DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
tiamenidine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
alpha-2 adrenoreceptor agonists
2649
31428-61-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
tiamenidine hydrochloride
tiamenidine
thiamendidine
Molecular weight: 215.70
Formula: C8H10ClN3S
CLOGP: 1.01
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 36.42
ALOGS: -3.17
ROTB: 1
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
9.16
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Adrenergic receptor alpha-2
GPCR
ADA2B_RAT
ADA2C_RAT
ADA2A_RAT
IC50
8.04
CHEMBL
Adrenergic receptor alpha-1
GPCR
ADA1B_RAT
ADA1D_RAT
ADA1A_RAT
IC50
5.31
CHEMBL
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External reference:
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entries
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ID
Source
195V08O55G
UNII
3325
INN_ID
39974
PUBCHEM_CID
51274-83-0
SECONDARY_CAS_RN
C0076650
UMLSCUI
C010354
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:134896
CHEBI
CHEMBL2107008
ChEMBL_ID
CHEMBL295409
ChEMBL_ID
D06125
KEGG_DRUG
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Pharmaceutical products:
None
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tiamenidine