thymalfasin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2643 62304-98-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thymalfasin
  • Thymosin alpha1
  • zadaxin
A thymus hormone polypeptide found in thymosin fraction 5 (a crude thymus gland extract) but now produced by synthesis. It is used alone or with interferon as an immunomodulator for the treatment of CHRONIC HEPATITIS B and HEPATITIS C. Thymalfasin is also used for the treatment of chemotherapy-induced immunosuppression, and to enhance the efficacy of influenza and hepatitis B vaccines in immunocompromised patients.
  • Molecular weight: 3108.32
  • Formula: C129H215N33O55
  • CLOGP: 0
  • LIPINSKI: 3
  • HAC: 88
  • HDO: 49
  • TPSA: 1456.35
  • ALOGS: -4.08
  • ROTB: 111

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D007155 Immunologic Factors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.94 acidic
pKa2 3.2 acidic
pKa3 3.29 acidic
pKa4 3.51 acidic
pKa5 3.83 acidic
pKa6 3.97 acidic
pKa7 4.1 acidic
pKa8 4.24 acidic
pKa9 4.47 acidic
pKa10 4.81 acidic
pKa11 12.01 acidic
pKa12 12.31 acidic
pKa13 12.53 acidic
pKa14 12.62 acidic
pKa15 12.88 acidic
pKa16 12.89 acidic
pKa17 13.15 acidic
pKa18 13.18 acidic
pKa19 13.43 acidic
pKa20 13.43 acidic
pKa21 13.46 acidic
pKa22 13.52 acidic
pKa23 13.63 acidic
pKa24 13.79 acidic
pKa25 13.91 acidic
pKa26 13.96 acidic
pKa27 13.99 acidic
pKa28 11.41 Basic
pKa29 10.98 Basic
pKa30 10.63 Basic
pKa31 10.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D06116 KEGG_DRUG
C0076612 UMLSCUI
CHEBI:135915 CHEBI
CHEMBL2103979 ChEMBL_ID
D000077596 MESH_DESCRIPTOR_UI
DB04900 DRUGBANK_ID
7344 INN_ID
W0B22ISQ1C UNII
16130571 PUBCHEM_CID
38221 RXNORM
009083 NDDF
421968008 SNOMEDCT_US
422261006 SNOMEDCT_US

Pharmaceutical products:

None