tropatepine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
atropine derivatives	2772	27574-24-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: tropatepine tropatepine hydrochloride lepticur	Molecular weight: 333.49 Formula: C22H23NS CLOGP: 5.05 LIPINSKI: 1 HAC: 1 HDO: 0 TPSA: 3.24 ALOGS: -5.59 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

tropatepine
tropatepine hydrochloride
lepticur

Molecular weight: 333.49
Formula: C22H23NS
CLOGP: 5.05
LIPINSKI: 1
HAC: 1
HDO: 0
TPSA: 3.24
ALOGS: -5.59
ROTB: 0

Drug dosage:

None

ADMET properties:

Property	Value	Reference
Vd (Volume of distribution)	11.85 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	4.98 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	29.80 hours	Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Poisoning deliberate	155.69	52.77	41	1910	11177	63475894
Coma	140.74	52.77	58	1893	64306	63422765
Hepatocellular injury	71.17	52.77	28	1923	27353	63459718
Livedo reticularis	70.00	52.77	16	1935	2416	63484655
Neuroleptic malignant syndrome	68.34	52.77	22	1929	12034	63475037
Drug reaction with eosinophilia and systemic symptoms	62.15	52.77	27	1924	33809	63453262
Suicide attempt	60.95	52.77	32	1919	60886	63426185
Axonal neuropathy	59.42	52.77	12	1939	1010	63486061
Confusional state	58.14	52.77	52	1899	236328	63250743
Cardiogenic shock	56.11	52.77	21	1930	17911	63469160
Pneumonia aspiration	55.19	52.77	25	1926	34515	63452556

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	146.80	43.16	70	2501	45608	34908752
Intestinal obstruction	111.70	43.16	47	2524	22775	34931585
Necrotising colitis	96.14	43.16	21	2550	1067	34953293
Somnolence	95.85	43.16	73	2498	111043	34843317
Extrapyramidal disorder	78.26	43.16	31	2540	12849	34941511
Hepatocellular injury	77.20	43.16	36	2535	22175	34932185
Neuroleptic malignant syndrome	68.36	43.16	31	2540	17903	34936457
Rhabdomyolysis	68.10	43.16	49	2522	68114	34886246
Hyperthermia	59.18	43.16	24	2547	10553	34943807
Intestinal pseudo-obstruction	56.50	43.16	15	2556	1741	34952619
Urinary retention	55.38	43.16	34	2537	36254	34918106
Colitis ischaemic	55.30	43.16	20	2551	6455	34947905
Wrong patient received product	54.75	43.16	16	2555	2638	34951722
Subileus	51.78	43.16	16	2555	3187	34951173
Faecaloma	51.18	43.16	18	2553	5359	34949001
Intestinal ischaemia	48.16	43.16	19	2552	7775	34946585
Confusional state	43.24	43.16	53	2518	144107	34810253

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	268.17	40.93	125	4395	100524	79639344
Poisoning deliberate	163.22	40.93	55	4465	18773	79721095
Intestinal obstruction	144.71	40.93	63	4457	42957	79696911
Hepatocellular injury	138.60	40.93	63	4457	47530	79692338
Neuroleptic malignant syndrome	135.64	40.93	53	4467	27506	79712362
Somnolence	120.39	40.93	103	4417	238878	79500990
Rhabdomyolysis	115.12	40.93	72	4448	103059	79636809
Necrotising colitis	114.35	40.93	23	4497	1017	79738851
Extrapyramidal disorder	105.90	40.93	42	4478	22637	79717231
Urinary retention	101.93	40.93	54	4466	56576	79683292
Wrong patient received product	93.90	40.93	26	4494	4592	79735276
Confusional state	93.60	40.93	102	4418	317895	79421973
Hyperthermia	89.81	40.93	35	4485	18002	79721866
Colitis ischaemic	80.72	40.93	31	4489	15328	79724540
Faecaloma	77.87	40.93	28	4492	11536	79728332
Intestinal pseudo-obstruction	73.45	40.93	19	4501	2590	79737278
Behaviour disorder	73.17	40.93	23	4497	6290	79733578
Pneumonia aspiration	72.75	40.93	46	4474	66921	79672947
Subileus	67.20	40.93	21	4499	5633	79734235
Distal intestinal obstruction syndrome	66.55	40.93	14	4506	773	79739095
Livedo reticularis	51.96	40.93	16	4504	4087	79735781
Suicide attempt	48.35	40.93	39	4481	82893	79656975
Hyperleukocytosis	45.35	40.93	13	4507	2597	79737271
Pulmonary embolism	43.41	40.93	51	4469	171603	79568265
Intestinal ischaemia	43.15	40.93	19	4501	13251	79726617
HIV peripheral neuropathy	41.00	40.93	6	4514	36	79739832
Myocarditis septic	41.00	40.93	6	4514	36	79739832
Mydriasis	40.95	40.93	20	4500	17623	79722245

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N04AA12	NERVOUS SYSTEM ANTI-PARKINSON DRUGS ANTICHOLINERGIC AGENTS Tertiary amines

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.1	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D07303	KEGG_DRUG
C0077388	UMLSCUI
CHEBI:135419	CHEBI
CHEMBL2107294	ChEMBL_ID
DB13252	DRUGBANK_ID
C013322	MESH_SUPPLEMENTAL_RECORD_UI
3034047	PUBCHEM_CID
3250	INN_ID
27574-25-0	SECONDARY_CAS_RN
C27HY5RFU5	UNII
236190	RXNORM
005365	NDDF
005366	NDDF
734969000	SNOMEDCT_US
734970004	SNOMEDCT_US

Pharmaceutical products:

None