thiouracil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
uracil derivatives used as thyroid antagonists	2640	141-90-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: thiouracil nobilen 2-mercapto-4-hydroxypyrimidine 4-hydroxy-2-mercaptopyrimidine antagothyroil	Occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis. Molecular weight: 128.15 Formula: C4H4N2OS CLOGP: -0.59 LIPINSKI: 0 HAC: 3 HDO: 2 TPSA: 41.13 ALOGS: -1.58 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

thiouracil
nobilen
2-mercapto-4-hydroxypyrimidine
4-hydroxy-2-mercaptopyrimidine
antagothyroil

Occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis.

Molecular weight: 128.15
Formula: C4H4N2OS
CLOGP: -0.59
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 41.13
ALOGS: -1.58
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D013956	Antithyroid Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D006727	Hormone Antagonists
MeSH PA	D014665	Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Thyrotoxic crisis	indication	29028009	DOID:12837
Hyperthyroidism	indication	34486009	DOID:7998
Necrotizing vasculitis	contraindication	11791001
Hyperbilirubinemia	contraindication	14783006	DOID:2741
Agranulocytosis	contraindication	17182001	DOID:12987
Hypothyroidism	contraindication	40930008	DOID:1459
Interstitial pneumonia	contraindication	64667001
Leukopenia	contraindication	84828003	DOID:615
Pancytopenia	contraindication	127034005	DOID:12450
Liver function tests abnormal	contraindication	166603001
Drug-induced hepatitis	contraindication	235876009
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Bone marrow depression	contraindication	307762000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.02	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
C0039957	UMLSCUI
CHEMBL345768	ChEMBL_ID
1269845	PUBCHEM_CID
D013889	MESH_DESCRIPTOR_UI
59X161SCYL	UNII
55358003	SNOMEDCT_US
TUL	PDB_CHEM_ID

Pharmaceutical products:

None