azelnidipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 272 123524-52-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • azelnidipine
  • calblock
  • CS-905
  • Molecular weight: 582.66
  • Formula: C33H34N4O6
  • CLOGP: 6.96
  • LIPINSKI: 2
  • HAC: 10
  • HDO: 2
  • TPSA: 137.03
  • ALOGS: -5.85
  • ROTB: 11

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 49.33 30.86 22 694 44341 34911874
Cerebral infarction 38.30 30.86 16 700 27439 34928776
Renal impairment 33.69 30.86 22 694 94491 34861724

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral infarction 65.02 29.09 27 1601 45649 79697111
Hepatic function abnormal 64.80 29.09 31 1597 73076 79669684
Renal impairment 42.65 29.09 31 1597 157752 79585008
Cardiac failure 36.43 29.09 28 1600 154814 79587946
Platelet count decreased 32.81 29.09 29 1599 194635 79548125

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.74 Basic
pKa2 1.78 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER DRUG LABEL KEGG DRUG

External reference:

IDSource
D01145 KEGG_DRUG
C0753287 UMLSCUI
CHEBI:31247 CHEBI
CHEMBL1275868 ChEMBL_ID
DB09230 DRUGBANK_ID
C061679 MESH_SUPPLEMENTAL_RECORD_UI
7109 INN_ID
PV23P19YUG UNII
65948 PUBCHEM_CID

Pharmaceutical products:

None