 9.56 | 10 | 139632 | 310 | 50465172 |
Urinary hesitation | 15.10 | 9.56 | 23 | 139619 | 2006 | 50463476 |
Blood potassium decreased | 14.99 | 9.56 | 162 | 139480 | 36783 | 50428699 |
Renal impairment | 14.94 | 9.56 | 135 | 139507 | 75526 | 50389956 |
Periventricular leukomalacia | 14.73 | 9.56 | 6 | 139636 | 65 | 50465417 |
Hypotension | 14.62 | 9.56 | 792 | 138850 | 234677 | 50230805 |
Cognitive disorder | 14.59 | 9.56 | 186 | 139456 | 43937 | 50421545 |
Bone erosion | 14.56 | 9.56 | 7 | 139635 | 11680 | 50453802 |
Herpes zoster | 14.55 | 9.56 | 125 | 139517 | 70661 | 50394821 |
Brain contusion | 14.48 | 9.56 | 12 | 139630 | 530 | 50464952 |
Therapy non-responder | 14.48 | 9.56 | 82 | 139560 | 50940 | 50414542 |
Skin haemorrhage | 14.44 | 9.56 | 47 | 139595 | 6871 | 50458611 |
Injection site reaction | 14.42 | 9.56 | 80 | 139562 | 49952 | 50415530 |
Joint range of motion decreased | 14.31 | 9.56 | 18 | 139624 | 18494 | 50446988 |
Panniculitis | 14.30 | 9.56 | 3 | 139639 | 8500 | 50456982 |
Self-medication | 14.28 | 9.56 | 24 | 139618 | 2275 | 50463207 |
Terminal insomnia | 14.22 | 9.56 | 13 | 139629 | 656 | 50464826 |
Frostbite | 14.07 | 9.56 | 4 | 139638 | 12 | 50465470 |
Left ventricular hypertrophy | 14.04 | 9.56 | 37 | 139605 | 4808 | 50460674 |
Seizure | 13.97 | 9.56 | 425 | 139217 | 117449 | 50348033 |
Sensory loss | 13.90 | 9.56 | 50 | 139592 | 7688 | 50457794 |
Intravascular haemolysis | 13.78 | 9.56 | 9 | 139633 | 274 | 50465208 |
Atelectasis | 13.76 | 9.56 | 92 | 139550 | 18178 | 50447304 |
Pyrexia | 13.67 | 9.56 | 885 | 138757 | 379318 | 50086164 |
Spinal rod insertion | 13.60 | 9.56 | 4 | 139638 | 14 | 50465468 |
Self-injurious ideation | 13.49 | 9.56 | 23 | 139619 | 2206 | 50463276 |
Anhedonia | 13.41 | 9.56 | 57 | 139585 | 9467 | 50456015 |
Hepatotoxicity | 13.40 | 9.56 | 35 | 139607 | 27191 | 50438291 |
Prothrombin time prolonged | 13.32 | 9.56 | 54 | 139588 | 8784 | 50456698 |
Drug interaction | 13.31 | 9.56 | 676 | 138966 | 198945 | 50266537 |
Bipolar disorder | 13.30 | 9.56 | 45 | 139597 | 6712 | 50458770 |
Coordination abnormal | 13.25 | 9.56 | 65 | 139577 | 11469 | 50454013 |
Neonatal behavioural syndrome | 13.19 | 9.56 | 5 | 139637 | 44 | 50465438 |
Social anxiety disorder | 13.12 | 9.56 | 10 | 139632 | 391 | 50465091 |
Labelled drug-food interaction issue | 13.00 | 9.56 | 4 | 139638 | 17 | 50465465 |
Blastocystis infection | 13.00 | 9.56 | 4 | 139638 | 17 | 50465465 |
Aortic valve calcification | 12.99 | 9.56 | 10 | 139632 | 397 | 50465085 |
Dementia | 12.93 | 9.56 | 82 | 139560 | 15915 | 50449567 |
Diarrhoea | 12.85 | 9.56 | 1425 | 138217 | 587051 | 49878431 |
Motor dysfunction | 12.85 | 9.56 | 50 | 139592 | 7981 | 50457501 |
Aspartate aminotransferase increased | 12.63 | 9.56 | 293 | 139349 | 77705 | 50387777 |
Benzodiazepine drug level | 12.62 | 9.56 | 3 | 139639 | 3 | 50465479 |
Constipation | 12.61 | 9.56 | 630 | 139012 | 185078 | 50280404 |
Inappropriate schedule of product administration | 12.57 | 9.56 | 132 | 139510 | 71699 | 50393783 |
Blood pressure systolic abnormal | 12.39 | 9.56 | 3 | 139639 | 7703 | 50457779 |
Persecutory delusion | 12.35 | 9.56 | 23 | 139619 | 2364 | 50463118 |
Blood pressure diastolic decreased | 12.27 | 9.56 | 17 | 139625 | 16764 | 50448718 |
Type 2 diabetes mellitus | 12.22 | 9.56 | 51 | 139591 | 34324 | 50431158 |
Dizziness | 12.21 | 9.56 | 1112 | 138530 | 345257 | 50120225 |
Lethargy | 12.20 | 9.56 | 198 | 139444 | 49234 | 50416248 |
Accidental overdose | 12.19 | 9.56 | 94 | 139548 | 19439 | 50446043 |
Creatinine renal clearance decreased | 12.15 | 9.56 | 9 | 139633 | 11872 | 50453610 |
Intervertebral disc degeneration | 12.15 | 9.56 | 71 | 139571 | 13390 | 50452092 |
Automatism | 12.13 | 9.56 | 5 | 139637 | 56 | 50465426 |
Vertigo CNS origin | 12.01 | 9.56 | 4 | 139638 | 23 | 50465459 |
Psychomotor retardation | 11.90 | 9.56 | 28 | 139614 | 3390 | 50462092 |
Therapeutic response unexpected | 11.90 | 9.56 | 80 | 139562 | 15835 | 50449647 |
Drug dependence, antepartum | 11.87 | 9.56 | 4 | 139638 | 24 | 50465458 |
Cholecystectomy | 11.83 | 9.56 | 54 | 139588 | 9249 | 50456233 |
Euphoric mood | 11.78 | 9.56 | 31 | 139611 | 4024 | 50461458 |
Productive cough | 11.77 | 9.56 | 91 | 139551 | 52603 | 50412879 |
Inappropriate antidiuretic hormone secretion | 11.65 | 9.56 | 69 | 139573 | 13074 | 50452408 |
Waxy flexibility | 11.62 | 9.56 | 6 | 139636 | 116 | 50465366 |
Transplant rejection | 11.60 | 9.56 | 6 | 139636 | 9603 | 50455879 |
Spleen congestion | 11.53 | 9.56 | 6 | 139636 | 118 | 50465364 |
Middle insomnia | 11.46 | 9.56 | 56 | 139586 | 9865 | 50455617 |
Septic shock | 11.29 | 9.56 | 102 | 139540 | 57073 | 50408409 |
Influenza like illness | 11.29 | 9.56 | 222 | 139420 | 57237 | 50408245 |
Respiratory depression | 11.26 | 9.56 | 64 | 139578 | 11946 | 50453536 |
Spondylolisthesis | 11.25 | 9.56 | 26 | 139616 | 3111 | 50462371 |
Dreamy state | 11.22 | 9.56 | 4 | 139638 | 29 | 50465453 |
Enthesopathy | 11.18 | 9.56 | 3 | 139639 | 7190 | 50458292 |
Multiple injuries | 11.01 | 9.56 | 18 | 139624 | 1668 | 50463814 |
Angioedema | 10.99 | 9.56 | 60 | 139582 | 37616 | 50427866 |
Stress cardiomyopathy | 10.95 | 9.56 | 47 | 139595 | 7840 | 50457642 |
Depressive symptom | 10.91 | 9.56 | 26 | 139616 | 3174 | 50462308 |
Immunodeficiency | 10.87 | 9.56 | 15 | 139627 | 14813 | 50450669 |
Blood urea increased | 10.79 | 9.56 | 106 | 139536 | 23479 | 50442003 |
Transient ischaemic attack | 10.74 | 9.56 | 136 | 139506 | 32074 | 50433408 |
Neurotoxicity | 10.71 | 9.56 | 15 | 139627 | 14725 | 50450757 |
Poor sucking reflex | 10.66 | 9.56 | 7 | 139635 | 215 | 50465267 |
Neurogenic bladder | 10.60 | 9.56 | 24 | 139618 | 2833 | 50462649 |
Fibrocystic breast disease | 10.60 | 9.56 | 14 | 139628 | 1070 | 50464412 |
Drop attacks | 10.58 | 9.56 | 11 | 139631 | 651 | 50464831 |
Trance | 10.57 | 9.56 | 4 | 139638 | 35 | 50465447 |
Secretion discharge | 10.57 | 9.56 | 7 | 139635 | 9784 | 50455698 |
Asphyxia | 10.55 | 9.56 | 36 | 139606 | 5391 | 50460091 |
Amnestic disorder | 10.54 | 9.56 | 8 | 139634 | 311 | 50465171 |
Cytomegalovirus infection | 10.53 | 9.56 | 21 | 139621 | 17941 | 50447541 |
Head discomfort | 10.52 | 9.56 | 59 | 139583 | 10960 | 50454522 |
Disinhibition | 10.40 | 9.56 | 12 | 139630 | 798 | 50464684 |
Hepatosplenomegaly | 10.40 | 9.56 | 21 | 139621 | 2291 | 50463191 |
Mouth ulceration | 10.32 | 9.56 | 41 | 139601 | 27983 | 50437499 |
Toxic epidermal necrolysis | 10.32 | 9.56 | 27 | 139615 | 20965 | 50444517 |
Muscle rigidity | 10.31 | 9.56 | 54 | 139588 | 9775 | 50455707 |
Fear | 10.21 | 9.56 | 72 | 139570 | 14477 | 50451005 |
Oophorectomy bilateral | 10.19 | 9.56 | 4 | 139638 | 39 | 50465443 |
Cardiomegaly | 10.10 | 9.56 | 77 | 139565 | 15868 | 50449614 |
Ecchymosis | 10.08 | 9.56 | 55 | 139587 | 10114 | 50455368 |
Eustachian tube disorder | 10.05 | 9.56 | 5 | 139637 | 89 | 50465393 |
Spinal osteoarthritis | 10.04 | 9.56 | 70 | 139572 | 14022 | 50451460 |
Dysgeusia | 10.03 | 9.56 | 157 | 139485 | 38759 | 50426723 |
Flat affect | 10.00 | 9.56 | 15 | 139627 | 1290 | 50464192 |
Gun shot wound | 9.91 | 9.56 | 5 | 139637 | 92 | 50465390 |
Drug withdrawal syndrome neonatal | 9.85 | 9.56 | 18 | 139624 | 1823 | 50463659 |
Haemangioma of liver | 9.83 | 9.56 | 13 | 139629 | 995 | 50464487 |
Lymphatic disorder | 9.78 | 9.56 | 8 | 139634 | 347 | 50465135 |
Nervousness | 9.76 | 9.56 | 118 | 139524 | 27533 | 50437949 |
Bone scan abnormal | 9.72 | 9.56 | 8 | 139634 | 350 | 50465132 |
Sinus congestion | 9.72 | 9.56 | 69 | 139573 | 13902 | 50451580 |
Cholelithiasis | 9.71 | 9.56 | 153 | 139489 | 37820 | 50427662 |
Attention deficit hyperactivity disorder | 9.69 | 9.56 | 21 | 139621 | 2408 | 50463074 |
Sedation | 9.68 | 9.56 | 128 | 139514 | 30482 | 50435000 |
Leukocytosis | 9.62 | 9.56 | 100 | 139542 | 22479 | 50443003 |
Verbal abuse | 9.62 | 9.56 | 5 | 139637 | 98 | 50465384 |
Victim of chemical submission | 9.59 | 9.56 | 7 | 139635 | 256 | 50465226 |
Myelosuppression | 9.58 | 9.56 | 14 | 139628 | 13503 | 50451979 |
Homicidal ideation | 9.57 | 9.56 | 17 | 139625 | 1685 | 50463797 |
Diabetic ketoacidosis | 9.56 | 9.56 | 22 | 139620 | 17850 | 50447632 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Somnambulism | 547.23 | 10.18 | 225 | 79354 | 2573 | 29492375 |
Completed suicide | 465.15 | 10.18 | 854 | 78725 | 89392 | 29405556 |
Drug dependence | 299.03 | 10.18 | 324 | 79255 | 20657 | 29474291 |
Intentional overdose | 252.49 | 10.18 | 406 | 79173 | 38122 | 29456826 |
Amnesia | 242.72 | 10.18 | 302 | 79277 | 22341 | 29472607 |
Drug abuse | 187.13 | 10.18 | 555 | 79024 | 79328 | 29415620 |
Off label use | 156.57 | 10.18 | 363 | 79216 | 300437 | 29194511 |
Road traffic accident | 154.77 | 10.18 | 200 | 79379 | 15361 | 29479587 |
Suicide attempt | 145.00 | 10.18 | 298 | 79281 | 33812 | 29461136 |
Intentional self-injury | 125.24 | 10.18 | 161 | 79418 | 12300 | 29482648 |
Poisoning | 117.96 | 10.18 | 140 | 79439 | 9853 | 29485095 |
Respiratory arrest | 101.97 | 10.18 | 219 | 79360 | 25614 | 29469334 |
Drug withdrawal syndrome | 98.45 | 10.18 | 175 | 79404 | 17809 | 29477139 |
Impaired driving ability | 97.99 | 10.18 | 67 | 79512 | 2264 | 29492684 |
Insomnia | 97.07 | 10.18 | 484 | 79095 | 88277 | 29406671 |
Sopor | 89.68 | 10.18 | 128 | 79451 | 10806 | 29484142 |
Delirium | 87.67 | 10.18 | 269 | 79310 | 39128 | 29455820 |
Abnormal sleep-related event | 86.88 | 10.18 | 36 | 79543 | 420 | 29494528 |
Suicidal ideation | 85.76 | 10.18 | 246 | 79333 | 34470 | 29460478 |
Overdose | 83.57 | 10.18 | 430 | 79149 | 79389 | 29415559 |
Anxiety | 79.27 | 10.18 | 445 | 79134 | 84920 | 29410028 |
Confusional state | 79.24 | 10.18 | 602 | 78977 | 127275 | 29367673 |
Depression | 75.87 | 10.18 | 439 | 79140 | 84708 | 29410240 |
Homicide | 73.46 | 10.18 | 40 | 79539 | 888 | 29494060 |
Sleep-related eating disorder | 73.41 | 10.18 | 28 | 79551 | 258 | 29494690 |
Abnormal behaviour | 70.33 | 10.18 | 177 | 79402 | 22950 | 29471998 |
Product use in unapproved indication | 69.21 | 10.18 | 79 | 79500 | 86796 | 29408152 |
Somnolence | 69.03 | 10.18 | 461 | 79118 | 93494 | 29401454 |
Automatism | 65.67 | 10.18 | 20 | 79559 | 84 | 29494864 |
Disorientation | 65.15 | 10.18 | 201 | 79378 | 29314 | 29465634 |
Intentional product misuse | 57.92 | 10.18 | 215 | 79364 | 34446 | 29460502 |
Gun shot wound | 57.36 | 10.18 | 36 | 79543 | 1049 | 29493899 |
Drug ineffective | 55.70 | 10.18 | 668 | 78911 | 362502 | 29132446 |
Parasomnia | 53.44 | 10.18 | 24 | 79555 | 345 | 29494603 |
Drug abuser | 49.14 | 10.18 | 56 | 79523 | 3771 | 29491177 |
Fall | 42.13 | 10.18 | 690 | 78889 | 176488 | 29318460 |
Bradyphrenia | 41.63 | 10.18 | 54 | 79525 | 4160 | 29490788 |
Aggression | 40.35 | 10.18 | 196 | 79383 | 35345 | 29459603 |
Cardio-respiratory arrest | 38.15 | 10.18 | 250 | 79329 | 50351 | 29444597 |
Restlessness | 36.68 | 10.18 | 137 | 79442 | 22008 | 29472940 |
Thinking abnormal | 35.38 | 10.18 | 56 | 79523 | 5180 | 29489768 |
Nightmare | 35.35 | 10.18 | 88 | 79491 | 11329 | 29483619 |
Death | 35.25 | 10.18 | 679 | 78900 | 341405 | 29153543 |
Memory impairment | 33.06 | 10.18 | 189 | 79390 | 36281 | 29458667 |
Persistent depressive disorder | 32.80 | 10.18 | 16 | 79563 | 280 | 29494668 |
Hallucination | 31.95 | 10.18 | 218 | 79361 | 44494 | 29450454 |
Oedematous pancreatitis | 31.83 | 10.18 | 18 | 79561 | 431 | 29494517 |
Poisoning deliberate | 31.65 | 10.18 | 56 | 79523 | 5675 | 29489273 |
Coma | 31.64 | 10.18 | 198 | 79381 | 39252 | 29455696 |
Agitation | 31.40 | 10.18 | 241 | 79338 | 51063 | 29443885 |
Therapeutic product effect incomplete | 31.00 | 10.18 | 36 | 79543 | 39269 | 29455679 |
Legal problem | 30.25 | 10.18 | 13 | 79566 | 167 | 29494781 |
Rheumatoid arthritis | 29.28 | 10.18 | 26 | 79553 | 32126 | 29462822 |
Lower respiratory tract infection | 28.55 | 10.18 | 18 | 79561 | 26484 | 29468464 |
Drug tolerance | 28.49 | 10.18 | 32 | 79547 | 2121 | 29492827 |
Dependence | 28.35 | 10.18 | 23 | 79556 | 1012 | 29493936 |
Withdrawal syndrome | 28.21 | 10.18 | 79 | 79500 | 10913 | 29484035 |
Dissociative disorder | 28.16 | 10.18 | 13 | 79566 | 200 | 29494748 |
Toxicity to various agents | 27.83 | 10.18 | 637 | 78942 | 173024 | 29321924 |
Cytomegalovirus infection | 27.54 | 10.18 | 14 | 79565 | 23201 | 29471747 |
Acute kidney injury | 26.82 | 10.18 | 528 | 79051 | 264739 | 29230209 |
Initial insomnia | 26.54 | 10.18 | 35 | 79544 | 2740 | 29492208 |
Loss of consciousness | 26.34 | 10.18 | 310 | 79269 | 73746 | 29421202 |
Septic shock | 25.30 | 10.18 | 85 | 79494 | 62475 | 29432473 |
Joint swelling | 24.78 | 10.18 | 61 | 79518 | 49569 | 29445379 |
Multiple organ dysfunction syndrome | 24.68 | 10.18 | 87 | 79492 | 63029 | 29431919 |
Drug intolerance | 24.52 | 10.18 | 59 | 79520 | 48320 | 29446628 |
Febrile neutropenia | 24.51 | 10.18 | 189 | 79390 | 112051 | 29382897 |
Angioedema | 24.35 | 10.18 | 30 | 79549 | 31885 | 29463063 |
Incoherent | 23.92 | 10.18 | 41 | 79538 | 4051 | 29490897 |
Intentional product use issue | 23.85 | 10.18 | 49 | 79530 | 42449 | 29452499 |
Antidepressant drug level above therapeutic | 23.78 | 10.18 | 11 | 79568 | 170 | 29494778 |
Logorrhoea | 23.67 | 10.18 | 30 | 79549 | 2258 | 29492690 |
Treatment failure | 23.01 | 10.18 | 40 | 79539 | 36899 | 29458049 |
Circadian rhythm sleep disorder | 23.00 | 10.18 | 14 | 79565 | 386 | 29494562 |
Bradypnoea | 22.83 | 10.18 | 30 | 79549 | 2341 | 29492607 |
Panic attack | 22.51 | 10.18 | 61 | 79518 | 8265 | 29486683 |
Hallucination, visual | 22.50 | 10.18 | 90 | 79489 | 14925 | 29480023 |
Drug use disorder | 22.30 | 10.18 | 36 | 79543 | 3386 | 29491562 |
Neutropenia | 21.73 | 10.18 | 238 | 79341 | 131473 | 29363475 |
Distributive shock | 21.08 | 10.18 | 19 | 79560 | 966 | 29493982 |
Abnormal dreams | 21.07 | 10.18 | 53 | 79526 | 6867 | 29488081 |
Poor quality sleep | 20.58 | 10.18 | 54 | 79525 | 7179 | 29487769 |
Myelosuppression | 20.48 | 10.18 | 4 | 79575 | 12223 | 29482725 |
Anger | 20.27 | 10.18 | 70 | 79509 | 10820 | 29484128 |
Victim of chemical submission | 20.27 | 10.18 | 7 | 79572 | 47 | 29494901 |
Tachyphrenia | 20.14 | 10.18 | 20 | 79559 | 1149 | 29493799 |
Analgesic drug level above therapeutic | 20.09 | 10.18 | 11 | 79568 | 247 | 29494701 |
Hypokinesia | 20.08 | 10.18 | 55 | 79524 | 7499 | 29487449 |
Drug screen positive | 19.54 | 10.18 | 36 | 79543 | 3765 | 29491183 |
General physical health deterioration | 19.39 | 10.18 | 180 | 79399 | 102677 | 29392271 |
Infection | 19.31 | 10.18 | 124 | 79455 | 76627 | 29418321 |
Altered state of consciousness | 19.30 | 10.18 | 105 | 79474 | 19784 | 29475164 |
Dyspnoea | 19.16 | 10.18 | 703 | 78876 | 326029 | 29168919 |
Infusion related reaction | 18.87 | 10.18 | 58 | 79521 | 43828 | 29451120 |
Anterograde amnesia | 18.84 | 10.18 | 9 | 79570 | 150 | 29494798 |
Irritability | 18.27 | 10.18 | 112 | 79467 | 22040 | 29472908 |
Erythema | 18.09 | 10.18 | 124 | 79455 | 75482 | 29419466 |
Major depression | 18.07 | 10.18 | 35 | 79544 | 3800 | 29491148 |
Cardiac arrest | 17.99 | 10.18 | 327 | 79252 | 85264 | 29409684 |
Hyperlipidaemia | 17.71 | 10.18 | 74 | 79505 | 12516 | 29482432 |
Rectal haemorrhage | 17.61 | 10.18 | 42 | 79537 | 34507 | 29460441 |
Sepsis | 17.24 | 10.18 | 275 | 79304 | 142407 | 29352541 |
Encephalomalacia | 17.06 | 10.18 | 15 | 79564 | 738 | 29494210 |
Sleep talking | 16.93 | 10.18 | 12 | 79567 | 430 | 29494518 |
Sleep disorder | 16.88 | 10.18 | 118 | 79461 | 24268 | 29470680 |
Sleep apnoea syndrome | 16.47 | 10.18 | 92 | 79487 | 17507 | 29477441 |
Product use issue | 16.29 | 10.18 | 77 | 79502 | 51367 | 29443581 |
Paranoia | 16.27 | 10.18 | 61 | 79518 | 9816 | 29485132 |
Sexual abuse | 16 | 10.18 | 8 | 79571 | 148 | 29494800 |
Inappropriate antidiuretic hormone secretion | 15.96 | 10.18 | 65 | 79514 | 10867 | 29484081 |
Asthma | 15.82 | 10.18 | 43 | 79536 | 33806 | 29461142 |
Galactorrhoea | 15.80 | 10.18 | 11 | 79568 | 383 | 29494565 |
Condition aggravated | 15.72 | 10.18 | 288 | 79291 | 146007 | 29348941 |
Procalcitonin abnormal | 15.62 | 10.18 | 10 | 79569 | 302 | 29494646 |
Feeling abnormal | 15.58 | 10.18 | 219 | 79360 | 54226 | 29440722 |
Synovitis | 15.47 | 10.18 | 5 | 79574 | 10885 | 29484063 |
Stress at work | 15.44 | 10.18 | 8 | 79571 | 160 | 29494788 |
Loss of personal independence in daily activities | 15.43 | 10.18 | 28 | 79551 | 25412 | 29469536 |
Amimia | 15.31 | 10.18 | 4 | 79575 | 8 | 29494940 |
Cardiac failure | 15.26 | 10.18 | 138 | 79441 | 79149 | 29415799 |
Leukopenia | 15.02 | 10.18 | 87 | 79492 | 55116 | 29439832 |
Apallic syndrome | 14.98 | 10.18 | 9 | 79570 | 242 | 29494706 |
Drug withdrawal convulsions | 14.93 | 10.18 | 17 | 79562 | 1144 | 29493804 |
Hallucination, auditory | 14.78 | 10.18 | 58 | 79521 | 9535 | 29485413 |
Drug detoxification | 14.59 | 10.18 | 8 | 79571 | 180 | 29494768 |
Coagulation factor VII level decreased | 14.59 | 10.18 | 7 | 79572 | 118 | 29494830 |
Product substitution issue | 14.57 | 10.18 | 56 | 79523 | 9116 | 29485832 |
Dysarthria | 14.56 | 10.18 | 137 | 79442 | 30774 | 29464174 |
Urticaria | 14.42 | 10.18 | 87 | 79492 | 54573 | 29440375 |
Product dose omission issue | 14.39 | 10.18 | 178 | 79401 | 96205 | 29398743 |
Neurotoxicity | 14.31 | 10.18 | 11 | 79568 | 14602 | 29480346 |
Exposure via ingestion | 14.21 | 10.18 | 22 | 79557 | 1996 | 29492952 |
Renal impairment | 14.20 | 10.18 | 145 | 79434 | 81188 | 29413760 |
Drug diversion | 14.15 | 10.18 | 14 | 79565 | 801 | 29494147 |
Tubulointerstitial nephritis | 14.08 | 10.18 | 16 | 79563 | 17627 | 29477321 |
Nervousness | 14.03 | 10.18 | 64 | 79515 | 11242 | 29483706 |
Skin laceration | 14.01 | 10.18 | 63 | 79516 | 10999 | 29483949 |
Mania | 13.85 | 10.18 | 53 | 79526 | 8610 | 29486338 |
Heart rate decreased | 13.74 | 10.18 | 29 | 79550 | 24883 | 29470065 |
Labelled drug-food interaction medication error | 13.62 | 10.18 | 5 | 79574 | 41 | 29494907 |
Peripheral swelling | 13.58 | 10.18 | 108 | 79471 | 63631 | 29431317 |
Personality change | 13.58 | 10.18 | 35 | 79544 | 4603 | 29490345 |
Transplant rejection | 13.49 | 10.18 | 4 | 79575 | 9208 | 29485740 |
Substance-induced mood disorder | 13.38 | 10.18 | 6 | 79573 | 86 | 29494862 |
Stress cardiomyopathy | 13.30 | 10.18 | 19 | 79560 | 1605 | 29493343 |
Depressed level of consciousness | 13.28 | 10.18 | 155 | 79424 | 36787 | 29458161 |
Pyrexia | 13.22 | 10.18 | 636 | 78943 | 286986 | 29207962 |
Congenital hydrocephalus | 13.19 | 10.18 | 6 | 79573 | 89 | 29494859 |
Libido decreased | 13.17 | 10.18 | 33 | 79546 | 4265 | 29490683 |
Akathisia | 13.13 | 10.18 | 44 | 79535 | 6698 | 29488250 |
Psychomotor hyperactivity | 12.93 | 10.18 | 50 | 79529 | 8163 | 29486785 |
Alcohol use | 12.87 | 10.18 | 27 | 79552 | 3105 | 29491843 |
Slow speech | 12.78 | 10.18 | 14 | 79565 | 902 | 29494046 |
Hospitalisation | 12.77 | 10.18 | 72 | 79507 | 45916 | 29449032 |
Dry mouth | 12.58 | 10.18 | 101 | 79478 | 21683 | 29473265 |
Pulmonary fibrosis | 12.58 | 10.18 | 14 | 79565 | 15568 | 29479380 |
Mental status changes | 12.31 | 10.18 | 146 | 79433 | 34781 | 29460167 |
Prescription form tampering | 12.29 | 10.18 | 10 | 79569 | 442 | 29494506 |
Implant site inflammation | 12.25 | 10.18 | 6 | 79573 | 106 | 29494842 |
Labelled drug-drug interaction medication error | 12.11 | 10.18 | 9 | 79570 | 12150 | 29482798 |
Psychotic disorder | 12.10 | 10.18 | 95 | 79484 | 20259 | 29474689 |
Pilonidal cyst congenital | 11.96 | 10.18 | 4 | 79575 | 24 | 29494924 |
Drug resistance | 11.95 | 10.18 | 25 | 79554 | 21515 | 29473433 |
Toxic epidermal necrolysis | 11.91 | 10.18 | 19 | 79560 | 18134 | 29476814 |
Self-medication | 11.83 | 10.18 | 21 | 79558 | 2133 | 29492815 |
Pneumothorax traumatic | 11.72 | 10.18 | 5 | 79574 | 63 | 29494885 |
Aspergillus infection | 11.65 | 10.18 | 7 | 79572 | 10574 | 29484374 |
Amnestic disorder | 11.56 | 10.18 | 7 | 79572 | 191 | 29494757 |
Vascular dementia | 11.56 | 10.18 | 10 | 79569 | 481 | 29494467 |
Atelectasis | 11.56 | 10.18 | 76 | 79503 | 15316 | 29479632 |
Victim of homicide | 11.54 | 10.18 | 6 | 79573 | 121 | 29494827 |
Labile hypertension | 11.45 | 10.18 | 5 | 79574 | 67 | 29494881 |
COVID-19 | 11.34 | 10.18 | 54 | 79525 | 35960 | 29458988 |
Emotional distress | 11.29 | 10.18 | 70 | 79509 | 13825 | 29481123 |
Neutropenic sepsis | 11.27 | 10.18 | 9 | 79570 | 11718 | 29483230 |
Scar pain | 11.19 | 10.18 | 5 | 79574 | 71 | 29494877 |
Pre-existing condition improved | 11.16 | 10.18 | 21 | 79558 | 2232 | 29492716 |
Mental disorder | 11.12 | 10.18 | 66 | 79513 | 12839 | 29482109 |
Blood pressure fluctuation | 11.11 | 10.18 | 23 | 79556 | 19871 | 29475077 |
Hyperhidrosis | 11.01 | 10.18 | 239 | 79340 | 64301 | 29430647 |
Bipolar disorder | 10.84 | 10.18 | 26 | 79553 | 3269 | 29491679 |
Gastrooesophageal reflux disease | 10.81 | 10.18 | 131 | 79448 | 31365 | 29463583 |
Euphoric mood | 10.77 | 10.18 | 33 | 79546 | 4792 | 29490156 |
Alcohol interaction | 10.76 | 10.18 | 23 | 79556 | 2680 | 29492268 |
Erectile dysfunction | 10.68 | 10.18 | 84 | 79495 | 17925 | 29477023 |
Decreased interest | 10.68 | 10.18 | 20 | 79559 | 2118 | 29492830 |
Thrombotic microangiopathy | 10.65 | 10.18 | 5 | 79574 | 8676 | 29486272 |
Drug half-life reduced | 10.63 | 10.18 | 3 | 79576 | 9 | 29494939 |
Acute hepatic failure | 10.48 | 10.18 | 10 | 79569 | 11942 | 29483006 |
Pruritus | 10.46 | 10.18 | 237 | 79342 | 116612 | 29378336 |
Miosis | 10.43 | 10.18 | 46 | 79533 | 7963 | 29486985 |
Hangover | 10.41 | 10.18 | 13 | 79566 | 964 | 29493984 |
Product administration error | 10.35 | 10.18 | 70 | 79509 | 14240 | 29480708 |
Hypovolaemia | 10.32 | 10.18 | 46 | 79533 | 7999 | 29486949 |
Bradycardia | 10.25 | 10.18 | 120 | 79459 | 65509 | 29429439 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1343.35 | 9.63 | 2241 | 167788 | 222173 | 64106530 |
Somnambulism | 674.11 | 9.63 | 310 | 169719 | 4831 | 64323872 |
Drug dependence | 670.66 | 9.63 | 615 | 169414 | 32697 | 64296006 |
Drug abuse | 614.74 | 9.63 | 1185 | 168844 | 131189 | 64197514 |
Intentional overdose | 555.03 | 9.63 | 912 | 169117 | 89032 | 64239671 |
Amnesia | 421.60 | 9.63 | 576 | 169453 | 47693 | 64281010 |
Suicide attempt | 395.49 | 9.63 | 688 | 169341 | 70319 | 64258384 |
Sopor | 331.42 | 9.63 | 400 | 169629 | 29261 | 64299442 |
Off label use | 289.22 | 9.63 | 791 | 169238 | 632015 | 63696688 |
Intentional self-injury | 284.99 | 9.63 | 367 | 169662 | 28677 | 64300026 |
Poisoning | 259.16 | 9.63 | 304 | 169725 | 21575 | 64307128 |
Abnormal sleep-related event | 252.29 | 9.63 | 91 | 169938 | 722 | 64327981 |
Drug ineffective | 248.62 | 9.63 | 1257 | 168772 | 838990 | 63489713 |
Anxiety | 239.16 | 9.63 | 1113 | 168916 | 201536 | 64127167 |
Intentional product misuse | 238.92 | 9.63 | 564 | 169465 | 71731 | 64256972 |
Overdose | 238.91 | 9.63 | 942 | 169087 | 158624 | 64170079 |
Drug intolerance | 229.65 | 9.63 | 104 | 169925 | 187888 | 64140815 |
Respiratory arrest | 228.25 | 9.63 | 460 | 169569 | 52525 | 64276178 |
Drug withdrawal syndrome | 224.22 | 9.63 | 340 | 169689 | 30951 | 64297752 |
Synovitis | 209.39 | 9.63 | 13 | 170016 | 99077 | 64229626 |
Depression | 203.36 | 9.63 | 989 | 169040 | 182302 | 64146401 |
Joint swelling | 193.24 | 9.63 | 170 | 169859 | 215212 | 64113491 |
Contraindicated product administered | 184.75 | 9.63 | 31 | 169998 | 107798 | 64220905 |
Toxicity to various agents | 174.05 | 9.63 | 1589 | 168440 | 361924 | 63966779 |
Somnolence | 165.19 | 9.63 | 1009 | 169020 | 202636 | 64126067 |
Poisoning deliberate | 162.72 | 9.63 | 189 | 169840 | 13269 | 64315434 |
Infusion related reaction | 161.00 | 9.63 | 119 | 169910 | 164348 | 64164355 |
Cardio-respiratory arrest | 155.41 | 9.63 | 591 | 169438 | 97802 | 64230901 |
Rheumatoid arthritis | 151.81 | 9.63 | 126 | 169903 | 164168 | 64164535 |
Treatment failure | 151.64 | 9.63 | 59 | 169970 | 116757 | 64211946 |
Delirium | 150.92 | 9.63 | 463 | 169566 | 68731 | 64259972 |
Suicidal ideation | 149.58 | 9.63 | 450 | 169579 | 66092 | 64262611 |
Road traffic accident | 139.69 | 9.63 | 273 | 169756 | 30472 | 64298231 |
Hand deformity | 136.41 | 9.63 | 7 | 170022 | 62764 | 64265939 |
Lower respiratory tract infection | 136.34 | 9.63 | 40 | 169989 | 94574 | 64234129 |
Coma | 135.67 | 9.63 | 523 | 169506 | 87092 | 64241611 |
Sleep-related eating disorder | 134.95 | 9.63 | 55 | 169974 | 627 | 64328076 |
Peripheral swelling | 124.11 | 9.63 | 226 | 169803 | 208927 | 64119776 |
Fall | 123.39 | 9.63 | 1657 | 168372 | 415169 | 63913534 |
Abnormal behaviour | 119.49 | 9.63 | 270 | 169759 | 33352 | 64295351 |
Disorientation | 119.35 | 9.63 | 371 | 169658 | 55457 | 64273246 |
Insomnia | 109.21 | 9.63 | 893 | 169136 | 196943 | 64131760 |
Confusional state | 108.25 | 9.63 | 1108 | 168921 | 260036 | 64068667 |
Systemic lupus erythematosus | 107.88 | 9.63 | 35 | 169994 | 77577 | 64251126 |
Hypersensitivity | 104.73 | 9.63 | 226 | 169803 | 196226 | 64132477 |
Bradyphrenia | 100.42 | 9.63 | 124 | 169905 | 9282 | 64319421 |
Maternal exposure during pregnancy | 99.59 | 9.63 | 65 | 169964 | 95819 | 64232884 |
Arthropathy | 98.50 | 9.63 | 104 | 169925 | 120863 | 64207840 |
Drug abuser | 95.57 | 9.63 | 96 | 169933 | 5712 | 64322991 |
Product use in unapproved indication | 94.29 | 9.63 | 203 | 169826 | 176415 | 64152288 |
Loss of consciousness | 89.14 | 9.63 | 683 | 169346 | 147682 | 64181021 |
Homicide | 87.58 | 9.63 | 48 | 169981 | 1103 | 64327600 |
Restlessness | 86.52 | 9.63 | 266 | 169763 | 39519 | 64289184 |
Withdrawal syndrome | 86.10 | 9.63 | 191 | 169838 | 23301 | 64305402 |
Infection | 84.10 | 9.63 | 231 | 169798 | 184649 | 64144054 |
Pericarditis | 80.41 | 9.63 | 32 | 169997 | 62484 | 64266219 |
Glossodynia | 78.60 | 9.63 | 36 | 169993 | 64660 | 64264043 |
Impaired driving ability | 78.56 | 9.63 | 78 | 169951 | 4576 | 64324127 |
Drug use disorder | 76.51 | 9.63 | 87 | 169942 | 5967 | 64322736 |
Arthralgia | 74.84 | 9.63 | 775 | 169254 | 441485 | 63887218 |
Duodenal ulcer perforation | 74.79 | 9.63 | 4 | 170025 | 34621 | 64294082 |
Automatism | 72.83 | 9.63 | 24 | 170005 | 140 | 64328563 |
Hallucination | 71.64 | 9.63 | 380 | 169649 | 72408 | 64256295 |
Wound | 71.41 | 9.63 | 58 | 169971 | 76419 | 64252284 |
Agitation | 70.99 | 9.63 | 437 | 169592 | 87930 | 64240773 |
Therapeutic product effect incomplete | 70.54 | 9.63 | 102 | 169927 | 103380 | 64225323 |
Dependence | 68.82 | 9.63 | 52 | 169977 | 2103 | 64326600 |
Helicobacter infection | 68.02 | 9.63 | 10 | 170019 | 38352 | 64290351 |
Cardiac arrest | 64.85 | 9.63 | 656 | 169373 | 153408 | 64175295 |
Affect lability | 63.42 | 9.63 | 97 | 169932 | 8893 | 64319810 |
Nasopharyngitis | 60.60 | 9.63 | 288 | 169741 | 195785 | 64132918 |
Rash | 60.57 | 9.63 | 848 | 169181 | 457701 | 63871002 |
Alopecia | 60.04 | 9.63 | 229 | 169800 | 165461 | 64163242 |
Swelling | 58.99 | 9.63 | 220 | 169809 | 159998 | 64168705 |
Product use issue | 58.72 | 9.63 | 204 | 169825 | 151511 | 64177192 |
Hepatic enzyme increased | 58.59 | 9.63 | 163 | 169866 | 129780 | 64198923 |
Bradypnoea | 58.30 | 9.63 | 70 | 169959 | 5089 | 64323614 |
Miosis | 56.89 | 9.63 | 115 | 169914 | 13151 | 64315552 |
Intentional product use issue | 56.55 | 9.63 | 103 | 169926 | 95261 | 64233442 |
Parasomnia | 56.11 | 9.63 | 27 | 170002 | 468 | 64328235 |
Musculoskeletal stiffness | 55.96 | 9.63 | 154 | 169875 | 123052 | 64205651 |
Drug hypersensitivity | 55.85 | 9.63 | 382 | 169647 | 237433 | 64091270 |
Mental status changes | 55.27 | 9.63 | 312 | 169717 | 60850 | 64267853 |
Blood pressure fluctuation | 54.08 | 9.63 | 35 | 169994 | 51836 | 64276867 |
Dissociative disorder | 53.98 | 9.63 | 25 | 170004 | 396 | 64328307 |
Neutropenia | 53.30 | 9.63 | 391 | 169638 | 239233 | 64089470 |
Immobilisation prolonged | 52.50 | 9.63 | 17 | 170012 | 93 | 64328610 |
Hallucination, visual | 52.27 | 9.63 | 177 | 169852 | 27657 | 64301046 |
Drug withdrawal convulsions | 52.24 | 9.63 | 44 | 169985 | 2084 | 64326619 |
Initial insomnia | 51.75 | 9.63 | 70 | 169959 | 5734 | 64322969 |
Incoherent | 50.49 | 9.63 | 77 | 169952 | 7041 | 64321662 |
Abdominal discomfort | 50.01 | 9.63 | 279 | 169750 | 182043 | 64146660 |
Exposure via ingestion | 49.73 | 9.63 | 63 | 169966 | 4839 | 64323864 |
Mydriasis | 48.96 | 9.63 | 118 | 169911 | 15194 | 64313509 |
Altered state of consciousness | 48.95 | 9.63 | 214 | 169815 | 37688 | 64291015 |
Sleep disorder due to general medical condition, insomnia type | 48.59 | 9.63 | 6 | 170023 | 26264 | 64302439 |
Mental disorder | 46.90 | 9.63 | 165 | 169864 | 26280 | 64302423 |
Psychomotor skills impaired | 46.48 | 9.63 | 54 | 169975 | 3791 | 64324912 |
Condition aggravated | 45.21 | 9.63 | 700 | 169329 | 371726 | 63956977 |
Gun shot wound | 43.90 | 9.63 | 30 | 169999 | 1034 | 64327669 |
Dysarthria | 42.90 | 9.63 | 286 | 169743 | 59120 | 64269583 |
Folliculitis | 42.80 | 9.63 | 13 | 170016 | 30064 | 64298639 |
Sleep talking | 42.79 | 9.63 | 29 | 170000 | 986 | 64327717 |
Tremor | 42.74 | 9.63 | 587 | 169442 | 147643 | 64181060 |
Therapeutic product effect decreased | 42.70 | 9.63 | 158 | 169871 | 115193 | 64213510 |
Aggression | 42.53 | 9.63 | 237 | 169792 | 45995 | 64282708 |
Logorrhoea | 42.51 | 9.63 | 53 | 169976 | 4006 | 64324697 |
Blister | 41.58 | 9.63 | 95 | 169934 | 80872 | 64247831 |
Memory impairment | 41.56 | 9.63 | 376 | 169653 | 85306 | 64243397 |
Akathisia | 41.52 | 9.63 | 93 | 169936 | 11417 | 64317286 |
Disturbance in attention | 41.48 | 9.63 | 216 | 169813 | 40858 | 64287845 |
Cytomegalovirus infection | 40.30 | 9.63 | 24 | 170005 | 37175 | 64291528 |
Acute kidney injury | 39.72 | 9.63 | 892 | 169137 | 448348 | 63880355 |
Dyspnoea | 39.27 | 9.63 | 1524 | 168505 | 717150 | 63611553 |
Drug tolerance | 39.23 | 9.63 | 63 | 169966 | 6022 | 64322681 |
Septic shock | 38.00 | 9.63 | 146 | 169883 | 105291 | 64223412 |
Emotional distress | 37.42 | 9.63 | 191 | 169838 | 35847 | 64292856 |
Nightmare | 36.38 | 9.63 | 130 | 169899 | 20863 | 64307840 |
Depressed level of consciousness | 35.81 | 9.63 | 350 | 169679 | 81086 | 64247617 |
Behaviour disorder | 35.58 | 9.63 | 51 | 169978 | 4411 | 64324292 |
Urticaria | 35.37 | 9.63 | 235 | 169794 | 147082 | 64181621 |
Hypokinesia | 35.18 | 9.63 | 110 | 169919 | 16486 | 64312217 |
High risk sexual behaviour | 34.59 | 9.63 | 7 | 170022 | 0 | 64328703 |
Substance abuse | 34.55 | 9.63 | 76 | 169953 | 9216 | 64319487 |
Legal problem | 34.32 | 9.63 | 14 | 170015 | 160 | 64328543 |
Red blood cell sedimentation rate increased | 34.05 | 9.63 | 20 | 170009 | 31215 | 64297488 |
Hallucination, auditory | 33.84 | 9.63 | 110 | 169919 | 16829 | 64311874 |
Psychomotor hyperactivity | 33.65 | 9.63 | 99 | 169930 | 14352 | 64314351 |
Panic attack | 33.16 | 9.63 | 126 | 169903 | 20827 | 64307876 |
Parkinsonism | 33.03 | 9.63 | 98 | 169931 | 14275 | 64314428 |
Angioedema | 33.00 | 9.63 | 71 | 169958 | 61750 | 64266953 |
Major depression | 32.62 | 9.63 | 67 | 169962 | 7749 | 64320954 |
Gastrointestinal disorder | 32.47 | 9.63 | 124 | 169905 | 89585 | 64239118 |
Euphoric mood | 31.74 | 9.63 | 60 | 169969 | 6531 | 64322172 |
Muscle injury | 31.66 | 9.63 | 15 | 170014 | 26422 | 64302281 |
Anterograde amnesia | 31.14 | 9.63 | 20 | 170009 | 620 | 64328083 |
Blood pressure systolic increased | 30.59 | 9.63 | 52 | 169977 | 49401 | 64279302 |
Cough | 30.48 | 9.63 | 587 | 169442 | 301561 | 64027142 |
Erythema | 30.26 | 9.63 | 331 | 169698 | 186739 | 64141964 |
Head injury | 29.97 | 9.63 | 168 | 169861 | 32674 | 64296029 |
Drug screen positive | 29.91 | 9.63 | 54 | 169975 | 5675 | 64323028 |
Listless | 29.82 | 9.63 | 40 | 169989 | 3250 | 64325453 |
Persistent genital arousal disorder | 29.71 | 9.63 | 14 | 170015 | 231 | 64328472 |
Irritability | 29.67 | 9.63 | 182 | 169847 | 36564 | 64292139 |
Drug detoxification | 29.23 | 9.63 | 14 | 170015 | 240 | 64328463 |
Exposure during pregnancy | 29 | 9.63 | 106 | 169923 | 77569 | 64251134 |
Anaphylactic reaction | 28.85 | 9.63 | 89 | 169940 | 68575 | 64260128 |
Hyponatraemia | 28.72 | 9.63 | 550 | 169479 | 147789 | 64180914 |
Anger | 28.59 | 9.63 | 99 | 169930 | 15642 | 64313061 |
Carotid artery thrombosis | 28.31 | 9.63 | 29 | 170000 | 1766 | 64326937 |
Personality disorder | 27.98 | 9.63 | 47 | 169982 | 4664 | 64324039 |
Injury | 27.80 | 9.63 | 247 | 169782 | 55745 | 64272958 |
Product substitution issue | 27.11 | 9.63 | 106 | 169923 | 17755 | 64310948 |
Multiple organ dysfunction syndrome | 26.81 | 9.63 | 157 | 169872 | 101256 | 64227447 |
Death | 26.64 | 9.63 | 1022 | 169007 | 481683 | 63847020 |
Drug resistance | 26.57 | 9.63 | 32 | 169997 | 35070 | 64293633 |
Mucosal inflammation | 26.38 | 9.63 | 81 | 169948 | 62503 | 64266200 |
COVID-19 | 26.27 | 9.63 | 86 | 169943 | 65054 | 64263649 |
Wheezing | 26.27 | 9.63 | 116 | 169913 | 80463 | 64248240 |
Pruritus | 26.24 | 9.63 | 625 | 169404 | 311775 | 64016928 |
Alcohol use | 26.12 | 9.63 | 45 | 169984 | 4557 | 64324146 |
Reduced facial expression | 26.09 | 9.63 | 30 | 169999 | 2083 | 64326620 |
Discomfort | 26.02 | 9.63 | 117 | 169912 | 80761 | 64247942 |
General physical health deterioration | 25.52 | 9.63 | 382 | 169647 | 204043 | 64124660 |
Hyperlipidaemia | 25.43 | 9.63 | 124 | 169905 | 22852 | 64305851 |
Neurologic neglect syndrome | 25.26 | 9.63 | 26 | 170003 | 1592 | 64327111 |
Inappropriate antidiuretic hormone secretion | 25.18 | 9.63 | 121 | 169908 | 22168 | 64306535 |
Tension | 25.09 | 9.63 | 40 | 169989 | 3800 | 64324903 |
Myelosuppression | 24.94 | 9.63 | 16 | 170013 | 23814 | 64304889 |
Pyrexia | 24.77 | 9.63 | 1212 | 168817 | 557432 | 63771271 |
Premature delivery | 24.76 | 9.63 | 9 | 170020 | 18580 | 64310123 |
Renal impairment | 24.68 | 9.63 | 232 | 169797 | 134785 | 64193918 |
C-reactive protein increased | 24.52 | 9.63 | 148 | 169881 | 94761 | 64233942 |
Apathy | 24.32 | 9.63 | 75 | 169954 | 11157 | 64317546 |
Imprisonment | 24.19 | 9.63 | 16 | 170013 | 522 | 64328181 |
Productive cough | 24.10 | 9.63 | 105 | 169924 | 73098 | 64255605 |
Ill-defined disorder | 24.01 | 9.63 | 50 | 169979 | 44002 | 64284701 |
Oedematous pancreatitis | 23.13 | 9.63 | 19 | 170010 | 869 | 64327834 |
Laryngeal pain | 22.96 | 9.63 | 48 | 169981 | 5620 | 64323083 |
Neurotoxicity | 22.93 | 9.63 | 23 | 170006 | 27381 | 64301322 |
Psychotic disorder | 22.91 | 9.63 | 163 | 169866 | 34415 | 64294288 |
Pathogen resistance | 22.87 | 9.63 | 3 | 170026 | 12540 | 64316163 |
Self-medication | 22.84 | 9.63 | 40 | 169989 | 4105 | 64324598 |
Inadequate analgesia | 22.71 | 9.63 | 39 | 169990 | 3939 | 64324764 |
Heart rate decreased | 22.69 | 9.63 | 72 | 169957 | 54995 | 64273708 |
Inflammation | 22.52 | 9.63 | 92 | 169937 | 65208 | 64263495 |
Impaired healing | 22.26 | 9.63 | 83 | 169946 | 60390 | 64268313 |
Drug tolerance increased | 22.11 | 9.63 | 16 | 170013 | 605 | 64328098 |
Labelled drug-drug interaction medication error | 21.52 | 9.63 | 16 | 170013 | 22046 | 64306657 |
Victim of chemical submission | 21.43 | 9.63 | 12 | 170017 | 288 | 64328415 |
Brain contusion | 21.35 | 9.63 | 21 | 170008 | 1218 | 64327485 |
Adjustment disorder | 21.34 | 9.63 | 31 | 169998 | 2714 | 64325989 |
Toxic epidermal necrolysis | 21.27 | 9.63 | 41 | 169988 | 37125 | 64291578 |
Stress cardiomyopathy | 21.16 | 9.63 | 63 | 169966 | 9194 | 64319509 |
Obstructive airways disorder | 21.12 | 9.63 | 18 | 170011 | 23167 | 64305536 |
Mania | 21.06 | 9.63 | 92 | 169937 | 16194 | 64312509 |
Transplant rejection | 20.64 | 9.63 | 10 | 170019 | 17391 | 64311312 |
Abnormal dreams | 20.46 | 9.63 | 67 | 169962 | 10289 | 64318414 |
Galactorrhoea | 20.31 | 9.63 | 33 | 169996 | 3186 | 64325517 |
Accidental poisoning | 20.29 | 9.63 | 22 | 170007 | 1431 | 64327272 |
Multiple sclerosis relapse | 20.18 | 9.63 | 181 | 169848 | 40954 | 64287749 |
Asthma | 19.90 | 9.63 | 158 | 169871 | 95067 | 64233636 |
Multiple drug therapy | 19.82 | 9.63 | 27 | 170002 | 2227 | 64326476 |
Panic disorder | 19.80 | 9.63 | 30 | 169999 | 2727 | 64325976 |
Encephalomalacia | 19.75 | 9.63 | 19 | 170010 | 1072 | 64327631 |
Analgesic drug level above therapeutic | 19.74 | 9.63 | 13 | 170016 | 421 | 64328282 |
Bronchopulmonary aspergillosis | 19.72 | 9.63 | 13 | 170016 | 19072 | 64309631 |
Febrile neutropenia | 19.70 | 9.63 | 362 | 169667 | 187295 | 64141408 |
Prescription drug used without a prescription | 19.69 | 9.63 | 29 | 170000 | 2571 | 64326132 |
Femoral neck fracture | 19.59 | 9.63 | 59 | 169970 | 8665 | 64320038 |
Bipolar disorder | 19.40 | 9.63 | 50 | 169979 | 6711 | 64321992 |
Deep vein thrombosis | 19.34 | 9.63 | 387 | 169642 | 104795 | 64223908 |
Drug diversion | 19.10 | 9.63 | 19 | 170010 | 1117 | 64327586 |
Prothrombin time shortened | 19.06 | 9.63 | 30 | 169999 | 2819 | 64325884 |
Unresponsive to stimuli | 19.03 | 9.63 | 210 | 169819 | 50183 | 64278520 |
Psoriatic arthropathy | 18.97 | 9.63 | 55 | 169974 | 43226 | 64285477 |
Feeling drunk | 18.92 | 9.63 | 37 | 169992 | 4130 | 64324573 |
Illusion | 18.89 | 9.63 | 22 | 170007 | 1548 | 64327155 |
Pulmonary fibrosis | 18.86 | 9.63 | 31 | 169998 | 29847 | 64298856 |
Hepatotoxicity | 18.85 | 9.63 | 49 | 169980 | 39913 | 64288790 |
Thinking abnormal | 18.71 | 9.63 | 70 | 169959 | 11486 | 64317217 |
Hyperhidrosis | 18.63 | 9.63 | 446 | 169583 | 124474 | 64204229 |
Urinary retention | 18.56 | 9.63 | 205 | 169824 | 48996 | 64279707 |
Epstein-Barr virus infection | 18.50 | 9.63 | 5 | 170024 | 12483 | 64316220 |
Vision blurred | 18.21 | 9.63 | 337 | 169692 | 89979 | 64238724 |
Bulimia nervosa | 18.16 | 9.63 | 10 | 170019 | 232 | 64328471 |
Victim of homicide | 18.10 | 9.63 | 9 | 170020 | 168 | 64328535 |
Multiple sclerosis | 18.02 | 9.63 | 98 | 169931 | 18843 | 64309860 |
Diarrhoea | 17.95 | 9.63 | 1651 | 168378 | 721053 | 63607650 |
Self-injurious ideation | 17.81 | 9.63 | 31 | 169998 | 3166 | 64325537 |
Injection site pain | 17.65 | 9.63 | 198 | 169831 | 111210 | 64217493 |
Arthritis | 17.55 | 9.63 | 139 | 169890 | 83675 | 64245028 |
Cholecystitis chronic | 17.38 | 9.63 | 59 | 169970 | 9228 | 64319475 |
Blood pressure diastolic decreased | 17.23 | 9.63 | 20 | 170009 | 22281 | 64306422 |
Hangover | 17.06 | 9.63 | 23 | 170006 | 1878 | 64326825 |
Urinary hesitation | 16.96 | 9.63 | 32 | 169997 | 3478 | 64325225 |
Facial nerve disorder | 16.73 | 9.63 | 14 | 170015 | 657 | 64328046 |
Herpes zoster | 16.73 | 9.63 | 131 | 169898 | 79056 | 64249647 |
Blood pressure systolic abnormal | 16.71 | 9.63 | 3 | 170026 | 9939 | 64318764 |
Decreased interest | 16.69 | 9.63 | 31 | 169998 | 3329 | 64325374 |
Poor quality sleep | 16.67 | 9.63 | 96 | 169933 | 18855 | 64309848 |
Bone erosion | 16.52 | 9.63 | 5 | 170024 | 11590 | 64317113 |
Aplastic anaemia | 16.51 | 9.63 | 8 | 170021 | 13912 | 64314791 |
Dysphoria | 16.44 | 9.63 | 36 | 169993 | 4352 | 64324351 |
Foreign body | 16.44 | 9.63 | 26 | 170003 | 2453 | 64326250 |
Thrombotic microangiopathy | 16.34 | 9.63 | 12 | 170017 | 16643 | 64312060 |
Inappropriate schedule of product administration | 16.25 | 9.63 | 160 | 169869 | 92126 | 64236577 |
Posterior reversible encephalopathy syndrome | 16.24 | 9.63 | 22 | 170007 | 22924 | 64305779 |
Feeling abnormal | 16.16 | 9.63 | 464 | 169565 | 133138 | 64195565 |
Oropharyngeal pain | 16.11 | 9.63 | 153 | 169876 | 88714 | 64239989 |
Enthesopathy | 16 | 9.63 | 3 | 170026 | 9635 | 64319068 |
Sudden onset of sleep | 15.91 | 9.63 | 13 | 170016 | 590 | 64328113 |
Distributive shock | 15.79 | 9.63 | 22 | 170007 | 1853 | 64326850 |
Post transplant lymphoproliferative disorder | 15.78 | 9.63 | 3 | 170026 | 9541 | 64319162 |
Stomatitis | 15.75 | 9.63 | 199 | 169830 | 109406 | 64219297 |
Procalcitonin abnormal | 15.72 | 9.63 | 10 | 170019 | 305 | 64328398 |
Rhabdomyolysis | 15.72 | 9.63 | 334 | 169695 | 91392 | 64237311 |
Muscle rigidity | 15.69 | 9.63 | 89 | 169940 | 17384 | 64311319 |
Victim of sexual abuse | 15.68 | 9.63 | 11 | 170018 | 396 | 64328307 |
Live birth | 15.66 | 9.63 | 5 | 170024 | 11199 | 64317504 |
Bone marrow failure | 15.65 | 9.63 | 69 | 169960 | 47883 | 64280820 |
Hip arthroplasty | 15.60 | 9.63 | 20 | 170009 | 21331 | 64307372 |
Libido decreased | 15.44 | 9.63 | 37 | 169992 | 4747 | 64323956 |
Bipolar I disorder | 15.25 | 9.63 | 21 | 170008 | 1750 | 64326953 |
Device expulsion | 15.23 | 9.63 | 20 | 170009 | 21116 | 64307587 |
Skin ulcer | 15.13 | 9.63 | 62 | 169967 | 43912 | 64284791 |
Delusion | 15.03 | 9.63 | 90 | 169939 | 17924 | 64310779 |
Labelled drug-food interaction medication error | 14.99 | 9.63 | 6 | 170023 | 65 | 64328638 |
Inappropriate schedule of product discontinuation | 14.82 | 9.63 | 3 | 170026 | 0 | 64328703 |
Antidepressant drug level above therapeutic | 14.77 | 9.63 | 12 | 170017 | 540 | 64328163 |
Therapeutic response decreased | 14.76 | 9.63 | 79 | 169950 | 52109 | 64276594 |
Nervousness | 14.47 | 9.63 | 130 | 169899 | 29426 | 64299277 |
Tardive dyskinesia | 14.36 | 9.63 | 55 | 169974 | 9123 | 64319580 |
Tachyphrenia | 14.31 | 9.63 | 21 | 170008 | 1855 | 64326848 |
Nephropathy toxic | 14.31 | 9.63 | 15 | 170014 | 17499 | 64311204 |
Mobility decreased | 14.22 | 9.63 | 151 | 169878 | 85689 | 64243014 |
Depressed mood | 14.18 | 9.63 | 168 | 169861 | 40844 | 64287859 |
Disinhibition | 14.16 | 9.63 | 23 | 170006 | 2220 | 64326483 |
Cholecystectomy | 14.14 | 9.63 | 50 | 169979 | 7982 | 64320721 |
Circadian rhythm sleep disorder | 14.04 | 9.63 | 12 | 170017 | 580 | 64328123 |
Generalised anxiety disorder | 13.98 | 9.63 | 21 | 170008 | 1894 | 64326809 |
Dysuria | 13.98 | 9.63 | 171 | 169858 | 41886 | 64286817 |
Perseveration | 13.96 | 9.63 | 10 | 170019 | 372 | 64328331 |
Coagulation factor VII level decreased | 13.96 | 9.63 | 8 | 170021 | 201 | 64328502 |
Sepsis | 13.95 | 9.63 | 482 | 169547 | 229859 | 64098844 |
Intervertebral disc degeneration | 13.94 | 9.63 | 70 | 169959 | 13050 | 64315653 |
Neutropenic sepsis | 13.91 | 9.63 | 25 | 170004 | 23247 | 64305456 |
Fear | 13.89 | 9.63 | 96 | 169933 | 20075 | 64308628 |
Apallic syndrome | 13.77 | 9.63 | 14 | 170015 | 845 | 64327858 |
Diabetic ketoacidosis | 13.77 | 9.63 | 37 | 169992 | 29808 | 64298895 |
Accidental overdose | 13.67 | 9.63 | 142 | 169887 | 33415 | 64295288 |
Mouth ulceration | 13.66 | 9.63 | 42 | 169987 | 32402 | 64296301 |
Speech disorder | 13.61 | 9.63 | 191 | 169838 | 48250 | 64280453 |
Blastocystis infection | 13.57 | 9.63 | 4 | 170025 | 15 | 64328688 |
Therapy non-responder | 13.47 | 9.63 | 110 | 169919 | 65789 | 64262914 |
Poor venous access | 13.46 | 9.63 | 8 | 170021 | 12409 | 64316294 |
Persistent depressive disorder | 13.40 | 9.63 | 15 | 170014 | 1011 | 64327692 |
Atelectasis | 13.39 | 9.63 | 120 | 169909 | 27146 | 64301557 |
Product dose omission issue | 13.35 | 9.63 | 401 | 169628 | 194346 | 64134357 |
Sinusitis | 13.35 | 9.63 | 288 | 169741 | 145640 | 64183063 |
Lethargy | 13.31 | 9.63 | 267 | 169762 | 72327 | 64256376 |
Skin necrosis | 13.21 | 9.63 | 11 | 170018 | 14318 | 64314385 |
Dysphagia | 13.20 | 9.63 | 372 | 169657 | 106440 | 64222263 |
Cardiomegaly | 13.08 | 9.63 | 107 | 169922 | 23577 | 64305126 |
Immunodeficiency | 12.96 | 9.63 | 14 | 170015 | 16110 | 64312593 |
Staring | 12.94 | 9.63 | 23 | 170006 | 2387 | 64326316 |
Hypertensive heart disease | 12.90 | 9.63 | 30 | 169999 | 3774 | 64324929 |
Tachycardia | 12.84 | 9.63 | 499 | 169530 | 149080 | 64179623 |
Haematocrit decreased | 12.83 | 9.63 | 209 | 169820 | 54446 | 64274257 |
Labelled drug-food interaction issue | 12.82 | 9.63 | 4 | 170025 | 19 | 64328684 |
Diplopia | 12.74 | 9.63 | 117 | 169912 | 26648 | 64302055 |
Depressive symptom | 12.65 | 9.63 | 33 | 169996 | 4463 | 64324240 |
Sinus tachycardia | 12.55 | 9.63 | 135 | 169894 | 32053 | 64296650 |
Homicidal ideation | 12.52 | 9.63 | 27 | 170002 | 3230 | 64325473 |
Social anxiety disorder | 12.50 | 9.63 | 10 | 170019 | 440 | 64328263 |
Coagulation factor VIII level increased | 12.34 | 9.63 | 4 | 170025 | 22 | 64328681 |
Pneumonia | 12.24 | 9.63 | 1290 | 168739 | 558286 | 63770417 |
Adverse drug reaction | 12.22 | 9.63 | 70 | 169959 | 45394 | 64283309 |
Suspected suicide | 12.05 | 9.63 | 50 | 169979 | 8604 | 64320099 |
Drug dependence, antepartum | 12.04 | 9.63 | 4 | 170025 | 24 | 64328679 |
Hiatus hernia | 12.03 | 9.63 | 92 | 169937 | 19865 | 64308838 |
Substance-induced mood disorder | 12.02 | 9.63 | 6 | 170023 | 113 | 64328590 |
Eustachian tube disorder | 11.97 | 9.63 | 5 | 170024 | 61 | 64328642 |
Feeling of despair | 11.90 | 9.63 | 23 | 170006 | 2545 | 64326158 |
Attention deficit hyperactivity disorder | 11.86 | 9.63 | 24 | 170005 | 2746 | 64325957 |
Aspartate aminotransferase increased | 11.84 | 9.63 | 406 | 169623 | 119382 | 64209321 |
Peptic ulcer | 11.79 | 9.63 | 36 | 169993 | 5327 | 64323376 |
Anhedonia | 11.77 | 9.63 | 69 | 169960 | 13637 | 64315066 |
Syncope | 11.73 | 9.63 | 518 | 169511 | 157117 | 64171586 |
Neurogenic bladder | 11.69 | 9.63 | 28 | 170001 | 3591 | 64325112 |
Cerebral atrophy | 11.68 | 9.63 | 44 | 169985 | 7241 | 64321462 |
Bronchiectasis | 11.68 | 9.63 | 12 | 170017 | 14128 | 64314575 |
Blood potassium decreased | 11.63 | 9.63 | 160 | 169869 | 40239 | 64288464 |
Abulia | 11.59 | 9.63 | 13 | 170016 | 878 | 64327825 |
Eating disorder | 11.59 | 9.63 | 80 | 169949 | 16725 | 64311978 |
Palpitations | 11.58 | 9.63 | 359 | 169670 | 104129 | 64224574 |
Product complaint | 11.47 | 9.63 | 62 | 169967 | 11892 | 64316811 |
Cholestatic liver injury | 11.39 | 9.63 | 28 | 170001 | 3651 | 64325052 |
Dehydration | 11.38 | 9.63 | 689 | 169340 | 216074 | 64112629 |
Coordination abnormal | 11.38 | 9.63 | 73 | 169956 | 14891 | 64313812 |
Vertigo CNS origin | 11.28 | 9.63 | 4 | 170025 | 30 | 64328673 |
Cognitive disorder | 11.26 | 9.63 | 206 | 169823 | 54881 | 64273822 |
Fatigue | 11.25 | 9.63 | 1768 | 168261 | 746962 | 63581741 |
Disease progression | 11.18 | 9.63 | 286 | 169743 | 141394 | 64187309 |
Suicidal behaviour | 11.18 | 9.63 | 24 | 170005 | 2863 | 64325840 |
Carotid artery stenosis | 11.15 | 9.63 | 46 | 169983 | 7895 | 64320808 |
Acute graft versus host disease | 11.12 | 9.63 | 5 | 170024 | 9079 | 64319624 |
Blood testosterone decreased | 11.06 | 9.63 | 20 | 170009 | 2105 | 64326598 |
Dementia | 11.03 | 9.63 | 93 | 169936 | 20673 | 64308030 |
Lactic acidosis | 11.01 | 9.63 | 106 | 169923 | 61304 | 64267399 |
Tenosynovitis | 11.01 | 9.63 | 9 | 170020 | 11824 | 64316879 |
Pancreatic haemorrhage | 10.86 | 9.63 | 5 | 170024 | 78 | 64328625 |
Grip strength decreased | 10.80 | 9.63 | 9 | 170020 | 11715 | 64316988 |
Skin haemorrhage | 10.72 | 9.63 | 48 | 169981 | 8537 | 64320166 |
Loss of proprioception | 10.72 | 9.63 | 11 | 170018 | 671 | 64328032 |
Leukopenia | 10.71 | 9.63 | 195 | 169834 | 101047 | 64227656 |
Drug ineffective for unapproved indication | 10.65 | 9.63 | 44 | 169985 | 31089 | 64297614 |
Amnestic disorder | 10.62 | 9.63 | 10 | 170019 | 549 | 64328154 |
Cardiotoxicity | 10.61 | 9.63 | 7 | 170022 | 10267 | 64318436 |
Therapy partial responder | 10.56 | 9.63 | 7 | 170022 | 10241 | 64318462 |
Pain | 10.42 | 9.63 | 1289 | 168740 | 552222 | 63776481 |
Slow speech | 10.38 | 9.63 | 19 | 170010 | 2018 | 64326685 |
Refusal of treatment by relative | 10.35 | 9.63 | 11 | 170018 | 699 | 64328004 |
Dysgeusia | 10.35 | 9.63 | 178 | 169851 | 46869 | 64281834 |
Aspergillus infection | 10.33 | 9.63 | 17 | 170012 | 16362 | 64312341 |
Left ventricular dysfunction | 10.33 | 9.63 | 18 | 170011 | 16936 | 64311767 |
Therapeutic product effect increased | 10.22 | 9.63 | 15 | 170014 | 1325 | 64327378 |
Paranoia | 10.21 | 9.63 | 76 | 169953 | 16276 | 64312427 |
Sudden death | 10.15 | 9.63 | 89 | 169940 | 20007 | 64308696 |
Pleurodesis | 10.11 | 9.63 | 4 | 170025 | 42 | 64328661 |
Dyssomnia | 10.11 | 9.63 | 4 | 170025 | 42 | 64328661 |
Secretion discharge | 10.05 | 9.63 | 10 | 170019 | 11954 | 64316749 |
Coagulation factor V level decreased | 10.04 | 9.63 | 10 | 170019 | 589 | 64328114 |
Creatinine renal clearance decreased | 10.03 | 9.63 | 14 | 170015 | 14407 | 64314296 |
Respiratory disorder | 10.03 | 9.63 | 55 | 169974 | 36056 | 64292647 |
Psychomotor retardation | 9.91 | 9.63 | 33 | 169996 | 5110 | 64323593 |
Drug withdrawal maintenance therapy | 9.86 | 9.63 | 4 | 170025 | 45 | 64328658 |
Peripheral ischaemia | 9.84 | 9.63 | 46 | 169983 | 8332 | 64320371 |
Catatonia | 9.82 | 9.63 | 43 | 169986 | 7577 | 64321126 |
Sleep disorder | 9.77 | 9.63 | 216 | 169813 | 59493 | 64269210 |
Alanine aminotransferase abnormal | 9.76 | 9.63 | 3 | 170026 | 6885 | 64321818 |
Muscle spasms | 9.75 | 9.63 | 460 | 169569 | 140563 | 64188140 |
Product commingling | 9.75 | 9.63 | 5 | 170024 | 100 | 64328603 |
Activation syndrome | 9.69 | 9.63 | 7 | 170022 | 264 | 64328439 |
Transient ischaemic attack | 9.66 | 9.63 | 167 | 169862 | 44015 | 64284688 |
None
Source | Code | Description |
---|---|---|
ATC | N05CF02 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Benzodiazepine related drugs |
FDA CS | M0018233 | Pyridines |
FDA MoA | N0000000196 | GABA A Agonists |
FDA Chemical/Ingredient | N0000007570 | Pyridines |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D018755 | GABA Agonists |
MeSH PA | D058785 | GABA-A Receptor Agonists |
MeSH PA | D006993 | Hypnotics and Sedatives |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D000068776 | Sleep Aids, Pharmaceutical |
CHEBI has role | CHEBI:35488 | central nervous system depressants |
CHEBI has role | CHEBI:35717 | hypnotics |
CHEBI has role | CHEBI:51373 | gamma-aminobutyric acid receptor agonist |
FDA PE | N0000175728 | Central Nervous System Depression |
FDA EPC | N0000175759 | gamma-Aminobutyric Acid-ergic Agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Initial insomnia | indication | 59050008 | |
Insomnia | indication | 193462001 | |
Cognitive impairment following traumatic brain injury | off-label use | 127295002 | |
Arousal post traumatic brain injury | off-label use | 127295002 | |
Suicidal thoughts | contraindication | 6471006 | |
Hallucinations | contraindication | 7011001 | |
Asthenia | contraindication | 13791008 | |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Aggressive behavior | contraindication | 61372001 | |
Substance abuse | contraindication | 66214007 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Sleep automatism | contraindication | 247962006 | |
Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
Impaired cognition | contraindication | 386806002 | |
Memory impairment | contraindication | 386807006 | |
Attention deficit hyperactivity disorder | contraindication | 406506008 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 5.73 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7682628 | Feb. 16, 2025 | METHOD FOR TREATING INSOMNIA |
3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7682628 | Feb. 16, 2025 | METHOD FOR TREATING INSOMNIA |
10MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9597281 | April 6, 2027 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
5MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9597281 | April 6, 2027 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7658945 | April 15, 2027 | METHOD FOR TREATING INSOMNIA |
3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7658945 | April 15, 2027 | METHOD FOR TREATING INSOMNIA |
1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 8242131 | Aug. 20, 2029 | METHOD OF TREATING MIDDLE-OF-THE-NIGHT INSOMNIA |
3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 8242131 | Aug. 20, 2029 | METHOD OF TREATING MIDDLE-OF-THE-NIGHT INSOMNIA |
10MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9265720 | Feb. 25, 2031 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
5MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9265720 | Feb. 25, 2031 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
5MG/SPRAY | ZOLPIMIST | AYTU | N022196 | Dec. 19, 2008 | RX | SPRAY, METERED | ORAL | 8236285 | Aug. 7, 2032 | TREATMENT OF TRANSIENT INSOMNIA |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Gamma-aminobutyric acid receptor subunit alpha-1 | Ion channel | ALLOSTERIC MODULATOR | Ki | 7.68 | IUPHAR | IUPHAR | |||
GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 6.70 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-2/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.81 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-3/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.42 | WOMBAT-PK | CHEMBL | |||
GABA-A receptor alpha-1/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 7.57 | WOMBAT-PK | CHEMBL | |||
GABA A receptor alpha-3/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.16 | WOMBAT-PK | CHEMBL | |||
Gamma-aminobutyric acid receptor subunit alpha-2 | Ion channel | Ki | 6.39 | CHEMBL | |||||
Gamma-aminobutyric acid receptor subunit alpha-3 | Ion channel | Ki | 6.01 | CHEMBL | |||||
Multidrug resistance protein 1 | Transporter | Km | 3.70 | WOMBAT-PK | |||||
Gamma-aminobutyric acid receptor subunit alpha-2 | Ion channel | Ki | 6.12 | CHEMBL | |||||
Gamma-aminobutyric acid receptor subunit alpha-5 | Ion channel | Ki | 7.46 | CHEMBL | |||||
GABA A receptor alpha-6/beta-2/gamma-2 | Ion channel | Ki | 6.01 | CHEMBL | |||||
GABA-A receptor; alpha-1/beta-2/gamma-2 | Ion channel | Ki | 7.72 | CHEMBL | |||||
GABA A receptor alpha-2/beta-2/gamma-2 | Ion channel | Ki | 6.81 | CHEMBL | |||||
CAAX prenyl protease 2 | Enzyme | AC50 | 4.77 | CHEMBL | |||||
GABA-A receptor; anion channel | Ion channel | Ki | 7.60 | CHEMBL | |||||
GABA A receptor alpha-3/beta-2/gamma-2 | Ion channel | Ki | 6.42 | CHEMBL | |||||
Translocator protein | Membrane receptor | IC50 | 5.33 | CHEMBL | |||||
Gamma-aminobutyric acid receptor subunit alpha-1 | Ion channel | Ki | 7.30 | CHEMBL |
ID | Source |
---|---|
D00706 | KEGG_DRUG |
99294-93-6 | SECONDARY_CAS_RN |
4020811 | VANDF |
4023596 | VANDF |
C0078839 | UMLSCUI |
CHEBI:10125 | CHEBI |
CHEMBL911 | ChEMBL_ID |
CHEMBL3989820 | ChEMBL_ID |
DB00425 | DRUGBANK_ID |
CHEMBL1723343 | ChEMBL_ID |
D000077334 | MESH_DESCRIPTOR_UI |
5732 | PUBCHEM_CID |
4348 | IUPHAR_LIGAND_ID |
5741 | INN_ID |
7K383OQI23 | UNII |
131725 | RXNORM |
109404 | MMSL |
343 | MMSL |
5713 | MMSL |
d00910 | MMSL |
004146 | NDDF |
004147 | NDDF |
387569009 | SNOMEDCT_US |
395928005 | SNOMEDCT_US |
96231005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5401 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 34 sections |
Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5401 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 34 sections |
Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5421 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 34 sections |
Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5421 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 34 sections |
Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5501 | TABLET, COATED | 6.25 mg | ORAL | NDA | 34 sections |
Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5501 | TABLET, COATED | 6.25 mg | ORAL | NDA | 34 sections |
Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5521 | TABLET, COATED | 12.50 mg | ORAL | NDA | 34 sections |
Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5521 | TABLET, COATED | 12.50 mg | ORAL | NDA | 34 sections |
Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6010 | TABLET | 10 mg | ORAL | NDA | 33 sections |
Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6050 | TABLET | 5 mg | ORAL | NDA | 33 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0086 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 31 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0087 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0073 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 30 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0074 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 30 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8225 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 32 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8226 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 32 sections |
Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5315 | TABLET, EXTENDED RELEASE | 6.25 mg | ORAL | ANDA | 32 sections |
Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5316 | TABLET, EXTENDED RELEASE | 12.50 mg | ORAL | ANDA | 32 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5317 | TABLET, COATED | 5 mg | ORAL | ANDA | 31 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5318 | TABLET, COATED | 10 mg | ORAL | ANDA | 31 sections |
ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6082 | TABLET | 5 mg | ORAL | ANDA | 31 sections |
ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6083 | TABLET | 10 mg | ORAL | ANDA | 31 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1702 | TABLET, FILM COATED, EXTENDED RELEASE | 6.25 mg | ORAL | NDA AUTHORIZED GENERIC | 34 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1702 | TABLET, FILM COATED, EXTENDED RELEASE | 6.25 mg | ORAL | NDA AUTHORIZED GENERIC | 34 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1703 | TABLET, FILM COATED, EXTENDED RELEASE | 12.50 mg | ORAL | NDA AUTHORIZED GENERIC | 34 sections |
Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0955-1703 | TABLET, FILM COATED, EXTENDED RELEASE | 12.50 mg | ORAL | NDA AUTHORIZED GENERIC | 34 sections |
Zolpidem TartrateExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-116 | TABLET, FILM COATED, EXTENDED RELEASE | 12.50 mg | ORAL | ANDA | 32 sections |
Zolpidem TartrateExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-116 | TABLET, FILM COATED, EXTENDED RELEASE | 12.50 mg | ORAL | ANDA | 32 sections |
Zolpidem TartrateExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-117 | TABLET, FILM COATED, EXTENDED RELEASE | 6.25 mg | ORAL | ANDA | 32 sections |
Zolpidem TartrateExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-117 | TABLET, FILM COATED, EXTENDED RELEASE | 6.25 mg | ORAL | ANDA | 32 sections |