trimethadione ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2751 127-48-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trimethadione
  • tridione
  • trimetin
  • trimetadione
An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
  • Molecular weight: 143.14
  • Formula: C6H9NO3
  • CLOGP: -0.12
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 46.61
  • ALOGS: 0.17
  • ROTB: 0

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 279.44 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Jan. 25, 1946 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AC02 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Oxazolidine derivatives
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:176497 geroprotectors
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
FDA EPC N0000175753 Anti-epileptic Agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Absence seizure indication 79631006
Epilepsy indication 84757009 DOID:1826
Retinal disorder contraindication 29555009 DOID:5679
Proteinuria contraindication 29738008 DOID:576
Lymphadenopathy contraindication 30746006
Eaton-Lambert syndrome contraindication 56989000 DOID:0050214
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Disorder of optic nerve contraindication 77157004 DOID:1891
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Disease of liver contraindication 235856003 DOID:409
Lupus erythematosus and erythema multiforme-like syndrome contraindication 238926009
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Porphyria contraindication 418470004




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-dependent T-type calcium channel subunit alpha-1G Ion channel BLOCKER WOMBAT-PK CHEMBL

External reference:

IDSource
4018714 VUID
N0000147020 NUI
D00392 KEGG_DRUG
4018714 VANDF
C0041038 UMLSCUI
CHEBI:9727 CHEBI
CHEMBL695 ChEMBL_ID
DB00347 DRUGBANK_ID
D014293 MESH_DESCRIPTOR_UI
5576 PUBCHEM_CID
1714 INN_ID
7316 IUPHAR_LIGAND_ID
R7GV3H6FQ4 UNII
10827 RXNORM
1652 MMSL
5630 MMSL
d00945 MMSL
001627 NDDF
386170005 SNOMEDCT_US
70732003 SNOMEDCT_US

Pharmaceutical products:

None