vinburnine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vinca alkaloids 2824 4880-88-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vinburnine
  • vincamone
  • (-)-Vincamone
  • (-)-cis-Eburnamonine
  • l-Eburnamonine
  • Molecular weight: 294.40
  • Formula: C19H22N2O
  • CLOGP: 4.03
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 25.24
  • ALOGS: -3.23
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C04AX17 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
Other peripheral vasodilators

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.88 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M2 GPCR ALLOSTERIC MODULATOR Kd 4.20 IUPHAR
Muscarinic acetylcholine receptor M4 GPCR ALLOSTERIC MODULATOR Kd 4.60 IUPHAR
Muscarinic acetylcholine receptor M1 GPCR ALLOSTERIC MODULATOR Kd 5.10 IUPHAR
Muscarinic acetylcholine receptor M3 GPCR ALLOSTERIC MODULATOR Kd 5.20 IUPHAR

External reference:

IDSource
C0148398 UMLSCUI
D08676 KEGG_DRUG
57954 RXNORM
698873005 SNOMEDCT_US
005681 NDDF
CHEBI:4740 CHEBI
G54D0HMY25 UNII
4976 INN_ID
71203 PUBCHEM_CID
DB13793 DRUGBANK_ID
CHEMBL1892145 ChEMBL_ID
345 IUPHAR_LIGAND_ID

Pharmaceutical products:

None