DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
Scroll
Substructure SMILES Example:
n1cnccc1
trimazosin 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antihypertensive substances, prazosin derivatives
2747
35795-16-5
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
trimazosin hydrochloride
rimazosin hydrochloride monohydrate
trimazosin
trimazosin HCl
Molecular weight: 435.48
Formula: C20H29N5O6
CLOGP: 2.98
LIPINSKI: 1
HAC: 11
HDO: 2
TPSA: 132.50
ALOGS: -2.44
ROTB: 7
Drug dosage:
Dose
Unit
Route
0.30
g
O
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
61 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
t_half (Half-life)
3.10 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
0.96 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.18 L/kg
Lombardo F, Berellini G, Obach RS
Showing 1 to 4 of 4 entries
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C02CA03
CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
Alpha-adrenoreceptor antagonists
MeSH PA
D018663
Adrenergic Agents
MeSH PA
D058668
Adrenergic alpha-1 Receptor Antagonists
MeSH PA
D000317
Adrenergic alpha-Antagonists
MeSH PA
D018674
Adrenergic Antagonists
MeSH PA
D000959
Antihypertensive Agents
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D018377
Neurotransmitter Agents
MeSH PA
D014665
Vasodilator Agents
Showing 1 to 9 of 9 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Hypertensive disorder
indication
38341003
DOID:10763
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
6.01
Basic
pKa2
0.78
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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ID
Source
31L760807H
UNII
3519
INN_ID
37264
PUBCHEM_CID
53746-46-6
SECONDARY_CAS_RN
C005185
MESH_SUPPLEMENTAL_RECORD_UI
C0077147
UMLSCUI
CHEBI:135710
CHEBI
CHEMBL3989848
ChEMBL_ID
CHEMBL513301
ChEMBL_ID
D06234
KEGG_DRUG
Showing 1 to 10 of 11 entries
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Pharmaceutical products:
None
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trimazosin