azaribine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
ribofuranyl-derivatives of the "pyrazofurin" type 27 2169-64-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • azaribine
  • triazure
  • azaribin
  • triacetyl-6-azauridine
  • triacetyl azauridine
  • 6-azauridine triacetate
pyrimidine analogue; anti-metabolite used in psoriasis & mycosis fungoides
  • Molecular weight: 371.30
  • Formula: C14H17N3O9
  • CLOGP: 0.19
  • LIPINSKI: 1
  • HAC: 12
  • HDO: 1
  • TPSA: 149.90
  • ALOGS: -2.12
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,ITK,JAK1,JAK2,MAP3K21,MAP3K7,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK1,PDK2,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,PTK2,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 52
kinase-selectivity-class AXL,CDK9,GRK2,MAP2K6,MAP3K14,MAPK7,STK33,TEK 8
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003879 Dermatologic Agents
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:49103 drug metabolite
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:50748 antipsoriatic

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.42 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Orotidine 5'-phosphate decarboxylase Enzyme Ki 4.96 CHEMBL
Orotidine 5'-phosphate decarboxylase Enzyme Ki 7.19 CHEMBL

External reference:

IDSource
D03029 KEGG_DRUG
CHEBI:88272 CHEBI
CHEMBL515914 ChEMBL_ID
C100231 MESH_SUPPLEMENTAL_RECORD_UI
2502 INN_ID
K1U80DO9EB UNII
C0052757 UMLSCUI
C0004483 UMLSCUI
CHEMBL564201 ChEMBL_ID
16574 PUBCHEM_CID
54-25-1 SECONDARY_CAS_RN
5901 PUBCHEM_CID
7BVB29RCPR UNII
002651 NDDF
CHEBI:35668 CHEBI

Pharmaceutical products:

None