azimilide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| class III antiarrhythmics | 274 | 149908-53-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Hosey CM, Chan R, Benet LZ |
| Vd (Volume of distribution) | 13 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.06 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 79 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 290 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.74 | Basic |
| pKa2 | 4.74 | Basic |
| pKa3 | 0.93 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.40 | CHEMBL | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.74 | CHEMBL | |||||
| Potassium voltage-gated channel subfamily KQT member 1 | Ion channel | IC50 | 6.62 | CHEMBL | |||||
| Potassium voltage-gated channel subfamily KQT member 1 | Ion channel | BLOCKER | IC50 | 5.30 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D03037 | KEGG_DRUG |
| 149888-94-8 | SECONDARY_CAS_RN |
| C0252416 | UMLSCUI |
| CHEBI:34545 | CHEBI |
| CHEMBL123558 | ChEMBL_ID |
| CHEMBL3140370 | ChEMBL_ID |
| CHEMBL537847 | ChEMBL_ID |
| DB04957 | DRUGBANK_ID |
| C086123 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2588 | IUPHAR_LIGAND_ID |
| 7299 | INN_ID |
| 74QU6P2934 | UNII |
| 9571003 | PUBCHEM_CID |
Pharmaceutical products:
None