zolpidem 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| hypnotics/sedatives, zolpidem derivatives | 2870 | 82626-48-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of INSOMNIA.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 10 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 23 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.47 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 72 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.54 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 4.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.08 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.70 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 16, 1992 | FDA | SANOFI AVENTIS US |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 893.81 | 9.63 | 1391 | 144185 | 132442 | 56014049 |
| Drug abuse | 730.03 | 9.63 | 887 | 144689 | 66723 | 56079768 |
| Intentional overdose | 627.97 | 9.63 | 826 | 144750 | 67291 | 56079200 |
| Somnambulism | 514.05 | 9.63 | 255 | 145321 | 4837 | 56141654 |
| Rheumatoid arthritis | 511.84 | 9.63 | 176 | 145400 | 382428 | 55764063 |
| Suicide attempt | 443.69 | 9.63 | 642 | 144934 | 57194 | 56089297 |
| Drug dependence | 442.77 | 9.63 | 407 | 145169 | 22126 | 56124365 |
| Contraindicated product administered | 415.46 | 9.63 | 15 | 145561 | 186271 | 55960220 |
| Amnesia | 372.60 | 9.63 | 526 | 145050 | 45796 | 56100695 |
| Drug intolerance | 358.69 | 9.63 | 119 | 145457 | 264699 | 55881792 |
| Synovitis | 356.19 | 9.63 | 14 | 145562 | 161291 | 55985200 |
| Hand deformity | 322.00 | 9.63 | 5 | 145571 | 134487 | 56012004 |
| Treatment failure | 317.56 | 9.63 | 35 | 145541 | 170357 | 55976134 |
| Systemic lupus erythematosus | 306.96 | 9.63 | 49 | 145527 | 180029 | 55966462 |
| Joint swelling | 302.55 | 9.63 | 188 | 145388 | 289612 | 55856879 |
| Anxiety | 292.47 | 9.63 | 1129 | 144447 | 192043 | 55954448 |
| Infusion related reaction | 289.70 | 9.63 | 90 | 145486 | 208841 | 55937650 |
| Sopor | 280.25 | 9.63 | 307 | 145269 | 20615 | 56125876 |
| Drug ineffective | 274.26 | 9.63 | 1337 | 144239 | 917652 | 55228839 |
| Arthropathy | 267.57 | 9.63 | 92 | 145484 | 200183 | 55946308 |
| Intentional self-injury | 266.40 | 9.63 | 326 | 145250 | 24666 | 56121825 |
| Glossodynia | 265.48 | 9.63 | 39 | 145537 | 152419 | 55994072 |
| Insomnia | 239.64 | 9.63 | 1057 | 144519 | 190803 | 55955688 |
| Overdose | 222.33 | 9.63 | 690 | 144886 | 105140 | 56041351 |
| Off label use | 219.11 | 9.63 | 724 | 144852 | 555456 | 55591035 |
| Abnormal sleep-related event | 216.22 | 9.63 | 79 | 145497 | 667 | 56145824 |
| Depression | 211.17 | 9.63 | 974 | 144602 | 179143 | 55967348 |
| Pericarditis | 209.02 | 9.63 | 20 | 145556 | 108903 | 56037588 |
| Intentional product misuse | 207.45 | 9.63 | 430 | 145146 | 51074 | 56095417 |
| Wound | 199.24 | 9.63 | 56 | 145520 | 138748 | 56007743 |
| Alopecia | 194.57 | 9.63 | 286 | 145290 | 293172 | 55853319 |
| Somnolence | 188.80 | 9.63 | 880 | 144696 | 162533 | 55983958 |
| Poisoning deliberate | 182.43 | 9.63 | 173 | 145403 | 9780 | 56136711 |
| Maternal exposure during pregnancy | 181.55 | 9.63 | 135 | 145441 | 189418 | 55957073 |
| Peripheral swelling | 176.80 | 9.63 | 208 | 145368 | 234518 | 55911973 |
| Toxicity to various agents | 174.15 | 9.63 | 1084 | 144492 | 223480 | 55923011 |
| Swelling | 172.66 | 9.63 | 220 | 145356 | 239551 | 55906940 |
| Hypersensitivity | 169.82 | 9.63 | 250 | 145326 | 256158 | 55890333 |
| Lower respiratory tract infection | 169.09 | 9.63 | 44 | 145532 | 114750 | 56031741 |
| Abdominal discomfort | 168.82 | 9.63 | 286 | 145290 | 276988 | 55869503 |
| Poisoning | 151.10 | 9.63 | 176 | 145400 | 12637 | 56133854 |
| Drug withdrawal syndrome | 150.65 | 9.63 | 253 | 145323 | 25604 | 56120887 |
| Therapeutic product effect decreased | 143.40 | 9.63 | 136 | 145440 | 169316 | 55977175 |
| Helicobacter infection | 141.75 | 9.63 | 13 | 145563 | 73255 | 56073236 |
| Fall | 136.30 | 9.63 | 1468 | 144108 | 356042 | 55790449 |
| Coma | 134.62 | 9.63 | 399 | 145177 | 59256 | 56087235 |
| Suicidal ideation | 131.06 | 9.63 | 387 | 145189 | 57355 | 56089136 |
| Respiratory arrest | 129.57 | 9.63 | 261 | 145315 | 30364 | 56116127 |
| Product use issue | 127.44 | 9.63 | 177 | 145399 | 185864 | 55960627 |
| Cardio-respiratory arrest | 123.87 | 9.63 | 369 | 145207 | 54952 | 56091539 |
| Hepatic enzyme increased | 121.49 | 9.63 | 159 | 145417 | 171225 | 55975266 |
| Rash | 120.66 | 9.63 | 764 | 144812 | 492283 | 55654208 |
| Drug use disorder | 117.21 | 9.63 | 97 | 145479 | 4572 | 56141919 |
| Infection | 115.00 | 9.63 | 214 | 145362 | 199992 | 55946499 |
| Discomfort | 113.92 | 9.63 | 119 | 145457 | 141642 | 56004849 |
| Abnormal behaviour | 111.03 | 9.63 | 193 | 145383 | 20079 | 56126412 |
| Arthralgia | 110.95 | 9.63 | 801 | 144775 | 500868 | 55645623 |
| Impaired driving ability | 106.81 | 9.63 | 87 | 145489 | 4009 | 56142482 |
| Road traffic accident | 104.12 | 9.63 | 226 | 145350 | 27701 | 56118790 |
| Loss of consciousness | 103.62 | 9.63 | 557 | 145019 | 108792 | 56037699 |
| Musculoskeletal stiffness | 102.31 | 9.63 | 153 | 145423 | 155854 | 55990637 |
| Sleep-related eating disorder | 101.64 | 9.63 | 47 | 145529 | 757 | 56145734 |
| Folliculitis | 98.14 | 9.63 | 13 | 145563 | 54966 | 56091525 |
| Muscle injury | 94.71 | 9.63 | 12 | 145564 | 52488 | 56094003 |
| Blister | 93.72 | 9.63 | 86 | 145490 | 108801 | 56037690 |
| Sleep disorder due to general medical condition, insomnia type | 91.57 | 9.63 | 5 | 145571 | 43333 | 56103158 |
| Withdrawal syndrome | 84.94 | 9.63 | 163 | 145413 | 18299 | 56128192 |
| Affect lability | 82.87 | 9.63 | 116 | 145460 | 10009 | 56136482 |
| Disorientation | 80.79 | 9.63 | 243 | 145333 | 36370 | 56110121 |
| Therapeutic product effect incomplete | 80.76 | 9.63 | 93 | 145483 | 105938 | 56040553 |
| Hallucination | 80.58 | 9.63 | 295 | 145281 | 48854 | 56097637 |
| Restlessness | 80.24 | 9.63 | 198 | 145378 | 26388 | 56120103 |
| Mental status changes | 80.04 | 9.63 | 246 | 145330 | 37255 | 56109236 |
| Agitation | 79.31 | 9.63 | 321 | 145255 | 55715 | 56090776 |
| Mydriasis | 77.77 | 9.63 | 118 | 145458 | 10953 | 56135538 |
| Nasopharyngitis | 77.73 | 9.63 | 301 | 145275 | 220658 | 55925833 |
| Drug hypersensitivity | 77.57 | 9.63 | 407 | 145169 | 274798 | 55871693 |
| Product substitution issue | 71.01 | 9.63 | 132 | 145444 | 14467 | 56132024 |
| Bradyphrenia | 69.95 | 9.63 | 86 | 145490 | 6534 | 56139957 |
| Drug abuser | 64.79 | 9.63 | 56 | 145520 | 2803 | 56143688 |
| Tremor | 62.73 | 9.63 | 531 | 145045 | 120558 | 56025933 |
| Intentional product use issue | 62.31 | 9.63 | 101 | 145475 | 99632 | 56046859 |
| Ill-defined disorder | 60.32 | 9.63 | 53 | 145523 | 68490 | 56078001 |
| Dependence | 59.77 | 9.63 | 46 | 145530 | 1951 | 56144540 |
| Immobilisation prolonged | 57.77 | 9.63 | 18 | 145558 | 87 | 56146404 |
| Delirium | 57.35 | 9.63 | 240 | 145336 | 42277 | 56104214 |
| Carotid artery thrombosis | 57.12 | 9.63 | 47 | 145529 | 2197 | 56144294 |
| Hyponatraemia | 56.70 | 9.63 | 455 | 145121 | 101684 | 56044807 |
| Condition aggravated | 55.96 | 9.63 | 596 | 144980 | 344302 | 55802189 |
| Confusional state | 55.49 | 9.63 | 800 | 144776 | 207355 | 55939136 |
| Product use in unapproved indication | 55.36 | 9.63 | 183 | 145393 | 140639 | 56005852 |
| Impaired healing | 55.14 | 9.63 | 87 | 145489 | 86754 | 56059737 |
| Dysarthria | 54.72 | 9.63 | 225 | 145351 | 39325 | 56107166 |
| Cardiac arrest | 53.76 | 9.63 | 395 | 145181 | 85919 | 56060572 |
| Miosis | 53.17 | 9.63 | 75 | 145501 | 6517 | 56139974 |
| Pain | 52.96 | 9.63 | 1309 | 144267 | 661875 | 55484616 |
| Sleep talking | 52.69 | 9.63 | 32 | 145544 | 915 | 56145576 |
| Exposure during pregnancy | 51.67 | 9.63 | 180 | 145396 | 136162 | 56010329 |
| Mental disorder | 51.45 | 9.63 | 156 | 145420 | 23448 | 56123043 |
| Psoriatic arthropathy | 50.03 | 9.63 | 71 | 145505 | 73937 | 56072554 |
| Substance abuse | 49.79 | 9.63 | 60 | 145516 | 4465 | 56142026 |
| Neurologic neglect syndrome | 49.70 | 9.63 | 43 | 145533 | 2155 | 56144336 |
| Urinary retention | 48.99 | 9.63 | 172 | 145404 | 27902 | 56118589 |
| Parkinsonism | 48.56 | 9.63 | 88 | 145488 | 9458 | 56137033 |
| Personality disorder | 48.01 | 9.63 | 63 | 145513 | 5110 | 56141381 |
| Dissociative disorder | 47.51 | 9.63 | 20 | 145556 | 254 | 56146237 |
| Drug withdrawal convulsions | 46.61 | 9.63 | 34 | 145542 | 1328 | 56145163 |
| Drug detoxification | 45.48 | 9.63 | 17 | 145559 | 154 | 56146337 |
| Altered state of consciousness | 44.53 | 9.63 | 146 | 145430 | 22875 | 56123616 |
| Disturbance in attention | 44.13 | 9.63 | 184 | 145392 | 32356 | 56114135 |
| Listless | 43.07 | 9.63 | 43 | 145533 | 2589 | 56143902 |
| Gastrointestinal disorder | 42.56 | 9.63 | 149 | 145427 | 112553 | 56033938 |
| Red blood cell sedimentation rate increased | 42.10 | 9.63 | 21 | 145555 | 36602 | 56109889 |
| Emotional distress | 41.71 | 9.63 | 170 | 145406 | 29593 | 56116898 |
| Liver injury | 41.05 | 9.63 | 29 | 145547 | 41819 | 56104672 |
| Psychomotor skills impaired | 40.75 | 9.63 | 38 | 145538 | 2102 | 56144389 |
| Hip arthroplasty | 40.27 | 9.63 | 25 | 145551 | 38598 | 56107893 |
| Initial insomnia | 38.53 | 9.63 | 59 | 145517 | 5520 | 56140971 |
| Irritable bowel syndrome | 38.52 | 9.63 | 74 | 145502 | 68384 | 56078107 |
| Tardive dyskinesia | 38.29 | 9.63 | 72 | 145504 | 7959 | 56138532 |
| Persistent genital arousal disorder | 37.94 | 9.63 | 18 | 145558 | 308 | 56146183 |
| Bradypnoea | 37.77 | 9.63 | 44 | 145532 | 3159 | 56143332 |
| Exposure via ingestion | 37.24 | 9.63 | 41 | 145535 | 2767 | 56143724 |
| Motor dysfunction | 36.93 | 9.63 | 78 | 145498 | 9379 | 56137112 |
| Syncope | 35.95 | 9.63 | 433 | 145143 | 107766 | 56038725 |
| Logorrhoea | 35.89 | 9.63 | 37 | 145539 | 2315 | 56144176 |
| Memory impairment | 35.44 | 9.63 | 361 | 145215 | 86196 | 56060295 |
| Dehydration | 35.26 | 9.63 | 592 | 144984 | 158233 | 55988258 |
| Premature delivery | 35.11 | 9.63 | 13 | 145563 | 27047 | 56119444 |
| Drug screen positive | 34.99 | 9.63 | 44 | 145532 | 3420 | 56143071 |
| Depressed level of consciousness | 34.98 | 9.63 | 258 | 145318 | 56175 | 56090316 |
| Stomatitis | 34.91 | 9.63 | 177 | 145399 | 120633 | 56025858 |
| Hallucination, visual | 34.88 | 9.63 | 112 | 145464 | 17356 | 56129135 |
| High risk sexual behaviour | 34.72 | 9.63 | 7 | 145569 | 0 | 56146491 |
| Multiple drug therapy | 34.00 | 9.63 | 39 | 145537 | 2753 | 56143738 |
| Tachycardia | 34.00 | 9.63 | 421 | 145155 | 105455 | 56041036 |
| Panic attack | 33.73 | 9.63 | 123 | 145453 | 20324 | 56126167 |
| Akathisia | 33.37 | 9.63 | 71 | 145505 | 8581 | 56137910 |
| Bradykinesia | 33.05 | 9.63 | 51 | 145525 | 4803 | 56141688 |
| Adverse drug reaction | 32.79 | 9.63 | 75 | 145501 | 65057 | 56081434 |
| Adjustment disorder | 32.69 | 9.63 | 35 | 145541 | 2288 | 56144203 |
| Eating disorder | 32.65 | 9.63 | 108 | 145468 | 16997 | 56129494 |
| Victim of sexual abuse | 32.35 | 9.63 | 20 | 145556 | 591 | 56145900 |
| Blood pressure fluctuation | 31.15 | 9.63 | 35 | 145541 | 40325 | 56106166 |
| Hypokalaemia | 30.96 | 9.63 | 377 | 145199 | 94060 | 56052431 |
| Hallucination, auditory | 30.81 | 9.63 | 82 | 145494 | 11442 | 56135049 |
| Urticaria | 30.39 | 9.63 | 234 | 145342 | 144442 | 56002049 |
| Head injury | 30.36 | 9.63 | 137 | 145439 | 24929 | 56121562 |
| Wheezing | 29.81 | 9.63 | 97 | 145479 | 74929 | 56071562 |
| Sensory loss | 29.60 | 9.63 | 69 | 145507 | 8866 | 56137625 |
| Homicide | 29.47 | 9.63 | 16 | 145560 | 368 | 56146123 |
| Rhabdomyolysis | 29.39 | 9.63 | 193 | 145383 | 40465 | 56106026 |
| Skin haemorrhage | 29.01 | 9.63 | 66 | 145510 | 8347 | 56138144 |
| Hyperhidrosis | 28.87 | 9.63 | 371 | 145205 | 93717 | 56052774 |
| Nightmare | 28.42 | 9.63 | 102 | 145474 | 16724 | 56129767 |
| Coordination abnormal | 28.05 | 9.63 | 84 | 145492 | 12537 | 56133954 |
| Bulimia nervosa | 27.99 | 9.63 | 16 | 145560 | 408 | 56146083 |
| Live birth | 27.94 | 9.63 | 8 | 145568 | 19597 | 56126894 |
| Pruritus | 27.92 | 9.63 | 615 | 144961 | 316008 | 55830483 |
| Illusion | 27.80 | 9.63 | 22 | 145554 | 972 | 56145519 |
| Dysphagia | 27.68 | 9.63 | 329 | 145247 | 81618 | 56064873 |
| Inflammation | 27.65 | 9.63 | 89 | 145487 | 68982 | 56077509 |
| Anaphylactic reaction | 27.28 | 9.63 | 71 | 145505 | 58924 | 56087567 |
| C-reactive protein increased | 27.10 | 9.63 | 108 | 145468 | 78576 | 56067915 |
| Irritability | 26.83 | 9.63 | 149 | 145427 | 29439 | 56117052 |
| Sinus tachycardia | 26.68 | 9.63 | 122 | 145454 | 22322 | 56124169 |
| Prescription drug used without a prescription | 26.41 | 9.63 | 29 | 145547 | 1951 | 56144540 |
| Alcohol abuse | 26.36 | 9.63 | 29 | 145547 | 1955 | 56144536 |
| Blood pressure systolic increased | 25.83 | 9.63 | 41 | 145535 | 40795 | 56105696 |
| Abnormal dreams | 25.13 | 9.63 | 68 | 145508 | 9581 | 56136910 |
| Device expulsion | 25.07 | 9.63 | 25 | 145551 | 30424 | 56116067 |
| Vertigo | 24.98 | 9.63 | 233 | 145343 | 54339 | 56092152 |
| Knee arthroplasty | 24.76 | 9.63 | 48 | 145528 | 44211 | 56102280 |
| Peptic ulcer | 24.73 | 9.63 | 41 | 145535 | 4103 | 56142388 |
| General physical health deterioration | 24.68 | 9.63 | 301 | 145275 | 169709 | 55976782 |
| Type 2 diabetes mellitus | 24.37 | 9.63 | 53 | 145523 | 46809 | 56099682 |
| Deep vein thrombosis | 24.24 | 9.63 | 305 | 145271 | 76672 | 56069819 |
| Mania | 24.04 | 9.63 | 75 | 145501 | 11445 | 56135046 |
| Incoherent | 23.84 | 9.63 | 41 | 145535 | 4228 | 56142263 |
| Mobility decreased | 23.77 | 9.63 | 154 | 145422 | 98837 | 56047654 |
| Apathy | 23.74 | 9.63 | 59 | 145517 | 7895 | 56138596 |
| Cholecystitis chronic | 23.71 | 9.63 | 67 | 145509 | 9681 | 56136810 |
| Hemiplegia | 23.69 | 9.63 | 61 | 145515 | 8343 | 56138148 |
| Fatigue | 23.43 | 9.63 | 1740 | 143836 | 786812 | 55359679 |
| Rheumatoid nodule | 23.23 | 9.63 | 5 | 145571 | 14852 | 56131639 |
| Joint range of motion decreased | 23.06 | 9.63 | 19 | 145557 | 25346 | 56121145 |
| Foreign body | 22.97 | 9.63 | 28 | 145548 | 2108 | 56144383 |
| Drug tolerance | 22.90 | 9.63 | 49 | 145527 | 5945 | 56140546 |
| Hangover | 22.70 | 9.63 | 23 | 145553 | 1410 | 56145081 |
| Asthenia | 22.63 | 9.63 | 1094 | 144482 | 341879 | 55804612 |
| Grip strength decreased | 22.50 | 9.63 | 7 | 145569 | 16249 | 56130242 |
| Multiple sclerosis relapse | 22.22 | 9.63 | 195 | 145381 | 44708 | 56101783 |
| Hypotension | 22.14 | 9.63 | 824 | 144752 | 249684 | 55896807 |
| Behaviour disorder | 22.08 | 9.63 | 31 | 145545 | 2682 | 56143809 |
| Hiatus hernia | 22.02 | 9.63 | 105 | 145471 | 19547 | 56126944 |
| Therapy non-responder | 21.91 | 9.63 | 83 | 145493 | 61272 | 56085219 |
| Drug resistance | 21.83 | 9.63 | 13 | 145563 | 20529 | 56125962 |
| Labelled drug-food interaction issue | 21.74 | 9.63 | 6 | 145570 | 17 | 56146474 |
| Imprisonment | 21.73 | 9.63 | 11 | 145565 | 218 | 56146273 |
| Dysuria | 21.68 | 9.63 | 145 | 145431 | 30584 | 56115907 |
| Laryngeal pain | 21.59 | 9.63 | 39 | 145537 | 4181 | 56142310 |
| Diplopia | 21.51 | 9.63 | 107 | 145469 | 20262 | 56126229 |
| Psychomotor hyperactivity | 21.49 | 9.63 | 65 | 145511 | 9755 | 56136736 |
| Neutropenia | 21.48 | 9.63 | 284 | 145292 | 157883 | 55988608 |
| Product complaint | 21.34 | 9.63 | 73 | 145503 | 11687 | 56134804 |
| Obstructive airways disorder | 21.27 | 9.63 | 9 | 145567 | 17273 | 56129218 |
| COVID-19 | 21.10 | 9.63 | 111 | 145465 | 74947 | 56071544 |
| Influenza like illness | 20.65 | 9.63 | 245 | 145331 | 60743 | 56085748 |
| Feeling drunk | 20.63 | 9.63 | 36 | 145540 | 3756 | 56142735 |
| Sinus congestion | 20.61 | 9.63 | 88 | 145488 | 15636 | 56130855 |
| Major depression | 20.31 | 9.63 | 54 | 145522 | 7530 | 56138961 |
| Vision blurred | 20.20 | 9.63 | 314 | 145262 | 82629 | 56063862 |
| Feeling abnormal | 20.19 | 9.63 | 470 | 145106 | 133132 | 56013359 |
| Dyspnoea | 20.14 | 9.63 | 1292 | 144284 | 591285 | 55555206 |
| Cough | 20.11 | 9.63 | 515 | 145061 | 259446 | 55887045 |
| Reduced facial expression | 20.06 | 9.63 | 24 | 145552 | 1772 | 56144719 |
| Drug interaction | 20.01 | 9.63 | 696 | 144880 | 209059 | 55937432 |
| Anger | 19.92 | 9.63 | 71 | 145505 | 11601 | 56134890 |
| Bone erosion | 19.75 | 9.63 | 7 | 145569 | 14967 | 56131524 |
| Unresponsive to stimuli | 19.63 | 9.63 | 145 | 145431 | 31580 | 56114911 |
| Self-medication | 19.62 | 9.63 | 28 | 145548 | 2459 | 56144032 |
| Crying | 19.46 | 9.63 | 108 | 145468 | 21332 | 56125159 |
| Aortic valve calcification | 19.05 | 9.63 | 13 | 145563 | 456 | 56146035 |
| Peripheral circulatory failure | 18.92 | 9.63 | 17 | 145559 | 896 | 56145595 |
| Tension | 18.91 | 9.63 | 30 | 145546 | 2894 | 56143597 |
| Aggression | 18.76 | 9.63 | 109 | 145467 | 21897 | 56124594 |
| Depressive symptom | 18.46 | 9.63 | 33 | 145543 | 3508 | 56142983 |
| Injury | 18.35 | 9.63 | 236 | 145340 | 59615 | 56086876 |
| Cognitive disorder | 18.27 | 9.63 | 201 | 145375 | 48932 | 56097559 |
| Panic disorder | 18.14 | 9.63 | 27 | 145549 | 2464 | 56144027 |
| Inadequate analgesia | 18.10 | 9.63 | 28 | 145548 | 2643 | 56143848 |
| Arthritis | 18.04 | 9.63 | 168 | 145408 | 99684 | 56046807 |
| Dementia | 18.03 | 9.63 | 90 | 145486 | 17068 | 56129423 |
| Alcohol use | 17.77 | 9.63 | 24 | 145552 | 2001 | 56144490 |
| Psychotic disorder | 17.74 | 9.63 | 113 | 145463 | 23445 | 56123046 |
| Femoral neck fracture | 17.54 | 9.63 | 52 | 145524 | 7719 | 56138772 |
| Anterograde amnesia | 17.31 | 9.63 | 13 | 145563 | 531 | 56145960 |
| Blood potassium decreased | 17.14 | 9.63 | 164 | 145412 | 38508 | 56107983 |
| Facial nerve disorder | 17.08 | 9.63 | 13 | 145563 | 542 | 56145949 |
| Euphoric mood | 17.08 | 9.63 | 36 | 145540 | 4322 | 56142169 |
| Performance fear | 17.08 | 9.63 | 4 | 145572 | 4 | 56146487 |
| Sinusitis | 17.04 | 9.63 | 385 | 145191 | 197196 | 55949295 |
| Serotonin syndrome | 16.92 | 9.63 | 122 | 145454 | 26368 | 56120123 |
| Seizure | 16.75 | 9.63 | 433 | 145143 | 124686 | 56021805 |
| Decreased interest | 16.68 | 9.63 | 29 | 145547 | 3017 | 56143474 |
| Legal problem | 16.61 | 9.63 | 5 | 145571 | 21 | 56146470 |
| Sinus disorder | 16.58 | 9.63 | 101 | 145475 | 20633 | 56125858 |
| Hepatotoxicity | 16.39 | 9.63 | 35 | 145541 | 31118 | 56115373 |
| Coagulation factor V level decreased | 16.34 | 9.63 | 10 | 145566 | 290 | 56146201 |
| Affective disorder | 16.14 | 9.63 | 41 | 145535 | 5562 | 56140929 |
| Urinary hesitation | 16.13 | 9.63 | 23 | 145553 | 2019 | 56144472 |
| Thirst | 16.06 | 9.63 | 64 | 145512 | 11026 | 56135465 |
| Panniculitis | 16.04 | 9.63 | 3 | 145573 | 9839 | 56136652 |
| Compulsive shopping | 15.99 | 9.63 | 14 | 145562 | 713 | 56145778 |
| Left ventricular hypertrophy | 15.98 | 9.63 | 38 | 145538 | 4946 | 56141545 |
| Loss of proprioception | 15.94 | 9.63 | 11 | 145565 | 393 | 56146098 |
| Blood pressure systolic abnormal | 15.89 | 9.63 | 3 | 145573 | 9774 | 56136717 |
| Blood cholesterol increased | 15.89 | 9.63 | 116 | 145460 | 72463 | 56074028 |
| Mucosal inflammation | 15.88 | 9.63 | 57 | 145519 | 42753 | 56103738 |
| Anhedonia | 15.82 | 9.63 | 59 | 145517 | 9855 | 56136636 |
| Palpitations | 15.79 | 9.63 | 353 | 145223 | 99319 | 56047172 |
| Muscle rigidity | 15.79 | 9.63 | 62 | 145514 | 10609 | 56135882 |
| Inappropriate antidiuretic hormone secretion | 15.78 | 9.63 | 74 | 145502 | 13682 | 56132809 |
| Creatinine renal clearance decreased | 15.77 | 9.63 | 9 | 145567 | 14550 | 56131941 |
| Drug tolerance increased | 15.62 | 9.63 | 9 | 145567 | 233 | 56146258 |
| Tracheal atresia | 15.59 | 9.63 | 5 | 145571 | 27 | 56146464 |
| Protrusion tongue | 15.58 | 9.63 | 10 | 145566 | 316 | 56146175 |
| Prothrombin time shortened | 15.54 | 9.63 | 21 | 145555 | 1752 | 56144739 |
| Aspartate aminotransferase increased | 15.52 | 9.63 | 300 | 145276 | 82302 | 56064189 |
| Sleep terror | 15.52 | 9.63 | 14 | 145562 | 742 | 56145749 |
| Lethargy | 15.42 | 9.63 | 202 | 145374 | 51239 | 56095252 |
| Accidental poisoning | 15.40 | 9.63 | 13 | 145563 | 630 | 56145861 |
| Respiratory tract congestion | 15.14 | 9.63 | 80 | 145496 | 15511 | 56130980 |
| Self-injurious ideation | 15.04 | 9.63 | 24 | 145552 | 2326 | 56144165 |
| Macular degeneration | 15.03 | 9.63 | 16 | 145560 | 18892 | 56127599 |
| Emotional poverty | 14.93 | 9.63 | 10 | 145566 | 340 | 56146151 |
| Cholecystectomy | 14.93 | 9.63 | 57 | 145519 | 9627 | 56136864 |
| Brain contusion | 14.88 | 9.63 | 12 | 145564 | 545 | 56145946 |
| Myelosuppression | 14.75 | 9.63 | 14 | 145562 | 17441 | 56129050 |
| Blood pressure diastolic decreased | 14.65 | 9.63 | 17 | 145559 | 19306 | 56127185 |
| Sneezing | 14.54 | 9.63 | 79 | 145497 | 15481 | 56131010 |
| Dizziness | 14.53 | 9.63 | 1145 | 144431 | 374995 | 55771496 |
| Prothrombin time prolonged | 14.52 | 9.63 | 54 | 145522 | 9006 | 56137485 |
| Constipation | 14.33 | 9.63 | 649 | 144927 | 201294 | 55945197 |
| Intravascular haemolysis | 14.32 | 9.63 | 9 | 145567 | 274 | 56146217 |
| Terminal insomnia | 14.27 | 9.63 | 13 | 145563 | 698 | 56145793 |
| Atelectasis | 14.16 | 9.63 | 92 | 145484 | 19216 | 56127275 |
| Accidental overdose | 14.11 | 9.63 | 96 | 145480 | 20365 | 56126126 |
| Neurological examination normal | 14.09 | 9.63 | 4 | 145572 | 13 | 56146478 |
| Erythema | 13.97 | 9.63 | 302 | 145274 | 155637 | 55990854 |
| Spinal rod insertion | 13.86 | 9.63 | 4 | 145572 | 14 | 56146477 |
| Intervertebral disc degeneration | 13.75 | 9.63 | 73 | 145503 | 14181 | 56132310 |
| Social anxiety disorder | 13.50 | 9.63 | 10 | 145566 | 400 | 56146091 |
| Blastocystis infection | 13.25 | 9.63 | 4 | 145572 | 17 | 56146474 |
| Neuroglycopenia | 13.18 | 9.63 | 10 | 145566 | 415 | 56146076 |
| Colitis ulcerative | 13.17 | 9.63 | 27 | 145549 | 24364 | 56122127 |
| Sedation | 13.14 | 9.63 | 143 | 145433 | 34711 | 56111780 |
| Neurogenic bladder | 13.03 | 9.63 | 26 | 145550 | 3003 | 56143488 |
| Mood swings | 13.03 | 9.63 | 81 | 145495 | 16666 | 56129825 |
| Blood urea increased | 13.01 | 9.63 | 108 | 145468 | 24365 | 56122126 |
| Therapeutic response unexpected | 12.99 | 9.63 | 82 | 145494 | 16962 | 56129529 |
| Pulmonary vasculitis | 12.90 | 9.63 | 6 | 145570 | 98 | 56146393 |
| Pulmonary fibrosis | 12.87 | 9.63 | 37 | 145539 | 29721 | 56116770 |
| Cerebral atrophy | 12.85 | 9.63 | 34 | 145542 | 4726 | 56141765 |
| Benzodiazepine drug level | 12.81 | 9.63 | 3 | 145573 | 3 | 56146488 |
| Transient ischaemic attack | 12.77 | 9.63 | 138 | 145438 | 33439 | 56113052 |
| Anorexia nervosa | 12.74 | 9.63 | 8 | 145568 | 243 | 56146248 |
| Injection site reaction | 12.69 | 9.63 | 83 | 145493 | 53164 | 56093327 |
| Cholelithiasis | 12.69 | 9.63 | 157 | 145419 | 39307 | 56107184 |
| Disinhibition | 12.68 | 9.63 | 13 | 145563 | 808 | 56145683 |
| Periventricular leukomalacia | 12.58 | 9.63 | 6 | 145570 | 104 | 56146387 |
| Pyrexia | 12.53 | 9.63 | 923 | 144653 | 417850 | 55728641 |
| Neonatal behavioural syndrome | 12.52 | 9.63 | 5 | 145571 | 55 | 56146436 |
| Renal impairment | 12.43 | 9.63 | 141 | 145435 | 80572 | 56065919 |
| Diarrhoea | 12.41 | 9.63 | 1454 | 144122 | 637053 | 55509438 |
| Angioedema | 12.39 | 9.63 | 60 | 145516 | 41393 | 56105098 |
| Herpes zoster | 12.32 | 9.63 | 131 | 145445 | 75758 | 56070733 |
| Respiratory depression | 12.21 | 9.63 | 64 | 145512 | 12371 | 56134120 |
| Persecutory delusion | 12.20 | 9.63 | 23 | 145553 | 2547 | 56143944 |
| Automatism | 12.06 | 9.63 | 5 | 145571 | 61 | 56146430 |
| Autonomic nervous system imbalance | 12.06 | 9.63 | 23 | 145553 | 2570 | 56143921 |
| Enthesopathy | 12.04 | 9.63 | 3 | 145573 | 8060 | 56138431 |
| Bipolar disorder | 12 | 9.63 | 45 | 145531 | 7535 | 56138956 |
| Drug dependence, antepartum | 11.98 | 9.63 | 4 | 145572 | 25 | 56146466 |
| Inappropriate schedule of product administration | 11.95 | 9.63 | 148 | 145428 | 83239 | 56063252 |
| Accidental exposure to product | 11.91 | 9.63 | 29 | 145547 | 24618 | 56121873 |
| Spleen congestion | 11.90 | 9.63 | 6 | 145570 | 118 | 56146373 |
| Nervousness | 11.86 | 9.63 | 121 | 145455 | 28894 | 56117597 |
| Visual acuity reduced | 11.85 | 9.63 | 93 | 145483 | 20633 | 56125858 |
| Cardiomegaly | 11.80 | 9.63 | 78 | 145498 | 16389 | 56130102 |
| Psychomotor retardation | 11.79 | 9.63 | 28 | 145548 | 3641 | 56142850 |
| Death | 11.62 | 9.63 | 744 | 144832 | 340682 | 55805809 |
| Vertigo CNS origin | 11.60 | 9.63 | 4 | 145572 | 28 | 56146463 |
| Dysgeusia | 11.57 | 9.63 | 159 | 145417 | 40756 | 56105735 |
| Fear | 11.53 | 9.63 | 72 | 145504 | 14836 | 56131655 |
| Dreamy state | 11.48 | 9.63 | 4 | 145572 | 29 | 56146462 |
| Immunodeficiency | 11.42 | 9.63 | 15 | 145561 | 16142 | 56130349 |
| Restless legs syndrome | 11.38 | 9.63 | 79 | 145497 | 16868 | 56129623 |
| Ecchymosis | 11.36 | 9.63 | 55 | 145521 | 10301 | 56136190 |
| Spondylolisthesis | 11.30 | 9.63 | 26 | 145550 | 3313 | 56143178 |
| Multiple injuries | 11.26 | 9.63 | 18 | 145558 | 1748 | 56144743 |
| Head discomfort | 11.23 | 9.63 | 61 | 145515 | 11953 | 56134538 |
| Middle insomnia | 11.20 | 9.63 | 57 | 145519 | 10893 | 56135598 |
| Stress cardiomyopathy | 11.19 | 9.63 | 47 | 145529 | 8289 | 56138202 |
| Fibrocystic breast disease | 11.14 | 9.63 | 14 | 145562 | 1088 | 56145403 |
| Waxy flexibility | 11.13 | 9.63 | 6 | 145570 | 136 | 56146355 |
| Extrapyramidal disorder | 11.05 | 9.63 | 62 | 145514 | 12294 | 56134197 |
| Drop attacks | 11.05 | 9.63 | 11 | 145565 | 660 | 56145831 |
| Transplant rejection | 10.97 | 9.63 | 6 | 145570 | 9928 | 56136563 |
| Hypotonia | 10.94 | 9.63 | 48 | 145528 | 8629 | 56137862 |
| Gastric polyps | 10.93 | 9.63 | 25 | 145551 | 3173 | 56143318 |
| Housebound | 10.91 | 9.63 | 7 | 145569 | 221 | 56146270 |
| Amnestic disorder | 10.82 | 9.63 | 8 | 145568 | 319 | 56146172 |
| Neurotoxicity | 10.82 | 9.63 | 15 | 145561 | 15780 | 56130711 |
| Poor sucking reflex | 10.77 | 9.63 | 7 | 145569 | 226 | 56146265 |
| Hyperlipidaemia | 10.77 | 9.63 | 82 | 145494 | 18027 | 56128464 |
| Secretion discharge | 10.75 | 9.63 | 7 | 145569 | 10539 | 56135952 |
| Parasomnia | 10.75 | 9.63 | 9 | 145567 | 431 | 56146060 |
| Cytomegalovirus infection | 10.73 | 9.63 | 21 | 145555 | 19275 | 56127216 |
| Haemangioma congenital | 10.64 | 9.63 | 9 | 145567 | 437 | 56146054 |
| Hepatosplenomegaly | 10.60 | 9.63 | 21 | 145555 | 2412 | 56144079 |
| Hypoglycaemia | 10.58 | 9.63 | 203 | 145373 | 55612 | 56090879 |
| Asphyxia | 10.56 | 9.63 | 36 | 145540 | 5753 | 56140738 |
| Dysphoria | 10.55 | 9.63 | 32 | 145544 | 4810 | 56141681 |
| Trance | 10.53 | 9.63 | 4 | 145572 | 38 | 56146453 |
| Uveitis | 10.48 | 9.63 | 8 | 145568 | 11087 | 56135404 |
| Lupus-like syndrome | 10.47 | 9.63 | 10 | 145566 | 12417 | 56134074 |
| Spinal osteoarthritis | 10.46 | 9.63 | 70 | 145506 | 14766 | 56131725 |
| Malnutrition | 10.43 | 9.63 | 67 | 145509 | 13941 | 56132550 |
| Eustachian tube disorder | 10.36 | 9.63 | 5 | 145571 | 89 | 56146402 |
| Homicidal ideation | 10.33 | 9.63 | 17 | 145559 | 1691 | 56144800 |
| Speech disorder | 10.32 | 9.63 | 145 | 145431 | 37348 | 56109143 |
| Flat affect | 10.26 | 9.63 | 15 | 145561 | 1347 | 56145144 |
| Arterial occlusive disease | 10.18 | 9.63 | 34 | 145542 | 5376 | 56141115 |
| Labelled drug-drug interaction medication error | 10.14 | 9.63 | 9 | 145567 | 11577 | 56134914 |
| Intervertebral disc protrusion | 10.11 | 9.63 | 93 | 145483 | 21601 | 56124890 |
| Leukocytosis | 10.10 | 9.63 | 100 | 145476 | 23691 | 56122800 |
| Pelvic fracture | 10.09 | 9.63 | 60 | 145516 | 12153 | 56134338 |
| Haemangioma of liver | 10.08 | 9.63 | 13 | 145563 | 1036 | 56145455 |
| Blood alkaline phosphatase increased | 10.08 | 9.63 | 149 | 145427 | 38796 | 56107695 |
| Muscular weakness | 10.05 | 9.63 | 347 | 145229 | 104105 | 56042386 |
| Hypokinesia | 10.01 | 9.63 | 62 | 145514 | 12741 | 56133750 |
| Mouth ulceration | 10.00 | 9.63 | 41 | 145535 | 29599 | 56116892 |
| Multiple sclerosis | 10.00 | 9.63 | 113 | 145463 | 27689 | 56118802 |
| Productive cough | 9.98 | 9.63 | 95 | 145481 | 56137 | 56090354 |
| Barrett's oesophagus | 9.98 | 9.63 | 10 | 145566 | 605 | 56145886 |
| Verbal abuse | 9.93 | 9.63 | 5 | 145571 | 98 | 56146393 |
| Bone scan abnormal | 9.93 | 9.63 | 8 | 145568 | 363 | 56146128 |
| Therapeutic response shortened | 9.89 | 9.63 | 6 | 145570 | 9380 | 56137111 |
| Ischaemic cardiomyopathy | 9.88 | 9.63 | 20 | 145556 | 2334 | 56144157 |
| Toxic epidermal necrolysis | 9.83 | 9.63 | 27 | 145549 | 22015 | 56124476 |
| Ventricular fibrillation | 9.83 | 9.63 | 55 | 145521 | 10897 | 56135594 |
| Skin ulcer | 9.81 | 9.63 | 59 | 145517 | 38549 | 56107942 |
| Optic disc haemorrhage | 9.79 | 9.63 | 5 | 145571 | 101 | 56146390 |
| Poor quality sleep | 9.79 | 9.63 | 79 | 145497 | 17676 | 56128815 |
| Lymphatic disorder | 9.78 | 9.63 | 8 | 145568 | 371 | 56146120 |
| Atrioventricular block first degree | 9.76 | 9.63 | 39 | 145537 | 6726 | 56139765 |
| Galactorrhoea | 9.70 | 9.63 | 27 | 145549 | 3868 | 56142623 |
| Heart rate decreased | 9.64 | 9.63 | 63 | 145513 | 40364 | 56106127 |
| Adverse event | 9.64 | 9.63 | 94 | 145482 | 55282 | 56091209 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Somnambulism | 554.90 | 10.13 | 226 | 81830 | 2626 | 31612662 |
| Completed suicide | 489.36 | 10.13 | 861 | 81195 | 90653 | 31524635 |
| Drug dependence | 301.84 | 10.13 | 331 | 81725 | 22248 | 31593040 |
| Intentional overdose | 279.50 | 10.13 | 433 | 81623 | 40956 | 31574332 |
| Amnesia | 260.34 | 10.13 | 312 | 81744 | 23090 | 31592198 |
| Drug abuse | 253.17 | 10.13 | 642 | 81414 | 87116 | 31528172 |
| Insomnia | 239.25 | 10.13 | 660 | 81396 | 94176 | 31521112 |
| Suicide attempt | 186.51 | 10.13 | 341 | 81715 | 36907 | 31578381 |
| Off label use | 179.06 | 10.13 | 397 | 81659 | 346877 | 31268411 |
| Road traffic accident | 157.44 | 10.13 | 203 | 81853 | 16178 | 31599110 |
| Intentional self-injury | 150.47 | 10.13 | 179 | 81877 | 13136 | 31602152 |
| Poisoning | 119.57 | 10.13 | 141 | 81915 | 10250 | 31605038 |
| Respiratory arrest | 105.34 | 10.13 | 219 | 81837 | 26038 | 31589250 |
| Drug withdrawal syndrome | 103.24 | 10.13 | 179 | 81877 | 18571 | 31596717 |
| Impaired driving ability | 98.04 | 10.13 | 67 | 81989 | 2354 | 31612934 |
| Delirium | 96.16 | 10.13 | 280 | 81776 | 41141 | 31574147 |
| Suicidal ideation | 90.25 | 10.13 | 252 | 81804 | 36154 | 31579134 |
| Sopor | 88.08 | 10.13 | 128 | 81928 | 11424 | 31603864 |
| Abnormal sleep-related event | 86.95 | 10.13 | 36 | 82020 | 437 | 31614851 |
| Confusional state | 86.42 | 10.13 | 616 | 81440 | 132718 | 31482570 |
| Overdose | 86.11 | 10.13 | 440 | 81616 | 84224 | 31531064 |
| Anxiety | 81.63 | 10.13 | 457 | 81599 | 90576 | 31524712 |
| Depression | 78.85 | 10.13 | 452 | 81604 | 90363 | 31524925 |
| Somnolence | 76.79 | 10.13 | 480 | 81576 | 98965 | 31516323 |
| Homicide | 74.75 | 10.13 | 40 | 82016 | 892 | 31614396 |
| Sleep-related eating disorder | 72.89 | 10.13 | 28 | 82028 | 275 | 31615013 |
| Product use in unapproved indication | 72.56 | 10.13 | 90 | 81966 | 99081 | 31516207 |
| Abnormal behaviour | 71.35 | 10.13 | 177 | 81879 | 23651 | 31591637 |
| Drug use disorder | 70.60 | 10.13 | 68 | 81988 | 3915 | 31611373 |
| Disorientation | 67.70 | 10.13 | 204 | 81852 | 30540 | 31584748 |
| Automatism | 63.94 | 10.13 | 20 | 82036 | 98 | 31615190 |
| Parasomnia | 60.66 | 10.13 | 26 | 82030 | 346 | 31614942 |
| Drug ineffective | 59.93 | 10.13 | 696 | 81360 | 394877 | 31220411 |
| Gun shot wound | 58.37 | 10.13 | 36 | 82020 | 1058 | 31614230 |
| Rheumatoid arthritis | 54.21 | 10.13 | 28 | 82028 | 47781 | 31567507 |
| Intentional product misuse | 53.29 | 10.13 | 217 | 81839 | 37734 | 31577554 |
| Drug abuser | 52.01 | 10.13 | 57 | 81999 | 3823 | 31611465 |
| Bradyphrenia | 46.15 | 10.13 | 57 | 81999 | 4347 | 31610941 |
| Restlessness | 44.98 | 10.13 | 148 | 81908 | 23213 | 31592075 |
| Fall | 44.74 | 10.13 | 703 | 81353 | 185386 | 31429902 |
| Cardio-respiratory arrest | 42.61 | 10.13 | 254 | 81802 | 51472 | 31563816 |
| Poisoning deliberate | 41.58 | 10.13 | 71 | 81985 | 7273 | 31608015 |
| Aggression | 40.83 | 10.13 | 198 | 81858 | 37093 | 31578195 |
| Coma | 40.49 | 10.13 | 212 | 81844 | 40938 | 31574350 |
| Agitation | 39.00 | 10.13 | 257 | 81799 | 53912 | 31561376 |
| Thinking abnormal | 38.54 | 10.13 | 59 | 81997 | 5514 | 31609774 |
| Nightmare | 36.16 | 10.13 | 90 | 81966 | 12047 | 31603241 |
| Hallucination | 35.75 | 10.13 | 224 | 81832 | 46186 | 31569102 |
| Memory impairment | 35.17 | 10.13 | 193 | 81863 | 37937 | 31577351 |
| Withdrawal syndrome | 35.02 | 10.13 | 87 | 81969 | 11630 | 31603658 |
| Antidepressant drug level above therapeutic | 34.18 | 10.13 | 15 | 82041 | 212 | 31615076 |
| Therapeutic product effect incomplete | 33.70 | 10.13 | 38 | 82018 | 43658 | 31571630 |
| Persistent depressive disorder | 32.64 | 10.13 | 16 | 82040 | 295 | 31614993 |
| Death | 32.31 | 10.13 | 700 | 81356 | 359869 | 31255419 |
| Oedematous pancreatitis | 31.79 | 10.13 | 18 | 82038 | 450 | 31614838 |
| Toxicity to various agents | 31.02 | 10.13 | 650 | 81406 | 180837 | 31434451 |
| Legal problem | 30.74 | 10.13 | 13 | 82043 | 167 | 31615121 |
| Analgesic drug level above therapeutic | 30.29 | 10.13 | 15 | 82041 | 283 | 31615005 |
| Dependence | 30.12 | 10.13 | 24 | 82032 | 1070 | 31614218 |
| Dissociative disorder | 30.01 | 10.13 | 14 | 82042 | 230 | 31615058 |
| Lower respiratory tract infection | 29.89 | 10.13 | 18 | 82038 | 28219 | 31587069 |
| Loss of consciousness | 28.94 | 10.13 | 317 | 81739 | 77038 | 31538250 |
| Cytomegalovirus infection | 28.71 | 10.13 | 14 | 82042 | 24693 | 31590595 |
| Initial insomnia | 27.86 | 10.13 | 36 | 82020 | 2873 | 31612415 |
| Multiple organ dysfunction syndrome | 27.33 | 10.13 | 88 | 81968 | 68115 | 31547173 |
| Febrile neutropenia | 27.22 | 10.13 | 194 | 81862 | 121655 | 31493633 |
| Drug tolerance | 26.95 | 10.13 | 33 | 82023 | 2494 | 31612794 |
| Sleep disorder | 26.78 | 10.13 | 137 | 81919 | 26211 | 31589077 |
| Intentional product use issue | 26.43 | 10.13 | 55 | 82001 | 49292 | 31565996 |
| Acute kidney injury | 26.19 | 10.13 | 539 | 81517 | 279175 | 31336113 |
| Asthma | 25.90 | 10.13 | 44 | 82012 | 42567 | 31572721 |
| Joint swelling | 25.81 | 10.13 | 63 | 81993 | 53368 | 31561920 |
| Myelosuppression | 25.56 | 10.13 | 4 | 82052 | 14916 | 31600372 |
| Angioedema | 25.10 | 10.13 | 30 | 82026 | 33588 | 31581700 |
| Septic shock | 24.71 | 10.13 | 88 | 81968 | 66070 | 31549218 |
| Drug intolerance | 24.63 | 10.13 | 62 | 81994 | 51971 | 31563317 |
| Logorrhoea | 24.27 | 10.13 | 30 | 82026 | 2289 | 31612999 |
| Incoherent | 23.99 | 10.13 | 41 | 82015 | 4203 | 31611085 |
| Anger | 23.60 | 10.13 | 73 | 81983 | 11080 | 31604208 |
| Panic attack | 23.30 | 10.13 | 62 | 81994 | 8641 | 31606647 |
| Substance use disorder | 22.54 | 10.13 | 15 | 82041 | 504 | 31614784 |
| Altered state of consciousness | 22.48 | 10.13 | 111 | 81945 | 20940 | 31594348 |
| General physical health deterioration | 22.33 | 10.13 | 187 | 81869 | 113248 | 31502040 |
| Treatment failure | 22.24 | 10.13 | 45 | 82011 | 40747 | 31574541 |
| Circadian rhythm sleep disorder | 22.15 | 10.13 | 14 | 82042 | 430 | 31614858 |
| Bradypnoea | 22.05 | 10.13 | 30 | 82026 | 2517 | 31612771 |
| Hypokinesia | 22.02 | 10.13 | 58 | 81998 | 8034 | 31607254 |
| Hallucination, visual | 21.91 | 10.13 | 90 | 81966 | 15704 | 31599584 |
| Anterograde amnesia | 21.51 | 10.13 | 10 | 82046 | 163 | 31615125 |
| Abnormal dreams | 21.48 | 10.13 | 53 | 82003 | 7055 | 31608233 |
| Major depression | 21.34 | 10.13 | 39 | 82017 | 4214 | 31611074 |
| Neutropenia | 20.72 | 10.13 | 248 | 81808 | 140116 | 31475172 |
| Psoriasis | 20.34 | 10.13 | 58 | 81998 | 46661 | 31568627 |
| Drug screen positive | 20.19 | 10.13 | 36 | 82020 | 3816 | 31611472 |
| Victim of chemical submission | 20.16 | 10.13 | 7 | 82049 | 50 | 31615238 |
| Tachyphrenia | 20.12 | 10.13 | 20 | 82036 | 1197 | 31614091 |
| Infection | 20.01 | 10.13 | 127 | 81929 | 81804 | 31533484 |
| Poor quality sleep | 19.85 | 10.13 | 54 | 82002 | 7624 | 31607664 |
| Distributive shock | 19.84 | 10.13 | 19 | 82037 | 1086 | 31614202 |
| Condition aggravated | 19.45 | 10.13 | 303 | 81753 | 163706 | 31451582 |
| Infusion related reaction | 19.25 | 10.13 | 62 | 81994 | 47993 | 31567295 |
| Irritability | 19.22 | 10.13 | 113 | 81943 | 22776 | 31592512 |
| Cardiac arrest | 18.60 | 10.13 | 329 | 81727 | 88733 | 31526555 |
| Product use issue | 18.33 | 10.13 | 80 | 81976 | 56679 | 31558609 |
| Sepsis | 18.24 | 10.13 | 280 | 81776 | 151649 | 31463639 |
| Rectal haemorrhage | 18.17 | 10.13 | 42 | 82014 | 36262 | 31579026 |
| Encephalomalacia | 17.96 | 10.13 | 16 | 82040 | 833 | 31614455 |
| Dyspnoea | 17.83 | 10.13 | 718 | 81338 | 342761 | 31272527 |
| Synovitis | 17.55 | 10.13 | 5 | 82051 | 12278 | 31603010 |
| Inappropriate antidiuretic hormone secretion | 17.50 | 10.13 | 67 | 81989 | 11320 | 31603968 |
| Hyperlipidaemia | 17.48 | 10.13 | 74 | 81982 | 13086 | 31602202 |
| Loss of personal independence in daily activities | 17.38 | 10.13 | 29 | 82027 | 28259 | 31587029 |
| Drug withdrawal convulsions | 17.14 | 10.13 | 18 | 82038 | 1150 | 31614138 |
| Nervousness | 16.97 | 10.13 | 68 | 81988 | 11732 | 31603556 |
| Feeling abnormal | 16.68 | 10.13 | 223 | 81833 | 56779 | 31558509 |
| Product dose omission issue | 16.56 | 10.13 | 184 | 81872 | 105402 | 31509886 |
| Erythema | 16.52 | 10.13 | 131 | 81925 | 80274 | 31535014 |
| Procalcitonin abnormal | 16.49 | 10.13 | 11 | 82045 | 371 | 31614917 |
| Sleep talking | 16.48 | 10.13 | 12 | 82044 | 467 | 31614821 |
| Sleep apnoea syndrome | 16.32 | 10.13 | 93 | 81963 | 18532 | 31596756 |
| Sexual abuse | 16.29 | 10.13 | 8 | 82048 | 148 | 31615140 |
| Neurotoxicity | 16.27 | 10.13 | 11 | 82045 | 16215 | 31599073 |
| Prostate cancer | 16.14 | 10.13 | 47 | 82009 | 37554 | 31577734 |
| Cardiac failure | 15.89 | 10.13 | 144 | 81912 | 85809 | 31529479 |
| Dysarthria | 15.77 | 10.13 | 139 | 81917 | 31878 | 31583410 |
| Galactorrhoea | 15.52 | 10.13 | 11 | 82045 | 410 | 31614878 |
| Leukopenia | 15.51 | 10.13 | 87 | 81969 | 57741 | 31557547 |
| Amimia | 15.46 | 10.13 | 4 | 82052 | 8 | 31615280 |
| Paranoia | 15.32 | 10.13 | 61 | 81995 | 10494 | 31604794 |
| Apallic syndrome | 15.21 | 10.13 | 9 | 82047 | 245 | 31615043 |
| Product substitution issue | 14.91 | 10.13 | 56 | 82000 | 9376 | 31605912 |
| Coagulation factor VII level decreased | 14.84 | 10.13 | 7 | 82049 | 118 | 31615170 |
| Exposure via ingestion | 14.80 | 10.13 | 22 | 82034 | 2003 | 31613285 |
| Heart rate decreased | 14.72 | 10.13 | 32 | 82024 | 28234 | 31587054 |
| Alcohol use | 14.59 | 10.13 | 28 | 82028 | 3139 | 31612149 |
| Psoriatic arthropathy | 14.57 | 10.13 | 18 | 82038 | 19865 | 31595423 |
| Skin laceration | 14.32 | 10.13 | 63 | 81993 | 11328 | 31603960 |
| Peripheral swelling | 14.21 | 10.13 | 110 | 81946 | 67755 | 31547533 |
| Drug diversion | 14.21 | 10.13 | 14 | 82042 | 829 | 31614459 |
| Reduced facial expression | 14.19 | 10.13 | 14 | 82042 | 830 | 31614458 |
| Mental disorder | 14.10 | 10.13 | 72 | 81984 | 13762 | 31601526 |
| Vascular dementia | 13.81 | 10.13 | 11 | 82045 | 490 | 31614798 |
| Stress at work | 13.81 | 10.13 | 8 | 82048 | 209 | 31615079 |
| Labelled drug-food interaction medication error | 13.81 | 10.13 | 5 | 82051 | 41 | 31615247 |
| Transplant rejection | 13.78 | 10.13 | 4 | 82052 | 9704 | 31605584 |
| Renal impairment | 13.73 | 10.13 | 150 | 81906 | 86199 | 31529089 |
| Personality change | 13.70 | 10.13 | 35 | 82021 | 4760 | 31610528 |
| Drug detoxification | 13.68 | 10.13 | 8 | 82048 | 213 | 31615075 |
| Substance-induced mood disorder | 13.60 | 10.13 | 6 | 82050 | 86 | 31615202 |
| Hallucination, auditory | 13.56 | 10.13 | 58 | 81998 | 10302 | 31604986 |
| Pre-existing condition improved | 13.48 | 10.13 | 23 | 82033 | 2354 | 31612934 |
| Depressed level of consciousness | 13.43 | 10.13 | 156 | 81900 | 38445 | 31576843 |
| Congenital hydrocephalus | 13.41 | 10.13 | 6 | 82050 | 89 | 31615199 |
| Pulmonary fibrosis | 13.38 | 10.13 | 14 | 82042 | 16646 | 31598642 |
| Blood pressure fluctuation | 13.34 | 10.13 | 24 | 82032 | 22712 | 31592576 |
| Libido decreased | 13.32 | 10.13 | 33 | 82023 | 4403 | 31610885 |
| Slow speech | 13.29 | 10.13 | 15 | 82041 | 1039 | 31614249 |
| Mania | 13.29 | 10.13 | 53 | 82003 | 9124 | 31606164 |
| Tubulointerstitial nephritis | 13.28 | 10.13 | 17 | 82039 | 18479 | 31596809 |
| Toxic epidermal necrolysis | 12.96 | 10.13 | 19 | 82037 | 19505 | 31595783 |
| Mental status changes | 12.80 | 10.13 | 146 | 81910 | 35822 | 31579466 |
| Aspergillus infection | 12.70 | 10.13 | 7 | 82049 | 11521 | 31603767 |
| Drug resistance | 12.67 | 10.13 | 26 | 82030 | 23427 | 31591861 |
| Prescription form tampering | 12.63 | 10.13 | 10 | 82046 | 442 | 31614846 |
| Urticaria | 12.62 | 10.13 | 92 | 81964 | 57425 | 31557863 |
| Implant site inflammation | 12.47 | 10.13 | 6 | 82050 | 106 | 31615182 |
| Stress cardiomyopathy | 12.45 | 10.13 | 19 | 82037 | 1771 | 31613517 |
| Respiratory tract infection bacterial | 12.29 | 10.13 | 17 | 82039 | 1449 | 31613839 |
| Hospitalisation | 12.26 | 10.13 | 77 | 81979 | 49730 | 31565558 |
| Akathisia | 12.25 | 10.13 | 44 | 82012 | 7209 | 31608079 |
| Emotional distress | 12.13 | 10.13 | 71 | 81985 | 14285 | 31601003 |
| Psychomotor hyperactivity | 12.13 | 10.13 | 50 | 82006 | 8737 | 31606551 |
| Euphoric mood | 12.12 | 10.13 | 34 | 82022 | 4886 | 31610402 |
| Pilonidal cyst congenital | 12.12 | 10.13 | 4 | 82052 | 24 | 31615264 |
| Pruritus | 12.02 | 10.13 | 240 | 81816 | 124927 | 31490361 |
| Disturbance in attention | 11.86 | 10.13 | 99 | 81957 | 22351 | 31592937 |
| Labelled drug-drug interaction medication error | 11.82 | 10.13 | 10 | 82046 | 13153 | 31602135 |
| Pyrexia | 11.78 | 10.13 | 655 | 81401 | 303185 | 31312103 |
| Victim of homicide | 11.75 | 10.13 | 6 | 82050 | 121 | 31615167 |
| Crime | 11.63 | 10.13 | 5 | 82051 | 67 | 31615221 |
| Self-medication | 11.62 | 10.13 | 21 | 82035 | 2250 | 31613038 |
| Leukoplakia | 11.60 | 10.13 | 3 | 82053 | 6 | 31615282 |
| Labile hypertension | 11.44 | 10.13 | 5 | 82051 | 70 | 31615218 |
| Mucosal inflammation | 11.43 | 10.13 | 48 | 82008 | 34379 | 31580909 |
| Thrombotic microangiopathy | 11.32 | 10.13 | 5 | 82051 | 9346 | 31605942 |
| Delusion | 11.24 | 10.13 | 61 | 81995 | 11936 | 31603352 |
| Miosis | 11.23 | 10.13 | 48 | 82008 | 8522 | 31606766 |
| Atelectasis | 11.15 | 10.13 | 76 | 81980 | 16113 | 31599175 |
| Psychotic disorder | 11.09 | 10.13 | 97 | 81959 | 22196 | 31593092 |
| Dysphoria | 11.00 | 10.13 | 20 | 82036 | 2152 | 31613136 |
| Bronchiectasis | 10.99 | 10.13 | 3 | 82053 | 7577 | 31607711 |
| Decreased interest | 10.92 | 10.13 | 20 | 82036 | 2165 | 31613123 |
| Alcohol interaction | 10.87 | 10.13 | 23 | 82033 | 2766 | 31612522 |
| Scar pain | 10.84 | 10.13 | 5 | 82051 | 80 | 31615208 |
| Bradycardia | 10.79 | 10.13 | 121 | 81935 | 69206 | 31546082 |
| Drug half-life reduced | 10.74 | 10.13 | 3 | 82053 | 9 | 31615279 |
| Hangover | 10.73 | 10.13 | 13 | 82043 | 972 | 31614316 |
| Hyperhidrosis | 10.71 | 10.13 | 239 | 81817 | 67154 | 31548134 |
| Amnestic disorder | 10.68 | 10.13 | 7 | 82049 | 229 | 31615059 |
| Gastrooesophageal reflux disease | 10.53 | 10.13 | 134 | 81922 | 33737 | 31581551 |
| Blood pressure increased | 10.51 | 10.13 | 144 | 81912 | 79489 | 31535799 |
| Bipolar disorder | 10.45 | 10.13 | 27 | 82029 | 3697 | 31611591 |
| PO2 decreased | 10.31 | 10.13 | 16 | 82040 | 1513 | 31613775 |
| Hypovolaemia | 10.30 | 10.13 | 46 | 82010 | 8326 | 31606962 |
| Drug tolerance increased | 10.29 | 10.13 | 9 | 82047 | 457 | 31614831 |
| Pneumothorax traumatic | 10.21 | 10.13 | 5 | 82051 | 92 | 31615196 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 1436.66 | 9.58 | 2258 | 174879 | 224877 | 70526430 |
| Drug abuse | 857.11 | 9.58 | 1411 | 175726 | 145845 | 70605462 |
| Drug dependence | 714.28 | 9.58 | 654 | 176483 | 36667 | 70714640 |
| Somnambulism | 692.86 | 9.58 | 313 | 176824 | 4947 | 70746360 |
| Intentional overdose | 647.74 | 9.58 | 998 | 176139 | 97437 | 70653870 |
| Suicide attempt | 494.94 | 9.58 | 786 | 176351 | 78724 | 70672583 |
| Amnesia | 432.13 | 9.58 | 590 | 176547 | 51565 | 70699742 |
| Sopor | 361.68 | 9.58 | 418 | 176719 | 30849 | 70720458 |
| Rheumatoid arthritis | 353.85 | 9.58 | 143 | 176994 | 291662 | 70459645 |
| Off label use | 331.73 | 9.58 | 867 | 176270 | 742193 | 70009114 |
| Intentional self-injury | 316.62 | 9.58 | 393 | 176744 | 31257 | 70720050 |
| Insomnia | 308.27 | 9.58 | 1217 | 175920 | 216589 | 70534718 |
| Anxiety | 285.52 | 9.58 | 1198 | 175939 | 219132 | 70532175 |
| Drug ineffective | 269.74 | 9.58 | 1321 | 175816 | 938431 | 69812876 |
| Synovitis | 268.25 | 9.58 | 13 | 177124 | 129215 | 70622092 |
| Poisoning | 264.26 | 9.58 | 304 | 176833 | 22318 | 70728989 |
| Drug intolerance | 260.11 | 9.58 | 119 | 177018 | 225568 | 70525739 |
| Overdose | 259.35 | 9.58 | 972 | 176165 | 168773 | 70582534 |
| Abnormal sleep-related event | 251.27 | 9.58 | 91 | 177046 | 777 | 70750530 |
| Intentional product misuse | 250.00 | 9.58 | 589 | 176548 | 79006 | 70672301 |
| Drug withdrawal syndrome | 242.56 | 9.58 | 351 | 176786 | 32364 | 70718943 |
| Respiratory arrest | 242.44 | 9.58 | 462 | 176675 | 53471 | 70697836 |
| Joint swelling | 231.86 | 9.58 | 176 | 176961 | 253035 | 70498272 |
| Depression | 227.33 | 9.58 | 1042 | 176095 | 197932 | 70553375 |
| Contraindicated product administered | 226.84 | 9.58 | 33 | 177104 | 134579 | 70616728 |
| Poisoning deliberate | 214.14 | 9.58 | 238 | 176899 | 16822 | 70734485 |
| Toxicity to various agents | 198.67 | 9.58 | 1631 | 175506 | 380541 | 70370766 |
| Somnolence | 198.55 | 9.58 | 1062 | 176075 | 214544 | 70536763 |
| Infusion related reaction | 197.10 | 9.58 | 125 | 177012 | 197409 | 70553898 |
| Treatment failure | 187.43 | 9.58 | 63 | 177074 | 144079 | 70607228 |
| Hand deformity | 185.10 | 9.58 | 7 | 177130 | 86475 | 70664832 |
| Drug use disorder | 180.06 | 9.58 | 155 | 176982 | 7996 | 70743311 |
| Cardio-respiratory arrest | 171.89 | 9.58 | 598 | 176539 | 100079 | 70651228 |
| Suicidal ideation | 160.77 | 9.58 | 459 | 176678 | 69137 | 70682170 |
| Lower respiratory tract infection | 159.96 | 9.58 | 41 | 177096 | 111872 | 70639435 |
| Delirium | 159.82 | 9.58 | 479 | 176658 | 74135 | 70677172 |
| Coma | 154.59 | 9.58 | 543 | 176594 | 91301 | 70660006 |
| Systemic lupus erythematosus | 148.22 | 9.58 | 36 | 177101 | 101866 | 70649441 |
| Fall | 144.42 | 9.58 | 1719 | 175418 | 442377 | 70308930 |
| Peripheral swelling | 141.37 | 9.58 | 233 | 176904 | 236330 | 70514977 |
| Road traffic accident | 138.79 | 9.58 | 283 | 176854 | 34399 | 70716908 |
| Sleep-related eating disorder | 135.76 | 9.58 | 55 | 177082 | 654 | 70750653 |
| Arthropathy | 135.10 | 9.58 | 106 | 177031 | 149951 | 70601356 |
| Disorientation | 127.02 | 9.58 | 375 | 176762 | 57548 | 70693759 |
| Hypersensitivity | 126.76 | 9.58 | 238 | 176899 | 229574 | 70521733 |
| Abnormal behaviour | 124.68 | 9.58 | 271 | 176866 | 34438 | 70716869 |
| Maternal exposure during pregnancy | 120.59 | 9.58 | 69 | 177068 | 115276 | 70636031 |
| Confusional state | 119.37 | 9.58 | 1159 | 175978 | 283239 | 70468068 |
| Pericarditis | 119.20 | 9.58 | 32 | 177105 | 84673 | 70666634 |
| Bradyphrenia | 118.41 | 9.58 | 135 | 177002 | 9811 | 70741496 |
| Glossodynia | 113.80 | 9.58 | 37 | 177100 | 86450 | 70664857 |
| Duodenal ulcer perforation | 109.84 | 9.58 | 4 | 177133 | 51108 | 70700199 |
| Withdrawal syndrome | 102.96 | 9.58 | 206 | 176931 | 24698 | 70726609 |
| Helicobacter infection | 102.72 | 9.58 | 10 | 177127 | 55646 | 70695661 |
| Loss of consciousness | 101.21 | 9.58 | 701 | 176436 | 155015 | 70596292 |
| Drug abuser | 101.06 | 9.58 | 97 | 177040 | 5767 | 70745540 |
| Wound | 99.08 | 9.58 | 62 | 177075 | 98670 | 70652637 |
| Infection | 98.93 | 9.58 | 239 | 176898 | 210546 | 70540761 |
| Restlessness | 98.39 | 9.58 | 279 | 176858 | 41849 | 70709458 |
| Product use in unapproved indication | 96.00 | 9.58 | 237 | 176900 | 207241 | 70544066 |
| Arthralgia | 93.90 | 9.58 | 805 | 176332 | 502585 | 70248722 |
| Affect lability | 90.43 | 9.58 | 119 | 177018 | 10027 | 70741280 |
| Homicide | 89.28 | 9.58 | 48 | 177089 | 1122 | 70750185 |
| Agitation | 85.84 | 9.58 | 460 | 176677 | 92915 | 70658392 |
| Hallucination | 85.18 | 9.58 | 397 | 176740 | 75863 | 70675444 |
| Hepatic enzyme increased | 83.54 | 9.58 | 166 | 176971 | 156824 | 70594483 |
| Alopecia | 83.27 | 9.58 | 238 | 176899 | 198252 | 70553055 |
| Swelling | 80.62 | 9.58 | 224 | 176913 | 188315 | 70562992 |
| Therapeutic product effect incomplete | 80.36 | 9.58 | 109 | 177028 | 119773 | 70631534 |
| Impaired driving ability | 79.30 | 9.58 | 78 | 177059 | 4779 | 70746528 |
| Musculoskeletal stiffness | 77.12 | 9.58 | 158 | 176979 | 147602 | 70603705 |
| Intentional product use issue | 75.82 | 9.58 | 114 | 177023 | 120028 | 70631279 |
| Product use issue | 73.11 | 9.58 | 219 | 176918 | 179718 | 70571589 |
| Dependence | 72.76 | 9.58 | 54 | 177083 | 2246 | 70749061 |
| Rash | 72.59 | 9.58 | 871 | 176266 | 509691 | 70241616 |
| Abdominal discomfort | 72.47 | 9.58 | 283 | 176854 | 214375 | 70536932 |
| Automatism | 72.31 | 9.58 | 24 | 177113 | 153 | 70751154 |
| Cardiac arrest | 71.25 | 9.58 | 660 | 176477 | 159174 | 70592133 |
| Therapeutic product effect decreased | 69.60 | 9.58 | 159 | 176978 | 142859 | 70608448 |
| Sleep disorder due to general medical condition, insomnia type | 67.06 | 9.58 | 6 | 177131 | 35726 | 70715581 |
| Dissociative disorder | 66.74 | 9.58 | 30 | 177107 | 468 | 70750839 |
| Folliculitis | 66.02 | 9.58 | 13 | 177124 | 42557 | 70708750 |
| Nasopharyngitis | 63.44 | 9.58 | 312 | 176825 | 221894 | 70529413 |
| Parasomnia | 61.90 | 9.58 | 29 | 177108 | 500 | 70750807 |
| Drug hypersensitivity | 61.63 | 9.58 | 393 | 176744 | 262066 | 70489241 |
| Initial insomnia | 60.93 | 9.58 | 77 | 177060 | 6232 | 70745075 |
| Mental status changes | 60.82 | 9.58 | 315 | 176822 | 62786 | 70688521 |
| Dysarthria | 60.02 | 9.58 | 311 | 176826 | 62002 | 70689305 |
| Blister | 60.00 | 9.58 | 99 | 177038 | 100427 | 70650880 |
| Condition aggravated | 59.41 | 9.58 | 733 | 176404 | 426902 | 70324405 |
| Blood pressure fluctuation | 59.27 | 9.58 | 37 | 177100 | 58975 | 70692332 |
| Miosis | 58.71 | 9.58 | 117 | 177020 | 13984 | 70737323 |
| Bradypnoea | 58.16 | 9.58 | 70 | 177067 | 5389 | 70745918 |
| Drug withdrawal convulsions | 56.08 | 9.58 | 45 | 177092 | 2103 | 70749204 |
| Altered state of consciousness | 55.95 | 9.58 | 223 | 176914 | 39799 | 70711508 |
| Carotid artery thrombosis | 55.39 | 9.58 | 48 | 177089 | 2498 | 70748809 |
| Immobilisation prolonged | 53.41 | 9.58 | 17 | 177120 | 93 | 70751214 |
| Muscle injury | 53.29 | 9.58 | 15 | 177122 | 38479 | 70712828 |
| Personality disorder | 52.46 | 9.58 | 67 | 177070 | 5481 | 70745826 |
| Hallucination, visual | 52.42 | 9.58 | 177 | 176960 | 29160 | 70722147 |
| Exposure via ingestion | 52.32 | 9.58 | 63 | 177074 | 4852 | 70746455 |
| Incoherent | 52.13 | 9.58 | 77 | 177060 | 7229 | 70744078 |
| Neurologic neglect syndrome | 52.03 | 9.58 | 45 | 177092 | 2336 | 70748971 |
| Mental disorder | 51.01 | 9.58 | 171 | 176966 | 28069 | 70723238 |
| Neutropenia | 50.66 | 9.58 | 405 | 176732 | 256751 | 70494556 |
| Tremor | 50.64 | 9.58 | 603 | 176534 | 155021 | 70596286 |
| Mydriasis | 50.09 | 9.58 | 119 | 177018 | 16034 | 70735273 |
| Disturbance in attention | 47.66 | 9.58 | 223 | 176914 | 42671 | 70708636 |
| Logorrhoea | 45.88 | 9.58 | 54 | 177083 | 4060 | 70747247 |
| Memory impairment | 45.60 | 9.58 | 391 | 176746 | 92250 | 70659057 |
| Psoriatic arthropathy | 45.34 | 9.58 | 57 | 177080 | 64714 | 70686593 |
| Discomfort | 45.24 | 9.58 | 125 | 177012 | 105311 | 70645996 |
| Red blood cell sedimentation rate increased | 45.04 | 9.58 | 20 | 177117 | 38622 | 70712685 |
| Aggression | 44.73 | 9.58 | 239 | 176898 | 48207 | 70703100 |
| Akathisia | 44.16 | 9.58 | 96 | 177041 | 12197 | 70739110 |
| Psychomotor skills impaired | 44.12 | 9.58 | 54 | 177083 | 4230 | 70747077 |
| Sleep talking | 43.55 | 9.58 | 29 | 177108 | 1012 | 70750295 |
| Gun shot wound | 43.43 | 9.58 | 30 | 177107 | 1113 | 70750194 |
| Drug detoxification | 42.70 | 9.58 | 19 | 177118 | 289 | 70751018 |
| Emotional distress | 41.81 | 9.58 | 194 | 176943 | 36994 | 70714313 |
| Parkinsonism | 41.29 | 9.58 | 107 | 177030 | 15218 | 70736089 |
| Cytomegalovirus infection | 41.23 | 9.58 | 24 | 177113 | 39734 | 70711573 |
| Euphoric mood | 39.95 | 9.58 | 66 | 177071 | 6823 | 70744484 |
| Urticaria | 39.87 | 9.58 | 241 | 176896 | 162808 | 70588499 |
| Gastrointestinal disorder | 39.51 | 9.58 | 133 | 177004 | 105294 | 70646013 |
| Major depression | 39.19 | 9.58 | 74 | 177063 | 8500 | 70742807 |
| Nightmare | 38.99 | 9.58 | 133 | 177004 | 22023 | 70729284 |
| Persistent genital arousal disorder | 38.81 | 9.58 | 18 | 177119 | 303 | 70751004 |
| Dyspnoea | 37.69 | 9.58 | 1557 | 175580 | 768503 | 69982804 |
| Wheezing | 37.24 | 9.58 | 116 | 177021 | 94054 | 70657253 |
| Substance abuse | 36.69 | 9.58 | 78 | 177059 | 9759 | 70741548 |
| Panic attack | 36.52 | 9.58 | 130 | 177007 | 21989 | 70729318 |
| Impaired healing | 35.91 | 9.58 | 83 | 177054 | 74291 | 70677016 |
| Acute kidney injury | 35.81 | 9.58 | 907 | 176230 | 473717 | 70277590 |
| Hypokinesia | 35.51 | 9.58 | 110 | 177027 | 17322 | 70733985 |
| Septic shock | 35.35 | 9.58 | 152 | 176985 | 112106 | 70639201 |
| Drug tolerance | 35.06 | 9.58 | 65 | 177072 | 7363 | 70743944 |
| Legal problem | 35.05 | 9.58 | 14 | 177123 | 160 | 70751147 |
| Depressed level of consciousness | 34.97 | 9.58 | 353 | 176784 | 87078 | 70664229 |
| High risk sexual behaviour | 34.97 | 9.58 | 7 | 177130 | 0 | 70751307 |
| Angioedema | 34.93 | 9.58 | 71 | 177066 | 66539 | 70684768 |
| General physical health deterioration | 34.86 | 9.58 | 399 | 176738 | 235632 | 70515675 |
| Psychomotor hyperactivity | 34.85 | 9.58 | 101 | 177036 | 15332 | 70735975 |
| Exposure during pregnancy | 34.72 | 9.58 | 108 | 177029 | 87609 | 70663698 |
| Blood pressure systolic increased | 34.52 | 9.58 | 56 | 177081 | 57203 | 70694104 |
| Myelosuppression | 34.52 | 9.58 | 16 | 177121 | 30129 | 70721178 |
| Hallucination, auditory | 34.00 | 9.58 | 112 | 177025 | 18216 | 70733091 |
| Asthma | 33.65 | 9.58 | 171 | 176966 | 120622 | 70630685 |
| Ill-defined disorder | 33.51 | 9.58 | 53 | 177084 | 54688 | 70696619 |
| Anterograde amnesia | 33.46 | 9.58 | 21 | 177116 | 661 | 70750646 |
| Adjustment disorder | 32.98 | 9.58 | 40 | 177097 | 3104 | 70748203 |
| Drug screen positive | 32.59 | 9.58 | 55 | 177082 | 5785 | 70745522 |
| Behaviour disorder | 32.56 | 9.58 | 53 | 177084 | 5411 | 70745896 |
| Inflammation | 32.46 | 9.58 | 95 | 177042 | 78570 | 70672737 |
| Irritability | 32.23 | 9.58 | 184 | 176953 | 38041 | 70713266 |
| Anger | 32.12 | 9.58 | 101 | 177036 | 16031 | 70735276 |
| Listless | 32.08 | 9.58 | 42 | 177095 | 3521 | 70747786 |
| Anaphylactic reaction | 32.07 | 9.58 | 89 | 177048 | 74885 | 70676422 |
| Head injury | 31.91 | 9.58 | 169 | 176968 | 33972 | 70717335 |
| Hyponatraemia | 31.69 | 9.58 | 569 | 176568 | 159518 | 70591789 |
| C-reactive protein increased | 31.61 | 9.58 | 155 | 176982 | 110362 | 70640945 |
| Inappropriate antidiuretic hormone secretion | 30.40 | 9.58 | 127 | 177010 | 23149 | 70728158 |
| Motor dysfunction | 29.96 | 9.58 | 86 | 177051 | 12984 | 70738323 |
| Pruritus | 29.75 | 9.58 | 647 | 176490 | 344913 | 70406394 |
| Analgesic drug level above therapeutic | 29.48 | 9.58 | 17 | 177120 | 457 | 70750850 |
| Alcohol use | 29.11 | 9.58 | 46 | 177091 | 4581 | 70746726 |
| Erythema | 28.43 | 9.58 | 340 | 176797 | 199223 | 70552084 |
| Premature delivery | 28.22 | 9.58 | 9 | 177128 | 21295 | 70730012 |
| Product substitution issue | 28.19 | 9.58 | 106 | 177031 | 18407 | 70732900 |
| Reduced facial expression | 28.12 | 9.58 | 32 | 177105 | 2320 | 70748987 |
| Multiple organ dysfunction syndrome | 27.79 | 9.58 | 158 | 176979 | 108357 | 70642950 |
| Self-medication | 27.71 | 9.58 | 44 | 177093 | 4399 | 70746908 |
| Bradykinesia | 27.42 | 9.58 | 59 | 177078 | 7443 | 70743864 |
| Mucosal inflammation | 27.23 | 9.58 | 83 | 177054 | 67767 | 70683540 |
| Substance use disorder | 26.53 | 9.58 | 18 | 177119 | 648 | 70750659 |
| Hyperlipidaemia | 26.46 | 9.58 | 124 | 177013 | 23739 | 70727568 |
| Drug resistance | 26.32 | 9.58 | 34 | 177103 | 38156 | 70713151 |
| Multiple drug therapy | 26.25 | 9.58 | 36 | 177101 | 3156 | 70748151 |
| Apathy | 26.00 | 9.58 | 77 | 177060 | 11831 | 70739476 |
| Heart rate decreased | 25.51 | 9.58 | 75 | 177062 | 61940 | 70689367 |
| Tension | 25.31 | 9.58 | 40 | 177097 | 3984 | 70747323 |
| Cough | 25.26 | 9.58 | 619 | 176518 | 324758 | 70426549 |
| Urinary retention | 24.97 | 9.58 | 220 | 176917 | 52300 | 70699007 |
| Imprisonment | 24.63 | 9.58 | 16 | 177121 | 535 | 70750772 |
| Coordination abnormal | 24.48 | 9.58 | 92 | 177045 | 15974 | 70735333 |
| Neurotoxicity | 24.47 | 9.58 | 23 | 177114 | 29803 | 70721504 |
| Laryngeal pain | 24.42 | 9.58 | 48 | 177089 | 5680 | 70745627 |
| Mania | 24.25 | 9.58 | 96 | 177041 | 17078 | 70734229 |
| Dysphagia | 24.10 | 9.58 | 406 | 176731 | 112428 | 70638879 |
| Multiple sclerosis relapse | 24.10 | 9.58 | 187 | 176950 | 42830 | 70708477 |
| Stomatitis | 24.09 | 9.58 | 205 | 176932 | 128306 | 70623001 |
| Obstructive airways disorder | 24.05 | 9.58 | 18 | 177119 | 26095 | 70725212 |
| Psychotic disorder | 23.45 | 9.58 | 168 | 176969 | 37533 | 70713774 |
| Inadequate analgesia | 23.24 | 9.58 | 39 | 177098 | 4083 | 70747224 |
| Eating disorder | 23.24 | 9.58 | 100 | 177037 | 18465 | 70732842 |
| Labelled drug-drug interaction medication error | 23.04 | 9.58 | 16 | 177121 | 24111 | 70727196 |
| Hyperhidrosis | 23.04 | 9.58 | 459 | 176678 | 131127 | 70620180 |
| Pathogen resistance | 22.96 | 9.58 | 3 | 177134 | 13276 | 70738031 |
| Productive cough | 22.90 | 9.58 | 109 | 177028 | 78228 | 70673079 |
| Drug tolerance increased | 22.80 | 9.58 | 16 | 177121 | 609 | 70750698 |
| Bone erosion | 22.77 | 9.58 | 5 | 177132 | 15168 | 70736139 |
| Antidepressant drug level above therapeutic | 22.75 | 9.58 | 16 | 177121 | 611 | 70750696 |
| Skin haemorrhage | 22.39 | 9.58 | 66 | 177071 | 10114 | 70741193 |
| Illusion | 22.30 | 9.58 | 24 | 177113 | 1635 | 70749672 |
| Sensory loss | 22.29 | 9.58 | 71 | 177066 | 11348 | 70739959 |
| Pulmonary fibrosis | 22.18 | 9.58 | 32 | 177105 | 34278 | 70717029 |
| Blood pressure systolic abnormal | 22.12 | 9.58 | 3 | 177134 | 12906 | 70738401 |
| Labelled drug-food interaction issue | 22.04 | 9.58 | 7 | 177130 | 38 | 70751269 |
| COVID-19 | 22.00 | 9.58 | 164 | 176973 | 105593 | 70645714 |
| Oedematous pancreatitis | 21.84 | 9.58 | 19 | 177118 | 994 | 70750313 |
| Pyrexia | 21.82 | 9.58 | 1267 | 175870 | 605685 | 70145622 |
| Renal impairment | 21.75 | 9.58 | 242 | 176895 | 143695 | 70607612 |
| Toxic epidermal necrolysis | 21.74 | 9.58 | 41 | 177096 | 39516 | 70711791 |
| Deep vein thrombosis | 21.72 | 9.58 | 394 | 176743 | 110648 | 70640659 |
| Abnormal dreams | 21.68 | 9.58 | 67 | 177070 | 10536 | 70740771 |
| Brain contusion | 21.54 | 9.58 | 21 | 177116 | 1273 | 70750034 |
| Hip arthroplasty | 21.43 | 9.58 | 23 | 177114 | 28017 | 70723290 |
| Unresponsive to stimuli | 21.40 | 9.58 | 211 | 176926 | 51720 | 70699587 |
| Rhabdomyolysis | 21.35 | 9.58 | 347 | 176790 | 95413 | 70655894 |
| Hepatotoxicity | 21.30 | 9.58 | 49 | 177088 | 43937 | 70707370 |
| Encephalomalacia | 21.16 | 9.58 | 20 | 177117 | 1166 | 70750141 |
| Peripheral circulatory failure | 21.05 | 9.58 | 19 | 177118 | 1044 | 70750263 |
| Blood pressure diastolic decreased | 21.01 | 9.58 | 20 | 177117 | 25760 | 70725547 |
| Stress cardiomyopathy | 20.80 | 9.58 | 63 | 177074 | 9799 | 70741508 |
| Dysphoria | 20.78 | 9.58 | 39 | 177098 | 4459 | 70746848 |
| Muscle rigidity | 20.74 | 9.58 | 97 | 177040 | 18553 | 70732754 |
| Vision blurred | 20.73 | 9.58 | 343 | 176794 | 94641 | 70656666 |
| Aplastic anaemia | 20.53 | 9.58 | 8 | 177129 | 16708 | 70734599 |
| Galactorrhoea | 20.45 | 9.58 | 33 | 177104 | 3345 | 70747962 |
| Feeling drunk | 20.34 | 9.58 | 38 | 177099 | 4329 | 70746978 |
| Transplant rejection | 20.26 | 9.58 | 10 | 177127 | 18161 | 70733146 |
| Therapy non-responder | 20.23 | 9.58 | 111 | 177026 | 76804 | 70674503 |
| Panic disorder | 20.17 | 9.58 | 30 | 177107 | 2834 | 70748473 |
| Febrile neutropenia | 20.13 | 9.58 | 374 | 176763 | 203944 | 70547363 |
| Femoral neck fracture | 20.13 | 9.58 | 59 | 177078 | 9014 | 70742293 |
| Thinking abnormal | 20.04 | 9.58 | 71 | 177066 | 11980 | 70739327 |
| Injury | 19.98 | 9.58 | 250 | 176887 | 64995 | 70686312 |
| Inappropriate schedule of product administration | 19.96 | 9.58 | 172 | 176965 | 107383 | 70643924 |
| Bronchopulmonary aspergillosis | 19.96 | 9.58 | 14 | 177123 | 20988 | 70730319 |
| Death | 19.92 | 9.58 | 1056 | 176081 | 509005 | 70242302 |
| Mobility decreased | 19.89 | 9.58 | 163 | 176974 | 102836 | 70648471 |
| Prothrombin time shortened | 19.55 | 9.58 | 30 | 177107 | 2912 | 70748395 |
| Accidental poisoning | 19.41 | 9.58 | 22 | 177115 | 1588 | 70749719 |
| Self-injurious ideation | 19.38 | 9.58 | 32 | 177105 | 3306 | 70748001 |
| Victim of sexual abuse | 19.36 | 9.58 | 13 | 177124 | 460 | 70750847 |
| Hangover | 19.32 | 9.58 | 24 | 177113 | 1909 | 70749398 |
| Prescription drug used without a prescription | 19.14 | 9.58 | 30 | 177107 | 2967 | 70748340 |
| Drug diversion | 19.01 | 9.58 | 19 | 177118 | 1187 | 70750120 |
| Cholecystitis chronic | 18.94 | 9.58 | 59 | 177078 | 9317 | 70741990 |
| Foreign body | 18.86 | 9.58 | 28 | 177109 | 2640 | 70748667 |
| Feeling abnormal | 18.80 | 9.58 | 477 | 176660 | 141842 | 70609465 |
| Pain | 18.76 | 9.58 | 1335 | 175802 | 627481 | 70123826 |
| Diarrhoea | 18.63 | 9.58 | 1694 | 175443 | 781647 | 69969660 |
| Victim of homicide | 18.56 | 9.58 | 9 | 177128 | 168 | 70751139 |
| Bipolar disorder | 18.36 | 9.58 | 51 | 177086 | 7557 | 70743750 |
| Sinus tachycardia | 18.21 | 9.58 | 146 | 176991 | 33767 | 70717540 |
| Victim of chemical submission | 18.09 | 9.58 | 12 | 177125 | 416 | 70750891 |
| Live birth | 17.93 | 9.58 | 6 | 177131 | 13773 | 70737534 |
| Bulimia nervosa | 17.85 | 9.58 | 10 | 177127 | 254 | 70751053 |
| Poor quality sleep | 17.84 | 9.58 | 99 | 177038 | 20250 | 70731057 |
| Arthritis | 17.61 | 9.58 | 158 | 176979 | 97822 | 70653485 |
| Syncope | 17.57 | 9.58 | 540 | 176597 | 165169 | 70586138 |
| Enthesopathy | 17.54 | 9.58 | 3 | 177134 | 10866 | 70740441 |
| Prostate cancer | 17.39 | 9.58 | 32 | 177105 | 31131 | 70720176 |
| Decreased interest | 17.37 | 9.58 | 31 | 177106 | 3410 | 70747897 |
| Hiatus hernia | 17.33 | 9.58 | 101 | 177036 | 21033 | 70730274 |
| Delusion | 17.32 | 9.58 | 94 | 177043 | 19071 | 70732236 |
| Nervousness | 17.27 | 9.58 | 135 | 177002 | 30985 | 70720322 |
| Performance fear | 17.22 | 9.58 | 4 | 177133 | 4 | 70751303 |
| Irritable bowel syndrome | 17.16 | 9.58 | 67 | 177070 | 50783 | 70700524 |
| Sinus disorder | 17.14 | 9.58 | 93 | 177044 | 18866 | 70732441 |
| Colitis ulcerative | 17.07 | 9.58 | 37 | 177100 | 33886 | 70717421 |
| Urinary hesitation | 17.00 | 9.58 | 32 | 177105 | 3667 | 70747640 |
| Depressive symptom | 16.97 | 9.58 | 39 | 177098 | 5142 | 70746165 |
| Grip strength decreased | 16.94 | 9.58 | 9 | 177128 | 15676 | 70735631 |
| Sinus congestion | 16.92 | 9.58 | 87 | 177050 | 17286 | 70734021 |
| Thrombotic microangiopathy | 16.83 | 9.58 | 12 | 177125 | 17836 | 70733471 |
| Post transplant lymphoproliferative disorder | 16.82 | 9.58 | 3 | 177134 | 10542 | 70740765 |
| Procalcitonin abnormal | 16.80 | 9.58 | 11 | 177126 | 373 | 70750934 |
| Epstein-Barr virus infection | 16.74 | 9.58 | 6 | 177131 | 13192 | 70738115 |
| Facial nerve disorder | 16.70 | 9.58 | 14 | 177123 | 696 | 70750611 |
| Therapeutic response decreased | 16.70 | 9.58 | 82 | 177055 | 58371 | 70692936 |
| Palpitations | 16.69 | 9.58 | 378 | 176759 | 110375 | 70640932 |
| Tachycardia | 16.64 | 9.58 | 516 | 176621 | 158030 | 70593277 |
| Accidental overdose | 16.63 | 9.58 | 147 | 176990 | 34974 | 70716333 |
| Liver injury | 16.61 | 9.58 | 50 | 177087 | 40985 | 70710322 |
| Peptic ulcer | 16.55 | 9.58 | 41 | 177096 | 5672 | 70745635 |
| Posterior reversible encephalopathy syndrome | 16.53 | 9.58 | 22 | 177115 | 24380 | 70726927 |
| Adverse drug reaction | 16.32 | 9.58 | 73 | 177064 | 53271 | 70698036 |
| Libido decreased | 16.10 | 9.58 | 37 | 177100 | 4879 | 70746428 |
| Tardive dyskinesia | 16.08 | 9.58 | 58 | 177079 | 9871 | 70741436 |
| Sudden onset of sleep | 16.08 | 9.58 | 13 | 177124 | 614 | 70750693 |
| Disinhibition | 16.05 | 9.58 | 24 | 177113 | 2277 | 70749030 |
| Dysuria | 16.02 | 9.58 | 180 | 176957 | 45614 | 70705693 |
| Speech disorder | 16.00 | 9.58 | 195 | 176942 | 50385 | 70700922 |
| Herpes zoster | 15.95 | 9.58 | 136 | 177001 | 85099 | 70666208 |
| Skin ulcer | 15.89 | 9.58 | 64 | 177073 | 48081 | 70703226 |
| Cholecystectomy | 15.83 | 9.58 | 52 | 177085 | 8445 | 70742862 |
| Lethargy | 15.78 | 9.58 | 270 | 176867 | 74980 | 70676327 |
| Cerebral atrophy | 15.72 | 9.58 | 48 | 177089 | 7499 | 70743808 |
| Hypertensive heart disease | 15.71 | 9.58 | 32 | 177105 | 3884 | 70747423 |
| Cardiomegaly | 15.63 | 9.58 | 110 | 177027 | 24435 | 70726872 |
| Cognitive disorder | 15.55 | 9.58 | 226 | 176911 | 60730 | 70690577 |
| Circadian rhythm sleep disorder | 15.45 | 9.58 | 13 | 177124 | 650 | 70750657 |
| Dehydration | 15.30 | 9.58 | 701 | 176436 | 225441 | 70525866 |
| Skin necrosis | 15.30 | 9.58 | 11 | 177126 | 16280 | 70735027 |
| Dementia | 15.29 | 9.58 | 102 | 177035 | 22263 | 70729044 |
| Joint range of motion decreased | 15.18 | 9.58 | 26 | 177111 | 26000 | 70725307 |
| Device expulsion | 15.13 | 9.58 | 20 | 177117 | 22226 | 70729081 |
| Neurogenic bladder | 15.11 | 9.58 | 31 | 177106 | 3782 | 70747525 |
| Injection site pain | 15.03 | 9.58 | 205 | 176932 | 117414 | 70633893 |
| Fear | 14.89 | 9.58 | 96 | 177041 | 20715 | 70730592 |
| Bipolar I disorder | 14.84 | 9.58 | 21 | 177116 | 1896 | 70749411 |
| Depressed mood | 14.77 | 9.58 | 171 | 176966 | 43649 | 70707658 |
| Tachyphrenia | 14.55 | 9.58 | 21 | 177116 | 1930 | 70749377 |
| Sneezing | 14.55 | 9.58 | 82 | 177055 | 16869 | 70734438 |
| Intervertebral disc degeneration | 14.52 | 9.58 | 71 | 177066 | 13829 | 70737478 |
| Neurological examination normal | 14.47 | 9.58 | 4 | 177133 | 12 | 70751295 |
| Perseveration | 14.45 | 9.58 | 10 | 177127 | 372 | 70750935 |
| Loss of personal independence in daily activities | 14.36 | 9.58 | 139 | 176998 | 84771 | 70666536 |
| Nephropathy toxic | 14.35 | 9.58 | 15 | 177122 | 18499 | 70732808 |
| Poor venous access | 14.20 | 9.58 | 10 | 177127 | 14961 | 70736346 |
| Generalised anxiety disorder | 14.11 | 9.58 | 21 | 177116 | 1984 | 70749323 |
| Haematocrit decreased | 14.10 | 9.58 | 211 | 176926 | 57047 | 70694260 |
| Apallic syndrome | 14.08 | 9.58 | 14 | 177123 | 869 | 70750438 |
| Sleep disorder | 14.04 | 9.58 | 249 | 176888 | 69623 | 70681684 |
| Diplopia | 13.95 | 9.58 | 119 | 177018 | 28028 | 70723279 |
| Persistent depressive disorder | 13.89 | 9.58 | 15 | 177122 | 1026 | 70750281 |
| Immunodeficiency | 13.86 | 9.58 | 14 | 177123 | 17541 | 70733766 |
| Coagulation factor VII level decreased | 13.84 | 9.58 | 8 | 177129 | 216 | 70751091 |
| Mouth ulceration | 13.79 | 9.58 | 42 | 177095 | 34307 | 70717000 |
| Blastocystis infection | 13.79 | 9.58 | 4 | 177133 | 15 | 70751292 |
| Aspartate aminotransferase increased | 13.78 | 9.58 | 415 | 176722 | 126563 | 70624744 |
| Distributive shock | 13.74 | 9.58 | 22 | 177115 | 2215 | 70749092 |
| Oropharyngeal pain | 13.74 | 9.58 | 164 | 176973 | 96146 | 70655161 |
| Tenosynovitis | 13.71 | 9.58 | 9 | 177128 | 13967 | 70737340 |
| Therapy partial responder | 13.70 | 9.58 | 7 | 177130 | 12467 | 70738840 |
| Bronchiectasis | 13.70 | 9.58 | 12 | 177125 | 16085 | 70735222 |
| Staring | 13.53 | 9.58 | 23 | 177114 | 2433 | 70748874 |
| Product dose omission issue | 13.44 | 9.58 | 427 | 176710 | 217041 | 70534266 |
| Neuroglycopenia | 13.37 | 9.58 | 10 | 177127 | 421 | 70750886 |
| Sinusitis | 13.35 | 9.58 | 321 | 176816 | 168874 | 70582433 |
| Anorexia nervosa | 13.30 | 9.58 | 8 | 177129 | 233 | 70751074 |
| Bone marrow failure | 13.29 | 9.58 | 70 | 177067 | 48940 | 70702367 |
| Creatinine renal clearance decreased | 13.26 | 9.58 | 14 | 177123 | 17186 | 70734121 |
| Homicidal ideation | 13.15 | 9.58 | 27 | 177110 | 3296 | 70748011 |
| Atelectasis | 13.09 | 9.58 | 120 | 177017 | 28842 | 70722465 |
| Diabetic ketoacidosis | 13.04 | 9.58 | 38 | 177099 | 31474 | 70719833 |
| Anhedonia | 13.04 | 9.58 | 70 | 177067 | 14143 | 70737164 |
| Suspected suicide | 12.97 | 9.58 | 50 | 177087 | 8784 | 70742523 |
| Blood potassium decreased | 12.75 | 9.58 | 162 | 176975 | 42259 | 70709048 |
| Neutropenic sepsis | 12.56 | 9.58 | 27 | 177110 | 24803 | 70726504 |
| Hemiplegia | 12.45 | 9.58 | 68 | 177069 | 13827 | 70737480 |
| Product complaint | 12.44 | 9.58 | 62 | 177075 | 12169 | 70739138 |
| Affective disorder | 12.38 | 9.58 | 44 | 177093 | 7435 | 70743872 |
| Feeling of despair | 12.26 | 9.58 | 23 | 177114 | 2628 | 70748679 |
| Eustachian tube disorder | 12.23 | 9.58 | 5 | 177132 | 61 | 70751246 |
| Hypokalaemia | 12.22 | 9.58 | 421 | 176716 | 130767 | 70620540 |
| Weight increased | 12.20 | 9.58 | 488 | 176649 | 241843 | 70509464 |
| Disease progression | 12.15 | 9.58 | 298 | 176839 | 156374 | 70594933 |
| Social anxiety disorder | 12.14 | 9.58 | 10 | 177127 | 485 | 70750822 |
| Coagulation factor VIII level increased | 12.12 | 9.58 | 4 | 177133 | 25 | 70751282 |
| Drug dependence, antepartum | 12.12 | 9.58 | 4 | 177133 | 25 | 70751282 |
| Substance-induced mood disorder | 12.05 | 9.58 | 6 | 177131 | 119 | 70751188 |
| Sudden death | 12.04 | 9.58 | 92 | 177045 | 20972 | 70730335 |
| Catatonia | 11.92 | 9.58 | 46 | 177091 | 8087 | 70743220 |
| Asthenia | 11.87 | 9.58 | 1311 | 175826 | 456355 | 70294952 |
| Influenza like illness | 11.80 | 9.58 | 229 | 176908 | 65102 | 70686205 |
| Abulia | 11.66 | 9.58 | 13 | 177124 | 922 | 70750385 |
| Dysgeusia | 11.64 | 9.58 | 181 | 176956 | 49321 | 70701986 |
| Therapeutic response shortened | 11.63 | 9.58 | 9 | 177128 | 12829 | 70738478 |
| Carotid artery stenosis | 11.60 | 9.58 | 46 | 177091 | 8190 | 70743117 |
| Transient ischaemic attack | 11.58 | 9.58 | 170 | 176967 | 45774 | 70705533 |
| Attention deficit hyperactivity disorder | 11.51 | 9.58 | 24 | 177113 | 2963 | 70748344 |
| Joint effusion | 11.49 | 9.58 | 13 | 177124 | 15464 | 70735843 |
| Alanine aminotransferase abnormal | 11.42 | 9.58 | 3 | 177134 | 8056 | 70743251 |
| PCO2 decreased | 11.41 | 9.58 | 24 | 177113 | 2980 | 70748327 |
| Slow speech | 11.39 | 9.58 | 20 | 177117 | 2172 | 70749135 |
| Sepsis | 11.35 | 9.58 | 497 | 176640 | 244048 | 70507259 |
| Muscle spasticity | 11.25 | 9.58 | 86 | 177051 | 19603 | 70731704 |
| Suicidal behaviour | 11.13 | 9.58 | 24 | 177113 | 3032 | 70748275 |
| Acute graft versus host disease | 11.06 | 9.58 | 5 | 177132 | 9557 | 70741750 |
| Drug ineffective for unapproved indication | 11.04 | 9.58 | 54 | 177083 | 38484 | 70712823 |
| Cardiotoxicity | 11.03 | 9.58 | 7 | 177130 | 11063 | 70740244 |
| Fatigue | 10.97 | 9.58 | 1851 | 175286 | 822468 | 69928839 |
| SARS-CoV-2 test positive | 10.96 | 9.58 | 4 | 177133 | 8697 | 70742610 |
| Vertigo CNS origin | 10.96 | 9.58 | 4 | 177133 | 35 | 70751272 |
| Diverticulum | 10.95 | 9.58 | 65 | 177072 | 13628 | 70737679 |
| Labelled drug-food interaction medication error | 10.94 | 9.58 | 6 | 177131 | 146 | 70751161 |
| Pancreatic haemorrhage | 10.90 | 9.58 | 5 | 177132 | 82 | 70751225 |
| Inappropriate schedule of product discontinuation | 10.85 | 9.58 | 3 | 177134 | 9 | 70751298 |
| Vascular dementia | 10.83 | 9.58 | 12 | 177125 | 845 | 70750462 |
| Peripheral ischaemia | 10.83 | 9.58 | 47 | 177090 | 8711 | 70742596 |
| Refusal of treatment by relative | 10.75 | 9.58 | 11 | 177126 | 707 | 70750600 |
| Paranoia | 10.73 | 9.58 | 77 | 177060 | 17211 | 70734096 |
| Oesophageal carcinoma | 10.68 | 9.58 | 5 | 177132 | 9361 | 70741946 |
| Sedation | 10.66 | 9.58 | 170 | 176967 | 46561 | 70704746 |
| Aortic valve calcification | 10.65 | 9.58 | 11 | 177126 | 715 | 70750592 |
| Blood testosterone decreased | 10.62 | 9.58 | 20 | 177117 | 2293 | 70749014 |
| Secretion discharge | 10.58 | 9.58 | 10 | 177127 | 12923 | 70738384 |
| Loss of proprioception | 10.53 | 9.58 | 11 | 177126 | 724 | 70750583 |
| Leukopenia | 10.50 | 9.58 | 195 | 176942 | 106365 | 70644942 |
| Electrocardiogram QT prolonged | 10.46 | 9.58 | 278 | 176859 | 83239 | 70668068 |
| Medication error | 10.45 | 9.58 | 200 | 176937 | 56712 | 70694595 |
| Coagulation factor V level decreased | 10.45 | 9.58 | 10 | 177127 | 592 | 70750715 |
| Left ventricular dysfunction | 10.42 | 9.58 | 18 | 177119 | 17939 | 70733368 |
| Amnestic disorder | 10.41 | 9.58 | 10 | 177127 | 595 | 70750712 |
| Therapeutic product effect increased | 10.41 | 9.58 | 15 | 177122 | 1377 | 70749930 |
| Dyssomnia | 10.32 | 9.58 | 4 | 177133 | 42 | 70751265 |
| Muscle spasms | 10.30 | 9.58 | 477 | 176660 | 153569 | 70597738 |
| Aspergillus infection | 10.28 | 9.58 | 18 | 177119 | 17850 | 70733457 |
| Seizure | 10.23 | 9.58 | 543 | 176594 | 177419 | 70573888 |
| Cholestatic liver injury | 10.12 | 9.58 | 28 | 177109 | 4140 | 70747167 |
| Sudden cardiac death | 10.11 | 9.58 | 31 | 177106 | 4854 | 70746453 |
| Fibromyalgia | 10.06 | 9.58 | 74 | 177063 | 47800 | 70703507 |
| Respiratory disorder | 9.99 | 9.58 | 57 | 177080 | 39066 | 70712241 |
| Mood swings | 9.97 | 9.58 | 79 | 177058 | 18207 | 70733100 |
| Dermatitis allergic | 9.97 | 9.58 | 16 | 177121 | 16415 | 70734892 |
| Neutrophil count increased | 9.90 | 9.58 | 34 | 177103 | 26761 | 70724546 |
| Activation syndrome | 9.87 | 9.58 | 7 | 177130 | 271 | 70751036 |
| Product commingling | 9.87 | 9.58 | 5 | 177132 | 103 | 70751204 |
| Hypoosmolar state | 9.76 | 9.58 | 7 | 177130 | 276 | 70751031 |
| Coeliac artery compression syndrome | 9.70 | 9.58 | 5 | 177132 | 107 | 70751200 |
| Tendonitis | 9.65 | 9.58 | 26 | 177111 | 22096 | 70729211 |
| Enuresis | 9.60 | 9.58 | 22 | 177115 | 2895 | 70748412 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05CF02 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Benzodiazepine related drugs |
| FDA CS | M0018233 | Pyridines |
| FDA MoA | N0000000196 | GABA A Agonists |
| FDA Chemical/Ingredient | N0000007570 | Pyridines |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018682 | GABA Agents |
| MeSH PA | D018755 | GABA Agonists |
| MeSH PA | D058785 | GABA-A Receptor Agonists |
| MeSH PA | D006993 | Hypnotics and Sedatives |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D000068776 | Sleep Aids, Pharmaceutical |
| CHEBI has role | CHEBI:35488 | central nervous system depressants |
| CHEBI has role | CHEBI:35717 | hypnotics |
| CHEBI has role | CHEBI:51373 | gamma-aminobutyric acid receptor agonist |
| FDA PE | N0000175728 | Central Nervous System Depression |
| FDA EPC | N0000175759 | gamma-Aminobutyric Acid-ergic Agonist |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Initial insomnia | indication | 59050008 | |
| Insomnia | indication | 193462001 | |
| Cognitive impairment following traumatic brain injury | off-label use | 127295002 | |
| Arousal post traumatic brain injury | off-label use | 127295002 | |
| Suicidal thoughts | contraindication | 6471006 | |
| Hallucinations | contraindication | 7011001 | |
| Asthenia | contraindication | 13791008 | |
| Alcohol intoxication | contraindication | 25702006 | |
| Depressive disorder | contraindication | 35489007 | |
| Aggressive behavior | contraindication | 61372001 | |
| Substance abuse | contraindication | 66214007 | |
| Sleep apnea | contraindication | 73430006 | DOID:0050847 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Sleep automatism | contraindication | 247962006 | |
| Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
| Impaired cognition | contraindication | 386806002 | |
| Memory impairment | contraindication | 386807006 | |
| Attention deficit hyperactivity disorder | contraindication | 406506008 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.73 | Basic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7682628 | Feb. 16, 2025 | METHOD FOR TREATING INSOMNIA |
| 3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7682628 | Feb. 16, 2025 | METHOD FOR TREATING INSOMNIA |
| 10MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9597281 | April 6, 2027 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 5MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9597281 | April 6, 2027 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7658945 | April 15, 2027 | METHOD FOR TREATING INSOMNIA |
| 3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 7658945 | April 15, 2027 | METHOD FOR TREATING INSOMNIA |
| 1.75MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 8242131 | Aug. 20, 2029 | METHOD OF TREATING MIDDLE-OF-THE-NIGHT INSOMNIA |
| 3.5MG | INTERMEZZO | PURDUE PHARMA | N022328 | Nov. 23, 2011 | DISCN | TABLET | SUBLINGUAL | 8242131 | Aug. 20, 2029 | METHOD OF TREATING MIDDLE-OF-THE-NIGHT INSOMNIA |
| 10MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9265720 | Feb. 25, 2031 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 5MG | EDLUAR | MYLAN SPECIALITY LP | N021997 | March 13, 2009 | RX | TABLET | SUBLINGUAL | 9265720 | Feb. 25, 2031 | METHOD OF TREATING INSOMNIA CHARACTERIZED BY DIFFICULTY WITH SLEEP ONSET |
| 5MG/SPRAY | ZOLPIMIST | AYTU | N022196 | Dec. 19, 2008 | RX | SPRAY, METERED | ORAL | 8236285 | Aug. 7, 2032 | TREATMENT OF TRANSIENT INSOMNIA |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-1 | Ion channel | ALLOSTERIC MODULATOR | Ki | 7.68 | IUPHAR | IUPHAR | |||
| GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 6.70 | WOMBAT-PK | CHEMBL | |||
| GABA-A receptor alpha-2/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.81 | WOMBAT-PK | CHEMBL | |||
| GABA-A receptor alpha-3/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.42 | WOMBAT-PK | CHEMBL | |||
| GABA-A receptor alpha-1/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 7.57 | WOMBAT-PK | CHEMBL | |||
| GABA A receptor alpha-3/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | Ki | 6.16 | WOMBAT-PK | CHEMBL | |||
| Gamma-aminobutyric acid receptor subunit alpha-2 | Ion channel | Ki | 6.39 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-3 | Ion channel | Ki | 6.01 | CHEMBL | |||||
| Multidrug resistance protein 1 | Transporter | Km | 3.70 | WOMBAT-PK | |||||
| Gamma-aminobutyric acid receptor subunit alpha-2 | Ion channel | Ki | 6.12 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-5 | Ion channel | Ki | 7.46 | CHEMBL | |||||
| GABA A receptor alpha-6/beta-2/gamma-2 | Ion channel | Ki | 6.01 | CHEMBL | |||||
| GABA-A receptor; alpha-1/beta-2/gamma-2 | Ion channel | Ki | 7.72 | CHEMBL | |||||
| GABA A receptor alpha-2/beta-2/gamma-2 | Ion channel | Ki | 6.81 | CHEMBL | |||||
| CAAX prenyl protease 2 | Enzyme | AC50 | 4.77 | CHEMBL | |||||
| GABA-A receptor; anion channel | Ion channel | Ki | 7.60 | CHEMBL | |||||
| GABA A receptor alpha-3/beta-2/gamma-2 | Ion channel | Ki | 6.42 | CHEMBL | |||||
| Translocator protein | Membrane receptor | IC50 | 5.33 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-1 | Ion channel | Ki | 7.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00706 | KEGG_DRUG |
| 99294-93-6 | SECONDARY_CAS_RN |
| 4020811 | VANDF |
| 4023596 | VANDF |
| C0078839 | UMLSCUI |
| CHEBI:10125 | CHEBI |
| R5R | PDB_CHEM_ID |
| CHEMBL911 | ChEMBL_ID |
| CHEMBL3989820 | ChEMBL_ID |
| DB00425 | DRUGBANK_ID |
| CHEMBL1723343 | ChEMBL_ID |
| D000077334 | MESH_DESCRIPTOR_UI |
| 5732 | PUBCHEM_CID |
| 4348 | IUPHAR_LIGAND_ID |
| 5741 | INN_ID |
| 7K383OQI23 | UNII |
| 131725 | RXNORM |
| 109404 | MMSL |
| 343 | MMSL |
| 5713 | MMSL |
| d00910 | MMSL |
| 004146 | NDDF |
| 004147 | NDDF |
| 387569009 | SNOMEDCT_US |
| 395928005 | SNOMEDCT_US |
| 96231005 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5401 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 34 sections |
| Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5401 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 34 sections |
| Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5421 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 34 sections |
| Ambien | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5421 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 34 sections |
| Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5501 | TABLET, COATED | 6.25 mg | ORAL | NDA | 34 sections |
| Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5501 | TABLET, COATED | 6.25 mg | ORAL | NDA | 34 sections |
| Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5521 | TABLET, COATED | 12.50 mg | ORAL | NDA | 34 sections |
| Ambien CR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5521 | TABLET, COATED | 12.50 mg | ORAL | NDA | 34 sections |
| Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6010 | TABLET | 10 mg | ORAL | NDA | 33 sections |
| Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6010 | TABLET | 10 mg | ORAL | NDA | 33 sections |
| Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6050 | TABLET | 5 mg | ORAL | NDA | 33 sections |
| Edluar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0037-6050 | TABLET | 5 mg | ORAL | NDA | 33 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0086 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0087 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0073 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0073 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0074 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0074 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8225 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 32 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8226 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 32 sections |
| Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5315 | TABLET, EXTENDED RELEASE | 6.25 mg | ORAL | ANDA | 32 sections |
| Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5315 | TABLET, EXTENDED RELEASE | 6.25 mg | ORAL | ANDA | 32 sections |
| Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5316 | TABLET, EXTENDED RELEASE | 12.50 mg | ORAL | ANDA | 32 sections |
| Zolpidem tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5316 | TABLET, EXTENDED RELEASE | 12.50 mg | ORAL | ANDA | 32 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5317 | TABLET, COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5317 | TABLET, COATED | 5 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5318 | TABLET, COATED | 10 mg | ORAL | ANDA | 31 sections |
| Zolpidem Tartrate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5318 | TABLET, COATED | 10 mg | ORAL | ANDA | 31 sections |
| ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6082 | TABLET | 5 mg | ORAL | ANDA | 31 sections |
| ZOLPIDEM TARTRATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6082 | TABLET | 5 mg | ORAL | ANDA | 31 sections |