tridihexethyl 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2737 | 60-49-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
synonym Pathilon refers to chloride; RN given refers to parent cpd; structure
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.13 | g | O |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 15, 1954 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A03AB08 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS Synthetic anticholinergics, quaternary ammonium compounds |
| CHEBI has role | CHEBI:48876 | muscarinic antagonists |
| CHEBI has role | CHEBI:49201 | anti-ulcer drugs |
| CHEBI has role | CHEBI:53784 | antispasmodics |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Peptic ulcer | indication | 13200003 | DOID:750 |
| Gastric ulcer | indication | 397825006 | DOID:10808 |
| Irritable bowel syndrome | off-label use | 10743008 | DOID:9778 |
| Suicidal thoughts | contraindication | 6471006 | |
| Alcoholism | contraindication | 7200002 | |
| Lowered convulsive threshold | contraindication | 19260006 | |
| Substance abuse | contraindication | 66214007 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Seizure disorder | contraindication | 128613002 | |
| Acute intermittent porphyria | contraindication | 234422006 | DOID:3890 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Pregnancy, function | contraindication | 289908002 | |
| Breastfeeding (mother) | contraindication | 413712001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | GPCR | ANTAGONIST | CHEMBL | CHEMBL | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | ANTAGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019955 | VUID |
| N0000148040 | NUI |
| D00723 | KEGG_DRUG |
| 4310-35-4 | SECONDARY_CAS_RN |
| 4017914 | VANDF |
| 4019955 | VANDF |
| C0077081 | UMLSCUI |
| CHEBI:9701 | CHEBI |
| CHEMBL1201354 | ChEMBL_ID |
| DB00505 | DRUGBANK_ID |
| C005386 | MESH_SUPPLEMENTAL_RECORD_UI |
| 20299 | PUBCHEM_CID |
| 125-99-5 | SECONDARY_CAS_RN |
| 7HE50A367X | UNII |
| 38617 | RXNORM |
| 001744 | NDDF |
| 004700 | NDDF |
| 36872003 | SNOMEDCT_US |
| 76787008 | SNOMEDCT_US |
| CHEMBL1200771 | ChEMBL_ID |
| CHEMBL2107686 | ChEMBL_ID |
| 551 | INN_ID |
Pharmaceutical products:
None