tiamenidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
alpha-2 adrenoreceptor agonists	2649	31428-61-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

tiamenidine hydrochloride
tiamenidine
thiamendidine

Molecular weight: 215.70
Formula: C8H10ClN3S
CLOGP: 1.01
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 36.42
ALOGS: -3.17
ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.16	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		IC50	8.04		CHEMBL
Adrenergic receptor alpha-1	GPCR		ADA1B_RAT ADA1D_RAT ADA1A_RAT		IC50	5.31		CHEMBL

External reference:

ID	Source
D06125	KEGG_DRUG
51274-83-0	SECONDARY_CAS_RN
C0076650	UMLSCUI
CHEBI:134896	CHEBI
CHEMBL295409	ChEMBL_ID
CHEMBL2107008	ChEMBL_ID
39974	PUBCHEM_CID
C010354	MESH_SUPPLEMENTAL_RECORD_UI
3325	INN_ID
195V08O55G	UNII

Pharmaceutical products:

None