triclofos Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2735 306-52-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triclofos
  • trichlophos
  • trichloroethyl dihydrogen phosphate
  • trichloroethyl phosphate
  • triclofos sodium
derivative 7 metabolic precursor of trichloroethanol; RN given refers to parent cpd; structure
  • Molecular weight: 229.37
  • Formula: C2H4Cl3O4P
  • CLOGP: -0.11
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 66.76
  • ALOGS: -1.47
  • ROTB: 3

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05CM07 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Other hypnotics and sedatives

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.37 acidic
pKa2 6.42 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE MODULATOR CHEMBL CHEMBL

External reference:

IDSource
C0077073 UMLSCUI
D00388 KEGG_DRUG
421583009 SNOMEDCT_US
420762008 SNOMEDCT_US
38610 RXNORM
004583 NDDF
9F90KA5Q8U UNII
7246-20-0 SECONDARY_CAS_RN
5563 PUBCHEM_CID
CHEBI:9695 CHEBI
CHEMBL1200789 ChEMBL_ID
1518 INN_ID
C004345 MESH_SUPPLEMENTAL_RECORD_UI
DB06753 DRUGBANK_ID
CHEMBL1201317 ChEMBL_ID

Pharmaceutical products:

None