tiamenidine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihypertensives, clonidine derivatives 2649 31428-61-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tiamenidine hydrochloride
  • tiamenidine
  • thiamendidine
  • Molecular weight: 215.70
  • Formula: C8H10ClN3S
  • CLOGP: 1.14
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 36.42
  • ALOGS: -3.13
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.16 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenergic receptor alpha-2 GPCR IC50 8.04 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 5.31 CHEMBL

External reference:

IDSource
D06125 KEGG_DRUG
195V08O55G UNII
3325 INN_ID
51274-83-0 SECONDARY_CAS_RN
39974 PUBCHEM_CID
CHEBI:134896 CHEBI
CHEMBL295409 ChEMBL_ID
C010354 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2107008 ChEMBL_ID

Pharmaceutical products:

None