tranilast Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiasthmatics or antiallergics, not acting primarily as antihistaminics anti-allergic or anti-inflammatory, not acting as anti-histaminics 2714 53902-12-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tranilast hydrate
  • tranilast sodium
  • tranilast
  • rizaben
antiallergic drug; potent inhibitor of homologous passive cutaneous anaphylaxis; structure
  • Molecular weight: 327.34
  • Formula: C18H17NO5
  • CLOGP: 3.99
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 84.86
  • ALOGS: -4.59
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D006401 Hematologic Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D010975 Platelet Aggregation Inhibitors
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:38215 calcium channel blockers
CHEBI has role CHEBI:49167 anti-asthmatic agents
CHEBI has role CHEBI:50857 anti-allergic agents
CHEBI has role CHEBI:62868 antihepatotoxic agent
CHEBI has role CHEBI:72768 ahr agonists
CHEBI has role CHEBI:76595 nephroprotective agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertrophic scar indication 19843006
Atopic dermatitis indication 24079001 DOID:3310
Keloid scar indication 33659008
Allergic rhinitis indication 61582004
Asthma indication 195967001 DOID:2841

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.97 acidic
pKa2 11.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Hematopoietic prostaglandin D synthase Enzyme IC50 4.94 CHEMBL

External reference:

IDSource
D02027 KEGG_DRUG
C0146337 UMLSCUI
CHEBI:77572 CHEBI
D27 PDB_CHEM_ID
CHEMBL415324 ChEMBL_ID
C012293 MESH_SUPPLEMENTAL_RECORD_UI
5070 INN_ID
DB07615 DRUGBANK_ID
HVF50SMY6E UNII
5282230 PUBCHEM_CID
6326 IUPHAR_LIGAND_ID
57330 RXNORM
009960 NDDF

Pharmaceutical products:

None