tridihexethyl Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2737 60-49-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tridihexethyl
  • tridihexethyl chloride
  • tridihexethyl iodide
synonym Pathilon refers to chloride; RN given refers to parent cpd; structure
  • Molecular weight: 318.52
  • Formula: C21H36NO
  • CLOGP: 1.32
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -7.32
  • ROTB: 8

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.13 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 15, 1954 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AB08 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Synthetic anticholinergics, quaternary ammonium compounds
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:53784 antispasmodic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Gastric ulcer indication 397825006 DOID:10808
Irritable bowel syndrome off-label use 10743008 DOID:9778
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Lowered convulsive threshold contraindication 19260006
Substance abuse contraindication 66214007
Kidney disease contraindication 90708001 DOID:557
Seizure disorder contraindication 128613002
Acute intermittent porphyria contraindication 234422006 DOID:3890
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST CHEMBL CHEMBL
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

IDSource
4019955 VUID
N0000148040 NUI
C0077081 UMLSCUI
D00723 KEGG_DRUG
25YK75CYMX UNII
4310-35-4 SECONDARY_CAS_RN
4019955 VANDF
38617 RXNORM
36872003 SNOMEDCT_US
004700 NDDF
551 INN_ID
DB00505 DRUGBANK_ID
CHEMBL1200771 ChEMBL_ID
C005386 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:9701 CHEBI
20299 PUBCHEM_CID
CHEMBL1201354 ChEMBL_ID
CHEMBL2107686 ChEMBL_ID

Pharmaceutical products:

None