tranilast 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antiasthmatics or antiallergics, not acting primarily as antihistaminics anti-allergic or anti-inflammatory, not acting as anti-histaminics | 2714 | 53902-12-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
antiallergic drug; potent inhibitor of homologous passive cutaneous anaphylaxis; structure
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.01 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D018926 | Anti-Allergic Agents |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D018494 | Histamine Agents |
| MeSH PA | D006633 | Histamine Antagonists |
| MeSH PA | D006634 | Histamine H1 Antagonists |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D010975 | Platelet Aggregation Inhibitors |
| MeSH PA | D018689 | Sensory System Agents |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:38215 | calcium channel blockers |
| CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
| CHEBI has role | CHEBI:50857 | anti-allergic drugs |
| CHEBI has role | CHEBI:62868 | hepatoprotective agents |
| CHEBI has role | CHEBI:72768 | AhR agonist |
| CHEBI has role | CHEBI:76595 | nephroprotective agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertrophic scar | indication | 19843006 | |
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Keloid scar | indication | 33659008 | |
| Allergic rhinitis | indication | 61582004 | |
| Asthma | indication | 195967001 | DOID:2841 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.97 | acidic |
| pKa2 | 11.7 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Hematopoietic prostaglandin D synthase | Enzyme | IC50 | 4.94 | CHEMBL | |||||
| Transient receptor potential cation channel subfamily V member 2 | Ion channel | BLOCKER | IC50 | 5 | IUPHAR | ||||
| NACHT, LRR and PYD domains-containing protein 3 | Unclassified | IC50 | 4.60 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02027 | KEGG_DRUG |
| C0146337 | UMLSCUI |
| CHEBI:77572 | CHEBI |
| D27 | PDB_CHEM_ID |
| CHEMBL415324 | ChEMBL_ID |
| DB07615 | DRUGBANK_ID |
| C012293 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5282230 | PUBCHEM_CID |
| 6326 | IUPHAR_LIGAND_ID |
| 5070 | INN_ID |
| HVF50SMY6E | UNII |
| 57330 | RXNORM |
| 009960 | NDDF |
Pharmaceutical products:
None