valganciclovir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antivirals bicyclic heterocycle compounds | 2801 | 175865-59-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Valganciclovir is an L-valyl ester (prodrug) of ganciclovir that exists as a mixture of two diastereomers. After oral administration, both diastereomers are rapidly converted to ganciclovir by intestinal and hepatic esterases. Ganciclovir is a synthetic analogue of 2'-deoxyguanosine, which inhibits replication of human CMV in cell culture and in vivo.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.90 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 70 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 84.66 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 61 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 29, 2001 | FDA | HOFFMANN LA ROCHE | |
| Nov. 5, 2004 | PMDA | Tanabe Seiyaku Co., Ltd. |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cytomegalovirus infection | 1007.15 | 19.35 | 324 | 16241 | 20628 | 63451829 |
| Leukopenia | 486.80 | 19.35 | 283 | 16282 | 77007 | 63395450 |
| Cytomegalovirus viraemia | 485.92 | 19.35 | 137 | 16428 | 5512 | 63466945 |
| Transplant rejection | 469.96 | 19.35 | 155 | 16410 | 10625 | 63461832 |
| Pathogen resistance | 378.04 | 19.35 | 116 | 16449 | 6282 | 63466175 |
| Drug resistance | 362.63 | 19.35 | 157 | 16408 | 22776 | 63449681 |
| Neutropenia | 302.94 | 19.35 | 295 | 16270 | 174710 | 63297747 |
| Off label use | 231.93 | 19.35 | 528 | 16037 | 673934 | 62798523 |
| BK virus infection | 221.80 | 19.35 | 66 | 16499 | 3213 | 63469244 |
| Kidney transplant rejection | 212.81 | 19.35 | 68 | 16497 | 4203 | 63468254 |
| Polyomavirus-associated nephropathy | 178.00 | 19.35 | 49 | 16516 | 1799 | 63470658 |
| Pancytopenia | 164.72 | 19.35 | 162 | 16403 | 96771 | 63375686 |
| Cytomegalovirus infection reactivation | 164.69 | 19.35 | 55 | 16510 | 3908 | 63468549 |
| Immunosuppressant drug level increased | 161.22 | 19.35 | 53 | 16512 | 3585 | 63468872 |
| Agranulocytosis | 147.27 | 19.35 | 88 | 16477 | 25046 | 63447411 |
| Epstein-Barr virus infection | 139.99 | 19.35 | 59 | 16506 | 7991 | 63464466 |
| Cytomegalovirus gastrointestinal infection | 129.99 | 19.35 | 27 | 16538 | 283 | 63472174 |
| Smooth muscle cell neoplasm | 127.69 | 19.35 | 32 | 16533 | 809 | 63471648 |
| Transplant dysfunction | 124.02 | 19.35 | 47 | 16518 | 4825 | 63467632 |
| Cytomegalovirus colitis | 123.26 | 19.35 | 39 | 16526 | 2333 | 63470124 |
| Encephalitis cytomegalovirus | 119.28 | 19.35 | 28 | 16537 | 533 | 63471924 |
| Post transplant lymphoproliferative disorder | 115.43 | 19.35 | 45 | 16520 | 4986 | 63467471 |
| Delayed graft function | 105.35 | 19.35 | 29 | 16536 | 1064 | 63471393 |
| Blood creatinine increased | 101.87 | 19.35 | 120 | 16445 | 87724 | 63384733 |
| Nocardiosis | 100.65 | 19.35 | 32 | 16533 | 1944 | 63470513 |
| Lung transplant rejection | 100.57 | 19.35 | 27 | 16538 | 900 | 63471557 |
| Acute kidney injury | 96.16 | 19.35 | 212 | 16353 | 263203 | 63209254 |
| Lymphocele | 94.35 | 19.35 | 25 | 16540 | 792 | 63471665 |
| Complications of transplanted kidney | 93.44 | 19.35 | 32 | 16533 | 2454 | 63470003 |
| Posterior reversible encephalopathy syndrome | 92.01 | 19.35 | 57 | 16508 | 17288 | 63455169 |
| Cytomegalovirus chorioretinitis | 91.18 | 19.35 | 29 | 16536 | 1764 | 63470693 |
| Thrombotic microangiopathy | 86.30 | 19.35 | 46 | 16519 | 10515 | 63461942 |
| Fatigue | 86.22 | 19.35 | 64 | 16501 | 887964 | 62584493 |
| Arthralgia | 85.10 | 19.35 | 22 | 16543 | 569688 | 62902769 |
| Graft versus host disease | 83.54 | 19.35 | 39 | 16526 | 6724 | 63465733 |
| Bronchopulmonary aspergillosis | 83.17 | 19.35 | 42 | 16523 | 8593 | 63463864 |
| Renal transplant failure | 81.76 | 19.35 | 22 | 16543 | 740 | 63471717 |
| Renal tubular necrosis | 81.24 | 19.35 | 46 | 16519 | 11832 | 63460625 |
| Pneumocystis jirovecii pneumonia | 80.75 | 19.35 | 52 | 16513 | 16862 | 63455595 |
| Ureaplasma infection | 80.35 | 19.35 | 21 | 16544 | 630 | 63471827 |
| Nephropathy toxic | 79.47 | 19.35 | 42 | 16523 | 9437 | 63463020 |
| Pneumonia cytomegaloviral | 77.40 | 19.35 | 27 | 16538 | 2187 | 63470270 |
| Thrombocytopenia | 77.11 | 19.35 | 140 | 16425 | 151017 | 63321440 |
| Hyperammonaemia | 73.51 | 19.35 | 33 | 16532 | 5199 | 63467258 |
| Human ehrlichiosis | 72.23 | 19.35 | 15 | 16550 | 157 | 63472300 |
| Klebsiella infection | 71.94 | 19.35 | 38 | 16527 | 8528 | 63463929 |
| Strongyloidiasis | 71.03 | 19.35 | 22 | 16543 | 1226 | 63471231 |
| Escherichia infection | 70.41 | 19.35 | 43 | 16522 | 12711 | 63459746 |
| Cytomegalovirus test positive | 69.25 | 19.35 | 27 | 16538 | 2991 | 63469466 |
| Enterococcal infection | 66.43 | 19.35 | 35 | 16530 | 7813 | 63464644 |
| Pain | 65.99 | 19.35 | 58 | 16507 | 740570 | 62731887 |
| Renal transplant | 64.76 | 19.35 | 21 | 16544 | 1359 | 63471098 |
| Renal impairment | 64.16 | 19.35 | 96 | 16469 | 88259 | 63384198 |
| Scedosporium infection | 63.93 | 19.35 | 17 | 16548 | 546 | 63471911 |
| Adenovirus infection | 61.50 | 19.35 | 26 | 16539 | 3545 | 63468912 |
| Polyomavirus viraemia | 59.46 | 19.35 | 17 | 16548 | 717 | 63471740 |
| Transplant failure | 58 | 19.35 | 20 | 16545 | 1565 | 63470892 |
| Aspergillus infection | 57.13 | 19.35 | 32 | 16533 | 8061 | 63464396 |
| Lymphopenia | 56.27 | 19.35 | 43 | 16522 | 18284 | 63454173 |
| Neutrophil Pelger-Huet anomaly present | 55.74 | 19.35 | 11 | 16554 | 87 | 63472370 |
| Viraemia | 53.62 | 19.35 | 18 | 16547 | 1298 | 63471159 |
| Septic shock | 53.60 | 19.35 | 76 | 16489 | 66553 | 63405904 |
| Intentional product use issue | 53.57 | 19.35 | 109 | 16456 | 127783 | 63344674 |
| Sepsis | 52.13 | 19.35 | 120 | 16445 | 153003 | 63319454 |
| Fall | 51.58 | 19.35 | 19 | 16546 | 392315 | 63080142 |
| Peripheral swelling | 51.36 | 19.35 | 5 | 16560 | 265937 | 63206520 |
| Graft loss | 50.73 | 19.35 | 13 | 16552 | 360 | 63472097 |
| Myelosuppression | 50.54 | 19.35 | 45 | 16520 | 23658 | 63448799 |
| Joint swelling | 50.09 | 19.35 | 12 | 16553 | 327654 | 63144803 |
| Adenoviral hepatitis | 49.80 | 19.35 | 13 | 16552 | 388 | 63472069 |
| Bone marrow failure | 49.74 | 19.35 | 49 | 16516 | 29241 | 63443216 |
| Epstein-Barr virus infection reactivation | 49.37 | 19.35 | 15 | 16550 | 783 | 63471674 |
| Swelling | 48.68 | 19.35 | 7 | 16558 | 275371 | 63197086 |
| No adverse event | 48.67 | 19.35 | 57 | 16508 | 41348 | 63431109 |
| Liver transplant rejection | 48.25 | 19.35 | 17 | 16548 | 1418 | 63471039 |
| Pseudomonas infection | 47.50 | 19.35 | 32 | 16533 | 11181 | 63461276 |
| Systemic candida | 47.29 | 19.35 | 21 | 16544 | 3224 | 63469233 |
| Infusion related reaction | 46.41 | 19.35 | 5 | 16560 | 245516 | 63226941 |
| Hypersensitivity | 46.17 | 19.35 | 10 | 16555 | 292675 | 63179782 |
| Urosepsis | 45.23 | 19.35 | 38 | 16527 | 18486 | 63453971 |
| SARS-CoV-2 RNA increased | 45.08 | 19.35 | 9 | 16556 | 76 | 63472381 |
| Product use in unapproved indication | 44.92 | 19.35 | 125 | 16440 | 178955 | 63293502 |
| Pyelonephritis | 44.50 | 19.35 | 37 | 16528 | 17741 | 63454716 |
| Cytopenia | 44.17 | 19.35 | 31 | 16534 | 11570 | 63460887 |
| Toxoplasmosis | 43.53 | 19.35 | 16 | 16549 | 1507 | 63470950 |
| Mucormycosis | 43.19 | 19.35 | 19 | 16546 | 2852 | 63469605 |
| Hepatocellular injury | 43.17 | 19.35 | 44 | 16521 | 27337 | 63445120 |
| Abdominal discomfort | 43.07 | 19.35 | 15 | 16550 | 320870 | 63151587 |
| Dizziness | 42.81 | 19.35 | 30 | 16535 | 429895 | 63042562 |
| Anaemia | 42.44 | 19.35 | 170 | 16395 | 293260 | 63179197 |
| Pneumonia fungal | 42.44 | 19.35 | 23 | 16542 | 5432 | 63467025 |
| Adrenal mass | 42.25 | 19.35 | 14 | 16551 | 970 | 63471487 |
| Oesophageal candidiasis | 41.63 | 19.35 | 23 | 16542 | 5640 | 63466817 |
| Bacterial infection | 41.53 | 19.35 | 37 | 16528 | 19462 | 63452995 |
| Pericarditis constrictive | 41.40 | 19.35 | 11 | 16554 | 352 | 63472105 |
| Parvovirus B19 infection | 41.09 | 19.35 | 12 | 16553 | 546 | 63471911 |
| Cholestasis | 40.53 | 19.35 | 44 | 16521 | 29390 | 63443067 |
| Proteus infection | 40.37 | 19.35 | 14 | 16551 | 1114 | 63471343 |
| Cryptococcosis | 40.02 | 19.35 | 14 | 16551 | 1143 | 63471314 |
| Cytomegalovirus oesophagitis | 39.70 | 19.35 | 10 | 16555 | 258 | 63472199 |
| Venoocclusive liver disease | 39.33 | 19.35 | 21 | 16544 | 4814 | 63467643 |
| Weight increased | 38.97 | 19.35 | 10 | 16555 | 260782 | 63211675 |
| Multiple organ dysfunction syndrome | 38.82 | 19.35 | 60 | 16505 | 56692 | 63415765 |
| Alopecia | 38.56 | 19.35 | 20 | 16545 | 337516 | 63134941 |
| Cervicitis | 37.74 | 19.35 | 11 | 16554 | 497 | 63471960 |
| Drug hypersensitivity | 37.63 | 19.35 | 17 | 16548 | 310670 | 63161787 |
| Drug level increased | 36.69 | 19.35 | 37 | 16528 | 22699 | 63449758 |
| Acinetobacter infection | 35.75 | 19.35 | 14 | 16551 | 1569 | 63470888 |
| Pleural mesothelioma malignant | 35.74 | 19.35 | 7 | 16558 | 53 | 63472404 |
| JC virus infection | 35.54 | 19.35 | 15 | 16550 | 2036 | 63470421 |
| Brain abscess | 35.08 | 19.35 | 15 | 16550 | 2103 | 63470354 |
| Cystitis haemorrhagic | 33.80 | 19.35 | 18 | 16547 | 4105 | 63468352 |
| Pyrexia | 33.80 | 19.35 | 224 | 16341 | 470254 | 63002203 |
| Urinary tract infection | 33.30 | 19.35 | 147 | 16418 | 264537 | 63207920 |
| Systemic lupus erythematosus | 33.21 | 19.35 | 7 | 16558 | 208911 | 63263546 |
| Renal artery stenosis | 33.21 | 19.35 | 14 | 16551 | 1895 | 63470562 |
| Pain in extremity | 33.15 | 19.35 | 23 | 16542 | 331463 | 63140994 |
| Aplasia pure red cell | 32.37 | 19.35 | 18 | 16547 | 4469 | 63467988 |
| Escherichia urinary tract infection | 32.26 | 19.35 | 26 | 16539 | 11936 | 63460521 |
| Drug intolerance | 31.41 | 19.35 | 21 | 16544 | 308640 | 63163817 |
| Product dose omission issue | 31.34 | 19.35 | 11 | 16554 | 234302 | 63238155 |
| Superinfection bacterial | 31.05 | 19.35 | 10 | 16555 | 633 | 63471824 |
| Drug interaction | 30.92 | 19.35 | 130 | 16435 | 229001 | 63243456 |
| Ascites | 30.61 | 19.35 | 45 | 16520 | 40683 | 63431774 |
| Parainfluenzae virus infection | 30.55 | 19.35 | 14 | 16551 | 2313 | 63470144 |
| Urate nephropathy | 30.51 | 19.35 | 7 | 16558 | 120 | 63472337 |
| Rash | 30.45 | 19.35 | 63 | 16502 | 560808 | 62911649 |
| Human herpesvirus 8 infection | 30.29 | 19.35 | 8 | 16557 | 250 | 63472207 |
| Epstein-Barr virus associated lymphoproliferative disorder | 30.01 | 19.35 | 13 | 16552 | 1881 | 63470576 |
| Tonic clonic movements | 29.99 | 19.35 | 12 | 16553 | 1423 | 63471034 |
| Mesothelioma malignant | 29.61 | 19.35 | 6 | 16559 | 55 | 63472402 |
| Cytomegalovirus enteritis | 29.34 | 19.35 | 8 | 16557 | 283 | 63472174 |
| Eye infection toxoplasmal | 29.23 | 19.35 | 8 | 16557 | 287 | 63472170 |
| Venous haemorrhage | 29.18 | 19.35 | 8 | 16557 | 289 | 63472168 |
| Septal panniculitis | 28.87 | 19.35 | 6 | 16559 | 63 | 63472394 |
| Dyspnoea | 28.32 | 19.35 | 84 | 16481 | 661229 | 62811228 |
| Escherichia sepsis | 27.94 | 19.35 | 17 | 16548 | 4990 | 63467467 |
| Complications of transplant surgery | 27.93 | 19.35 | 7 | 16558 | 177 | 63472280 |
| Pancreatic pseudoaneurysm | 27.70 | 19.35 | 6 | 16559 | 78 | 63472379 |
| Cytomegalovirus gastritis | 27.67 | 19.35 | 7 | 16558 | 184 | 63472273 |
| Superinfection viral | 27.65 | 19.35 | 5 | 16560 | 23 | 63472434 |
| Urinary tract infection bacterial | 27.58 | 19.35 | 17 | 16548 | 5105 | 63467352 |
| Cytomegalovirus hepatitis | 27.52 | 19.35 | 8 | 16557 | 358 | 63472099 |
| Colon injury | 27.49 | 19.35 | 7 | 16558 | 189 | 63472268 |
| Reticulocytopenia | 27.42 | 19.35 | 6 | 16559 | 82 | 63472375 |
| Insomnia | 27.29 | 19.35 | 11 | 16554 | 215241 | 63257216 |
| Febrile neutropenia | 27.07 | 19.35 | 80 | 16485 | 118369 | 63354088 |
| Hyperuricaemia | 26.84 | 19.35 | 17 | 16548 | 5353 | 63467104 |
| Epstein-Barr viraemia | 26.63 | 19.35 | 10 | 16555 | 1000 | 63471457 |
| Hydronephrosis | 26.29 | 19.35 | 22 | 16543 | 10640 | 63461817 |
| Diabetes mellitus | 26.28 | 19.35 | 50 | 16515 | 55760 | 63416697 |
| Hepatic necrosis | 25.95 | 19.35 | 17 | 16548 | 5670 | 63466787 |
| Feeling abnormal | 25.67 | 19.35 | 4 | 16561 | 148388 | 63324069 |
| Back pain | 25.51 | 19.35 | 19 | 16546 | 264126 | 63208331 |
| Citrobacter infection | 25.50 | 19.35 | 8 | 16557 | 465 | 63471992 |
| Urticaria | 25.45 | 19.35 | 6 | 16559 | 165796 | 63306661 |
| Respiratory failure | 25.41 | 19.35 | 71 | 16494 | 101787 | 63370670 |
| Muscle spasms | 25.29 | 19.35 | 5 | 16560 | 156145 | 63316312 |
| Central nervous system fungal infection | 25.09 | 19.35 | 6 | 16559 | 124 | 63472333 |
| Infection reactivation | 24.96 | 19.35 | 10 | 16555 | 1189 | 63471268 |
| Acute graft versus host disease | 24.62 | 19.35 | 15 | 16550 | 4413 | 63468044 |
| Microsporidia infection | 24.60 | 19.35 | 7 | 16558 | 290 | 63472167 |
| Liver transplant | 24.60 | 19.35 | 12 | 16553 | 2279 | 63470178 |
| Oral candidiasis | 24.51 | 19.35 | 30 | 16535 | 22768 | 63449689 |
| Herpes simplex | 24.50 | 19.35 | 19 | 16546 | 8252 | 63464205 |
| Rhinovirus infection | 24.30 | 19.35 | 15 | 16550 | 4514 | 63467943 |
| Pancreas transplant rejection | 24.12 | 19.35 | 6 | 16559 | 147 | 63472310 |
| Pulmonary mucormycosis | 23.81 | 19.35 | 7 | 16558 | 326 | 63472131 |
| Herpes simplex viraemia | 23.75 | 19.35 | 7 | 16558 | 329 | 63472128 |
| Heart transplant rejection | 23.44 | 19.35 | 8 | 16557 | 607 | 63471850 |
| Graft versus host disease in gastrointestinal tract | 23.37 | 19.35 | 13 | 16552 | 3228 | 63469229 |
| Malaise | 23.16 | 19.35 | 46 | 16519 | 415908 | 63056549 |
| Renal lymphocele | 23.08 | 19.35 | 5 | 16560 | 65 | 63472392 |
| Herpes simplex oesophagitis | 22.99 | 19.35 | 6 | 16559 | 179 | 63472278 |
| Bacteriuria | 22.68 | 19.35 | 9 | 16556 | 1044 | 63471413 |
| Nasopharyngitis | 22.42 | 19.35 | 20 | 16545 | 254237 | 63218220 |
| Bacteraemia | 22.26 | 19.35 | 25 | 16540 | 17323 | 63455134 |
| Disseminated cryptococcosis | 21.97 | 19.35 | 7 | 16558 | 428 | 63472029 |
| Contusion | 21.93 | 19.35 | 6 | 16559 | 150038 | 63322419 |
| Respiratory tract infection viral | 21.89 | 19.35 | 11 | 16554 | 2226 | 63470231 |
| Pericarditis | 21.76 | 19.35 | 4 | 16561 | 131575 | 63340882 |
| Pneumonia influenzal | 21.62 | 19.35 | 10 | 16555 | 1687 | 63470770 |
| Pulmonary alveolar haemorrhage | 21.41 | 19.35 | 14 | 16551 | 4654 | 63467803 |
| Calciphylaxis | 21.28 | 19.35 | 12 | 16553 | 3060 | 63469397 |
| Escherichia bacteraemia | 21.19 | 19.35 | 13 | 16552 | 3870 | 63468587 |
| Glomerulonephritis | 21.02 | 19.35 | 10 | 16555 | 1796 | 63470661 |
| Viral mutation identified | 21.00 | 19.35 | 10 | 16555 | 1800 | 63470657 |
| Renal failure | 20.99 | 19.35 | 73 | 16492 | 117579 | 63354878 |
| Genital lesion | 20.99 | 19.35 | 6 | 16559 | 253 | 63472204 |
| Hypercalcaemia | 20.86 | 19.35 | 31 | 16534 | 28291 | 63444166 |
| Complications of transplanted lung | 20.76 | 19.35 | 6 | 16559 | 263 | 63472194 |
| Hepatic cyst infection | 20.74 | 19.35 | 5 | 16560 | 107 | 63472350 |
| Anorexia nervosa | 20.74 | 19.35 | 6 | 16559 | 264 | 63472193 |
| Headache | 20.72 | 19.35 | 90 | 16475 | 633151 | 62839306 |
| Haemolytic uraemic syndrome | 20.72 | 19.35 | 11 | 16554 | 2492 | 63469965 |
| Hypertensive emergency | 20.63 | 19.35 | 10 | 16555 | 1872 | 63470585 |
| Haematotoxicity | 20.38 | 19.35 | 18 | 16547 | 9358 | 63463099 |
| Asterixis | 20.21 | 19.35 | 9 | 16556 | 1390 | 63471067 |
| Herpes simplex reactivation | 20.14 | 19.35 | 7 | 16558 | 561 | 63471896 |
| Hyperkalaemia | 20.11 | 19.35 | 44 | 16521 | 54159 | 63418298 |
| Coronavirus infection | 20.04 | 19.35 | 13 | 16552 | 4265 | 63468192 |
| Nephrogenic diabetes insipidus | 19.97 | 19.35 | 8 | 16557 | 951 | 63471506 |
| Immunosuppressant drug level decreased | 19.94 | 19.35 | 8 | 16557 | 955 | 63471502 |
| Delayed engraftment | 19.70 | 19.35 | 5 | 16560 | 133 | 63472324 |
| Obliterative bronchiolitis | 19.62 | 19.35 | 10 | 16555 | 2085 | 63470372 |
| Epstein-Barr virus test positive | 19.48 | 19.35 | 7 | 16558 | 618 | 63471839 |
| Serum sickness | 19.35 | 19.35 | 11 | 16554 | 2849 | 63469608 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cytomegalovirus infection | 832.90 | 16.08 | 401 | 25739 | 25734 | 34905057 |
| Cytomegalovirus viraemia | 644.07 | 16.08 | 233 | 25907 | 7197 | 34923594 |
| Leukopenia | 512.38 | 16.08 | 403 | 25737 | 62453 | 34868338 |
| Transplant rejection | 462.84 | 16.08 | 201 | 25939 | 10110 | 34920681 |
| Drug resistance | 349.24 | 16.08 | 226 | 25914 | 25701 | 34905090 |
| Polyomavirus-associated nephropathy | 243.86 | 16.08 | 96 | 26044 | 3748 | 34927043 |
| Pathogen resistance | 238.18 | 16.08 | 124 | 26016 | 9358 | 34921433 |
| Neutropenia | 220.94 | 16.08 | 409 | 25731 | 156369 | 34774422 |
| Kidney transplant rejection | 208.46 | 16.08 | 105 | 26035 | 7392 | 34923399 |
| Complications of transplanted kidney | 197.46 | 16.08 | 87 | 26053 | 4522 | 34926269 |
| Cytomegalovirus colitis | 196.00 | 16.08 | 75 | 26065 | 2709 | 34928082 |
| Off label use | 188.36 | 16.08 | 712 | 25428 | 418812 | 34511979 |
| Nocardiosis | 183.67 | 16.08 | 79 | 26061 | 3872 | 34926919 |
| Delayed graft function | 175.10 | 16.08 | 65 | 26075 | 2156 | 34928635 |
| BK virus infection | 173.24 | 16.08 | 85 | 26055 | 5653 | 34925138 |
| Cytomegalovirus chorioretinitis | 161.06 | 16.08 | 70 | 26070 | 3519 | 34927272 |
| Post transplant lymphoproliferative disorder | 160.01 | 16.08 | 84 | 26056 | 6444 | 34924347 |
| Transplant dysfunction | 153.55 | 16.08 | 62 | 26078 | 2587 | 34928204 |
| Pneumonia cytomegaloviral | 151.67 | 16.08 | 64 | 26076 | 2990 | 34927801 |
| Cytomegalovirus infection reactivation | 146.15 | 16.08 | 73 | 26067 | 5045 | 34925746 |
| Pancytopenia | 142.28 | 16.08 | 255 | 25885 | 94902 | 34835889 |
| Immunosuppressant drug level increased | 134.57 | 16.08 | 73 | 26067 | 5982 | 34924809 |
| Encephalitis cytomegalovirus | 130.05 | 16.08 | 38 | 26102 | 580 | 34930211 |
| Epstein-Barr virus infection | 116.34 | 16.08 | 72 | 26068 | 7556 | 34923235 |
| Immune reconstitution inflammatory syndrome | 112.06 | 16.08 | 74 | 26066 | 8685 | 34922106 |
| Aspergillus infection | 111.38 | 16.08 | 84 | 26056 | 12170 | 34918621 |
| Cytomegalovirus syndrome | 110.84 | 16.08 | 24 | 26116 | 93 | 34930698 |
| Mucormycosis | 108.57 | 16.08 | 63 | 26077 | 5879 | 34924912 |
| Agranulocytosis | 108.24 | 16.08 | 110 | 26030 | 23711 | 34907080 |
| Pulmonary nocardiosis | 107.65 | 16.08 | 36 | 26104 | 872 | 34929919 |
| Human ehrlichiosis | 106.05 | 16.08 | 29 | 26111 | 343 | 34930448 |
| Cytomegalovirus enteritis | 105.92 | 16.08 | 31 | 26109 | 476 | 34930315 |
| Malacoplakia | 99.84 | 16.08 | 29 | 26111 | 433 | 34930358 |
| Cytomegalovirus gastrointestinal infection | 99.56 | 16.08 | 25 | 26115 | 206 | 34930585 |
| Thrombotic microangiopathy | 96.90 | 16.08 | 73 | 26067 | 10557 | 34920234 |
| Cytomegalovirus test positive | 95.21 | 16.08 | 50 | 26090 | 3836 | 34926955 |
| Renal impairment | 88.65 | 16.08 | 209 | 25931 | 94304 | 34836487 |
| Pneumocystis jirovecii pneumonia | 80.53 | 16.08 | 86 | 26054 | 19624 | 34911167 |
| Nephropathy toxic | 79.93 | 16.08 | 70 | 26070 | 12518 | 34918273 |
| Septic shock | 79.83 | 16.08 | 170 | 25970 | 71664 | 34859127 |
| Escherichia infection | 78.22 | 16.08 | 58 | 26082 | 8187 | 34922604 |
| Lung transplant rejection | 76.74 | 16.08 | 27 | 26113 | 765 | 34930026 |
| Enterococcal infection | 76.27 | 16.08 | 60 | 26080 | 9246 | 34921545 |
| Lymphopenia | 75.23 | 16.08 | 76 | 26064 | 16259 | 34914532 |
| Fall | 75.02 | 16.08 | 29 | 26111 | 202856 | 34727935 |
| Enterovirus infection | 74.59 | 16.08 | 28 | 26112 | 958 | 34929833 |
| Cryptococcosis | 73.50 | 16.08 | 36 | 26104 | 2383 | 34928408 |
| Fatigue | 72.79 | 16.08 | 103 | 26037 | 370550 | 34560241 |
| Klebsiella infection | 69.91 | 16.08 | 55 | 26085 | 8476 | 34922315 |
| Renal artery stenosis | 69.75 | 16.08 | 34 | 26106 | 2227 | 34928564 |
| Liver transplant rejection | 68.80 | 16.08 | 33 | 26107 | 2086 | 34928705 |
| Rectal prolapse | 68.38 | 16.08 | 22 | 26118 | 470 | 34930321 |
| Bone marrow failure | 67.97 | 16.08 | 96 | 26044 | 29157 | 34901634 |
| Cytomegalovirus oesophagitis | 67.77 | 16.08 | 22 | 26118 | 484 | 34930307 |
| Renal cyst haemorrhage | 66.59 | 16.08 | 23 | 26117 | 616 | 34930175 |
| Myelosuppression | 66.55 | 16.08 | 77 | 26063 | 19188 | 34911603 |
| Mycobacterium avium complex infection | 66.37 | 16.08 | 34 | 26106 | 2477 | 34928314 |
| Pseudomonas infection | 65.21 | 16.08 | 62 | 26078 | 12320 | 34918471 |
| Trichophytosis | 64.96 | 16.08 | 19 | 26121 | 291 | 34930500 |
| Polyomavirus viraemia | 64.87 | 16.08 | 25 | 26115 | 920 | 34929871 |
| Intraductal papillary mucinous neoplasm | 62.58 | 16.08 | 21 | 26119 | 514 | 34930277 |
| Glomerulosclerosis | 60.64 | 16.08 | 23 | 26117 | 810 | 34929981 |
| Dermatophytosis | 60.41 | 16.08 | 17 | 26123 | 225 | 34930566 |
| Intentional product use issue | 60.13 | 16.08 | 136 | 26004 | 59680 | 34871111 |
| Pain | 56.98 | 16.08 | 42 | 26098 | 204633 | 34726158 |
| Vena cava injury | 54.71 | 16.08 | 17 | 26123 | 323 | 34930468 |
| Somnolence | 54.19 | 16.08 | 9 | 26131 | 111107 | 34819684 |
| Candida infection | 53.29 | 16.08 | 66 | 26074 | 17649 | 34913142 |
| Myocardial infarction | 52.43 | 16.08 | 13 | 26127 | 121072 | 34809719 |
| Focal segmental glomerulosclerosis | 52.31 | 16.08 | 27 | 26113 | 1998 | 34928793 |
| Viral load increased | 52.10 | 16.08 | 29 | 26111 | 2498 | 34928293 |
| Disseminated varicella zoster virus infection | 51.44 | 16.08 | 16 | 26124 | 305 | 34930486 |
| Bronchopulmonary aspergillosis | 51.31 | 16.08 | 59 | 26081 | 14600 | 34916191 |
| SARS-CoV-2 antibody test positive | 51.01 | 16.08 | 17 | 26123 | 407 | 34930384 |
| Product use in unapproved indication | 50.97 | 16.08 | 198 | 25942 | 117301 | 34813490 |
| Toxoplasmosis | 50.48 | 16.08 | 23 | 26117 | 1293 | 34929498 |
| Product dose omission issue | 49.65 | 16.08 | 14 | 26126 | 119697 | 34811094 |
| Parvovirus B19 infection | 49.51 | 16.08 | 20 | 26120 | 835 | 34929956 |
| Abdominal wall haemorrhage | 48.60 | 16.08 | 17 | 26123 | 473 | 34930318 |
| Cytopenia | 47.58 | 16.08 | 53 | 26087 | 12670 | 34918121 |
| Actinic keratosis | 47.57 | 16.08 | 34 | 26106 | 4533 | 34926258 |
| Large intestinal ulcer | 47.28 | 16.08 | 25 | 26115 | 1944 | 34928847 |
| Subcapsular renal haematoma | 47.06 | 16.08 | 16 | 26124 | 408 | 34930383 |
| Pain in extremity | 46.85 | 16.08 | 18 | 26122 | 126495 | 34804296 |
| Brain abscess | 46.39 | 16.08 | 29 | 26111 | 3096 | 34927695 |
| Pyelonephritis fungal | 46.15 | 16.08 | 11 | 26129 | 71 | 34930720 |
| Dizziness | 45.54 | 16.08 | 58 | 26082 | 218463 | 34712328 |
| Thrombocytopenia | 44.93 | 16.08 | 233 | 25907 | 156014 | 34774777 |
| Vascular anastomotic haemorrhage | 44.71 | 16.08 | 14 | 26126 | 273 | 34930518 |
| Kidney fibrosis | 44.39 | 16.08 | 25 | 26115 | 2203 | 34928588 |
| Squamous cell carcinoma of skin | 43.59 | 16.08 | 47 | 26093 | 10834 | 34919957 |
| Renal tubular necrosis | 43.33 | 16.08 | 56 | 26084 | 15624 | 34915167 |
| Fungal skin infection | 43.07 | 16.08 | 26 | 26114 | 2608 | 34928183 |
| Carotid arteriosclerosis | 42.95 | 16.08 | 23 | 26117 | 1835 | 34928956 |
| Granulomatous dermatitis | 41.40 | 16.08 | 13 | 26127 | 256 | 34930535 |
| Perineal cyst | 41.26 | 16.08 | 13 | 26127 | 259 | 34930532 |
| Syncope | 41.20 | 16.08 | 9 | 26131 | 91442 | 34839349 |
| Lymphocele | 40.64 | 16.08 | 20 | 26120 | 1337 | 34929454 |
| Pyrexia | 39.03 | 16.08 | 400 | 25740 | 332613 | 34598178 |
| Infection reactivation | 38.77 | 16.08 | 20 | 26120 | 1478 | 34929313 |
| Pericarditis fungal | 38.72 | 16.08 | 11 | 26129 | 151 | 34930640 |
| Clostridium difficile colitis | 38.58 | 16.08 | 53 | 26087 | 15677 | 34915114 |
| Pneumocystis jirovecii infection | 38.38 | 16.08 | 21 | 26119 | 1749 | 34929042 |
| Escherichia urinary tract infection | 38.32 | 16.08 | 27 | 26113 | 3519 | 34927272 |
| Transplant failure | 38.27 | 16.08 | 27 | 26113 | 3526 | 34927265 |
| Hyperparathyroidism secondary | 37.91 | 16.08 | 20 | 26120 | 1548 | 34929243 |
| Graft versus host disease | 37.77 | 16.08 | 43 | 26097 | 10526 | 34920265 |
| Pulmonary mucormycosis | 37.52 | 16.08 | 16 | 26124 | 767 | 34930024 |
| Renal tubular injury | 37.14 | 16.08 | 17 | 26123 | 966 | 34929825 |
| Vascular compression | 37.12 | 16.08 | 13 | 26127 | 363 | 34930428 |
| Rash | 36.94 | 16.08 | 69 | 26071 | 222683 | 34708108 |
| Constipation | 36.94 | 16.08 | 29 | 26111 | 136953 | 34793838 |
| Haemophagocytic lymphohistiocytosis | 36.89 | 16.08 | 47 | 26093 | 12926 | 34917865 |
| Cystitis haemorrhagic | 36.89 | 16.08 | 32 | 26108 | 5647 | 34925144 |
| JC virus infection | 36.63 | 16.08 | 22 | 26118 | 2186 | 34928605 |
| Dyspnoea | 36.27 | 16.08 | 152 | 25988 | 376630 | 34554161 |
| Arthralgia | 35.54 | 16.08 | 45 | 26095 | 169996 | 34760795 |
| Nausea | 35.32 | 16.08 | 133 | 26007 | 339775 | 34591016 |
| Renal transplant failure | 35.23 | 16.08 | 17 | 26123 | 1089 | 34929702 |
| Disseminated cytomegaloviral infection | 35.11 | 16.08 | 11 | 26129 | 215 | 34930576 |
| Strongyloidiasis | 34.90 | 16.08 | 23 | 26117 | 2688 | 34928103 |
| Aortic dilatation | 34.24 | 16.08 | 18 | 26122 | 1383 | 34929408 |
| Hepatic artery thrombosis | 34.10 | 16.08 | 11 | 26129 | 237 | 34930554 |
| Staphylococcal mediastinitis | 33.92 | 16.08 | 8 | 26132 | 49 | 34930742 |
| Liver transplant | 33.84 | 16.08 | 22 | 26118 | 2512 | 34928279 |
| Anxiety | 33.84 | 16.08 | 16 | 26124 | 99412 | 34831379 |
| Botulism | 33.72 | 16.08 | 10 | 26130 | 161 | 34930630 |
| Rhinovirus infection | 33.68 | 16.08 | 27 | 26113 | 4272 | 34926519 |
| Fungal endocarditis | 33.20 | 16.08 | 12 | 26128 | 368 | 34930423 |
| Malaise | 33.12 | 16.08 | 55 | 26085 | 185770 | 34745021 |
| Gastroenteritis Escherichia coli | 32.69 | 16.08 | 12 | 26128 | 385 | 34930406 |
| Depression | 32.47 | 16.08 | 16 | 26124 | 97082 | 34833709 |
| Staphylococcal infection | 32.35 | 16.08 | 74 | 26066 | 32686 | 34898105 |
| Tubulointerstitial nephritis | 32.17 | 16.08 | 57 | 26083 | 20967 | 34909824 |
| Cytomegalovirus nephritis | 31.85 | 16.08 | 9 | 26131 | 121 | 34930670 |
| Blood creatinine increased | 31.80 | 16.08 | 148 | 25992 | 94828 | 34835963 |
| Asthenia | 31.69 | 16.08 | 87 | 26053 | 245164 | 34685627 |
| Mean cell volume increased | 31.65 | 16.08 | 23 | 26117 | 3146 | 34927645 |
| Retinal scar | 31.42 | 16.08 | 11 | 26129 | 307 | 34930484 |
| Gene mutation | 31.35 | 16.08 | 17 | 26123 | 1391 | 34929400 |
| Feeling abnormal | 31.09 | 16.08 | 5 | 26135 | 63230 | 34867561 |
| Hyperparathyroidism | 30.70 | 16.08 | 16 | 26124 | 1208 | 34929583 |
| Cardiac failure congestive | 30.56 | 16.08 | 12 | 26128 | 83258 | 34847533 |
| Viraemia | 30.53 | 16.08 | 16 | 26124 | 1222 | 34929569 |
| Hypogammaglobulinaemia | 30.25 | 16.08 | 33 | 26107 | 7707 | 34923084 |
| Cell-mediated cytotoxicity | 30.25 | 16.08 | 7 | 26133 | 39 | 34930752 |
| Granulomatous rosacea | 30.23 | 16.08 | 9 | 26131 | 147 | 34930644 |
| Gastritis fungal | 30.12 | 16.08 | 8 | 26132 | 84 | 34930707 |
| Cytomegalovirus gastritis | 30.02 | 16.08 | 10 | 26130 | 239 | 34930552 |
| Cutaneous nocardiosis | 29.63 | 16.08 | 9 | 26131 | 158 | 34930633 |
| Blood 25-hydroxycholecalciferol decreased | 29.27 | 16.08 | 10 | 26130 | 259 | 34930532 |
| Steroid diabetes | 29.18 | 16.08 | 19 | 26121 | 2176 | 34928615 |
| Headache | 29.15 | 16.08 | 67 | 26073 | 200568 | 34730223 |
| Gastrointestinal haemorrhage | 28.95 | 16.08 | 15 | 26125 | 88462 | 34842329 |
| Chronic papillomatous dermatitis | 28.75 | 16.08 | 7 | 26133 | 50 | 34930741 |
| Disseminated trichosporonosis | 28.40 | 16.08 | 7 | 26133 | 53 | 34930738 |
| Renal tubular acidosis | 28.23 | 16.08 | 19 | 26121 | 2300 | 34928491 |
| Cerebral toxoplasmosis | 28.17 | 16.08 | 17 | 26123 | 1704 | 34929087 |
| Hepatosplenomegaly | 28.11 | 16.08 | 24 | 26116 | 4145 | 34926646 |
| Hyperhidrosis | 27.62 | 16.08 | 11 | 26129 | 75681 | 34855110 |
| Cytomegalovirus hepatitis | 27.39 | 16.08 | 11 | 26129 | 452 | 34930339 |
| Aplasia pure red cell | 27.26 | 16.08 | 28 | 26112 | 6104 | 34924687 |
| Malignant neoplasm progression | 27.25 | 16.08 | 16 | 26124 | 88030 | 34842761 |
| Muscle spasms | 27.20 | 16.08 | 11 | 26129 | 74990 | 34855801 |
| Progressive multifocal leukoencephalopathy | 27.17 | 16.08 | 35 | 26105 | 9729 | 34921062 |
| Intervertebral disc space narrowing | 27.06 | 16.08 | 14 | 26126 | 1041 | 34929750 |
| Glomerulonephropathy | 27.03 | 16.08 | 9 | 26131 | 215 | 34930576 |
| Scrotal ulcer | 26.94 | 16.08 | 11 | 26129 | 472 | 34930319 |
| Multiple organ dysfunction syndrome | 26.88 | 16.08 | 121 | 26019 | 76445 | 34854346 |
| Diverticulum intestinal | 26.81 | 16.08 | 23 | 26117 | 3998 | 34926793 |
| Fungal infection | 26.73 | 16.08 | 45 | 26095 | 15890 | 34914901 |
| Epstein-Barr virus infection reactivation | 26.46 | 16.08 | 14 | 26126 | 1090 | 34929701 |
| Proteus infection | 26.44 | 16.08 | 14 | 26126 | 1092 | 34929699 |
| Swelling of eyelid | 26.38 | 16.08 | 14 | 26126 | 1097 | 34929694 |
| Penile ulceration | 26.06 | 16.08 | 11 | 26129 | 514 | 34930277 |
| Back pain | 25.67 | 16.08 | 32 | 26108 | 121757 | 34809034 |
| Protothecosis | 25.55 | 16.08 | 6 | 26134 | 36 | 34930755 |
| Heart transplant rejection | 25.03 | 16.08 | 14 | 26126 | 1217 | 34929574 |
| Peripheral swelling | 25.00 | 16.08 | 13 | 26127 | 76528 | 34854263 |
| Joint swelling | 24.82 | 16.08 | 7 | 26133 | 59883 | 34870908 |
| Urticaria | 24.57 | 16.08 | 8 | 26132 | 62369 | 34868422 |
| Nasopharyngitis | 24.20 | 16.08 | 11 | 26129 | 69957 | 34860834 |
| Epstein-Barr viraemia | 24.20 | 16.08 | 14 | 26126 | 1298 | 34929493 |
| Odynophagia | 24.16 | 16.08 | 25 | 26115 | 5496 | 34925295 |
| Aortic arteriosclerosis | 24.00 | 16.08 | 23 | 26117 | 4613 | 34926178 |
| Isosporiasis | 23.47 | 16.08 | 7 | 26133 | 115 | 34930676 |
| End stage renal disease | 23.47 | 16.08 | 31 | 26109 | 8830 | 34921961 |
| Graft loss | 23.46 | 16.08 | 12 | 26128 | 871 | 34929920 |
| Neutropenic colitis | 23.06 | 16.08 | 19 | 26121 | 3125 | 34927666 |
| Oesophagopleural fistula | 23.04 | 16.08 | 6 | 26134 | 58 | 34930733 |
| Myocarditis toxoplasmal | 23.04 | 16.08 | 6 | 26134 | 58 | 34930733 |
| Gait disturbance | 22.97 | 16.08 | 18 | 26122 | 85122 | 34845669 |
| No adverse event | 22.87 | 16.08 | 52 | 26088 | 22875 | 34907916 |
| Drug intolerance | 22.83 | 16.08 | 8 | 26132 | 59562 | 34871229 |
| Therapeutic product effect incomplete | 22.70 | 16.08 | 5 | 26135 | 50536 | 34880255 |
| Type 3 diabetes mellitus | 22.58 | 16.08 | 5 | 26135 | 22 | 34930769 |
| Encephalitis viral | 22.53 | 16.08 | 13 | 26127 | 1199 | 34929592 |
| Organising pneumonia | 22.51 | 16.08 | 25 | 26115 | 5954 | 34924837 |
| Eye infection toxoplasmal | 22.49 | 16.08 | 8 | 26132 | 234 | 34930557 |
| Human polyomavirus infection | 22.39 | 16.08 | 11 | 26129 | 733 | 34930058 |
| Optic discs blurred | 22.17 | 16.08 | 6 | 26134 | 68 | 34930723 |
| Immunosuppressant drug level decreased | 22.12 | 16.08 | 13 | 26127 | 1241 | 34929550 |
| Epistaxis | 22.03 | 16.08 | 8 | 26132 | 58243 | 34872548 |
| Pneumonia necrotising | 21.97 | 16.08 | 11 | 26129 | 763 | 34930028 |
| Biloma | 21.94 | 16.08 | 6 | 26134 | 71 | 34930720 |
| Bacterial toxaemia | 21.91 | 16.08 | 7 | 26133 | 146 | 34930645 |
| Pruritus | 21.77 | 16.08 | 46 | 26094 | 141935 | 34788856 |
| Agitation | 21.51 | 16.08 | 8 | 26132 | 57391 | 34873400 |
| Acute kidney injury | 21.32 | 16.08 | 333 | 25807 | 304655 | 34626136 |
| Graft versus host disease in skin | 21.32 | 16.08 | 20 | 26120 | 3905 | 34926886 |
| Immune recovery uveitis | 21.29 | 16.08 | 5 | 26135 | 30 | 34930761 |
| Blood creatine phosphokinase increased | 21.05 | 16.08 | 4 | 26136 | 44853 | 34885938 |
| Toxic optic neuropathy | 21.00 | 16.08 | 11 | 26129 | 839 | 34929952 |
| Lung transplant | 20.92 | 16.08 | 15 | 26125 | 2009 | 34928782 |
| Haemolytic anaemia | 20.87 | 16.08 | 32 | 26108 | 10447 | 34920344 |
| Anastomotic stenosis | 20.87 | 16.08 | 8 | 26132 | 290 | 34930501 |
| Left ventricular hypertrophy | 20.85 | 16.08 | 28 | 26112 | 8102 | 34922689 |
| Posterior reversible encephalopathy syndrome | 20.68 | 16.08 | 31 | 26109 | 9923 | 34920868 |
| Electrocardiogram QT prolonged | 20.67 | 16.08 | 3 | 26137 | 40949 | 34889842 |
| Erythrophagocytosis | 20.63 | 16.08 | 5 | 26135 | 35 | 34930756 |
| Pneumonia fungal | 20.62 | 16.08 | 26 | 26114 | 7074 | 34923717 |
| Osteomyelitis chronic | 20.54 | 16.08 | 8 | 26132 | 303 | 34930488 |
| Drug hypersensitivity | 20.52 | 16.08 | 18 | 26122 | 80511 | 34850280 |
| Staphylococcal skin infection | 20.48 | 16.08 | 11 | 26129 | 883 | 34929908 |
| Periorbital cellulitis | 20.44 | 16.08 | 8 | 26132 | 307 | 34930484 |
| Renal tubular atrophy | 20.28 | 16.08 | 12 | 26128 | 1160 | 34929631 |
| Restless legs syndrome | 20.26 | 16.08 | 28 | 26112 | 8326 | 34922465 |
| Rhabdomyolysis | 20.24 | 16.08 | 13 | 26127 | 68150 | 34862641 |
| Cutaneous mucormycosis | 20.21 | 16.08 | 7 | 26133 | 189 | 34930602 |
| Muscular weakness | 20.19 | 16.08 | 15 | 26125 | 72882 | 34857909 |
| Oedematous kidney | 20.15 | 16.08 | 5 | 26135 | 39 | 34930752 |
| Bacteraemia | 19.97 | 16.08 | 45 | 26095 | 19672 | 34911119 |
| Thrombotic thrombocytopenic purpura | 19.92 | 16.08 | 18 | 26122 | 3352 | 34927439 |
| Dehiscence | 19.88 | 16.08 | 6 | 26134 | 103 | 34930688 |
| Sepsis | 19.86 | 16.08 | 201 | 25939 | 166360 | 34764431 |
| Genitourinary tract infection | 19.82 | 16.08 | 6 | 26134 | 104 | 34930687 |
| Blood pressure increased | 19.79 | 16.08 | 22 | 26118 | 88080 | 34842711 |
| Spinal stenosis | 19.78 | 16.08 | 22 | 26118 | 5247 | 34925544 |
| Abdominal discomfort | 19.78 | 16.08 | 10 | 26130 | 59825 | 34870966 |
| Chest discomfort | 19.77 | 16.08 | 8 | 26132 | 54522 | 34876269 |
| Drug level increased | 19.73 | 16.08 | 48 | 26092 | 22048 | 34908743 |
| Blood pressure decreased | 19.60 | 16.08 | 7 | 26133 | 51508 | 34879283 |
| Death | 19.54 | 16.08 | 197 | 25943 | 397852 | 34532939 |
| IVth nerve paralysis | 19.46 | 16.08 | 6 | 26134 | 111 | 34930680 |
| Pneumonia pseudomonal | 19.44 | 16.08 | 19 | 26121 | 3903 | 34926888 |
| Blood glucose increased | 19.43 | 16.08 | 13 | 26127 | 66705 | 34864086 |
| Haemolytic uraemic syndrome | 19.29 | 16.08 | 15 | 26125 | 2271 | 34928520 |
| Cytomegalovirus gastroenteritis | 19.21 | 16.08 | 7 | 26133 | 220 | 34930571 |
| Brain herniation | 19.09 | 16.08 | 19 | 26121 | 3989 | 34926802 |
| Prophylaxis against transplant rejection | 19.04 | 16.08 | 5 | 26135 | 50 | 34930741 |
| Bronchial anastomosis complication | 19.02 | 16.08 | 4 | 26136 | 13 | 34930778 |
| Hypersensitivity | 19.01 | 16.08 | 11 | 26129 | 61024 | 34869767 |
| Spinal osteoarthritis | 19.01 | 16.08 | 26 | 26114 | 7657 | 34923134 |
| Disseminated aspergillosis | 19.00 | 16.08 | 10 | 26130 | 770 | 34930021 |
| Neutrophilic dermatosis | 18.88 | 16.08 | 7 | 26133 | 231 | 34930560 |
| Serum sickness | 18.81 | 16.08 | 14 | 26126 | 1986 | 34928805 |
| Trichophytic granuloma | 18.78 | 16.08 | 5 | 26135 | 53 | 34930738 |
| Oliguria | 18.71 | 16.08 | 27 | 26113 | 8353 | 34922438 |
| Meningitis cryptococcal | 18.62 | 16.08 | 15 | 26125 | 2389 | 34928402 |
| Klebsiella sepsis | 18.58 | 16.08 | 14 | 26126 | 2023 | 34928768 |
| Urogenital infection bacterial | 18.53 | 16.08 | 5 | 26135 | 56 | 34930735 |
| Renal tubular disorder | 18.50 | 16.08 | 20 | 26120 | 4623 | 34926168 |
| Hydronephrosis | 18.40 | 16.08 | 30 | 26110 | 10316 | 34920475 |
| American trypanosomiasis | 18.36 | 16.08 | 7 | 26133 | 250 | 34930541 |
| Musculoskeletal stiffness | 18.36 | 16.08 | 6 | 26134 | 46674 | 34884117 |
| Necrotising retinitis | 18.28 | 16.08 | 10 | 26130 | 832 | 34929959 |
| Infectious pleural effusion | 18.27 | 16.08 | 15 | 26125 | 2455 | 34928336 |
| Cerebrovascular accident | 18.16 | 16.08 | 22 | 26118 | 84789 | 34846002 |
| Abscess | 18.03 | 16.08 | 32 | 26108 | 11785 | 34919006 |
| Erythema | 18.00 | 16.08 | 24 | 26116 | 88756 | 34842035 |
| Activated partial thromboplastin time prolonged | 17.95 | 16.08 | 27 | 26113 | 8668 | 34922123 |
| Fusarium infection | 17.81 | 16.08 | 11 | 26129 | 1149 | 34929642 |
| Contusion | 17.59 | 16.08 | 3 | 26137 | 36361 | 34894430 |
| Alpha haemolytic streptococcal infection | 17.52 | 16.08 | 11 | 26129 | 1183 | 34929608 |
| Graft infection | 17.49 | 16.08 | 8 | 26132 | 454 | 34930337 |
| Blastomycosis | 17.45 | 16.08 | 8 | 26132 | 456 | 34930335 |
| Acinetobacter infection | 17.41 | 16.08 | 11 | 26129 | 1196 | 34929595 |
| Retinal artery occlusion | 17.29 | 16.08 | 13 | 26127 | 1872 | 34928919 |
| Gastric fistula | 17.19 | 16.08 | 5 | 26135 | 75 | 34930716 |
| Herpes simplex | 17.18 | 16.08 | 21 | 26119 | 5538 | 34925253 |
| Inappropriate schedule of product administration | 17.01 | 16.08 | 13 | 26127 | 62283 | 34868508 |
| Lymphorrhoea | 17.01 | 16.08 | 5 | 26135 | 78 | 34930713 |
| Post procedural bile leak | 16.94 | 16.08 | 7 | 26133 | 310 | 34930481 |
| Clostridium colitis | 16.83 | 16.08 | 11 | 26129 | 1268 | 34929523 |
| Mycobacterium fortuitum infection | 16.82 | 16.08 | 6 | 26134 | 177 | 34930614 |
| Hypoglycaemia | 16.80 | 16.08 | 10 | 26130 | 54630 | 34876161 |
| Paraspinal abscess | 16.61 | 16.08 | 5 | 26135 | 85 | 34930706 |
| Granuloma | 16.58 | 16.08 | 16 | 26124 | 3235 | 34927556 |
| Morganella infection | 16.55 | 16.08 | 8 | 26132 | 514 | 34930277 |
| Therapeutic product effect decreased | 16.51 | 16.08 | 3 | 26137 | 34740 | 34896051 |
| Hirsutism | 16.45 | 16.08 | 6 | 26134 | 189 | 34930602 |
| Renal and pancreas transplant rejection | 16.38 | 16.08 | 4 | 26136 | 29 | 34930762 |
| Cutaneous malacoplakia | 16.24 | 16.08 | 5 | 26135 | 92 | 34930699 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cytomegalovirus infection | 1470.00 | 15.25 | 608 | 38248 | 42036 | 79663496 |
| Cytomegalovirus viraemia | 1082.97 | 15.25 | 354 | 38502 | 12467 | 79693065 |
| Leukopenia | 949.66 | 15.25 | 631 | 38225 | 115882 | 79589650 |
| Transplant rejection | 799.55 | 15.25 | 315 | 38541 | 19122 | 79686410 |
| Drug resistance | 727.15 | 15.25 | 372 | 38484 | 41841 | 79663691 |
| Pathogen resistance | 588.22 | 15.25 | 232 | 38624 | 14110 | 79691422 |
| Neutropenia | 452.46 | 15.25 | 625 | 38231 | 287085 | 79418447 |
| Polyomavirus-associated nephropathy | 405.75 | 15.25 | 138 | 38718 | 5489 | 79700043 |
| Kidney transplant rejection | 400.06 | 15.25 | 160 | 38696 | 10086 | 79695446 |
| BK virus infection | 355.98 | 15.25 | 141 | 38715 | 8663 | 79696869 |
| Cytomegalovirus colitis | 322.57 | 15.25 | 111 | 38745 | 4574 | 79700958 |
| Complications of transplanted kidney | 289.36 | 15.25 | 111 | 38745 | 6255 | 79699277 |
| Cytomegalovirus infection reactivation | 288.72 | 15.25 | 121 | 38735 | 8595 | 79696937 |
| Immunosuppressant drug level increased | 281.32 | 15.25 | 120 | 38736 | 8907 | 79696625 |
| Delayed graft function | 280.52 | 15.25 | 93 | 38763 | 3414 | 79702118 |
| Pancytopenia | 278.05 | 15.25 | 372 | 38484 | 165373 | 79540159 |
| Nocardiosis | 272.44 | 15.25 | 103 | 38753 | 5576 | 79699956 |
| Post transplant lymphoproliferative disorder | 266.17 | 15.25 | 124 | 38732 | 11340 | 79694192 |
| Transplant dysfunction | 255.22 | 15.25 | 105 | 38751 | 7116 | 79698416 |
| Cytomegalovirus chorioretinitis | 246.93 | 15.25 | 95 | 38761 | 5395 | 79700137 |
| Encephalitis cytomegalovirus | 239.85 | 15.25 | 64 | 38792 | 1086 | 79704446 |
| Epstein-Barr virus infection | 236.32 | 15.25 | 123 | 38733 | 14293 | 79691239 |
| Agranulocytosis | 229.57 | 15.25 | 184 | 38672 | 44846 | 79660686 |
| Cytomegalovirus syndrome | 224.35 | 15.25 | 47 | 38809 | 254 | 79705278 |
| Pneumonia cytomegaloviral | 216.42 | 15.25 | 84 | 38772 | 4885 | 79700647 |
| Mucormycosis | 210.34 | 15.25 | 96 | 38760 | 8373 | 79697159 |
| Cytomegalovirus gastrointestinal infection | 210.01 | 15.25 | 49 | 38807 | 463 | 79705069 |
| Human ehrlichiosis | 180.18 | 15.25 | 44 | 38812 | 513 | 79705019 |
| Aspergillus infection | 178.24 | 15.25 | 113 | 38743 | 19048 | 79686484 |
| Off label use | 178.21 | 15.25 | 891 | 37965 | 906324 | 78799208 |
| Nephropathy toxic | 169.24 | 15.25 | 112 | 38744 | 20307 | 79685225 |
| Thrombotic microangiopathy | 165.64 | 15.25 | 110 | 38746 | 20059 | 79685473 |
| Pneumocystis jirovecii pneumonia | 157.56 | 15.25 | 129 | 38727 | 32379 | 79673153 |
| Fatigue | 155.89 | 15.25 | 135 | 38721 | 929592 | 78775940 |
| Renal impairment | 155.45 | 15.25 | 277 | 38579 | 157506 | 79548026 |
| Escherichia infection | 152.17 | 15.25 | 100 | 38756 | 17917 | 79687615 |
| Pain | 148.86 | 15.25 | 79 | 38777 | 703723 | 79001809 |
| Enterococcal infection | 147.27 | 15.25 | 93 | 38763 | 15567 | 79689965 |
| Lung transplant rejection | 144.37 | 15.25 | 46 | 38810 | 1485 | 79704047 |
| Klebsiella infection | 141.96 | 15.25 | 91 | 38765 | 15629 | 79689903 |
| Arthralgia | 136.66 | 15.25 | 54 | 38802 | 571749 | 79133783 |
| Septic shock | 133.20 | 15.25 | 225 | 38631 | 122576 | 79582956 |
| Polyomavirus viraemia | 131.47 | 15.25 | 44 | 38812 | 1663 | 79703869 |
| Cryptococcosis | 130.98 | 15.25 | 53 | 38803 | 3440 | 79702092 |
| Cytomegalovirus test positive | 130.86 | 15.25 | 62 | 38794 | 5885 | 79699647 |
| Bronchopulmonary aspergillosis | 126.33 | 15.25 | 97 | 38759 | 22197 | 79683335 |
| Pulmonary nocardiosis | 126.14 | 15.25 | 40 | 38816 | 1271 | 79704261 |
| Cytomegalovirus enteritis | 122.22 | 15.25 | 35 | 38821 | 779 | 79704753 |
| Lymphopenia | 121.00 | 15.25 | 108 | 38748 | 30449 | 79675083 |
| Fall | 118.20 | 15.25 | 45 | 38811 | 487584 | 79217948 |
| Smooth muscle cell neoplasm | 116.44 | 15.25 | 35 | 38821 | 927 | 79704605 |
| Pseudomonas infection | 116.37 | 15.25 | 90 | 38766 | 20813 | 79684719 |
| Immune reconstitution inflammatory syndrome | 112.47 | 15.25 | 75 | 38781 | 13766 | 79691766 |
| Renal tubular necrosis | 112.27 | 15.25 | 95 | 38761 | 24944 | 79680588 |
| Graft versus host disease | 111.56 | 15.25 | 77 | 38779 | 14949 | 79690583 |
| Bone marrow failure | 111.54 | 15.25 | 131 | 38725 | 50976 | 79654556 |
| Renal artery stenosis | 110.83 | 15.25 | 47 | 38809 | 3435 | 79702097 |
| Blood creatinine increased | 106.41 | 15.25 | 234 | 38622 | 154823 | 79550709 |
| Completed suicide | 105.87 | 15.25 | 3 | 38853 | 245764 | 79459768 |
| Thrombocytopenia | 104.42 | 15.25 | 325 | 38531 | 264934 | 79440598 |
| Malacoplakia | 102.95 | 15.25 | 29 | 38827 | 607 | 79704925 |
| Strongyloidiasis | 102.53 | 15.25 | 46 | 38810 | 3852 | 79701680 |
| Renal transplant failure | 100.27 | 15.25 | 37 | 38819 | 1870 | 79703662 |
| Acute kidney injury | 98.48 | 15.25 | 506 | 38350 | 518898 | 79186634 |
| Myelosuppression | 97.57 | 15.25 | 109 | 38747 | 40187 | 79665345 |
| Product use in unapproved indication | 96.00 | 15.25 | 304 | 38552 | 250055 | 79455477 |
| Toxoplasmosis | 94.56 | 15.25 | 39 | 38817 | 2658 | 79702874 |
| Lymphocele | 93.52 | 15.25 | 34 | 38822 | 1647 | 79703885 |
| Dizziness | 93.48 | 15.25 | 72 | 38784 | 526369 | 79179163 |
| Parvovirus B19 infection | 90.10 | 15.25 | 32 | 38824 | 1448 | 79704084 |
| Cytomegalovirus oesophagitis | 89.19 | 15.25 | 27 | 38829 | 733 | 79704799 |
| Posterior reversible encephalopathy syndrome | 88.76 | 15.25 | 85 | 38771 | 26196 | 79679336 |
| Joint swelling | 87.92 | 15.25 | 17 | 38839 | 288629 | 79416903 |
| Mycobacterium avium complex infection | 86.29 | 15.25 | 43 | 38813 | 4557 | 79700975 |
| Liver transplant rejection | 84.38 | 15.25 | 38 | 38818 | 3210 | 79702322 |
| Brain abscess | 83.42 | 15.25 | 43 | 38813 | 4893 | 79700639 |
| Pain in extremity | 82.84 | 15.25 | 37 | 38819 | 364501 | 79341031 |
| Cytopenia | 80.61 | 15.25 | 72 | 38784 | 20311 | 79685221 |
| Malaise | 78.38 | 15.25 | 74 | 38782 | 489795 | 79215737 |
| Peripheral swelling | 77.76 | 15.25 | 18 | 38838 | 269599 | 79435933 |
| Hypersensitivity | 76.65 | 15.25 | 17 | 38839 | 262222 | 79443310 |
| Product dose omission issue | 76.61 | 15.25 | 14 | 38842 | 247523 | 79458009 |
| Renal cyst haemorrhage | 74.46 | 15.25 | 23 | 38833 | 669 | 79704863 |
| Trichophytosis | 73.32 | 15.25 | 20 | 38836 | 370 | 79705162 |
| Ureaplasma infection | 72.75 | 15.25 | 25 | 38831 | 1025 | 79704507 |
| Headache | 72.50 | 15.25 | 130 | 38726 | 653642 | 79051890 |
| Rash | 71.59 | 15.25 | 107 | 38749 | 578251 | 79127281 |
| Transplant failure | 71.50 | 15.25 | 38 | 38818 | 4603 | 79700929 |
| Dyspnoea | 70.97 | 15.25 | 200 | 38656 | 856825 | 78848707 |
| Cystitis haemorrhagic | 70.45 | 15.25 | 48 | 38808 | 9124 | 79696408 |
| Drug intolerance | 69.77 | 15.25 | 21 | 38835 | 264098 | 79441434 |
| Nasopharyngitis | 69.25 | 15.25 | 19 | 38837 | 253862 | 79451670 |
| JC virus infection | 69.04 | 15.25 | 35 | 38821 | 3846 | 79701686 |
| Squamous cell carcinoma of skin | 68.63 | 15.25 | 56 | 38800 | 13977 | 79691555 |
| Epstein-Barr virus infection reactivation | 68.51 | 15.25 | 28 | 38828 | 1864 | 79703668 |
| Pyrexia | 68.49 | 15.25 | 564 | 38292 | 678145 | 79027387 |
| Infusion related reaction | 67.13 | 15.25 | 15 | 38841 | 230222 | 79475310 |
| Proteus infection | 65.46 | 15.25 | 28 | 38828 | 2090 | 79703442 |
| Anxiety | 65.21 | 15.25 | 20 | 38836 | 248492 | 79457040 |
| Actinic keratosis | 64.73 | 15.25 | 39 | 38817 | 6003 | 79699529 |
| Multiple organ dysfunction syndrome | 64.57 | 15.25 | 165 | 38691 | 120081 | 79585451 |
| Sepsis | 64.42 | 15.25 | 281 | 38575 | 269147 | 79436385 |
| Enterovirus infection | 64.37 | 15.25 | 27 | 38829 | 1920 | 79703612 |
| Drug hypersensitivity | 63.82 | 15.25 | 33 | 38823 | 298883 | 79406649 |
| Viraemia | 63.39 | 15.25 | 30 | 38826 | 2839 | 79702693 |
| Intraductal papillary mucinous neoplasm | 63.17 | 15.25 | 21 | 38835 | 777 | 79704755 |
| Nausea | 63.02 | 15.25 | 247 | 38609 | 956949 | 78748583 |
| Pyelonephritis fungal | 62.89 | 15.25 | 16 | 38840 | 223 | 79705309 |
| Pulmonary mucormycosis | 62.71 | 15.25 | 23 | 38833 | 1142 | 79704390 |
| Aplasia pure red cell | 62.68 | 15.25 | 42 | 38814 | 7768 | 79697764 |
| Viral load increased | 62.62 | 15.25 | 30 | 38826 | 2918 | 79702614 |
| Abdominal discomfort | 62.58 | 15.25 | 22 | 38834 | 250705 | 79454827 |
| Infection reactivation | 62.47 | 15.25 | 29 | 38827 | 2628 | 79702904 |
| Focal segmental glomerulosclerosis | 62.16 | 15.25 | 31 | 38825 | 3290 | 79702242 |
| Pneumonia fungal | 61.81 | 15.25 | 48 | 38808 | 11162 | 79694370 |
| Vena cava injury | 61.31 | 15.25 | 17 | 38839 | 335 | 79705197 |
| Therapeutic product effect decreased | 61.06 | 15.25 | 5 | 38851 | 163858 | 79541674 |
| Cytomegalovirus gastritis | 60.98 | 15.25 | 18 | 38838 | 447 | 79705085 |
| Hydronephrosis | 59.97 | 15.25 | 57 | 38799 | 17397 | 79688135 |
| Glomerulosclerosis | 59.84 | 15.25 | 22 | 38834 | 1100 | 79704432 |
| Candida infection | 59.73 | 15.25 | 83 | 38773 | 38131 | 79667401 |
| Adenovirus infection | 59.69 | 15.25 | 42 | 38814 | 8405 | 79697127 |
| Pyelonephritis | 59.68 | 15.25 | 61 | 38795 | 20327 | 79685205 |
| Somnolence | 59.59 | 15.25 | 21 | 38835 | 238960 | 79466572 |
| Feeling abnormal | 58.93 | 15.25 | 5 | 38851 | 159194 | 79546338 |
| Drug level increased | 58.83 | 15.25 | 84 | 38772 | 39567 | 79665965 |
| Graft loss | 57.66 | 15.25 | 21 | 38835 | 1022 | 79704510 |
| SARS-CoV-2 antibody test positive | 57.60 | 15.25 | 17 | 38839 | 422 | 79705110 |
| Renal transplant | 57.41 | 15.25 | 27 | 38829 | 2520 | 79703012 |
| Disseminated cytomegaloviral infection | 56.28 | 15.25 | 17 | 38839 | 458 | 79705074 |
| Dermatophytosis | 56.21 | 15.25 | 17 | 38839 | 460 | 79705072 |
| Escherichia urinary tract infection | 54.99 | 15.25 | 49 | 38807 | 13776 | 79691756 |
| Rhinovirus infection | 54.94 | 15.25 | 39 | 38817 | 7914 | 79697618 |
| Alopecia | 54.89 | 15.25 | 22 | 38834 | 231333 | 79474199 |
| Back pain | 54.67 | 15.25 | 41 | 38815 | 304139 | 79401393 |
| Fungal skin infection | 54.63 | 15.25 | 35 | 38821 | 6001 | 79699531 |
| Urticaria | 54.11 | 15.25 | 12 | 38844 | 185189 | 79520343 |
| Asthma | 53.61 | 15.25 | 3 | 38853 | 135092 | 79570440 |
| Acinetobacter infection | 52.21 | 15.25 | 26 | 38830 | 2751 | 79702781 |
| Subcapsular renal haematoma | 51.89 | 15.25 | 18 | 38838 | 759 | 79704773 |
| Musculoskeletal stiffness | 51.82 | 15.25 | 11 | 38845 | 174997 | 79530535 |
| Cytomegalovirus hepatitis | 51.73 | 15.25 | 18 | 38838 | 766 | 79704766 |
| Hypogammaglobulinaemia | 51.71 | 15.25 | 46 | 38810 | 12905 | 79692627 |
| Pericarditis fungal | 51.51 | 15.25 | 13 | 38843 | 175 | 79705357 |
| Haemophagocytic lymphohistiocytosis | 51.03 | 15.25 | 58 | 38798 | 21779 | 79683753 |
| Depression | 50.80 | 15.25 | 21 | 38835 | 216769 | 79488763 |
| Death | 50.73 | 15.25 | 127 | 38729 | 566387 | 79139145 |
| Vascular anastomotic haemorrhage | 50.63 | 15.25 | 14 | 38842 | 273 | 79705259 |
| Abdominal wall haemorrhage | 49.94 | 15.25 | 17 | 38839 | 677 | 79704855 |
| Granulomatous rosacea | 49.72 | 15.25 | 13 | 38843 | 203 | 79705329 |
| Muscle spasms | 49.70 | 15.25 | 12 | 38844 | 174718 | 79530814 |
| Eye infection toxoplasmal | 49.64 | 15.25 | 16 | 38840 | 536 | 79704996 |
| Contusion | 49.18 | 15.25 | 7 | 38849 | 148769 | 79556763 |
| Kidney fibrosis | 49.04 | 15.25 | 27 | 38829 | 3508 | 79702024 |
| Liver transplant | 48.55 | 15.25 | 29 | 38827 | 4394 | 79701138 |
| Epstein-Barr viraemia | 48.55 | 15.25 | 23 | 38833 | 2182 | 79703350 |
| Myocardial infarction | 47.96 | 15.25 | 15 | 38841 | 184114 | 79521418 |
| Weight increased | 47.81 | 15.25 | 39 | 38817 | 277347 | 79428185 |
| Disseminated varicella zoster virus infection | 47.49 | 15.25 | 16 | 38840 | 617 | 79704915 |
| Pericarditis constrictive | 47.27 | 15.25 | 16 | 38840 | 626 | 79704906 |
| Scedosporium infection | 47.21 | 15.25 | 20 | 38836 | 1458 | 79704074 |
| Perineal cyst | 46.89 | 15.25 | 13 | 38843 | 256 | 79705276 |
| Pruritus | 45.92 | 15.25 | 76 | 38780 | 394572 | 79310960 |
| Clostridium difficile colitis | 45.86 | 15.25 | 67 | 38789 | 32216 | 79673316 |
| Rectal prolapse | 45.76 | 15.25 | 22 | 38834 | 2156 | 79703376 |
| Staphylococcal infection | 45.76 | 15.25 | 93 | 38763 | 58202 | 79647330 |
| Graft versus host disease in skin | 44.79 | 15.25 | 31 | 38825 | 6042 | 79699490 |
| Fungal infection | 44.55 | 15.25 | 76 | 38780 | 41672 | 79663860 |
| Carotid arteriosclerosis | 44.49 | 15.25 | 23 | 38833 | 2633 | 79702899 |
| Steroid diabetes | 43.80 | 15.25 | 25 | 38831 | 3481 | 79702051 |
| Oesophageal candidiasis | 43.43 | 15.25 | 36 | 38820 | 9182 | 79696350 |
| Oesophageal atresia | 42.62 | 15.25 | 10 | 38846 | 97 | 79705435 |
| Viral mutation identified | 41.58 | 15.25 | 25 | 38831 | 3833 | 79701699 |
| Hyperammonaemia | 41.53 | 15.25 | 38 | 38818 | 11055 | 79694477 |
| Gene mutation | 41.40 | 15.25 | 22 | 38834 | 2664 | 79702868 |
| Left ventricular hypertrophy | 41.24 | 15.25 | 38 | 38818 | 11153 | 79694379 |
| Respiratory failure | 41.16 | 15.25 | 186 | 38670 | 180725 | 79524807 |
| Granulomatous dermatitis | 41.15 | 15.25 | 13 | 38843 | 408 | 79705124 |
| Haemolytic anaemia | 41.08 | 15.25 | 47 | 38809 | 17773 | 79687759 |
| Injection site pain | 40.90 | 15.25 | 7 | 38849 | 129831 | 79575701 |
| Herpes simplex | 40.36 | 15.25 | 39 | 38817 | 12148 | 79693384 |
| Heart transplant rejection | 40.29 | 15.25 | 18 | 38838 | 1492 | 79704040 |
| Serum sickness | 40.14 | 15.25 | 24 | 38832 | 3642 | 79701890 |
| Fungal endocarditis | 40.14 | 15.25 | 14 | 38842 | 600 | 79704932 |
| Intentional overdose | 40.12 | 15.25 | 3 | 38853 | 105957 | 79599575 |
| Hepatic artery thrombosis | 40.02 | 15.25 | 12 | 38844 | 315 | 79705217 |
| Tubulointerstitial nephritis | 40.01 | 15.25 | 69 | 38787 | 38166 | 79667366 |
| Pneumocystis jirovecii infection | 39.86 | 15.25 | 22 | 38834 | 2872 | 79702660 |
| Systemic candida | 39.79 | 15.25 | 30 | 38826 | 6676 | 79698856 |
| Encephalitis viral | 39.40 | 15.25 | 21 | 38835 | 2558 | 79702974 |
| Hyperparathyroidism secondary | 38.79 | 15.25 | 21 | 38835 | 2639 | 79702893 |
| Neutrophil Pelger-Huet anomaly present | 38.66 | 15.25 | 12 | 38844 | 355 | 79705177 |
| Anaemia | 38.59 | 15.25 | 358 | 38498 | 444657 | 79260875 |
| Cervicitis | 38.53 | 15.25 | 11 | 38845 | 242 | 79705290 |
| Cerebral toxoplasmosis | 38.26 | 15.25 | 20 | 38836 | 2342 | 79703190 |
| Gait disturbance | 37.23 | 15.25 | 28 | 38828 | 207478 | 79498054 |
| Staphylococcal mediastinitis | 37.20 | 15.25 | 8 | 38848 | 50 | 79705482 |
| Vascular compression | 37.19 | 15.25 | 13 | 38843 | 561 | 79704971 |
| Aortic dilatation | 37.16 | 15.25 | 18 | 38838 | 1794 | 79703738 |
| Systemic lupus erythematosus | 37.14 | 15.25 | 7 | 38849 | 121142 | 79584390 |
| Renal tubular injury | 37.02 | 15.25 | 17 | 38839 | 1502 | 79704030 |
| Discomfort | 36.97 | 15.25 | 8 | 38848 | 125609 | 79579923 |
| Swelling | 36.67 | 15.25 | 31 | 38825 | 216680 | 79488852 |
| Syncope | 36.54 | 15.25 | 21 | 38835 | 179428 | 79526104 |
| SARS-CoV-2 RNA increased | 36.17 | 15.25 | 9 | 38847 | 114 | 79705418 |
| Blood pressure increased | 36.05 | 15.25 | 30 | 38826 | 211330 | 79494202 |
| Central nervous system fungal infection | 35.99 | 15.25 | 12 | 38844 | 448 | 79705084 |
| Mobility decreased | 35.51 | 15.25 | 8 | 38848 | 122167 | 79583365 |
| Hyperkalaemia | 35.05 | 15.25 | 129 | 38727 | 114269 | 79591263 |
| Toxic optic neuropathy | 34.83 | 15.25 | 15 | 38841 | 1138 | 79704394 |
| Acute graft versus host disease | 34.54 | 15.25 | 33 | 38823 | 10134 | 79695398 |
| Adenoviral hepatitis | 34.53 | 15.25 | 14 | 38842 | 913 | 79704619 |
| Arthritis | 34.45 | 15.25 | 7 | 38849 | 114873 | 79590659 |
| Teratogenicity | 34.16 | 15.25 | 10 | 38846 | 241 | 79705291 |
| Cytomegalovirus nephritis | 33.87 | 15.25 | 9 | 38847 | 150 | 79705382 |
| Renal tubular atrophy | 33.78 | 15.25 | 17 | 38839 | 1839 | 79703693 |
| No adverse event | 33.65 | 15.25 | 63 | 38793 | 37129 | 79668403 |
| Loss of personal independence in daily activities | 33.50 | 15.25 | 5 | 38851 | 102575 | 79602957 |
| Haemolytic uraemic syndrome | 33.49 | 15.25 | 23 | 38833 | 4426 | 79701106 |
| Hyperhidrosis | 33.40 | 15.25 | 16 | 38840 | 151476 | 79554056 |
| Chest discomfort | 32.93 | 15.25 | 13 | 38843 | 138031 | 79567501 |
| Penile ulceration | 32.81 | 15.25 | 11 | 38845 | 418 | 79705114 |
| Scrotal ulcer | 32.78 | 15.25 | 11 | 38845 | 419 | 79705113 |
| Cell-mediated cytotoxicity | 32.65 | 15.25 | 7 | 38849 | 43 | 79705489 |
| Psoriasis | 32.64 | 15.25 | 3 | 38853 | 89584 | 79615948 |
| Progressive multifocal leukoencephalopathy | 32.57 | 15.25 | 45 | 38811 | 20555 | 79684977 |
| Graft versus host disease in gastrointestinal tract | 32.42 | 15.25 | 26 | 38830 | 6330 | 79699202 |
| Hyperuricaemia | 32.19 | 15.25 | 34 | 38822 | 11765 | 79693767 |
| Cytomegalovirus gastroenteritis | 31.96 | 15.25 | 11 | 38845 | 453 | 79705079 |
| Large intestinal ulcer | 31.93 | 15.25 | 23 | 38833 | 4774 | 79700758 |
| Cerebrovascular accident | 31.86 | 15.25 | 18 | 38838 | 155274 | 79550258 |
| Gastroenteritis Escherichia coli | 31.85 | 15.25 | 12 | 38844 | 643 | 79704889 |
| Migraine | 31.69 | 15.25 | 3 | 38853 | 87490 | 79618042 |
| Osteoarthritis | 31.61 | 15.25 | 3 | 38853 | 87306 | 79618226 |
| Constipation | 31.53 | 15.25 | 56 | 38800 | 282994 | 79422538 |
| Cutaneous nocardiosis | 31.23 | 15.25 | 9 | 38847 | 205 | 79705327 |
| Muscular weakness | 31.06 | 15.25 | 20 | 38836 | 160709 | 79544823 |
| Disseminated cryptococcosis | 31.06 | 15.25 | 16 | 38840 | 1818 | 79703714 |
| Superinfection bacterial | 30.83 | 15.25 | 15 | 38841 | 1509 | 79704023 |
| Colitis | 30.80 | 15.25 | 92 | 38764 | 73215 | 79632317 |
| Urosepsis | 30.63 | 15.25 | 50 | 38806 | 26445 | 79679087 |
| Oral candidiasis | 30.38 | 15.25 | 53 | 38803 | 29575 | 79675957 |
| Adrenal mass | 30.26 | 15.25 | 14 | 38842 | 1259 | 79704273 |
| Bacteraemia | 30.19 | 15.25 | 56 | 38800 | 32768 | 79672764 |
| Cardiac failure congestive | 29.95 | 15.25 | 16 | 38840 | 142386 | 79563146 |
| Hyperparathyroidism | 29.94 | 15.25 | 19 | 38837 | 3205 | 79702327 |
| Blood 25-hydroxycholecalciferol decreased | 29.85 | 15.25 | 10 | 38846 | 379 | 79705153 |
| Botulism | 29.80 | 15.25 | 10 | 38846 | 381 | 79705151 |
| Escherichia sepsis | 29.64 | 15.25 | 28 | 38828 | 8480 | 79697052 |
| Suicide attempt | 29.63 | 15.25 | 3 | 38853 | 82929 | 79622603 |
| Febrile neutropenia | 29.38 | 15.25 | 203 | 38653 | 230796 | 79474736 |
| Chronic papillomatous dermatitis | 29.37 | 15.25 | 7 | 38849 | 73 | 79705459 |
| Colon injury | 29.33 | 15.25 | 9 | 38847 | 256 | 79705276 |
| Hepatosplenomegaly | 29.22 | 15.25 | 24 | 38832 | 6045 | 79699487 |
| Blister | 28.92 | 15.25 | 11 | 38845 | 119465 | 79586067 |
| Retinal scar | 28.91 | 15.25 | 10 | 38846 | 418 | 79705114 |
| Glomerulonephritis | 28.85 | 15.25 | 19 | 38837 | 3414 | 79702118 |
| Donor specific antibody present | 28.84 | 15.25 | 9 | 38847 | 271 | 79705261 |
| Brain herniation | 28.79 | 15.25 | 26 | 38830 | 7437 | 79698095 |
| Prophylaxis against transplant rejection | 28.63 | 15.25 | 7 | 38849 | 82 | 79705450 |
| Mean cell volume increased | 28.59 | 15.25 | 24 | 38832 | 6229 | 79699303 |
| Palpitations | 28.48 | 15.25 | 13 | 38843 | 126597 | 79578935 |
| General physical health deterioration | 28.42 | 15.25 | 57 | 38799 | 275181 | 79430351 |
| Guillain-Barre syndrome | 28.40 | 15.25 | 28 | 38828 | 8937 | 79696595 |
| Sleep disorder | 28.38 | 15.25 | 4 | 38852 | 85673 | 79619859 |
| Hepatocellular injury | 28.37 | 15.25 | 68 | 38788 | 47525 | 79658007 |
| Therapeutic product effect incomplete | 28.23 | 15.25 | 17 | 38839 | 141628 | 79563904 |
| Odynophagia | 28.03 | 15.25 | 31 | 38825 | 11296 | 79694236 |
| Maternal exposure during pregnancy | 27.76 | 15.25 | 16 | 38840 | 136522 | 79569010 |
| Glomerulonephropathy | 27.69 | 15.25 | 9 | 38847 | 310 | 79705222 |
| Pneumonia pseudomonal | 27.67 | 15.25 | 23 | 38833 | 5888 | 79699644 |
| Gastritis fungal | 27.44 | 15.25 | 8 | 38848 | 190 | 79705342 |
| Stomatitis | 27.36 | 15.25 | 19 | 38837 | 146738 | 79558794 |
| Microsporidia infection | 27.33 | 15.25 | 12 | 38844 | 954 | 79704578 |
| Blastomycosis | 27.27 | 15.25 | 11 | 38845 | 708 | 79704824 |
| Dry mouth | 27.16 | 15.25 | 5 | 38851 | 88014 | 79617518 |
| Chest pain | 27.03 | 15.25 | 61 | 38795 | 282243 | 79423289 |
| Immunosuppressant drug level decreased | 26.96 | 15.25 | 15 | 38841 | 1989 | 79703543 |
| Mycobacterium fortuitum infection | 26.61 | 15.25 | 8 | 38848 | 212 | 79705320 |
| Clostridium difficile infection | 26.54 | 15.25 | 62 | 38794 | 42623 | 79662909 |
| Granuloma | 26.44 | 15.25 | 26 | 38830 | 8271 | 79697261 |
| Protothecosis | 26.39 | 15.25 | 6 | 38850 | 50 | 79705482 |
| Neutropenic colitis | 26.29 | 15.25 | 22 | 38834 | 5685 | 79699847 |
| Diabetes mellitus | 26.23 | 15.25 | 91 | 38765 | 78299 | 79627233 |
| Wheezing | 26.21 | 15.25 | 12 | 38844 | 116652 | 79588880 |
| Intervertebral disc space narrowing | 26.15 | 15.25 | 14 | 38842 | 1721 | 79703811 |
| End stage renal disease | 26.11 | 15.25 | 31 | 38825 | 12189 | 79693343 |
| Electrocardiogram QT prolonged | 26.10 | 15.25 | 6 | 38850 | 90380 | 79615152 |
| Meningitis cryptococcal | 26.10 | 15.25 | 18 | 38838 | 3488 | 79702044 |
| Abdominal pain upper | 26.10 | 15.25 | 43 | 38813 | 223776 | 79481756 |
| Memory impairment | 25.88 | 15.25 | 11 | 38845 | 111723 | 79593809 |
| Trichophytic granuloma | 25.68 | 15.25 | 6 | 38850 | 57 | 79705475 |
| Escherichia bacteraemia | 25.59 | 15.25 | 23 | 38833 | 6539 | 79698993 |
| Disseminated tuberculosis | 25.46 | 15.25 | 19 | 38837 | 4164 | 79701368 |
| Epstein-Barr virus test positive | 25.44 | 15.25 | 12 | 38844 | 1127 | 79704405 |
| Prostatitis | 25.38 | 15.25 | 19 | 38837 | 4183 | 79701349 |
| Venoocclusive liver disease | 25.38 | 15.25 | 30 | 38826 | 11741 | 79693791 |
| Asthenia | 25.33 | 15.25 | 146 | 38710 | 511543 | 79193989 |
| Inappropriate schedule of product administration | 25.31 | 15.25 | 17 | 38839 | 133611 | 79571921 |
| Flushing | 25.21 | 15.25 | 6 | 38850 | 88262 | 79617270 |
| Myocarditis toxoplasmal | 25.14 | 15.25 | 6 | 38850 | 63 | 79705469 |
| Infectious pleural effusion | 25.03 | 15.25 | 18 | 38838 | 3726 | 79701806 |
| Chronic graft versus host disease | 24.94 | 15.25 | 23 | 38833 | 6758 | 79698774 |
| Bacterial sepsis | 24.85 | 15.25 | 25 | 38831 | 8173 | 79697359 |
| Optic discs blurred | 24.72 | 15.25 | 6 | 38850 | 68 | 79705464 |
| Alpha haemolytic streptococcal infection | 24.68 | 15.25 | 15 | 38841 | 2345 | 79703187 |
| Disseminated trichosporonosis | 24.65 | 15.25 | 7 | 38849 | 151 | 79705381 |
| Pneumonia necrotising | 24.59 | 15.25 | 12 | 38844 | 1215 | 79704317 |
| Bacterial toxaemia | 24.43 | 15.25 | 7 | 38849 | 156 | 79705376 |
| Blood pressure decreased | 24.33 | 15.25 | 9 | 38847 | 99457 | 79606075 |
| Hypoaesthesia | 24.30 | 15.25 | 31 | 38825 | 179321 | 79526211 |
| Complications of transplanted lung | 24.20 | 15.25 | 9 | 38847 | 465 | 79705067 |
| Rhabdomyolysis | 24.13 | 15.25 | 10 | 38846 | 103121 | 79602411 |
| Graft infection | 23.97 | 15.25 | 10 | 38846 | 701 | 79704831 |
| Pancreatic pseudoaneurysm | 23.97 | 15.25 | 6 | 38850 | 78 | 79705454 |
| Pleural mesothelioma malignant | 23.94 | 15.25 | 7 | 38849 | 168 | 79705364 |
| Renal tubular disorder | 23.85 | 15.25 | 22 | 38834 | 6464 | 79699068 |
| Urate nephropathy | 23.67 | 15.25 | 7 | 38849 | 175 | 79705357 |
| Epstein-Barr virus associated lymphoproliferative disorder | 23.66 | 15.25 | 17 | 38839 | 3515 | 79702017 |
| Obliterative bronchiolitis | 23.62 | 15.25 | 16 | 38840 | 3012 | 79702520 |
| Chronic allograft nephropathy | 23.54 | 15.25 | 13 | 38843 | 1698 | 79703834 |
| Pancreas transplant rejection | 23.54 | 15.25 | 8 | 38848 | 317 | 79705215 |
| Isosporiasis | 23.45 | 15.25 | 7 | 38849 | 181 | 79705351 |
| Insomnia | 23.45 | 15.25 | 53 | 38803 | 245117 | 79460415 |
| Immune recovery uveitis | 23.42 | 15.25 | 5 | 38851 | 30 | 79705502 |
| Oliguria | 23.38 | 15.25 | 34 | 38822 | 16275 | 79689257 |
| Complications of transplant surgery | 23.37 | 15.25 | 10 | 38846 | 747 | 79704785 |
| Anaphylactic reaction | 23.32 | 15.25 | 6 | 38850 | 83737 | 79621795 |
| Oropharyngeal candidiasis | 23.22 | 15.25 | 13 | 38843 | 1744 | 79703788 |
| Wrong technique in product usage process | 23.22 | 15.25 | 4 | 38852 | 73871 | 79631661 |
| Dyspepsia | 23.17 | 15.25 | 12 | 38844 | 108675 | 79596857 |
| Venous haemorrhage | 22.87 | 15.25 | 8 | 38848 | 346 | 79705186 |
| Confusional state | 22.80 | 15.25 | 79 | 38777 | 317918 | 79387614 |
| Cutaneous mucormycosis | 22.65 | 15.25 | 7 | 38849 | 204 | 79705328 |
| Bacterial pyelonephritis | 22.60 | 15.25 | 9 | 38847 | 560 | 79704972 |
| Erythrophagocytosis | 22.51 | 15.25 | 5 | 38851 | 37 | 79705495 |
| Balance disorder | 22.47 | 15.25 | 10 | 38846 | 98847 | 79606685 |
| Benign prostatic hyperplasia | 22.44 | 15.25 | 28 | 38828 | 11584 | 79693948 |
| Urogenital infection bacterial | 22.42 | 15.25 | 6 | 38850 | 103 | 79705429 |
| Oxygen saturation decreased | 22.39 | 15.25 | 18 | 38838 | 129029 | 79576503 |
| Parainfluenzae virus infection | 22.32 | 15.25 | 20 | 38836 | 5662 | 79699870 |
| Organising pneumonia | 22.14 | 15.25 | 27 | 38829 | 10912 | 79694620 |
| Diverticulum intestinal | 22.07 | 15.25 | 24 | 38832 | 8581 | 79696951 |
| Superinfection viral | 22.06 | 15.25 | 5 | 38851 | 41 | 79705491 |
| Urinary tract infection bacterial | 22.02 | 15.25 | 21 | 38835 | 6435 | 79699097 |
| Lung transplant | 21.88 | 15.25 | 18 | 38838 | 4543 | 79700989 |
| Neck pain | 21.79 | 15.25 | 5 | 38851 | 75412 | 79630120 |
| Renal failure | 21.77 | 15.25 | 170 | 38686 | 200798 | 79504734 |
| Renal lymphocele | 21.70 | 15.25 | 6 | 38850 | 117 | 79705415 |
| Reticulocytopenia | 21.62 | 15.25 | 7 | 38849 | 238 | 79705294 |
| Necrotising retinitis | 21.48 | 15.25 | 11 | 38845 | 1234 | 79704298 |
| Epistaxis | 21.37 | 15.25 | 14 | 38842 | 111501 | 79594031 |
| Hepatic enzyme increased | 21.36 | 15.25 | 35 | 38821 | 182575 | 79522957 |
| Bacteriuria | 21.27 | 15.25 | 11 | 38845 | 1260 | 79704272 |
| Bacterial infection | 21.18 | 15.25 | 47 | 38809 | 31233 | 79674299 |
| Type 3 diabetes mellitus | 21.17 | 15.25 | 5 | 38851 | 50 | 79705482 |
| Acute respiratory distress syndrome | 21.12 | 15.25 | 58 | 38798 | 44009 | 79661523 |
| Renal tubular acidosis | 21.07 | 15.25 | 16 | 38840 | 3598 | 79701934 |
| Septal panniculitis | 21.02 | 15.25 | 6 | 38850 | 132 | 79705400 |
| Cytokine release syndrome | 20.99 | 15.25 | 51 | 38805 | 35947 | 79669585 |
| Oesophagopleural fistula | 20.91 | 15.25 | 5 | 38851 | 53 | 79705479 |
| Activated partial thromboplastin time prolonged | 20.89 | 15.25 | 30 | 38826 | 14198 | 79691334 |
| Paraesthesia | 20.43 | 15.25 | 34 | 38822 | 176289 | 79529243 |
| Delayed engraftment | 20.41 | 15.25 | 7 | 38849 | 285 | 79705247 |
| Post procedural urine leak | 20.37 | 15.25 | 6 | 38850 | 148 | 79705384 |
| Pneumonia klebsiella | 20.27 | 15.25 | 18 | 38838 | 5036 | 79700496 |
| Biloma | 20.25 | 15.25 | 6 | 38850 | 151 | 79705381 |
| Tonic clonic movements | 20.17 | 15.25 | 13 | 38843 | 2251 | 79703281 |
| Angioedema | 20.14 | 15.25 | 6 | 38850 | 76029 | 79629503 |
| Cytomegalovirus test negative | 19.88 | 15.25 | 3 | 38853 | 0 | 79705532 |
| Drug level fluctuating | 19.87 | 15.25 | 9 | 38847 | 770 | 79704762 |
| Agitation | 19.82 | 15.25 | 12 | 38844 | 99703 | 79605829 |
| Loss of consciousness | 19.82 | 15.25 | 32 | 38824 | 167911 | 79537621 |
| IVth nerve paralysis | 19.78 | 15.25 | 6 | 38850 | 164 | 79705368 |
| Human polyomavirus infection | 19.75 | 15.25 | 10 | 38846 | 1096 | 79704436 |
| Impaired healing | 19.71 | 15.25 | 9 | 38847 | 87646 | 79617886 |
| Ascites | 19.71 | 15.25 | 81 | 38775 | 75481 | 79630051 |
| Aortic arteriosclerosis | 19.68 | 15.25 | 23 | 38833 | 8895 | 79696637 |
| Disseminated aspergillosis | 19.65 | 15.25 | 10 | 38846 | 1108 | 79704424 |
| Pneumonia pneumococcal | 19.51 | 15.25 | 16 | 38840 | 4021 | 79701511 |
| Dehiscence | 19.34 | 15.25 | 6 | 38850 | 177 | 79705355 |
| Pneumonia cryptococcal | 19.32 | 15.25 | 11 | 38845 | 1524 | 79704008 |
| Meningitis viral | 19.17 | 15.25 | 12 | 38844 | 1976 | 79703556 |
| COVID-19 pneumonia | 19.15 | 15.25 | 43 | 38813 | 28806 | 79676726 |
| American trypanosomiasis | 19.06 | 15.25 | 7 | 38849 | 349 | 79705183 |
| Cytomegalovirus myocarditis | 19.03 | 15.25 | 4 | 38852 | 22 | 79705510 |
| Staphylococcal skin infection | 19.00 | 15.25 | 11 | 38845 | 1573 | 79703959 |
| Malignant neoplasm progression | 18.95 | 15.25 | 23 | 38833 | 135967 | 79569565 |
| Perinephric collection | 18.81 | 15.25 | 7 | 38849 | 362 | 79705170 |
| Immunosuppressant drug level | 18.74 | 15.25 | 4 | 38852 | 24 | 79705508 |
| Thyroid tuberculosis | 18.74 | 15.25 | 4 | 38852 | 24 | 79705508 |
| Cytomegalovirus enterocolitis | 18.55 | 15.25 | 11 | 38845 | 1644 | 79703888 |
| Suicidal ideation | 18.52 | 15.25 | 7 | 38849 | 76333 | 79629199 |
| Wound complication | 18.49 | 15.25 | 17 | 38839 | 4976 | 79700556 |
| Abscess | 18.46 | 15.25 | 37 | 38819 | 22914 | 79682618 |
| Drug interaction | 18.31 | 15.25 | 294 | 38562 | 414889 | 79290643 |
| Periorbital cellulitis | 18.31 | 15.25 | 9 | 38847 | 926 | 79704606 |
| Periostitis | 18.03 | 15.25 | 8 | 38848 | 652 | 79704880 |
| Adverse drug reaction | 18.02 | 15.25 | 5 | 38851 | 66387 | 79639145 |
| Viral uveitis | 18.01 | 15.25 | 5 | 38851 | 99 | 79705433 |
| Ill-defined disorder | 17.81 | 15.25 | 5 | 38851 | 65870 | 79639662 |
| Enterobacter infection | 17.81 | 15.25 | 16 | 38840 | 4546 | 79700986 |
| Mesothelioma malignant | 17.79 | 15.25 | 6 | 38850 | 232 | 79705300 |
| Erythema | 17.72 | 15.25 | 53 | 38803 | 223237 | 79482295 |
| Post procedural bile leak | 17.71 | 15.25 | 7 | 38849 | 427 | 79705105 |
| Parvovirus infection | 17.66 | 15.25 | 8 | 38848 | 685 | 79704847 |
| Osteomyelitis chronic | 17.54 | 15.25 | 8 | 38848 | 696 | 79704836 |
| Fusarium infection | 17.52 | 15.25 | 11 | 38845 | 1821 | 79703711 |
| Pericarditis | 17.51 | 15.25 | 15 | 38841 | 104221 | 79601311 |
| Bicytopenia | 17.48 | 15.25 | 16 | 38840 | 4654 | 79700878 |
| Herpes simplex viraemia | 17.45 | 15.25 | 7 | 38849 | 444 | 79705088 |
| Retinal detachment | 17.40 | 15.25 | 22 | 38834 | 9225 | 79696307 |
| Anorexia nervosa | 17.37 | 15.25 | 6 | 38850 | 250 | 79705282 |
| Sinusitis | 17.31 | 15.25 | 44 | 38812 | 195457 | 79510075 |
| Hepatitis viral | 17.26 | 15.25 | 9 | 38847 | 1049 | 79704483 |
| Pneumonia influenzal | 17.25 | 15.25 | 13 | 38843 | 2891 | 79702641 |
| Medication error | 17.15 | 15.25 | 6 | 38850 | 68636 | 79636896 |
| Cutaneous malacoplakia | 17.14 | 15.25 | 5 | 38851 | 119 | 79705413 |
| Oesophageal ulcer | 17.10 | 15.25 | 19 | 38837 | 6956 | 79698576 |
| Herpes simplex reactivation | 17.04 | 15.25 | 7 | 38849 | 472 | 79705060 |
| Scopulariopsis infection | 17.02 | 15.25 | 5 | 38851 | 122 | 79705410 |
| Diffuse large B-cell lymphoma | 16.94 | 15.25 | 25 | 38831 | 12124 | 79693408 |
| Oesophagogastroscopy normal | 16.59 | 15.25 | 3 | 38853 | 6 | 79705526 |
| Hypervolaemia | 16.46 | 15.25 | 52 | 38804 | 42638 | 79662894 |
| Pulmonary interstitial emphysema syndrome | 16.45 | 15.25 | 7 | 38849 | 516 | 79705016 |
| Adenoviral haemorrhagic cystitis | 16.42 | 15.25 | 7 | 38849 | 518 | 79705014 |
| Anastomotic stenosis | 16.41 | 15.25 | 7 | 38849 | 519 | 79705013 |
| Renal and pancreas transplant rejection | 16.35 | 15.25 | 4 | 38852 | 47 | 79705485 |
| Heart rate increased | 16.21 | 15.25 | 21 | 38835 | 120703 | 79584829 |
| Cholestasis | 16.15 | 15.25 | 59 | 38797 | 52050 | 79653482 |
| Swelling of eyelid | 16.14 | 15.25 | 14 | 38842 | 3797 | 79701735 |
| Blood creatine phosphokinase increased | 16.13 | 15.25 | 6 | 38850 | 66084 | 79639448 |
| Dysgeusia | 16.10 | 15.25 | 4 | 38852 | 57173 | 79648359 |
| Type 2 diabetes mellitus | 16.08 | 15.25 | 4 | 38852 | 57118 | 79648414 |
| Klebsiella sepsis | 15.95 | 15.25 | 13 | 38843 | 3239 | 79702293 |
| Hypercalcaemia | 15.92 | 15.25 | 48 | 38808 | 38382 | 79667150 |
| Helicobacter infection | 15.92 | 15.25 | 7 | 38849 | 69697 | 79635835 |
| Retinal artery occlusion | 15.80 | 15.25 | 13 | 38843 | 3281 | 79702251 |
| Musculoskeletal pain | 15.70 | 15.25 | 16 | 38840 | 102338 | 79603194 |
| Neutrophilic dermatosis | 15.64 | 15.25 | 7 | 38849 | 583 | 79704949 |
| Intentional product misuse | 15.62 | 15.25 | 14 | 38842 | 95151 | 79610381 |
| Human herpesvirus 6 infection | 15.59 | 15.25 | 16 | 38840 | 5354 | 79700178 |
| Pseudomembranous colitis | 15.58 | 15.25 | 16 | 38840 | 5358 | 79700174 |
| Bronchial anastomosis complication | 15.57 | 15.25 | 4 | 38852 | 58 | 79705474 |
| Polycystic liver disease | 15.50 | 15.25 | 5 | 38851 | 168 | 79705364 |
| Gastroenteritis | 15.49 | 15.25 | 44 | 38812 | 34038 | 79671494 |
| Unevaluable event | 15.44 | 15.25 | 4 | 38852 | 55581 | 79649951 |
| Blood glucose increased | 15.44 | 15.25 | 20 | 38836 | 114955 | 79590577 |
| Disturbance in attention | 15.43 | 15.25 | 3 | 38853 | 50798 | 79654734 |
| Hepatic cyst infection | 15.41 | 15.25 | 5 | 38851 | 171 | 79705361 |
| Corynebacterium infection | 15.28 | 15.25 | 9 | 38847 | 1329 | 79704203 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J05AB14 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Nucleosides and nucleotides excl. reverse transcriptase inhibitors |
| FDA MoA | N0000020060 | DNA Polymerase Inhibitors |
| FDA EXT | N0000175459 | Nucleoside Analog |
| FDA EPC | N0000175461 | Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000998 | Antiviral Agents |
| CHEBI has role | CHEBI:36044 | antiviral drugs |
| CHEBI has role | CHEBI:50266 | Prodrugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Congenital cytomegalovirus infection | indication | 59527008 | |
| CMV Retinitis in AIDS Patients | indication | ||
| Prevention of CMV Disease After Kidney-Pancreas Transplantation | indication | ||
| Prevention of CMV Disease After Cardiac Transplantation | indication | ||
| Prevention of CMV Disease After Kidney Transplantation | indication | ||
| Prevention of Cytomegalovirus Disease | off-label use | ||
| Dehydration | contraindication | 34095006 | |
| Acute nephropathy | contraindication | 58574008 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Aplastic anemia | contraindication | 306058006 | DOID:12449 |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Granulocytopenic disorder | contraindication | 417672002 | |
| Severe Bone Marrow Depression | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.97 | acidic |
| pKa2 | 11.83 | acidic |
| pKa3 | 7.81 | Basic |
| pKa4 | 3.68 | Basic |
| pKa5 | 2.12 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| DNA polymerase catalytic subunit | Enzyme | INHIBITOR | DRUGBANK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021263 | VUID |
| N0000148704 | NUI |
| D02495 | KEGG_DRUG |
| 4021263 | VANDF |
| 4021264 | VANDF |
| 4030204 | VANDF |
| C0909381 | UMLSCUI |
| CHEBI:63635 | CHEBI |
| CHEMBL1201314 | ChEMBL_ID |
| CHEMBL252321 | ChEMBL_ID |
| CHEMBL400177 | ChEMBL_ID |
| DB01610 | DRUGBANK_ID |
| CHEMBL1200454 | ChEMBL_ID |
| D000077562 | MESH_DESCRIPTOR_UI |
| 135413535 | PUBCHEM_CID |
| 4716 | IUPHAR_LIGAND_ID |
| 7650 | INN_ID |
| GCU97FKN3R | UNII |
| 275891 | RXNORM |
| 15960 | MMSL |
| 231338 | MMSL |
| d04755 | MMSL |
| 009135 | NDDF |
| 009136 | NDDF |
| 129476000 | SNOMEDCT_US |
| 395266000 | SNOMEDCT_US |
| 412326001 | SNOMEDCT_US |
| 175865-60-8 | SECONDARY_CAS_RN |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Valcyte | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0038 | TABLET, FILM COATED | 450 mg | ORAL | NDA | 31 sections |
| Valcyte | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0038 | TABLET, FILM COATED | 450 mg | ORAL | NDA | 31 sections |
| Valcyte | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0039 | POWDER, FOR SOLUTION | 50 mg | ORAL | NDA | 31 sections |
| Valcyte | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0039 | POWDER, FOR SOLUTION | 50 mg | ORAL | NDA | 31 sections |
| Valganciclovir hydrochloride for Oral | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2579 | POWDER, FOR SOLUTION | 50 mg | ORAL | ANDA | 29 sections |
| Valganciclovir hydrochloride for Oral | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2579 | POWDER, FOR SOLUTION | 50 mg | ORAL | ANDA | 29 sections |
| Valganciclovir hydrochloride for Oral | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2579 | POWDER, FOR SOLUTION | 50 mg | ORAL | ANDA | 29 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-6330 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 32 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6796 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-765 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
| Valganciclovir | Human Prescription Drug Label | 1 | 27241-158 | TABLET | 450 mg | ORAL | ANDA | 28 sections |
| Valganciclovir hydrochloride | Human Prescription Drug Label | 1 | 27241-159 | POWDER, FOR SOLUTION | 50 mg | ORAL | ANDA | 28 sections |
| Valganciclovir | Human Prescription Drug Label | 1 | 31722-832 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
| VALGANCICLOVIR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-837 | POWDER, FOR SOLUTION | 50 mg | ORAL | ANDA | 27 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-875 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 29 sections |
| valganciclovir hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-356 | TABLET | 450 mg | ORAL | ANDA | 28 sections |
| valganciclovir hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-356 | TABLET | 450 mg | ORAL | ANDA | 28 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 48433-124 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-787 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55111-762 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
| Valganciclovir | Human Prescription Drug Label | 1 | 59651-444 | FOR SOLUTION | 50 mg | ORAL | ANDA | 28 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60429-846 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60429-846 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60687-765 | POWDER, FOR SOLUTION | 50 mg | ORAL | ANDA | 29 sections |
| Valcyte | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61269-480 | TABLET, FILM COATED | 450 mg | ORAL | NDA | 31 sections |
| Valcyte | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61269-485 | POWDER, FOR SOLUTION | 50 mg | ORAL | NDA | 31 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2288 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 31 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2288 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 31 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63739-076 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
| Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63739-076 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |