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tiocarlide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2673 | 910-86-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
major descriptor (68-85); on-line search PHENYLTHIOUREA/AA (68-85); Index Medicus search THIOCARLIDE (68-85); Antitubercular Agent
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 7 | g | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHA2,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MELK,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK10,STK33,SYK,TEK,TTK,ULK1 | 66 | |||
| kinase-selectivity-class | ACVR2B,AURKA,AXL,BRAF,CAMK2D,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,MAP3K21,MAPK7,MARK4,MET,NTRK3,PDK4,PRKDC,SIK2,STK10,STK33,TEK,TTK,TYRO3,ULK1 | 27 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J04AD02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Thiocarbamide derivatives |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000995 | Antitubercular Agents |
| CHEBI has role | CHEBI:33231 | antitubercular agent |
Related Drugs by ATC class:
J04AD Thiocarbamide derivatives 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pulmonary tuberculosis | indication | 154283005 | DOID:2957 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.94 | acidic |
| pKa2 | 11.52 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Epoxide hydrolase EphE; Hydrolase, alpha/beta hydrolase fold family | Enzyme | IC50 | 7.66 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07246 | KEGG_DRUG |
| C3652604 | UMLSCUI |
| CHEBI:135637 | CHEBI |
| CHEMBL214920 | ChEMBL_ID |
| DB13608 | DRUGBANK_ID |
| 3001386 | PUBCHEM_CID |
| C100189 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1597 | INN_ID |
| 43M23X81Y2 | UNII |
| 43M23X81Y2 | INXIGHT DRUGS |
Pharmaceutical products:
None