ubenimex 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
immunostimulants	2787	58970-76-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

ubenimex
bestatin

growth inhibitor; RN given refers to ((L-Leu)-(S-(R*,S*)))-isomer; structure

Molecular weight: 308.38
Formula: C16H24N2O4
CLOGP: -0.31
LIPINSKI: 0
HAC: 6
HDO: 4
TPSA: 112.65
ALOGS: -2.38
ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000276	Adjuvants, Immunologic
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D019380	Anti-HIV Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D044966	Anti-Retroviral Agents
MeSH PA	D000903	Antibiotics, Antineoplastic
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000998	Antiviral Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D007155	Immunologic Factors
MeSH PA	D011480	Protease Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.42	acidic
pKa2	10.69	acidic
pKa3	13.63	acidic
pKa4	7.98	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
72 kDa type IV collagenase	Enzyme	P08253	MMP2_HUMAN		IC50	5.47		CHEMBL
Aminopeptidase N	Enzyme	P15144	AMPN_HUMAN		IC50	5.62		CHEMBL
Cytosol aminopeptidase	Enzyme	P28838	AMPL_HUMAN		Ki	9.22		CHEMBL
Leukotriene A-4 hydrolase	Enzyme	P09960	LKHA4_HUMAN		IC50	6.30		CHEMBL
Puromycin-sensitive aminopeptidase	Enzyme	P55786	PSA_HUMAN		IC50	5.46		CHEMBL
Endoplasmic reticulum aminopeptidase 1	Enzyme	Q9NZ08	ERAP1_HUMAN		IC50	4.30		CHEMBL
Aminopeptidase N	Enzyme		AMPN_PIG		Ki	9.30		CHEMBL
M1 family aminopeptidase	Enzyme		AMP1_PLAFQ		Ki	6.72		CHEMBL
Aminopeptidase B	Enzyme		AMPB_MOUSE		IC50	5.22		CHEMBL
Leucyl-cystinyl aminopeptidase	Enzyme		LCAP_RAT		Ki	7.70		CHEMBL
Aminopeptidase B	Enzyme		AMPB_RAT		Ki	7.85		CHEMBL
Cytosol aminopeptidase	Enzyme		AMPL_BOVIN		Ki	6.30		CHEMBL
Aminopeptidase N	Enzyme		AMPN_MOUSE		Ki	5.52		CHEMBL
Bacterial leucyl aminopeptidase	Enzyme		AMPX_VIBPR		Ki	8.80		CHEMBL
Cytosol aminopeptidase	Enzyme		AMPL_PIG		IC50	5.28		CHEMBL
Aminopeptidase N	Enzyme		AMPN_RAT		IC50	4.71		CHEMBL

External reference:

ID	Source
D00087	KEGG_DRUG
C0053355	UMLSCUI
CHEBI:3070	CHEBI
BES	PDB_CHEM_ID
CHEMBL29292	ChEMBL_ID
DB03424	DRUGBANK_ID
C012211	MESH_SUPPLEMENTAL_RECORD_UI
72172	PUBCHEM_CID
5151	IUPHAR_LIGAND_ID
5940	INN_ID
I0J33N5627	UNII

Pharmaceutical products:

None