All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

thioridazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2637	50-52-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: thioridazine thioridazin dl-Thioridazine malloryl meleril thioridazine hydrochloride thioridazine HCl	A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA. Molecular weight: 370.57 Formula: C21H26N2S2 CLOGP: 6.20 LIPINSKI: 1 HAC: 2 HDO: 0 TPSA: 6.48 ALOGS: -5.64 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.30	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ
S (Water solubility)	0.00 mg/mL	Bocci G, Oprea TI, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose)	35.89 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	40 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
March 15, 1962	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Antipsychotic drug level below therapeutic	505.88	188.88	90	1603	2457	34952781
Therapeutic product effect variable	489.15	188.88	87	1606	2369	34952869
Disinhibition	484.64	188.88	90	1603	3136	34952102
Obsessive-compulsive disorder	471.09	188.88	96	1597	5468	34949770
Euphoric mood	434.46	188.88	90	1603	5551	34949687
Increased appetite	409.76	188.88	90	1603	7339	34947899
Akathisia	401.91	188.88	90	1603	8019	34947219
Suicide attempt	265.63	188.88	91	1602	39025	34916213
Therapeutic product effect incomplete	228.25	188.88	87	1606	50454	34904784
Leukopenia	203.07	188.88	85	1608	62771	34892467
Leukaemia	200.01	188.88	46	1647	4557	34950681

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Antipsychotic drug level below therapeutic	157.03	56.36	25	1097	1213	79742053
Therapeutic product effect variable	144.93	56.36	25	1097	1984	79741282
Disinhibition	138.51	56.36	25	1097	2573	79740693
Obsessive-compulsive disorder	117.94	56.36	25	1097	5902	79737364
Euphoric mood	111.34	56.36	25	1097	7701	79735565
Akathisia	107.83	56.36	27	1095	13232	79730034
Dyslipidaemia	101.16	56.36	25	1097	11608	79731658
Increased appetite	100.43	56.36	25	1097	11953	79731313
Obesity	77.82	56.36	26	1096	35099	79708167
Irritability	62.49	56.36	23	1099	41121	79702145
Prescribed overdose	60.59	56.36	22	1100	37861	79705405
Schizoaffective disorder	59.88	56.36	12	1110	2140	79741126

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AC02	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with piperidine structure
FDA CS	M0016525	Phenothiazines
MeSH PA	D014150	Antipsychotic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D015259	Dopamine Agents
MeSH PA	D018492	Dopamine Antagonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents
CHEBI has role	CHEBI:37890	alpha-adrenergic receptor blockaders
CHEBI has role	CHEBI:37955	H1 receptor antagonists
CHEBI has role	CHEBI:48279	serotonin antagonists
CHEBI has role	CHEBI:48561	dopaminergic antagonists
CHEBI has role	CHEBI:65190	typical antipsychotic drugs
CHEBI has role	CHEBI:76779	post-proline endopeptidase inhibitors
CHEBI has role	CHEBI:77402	EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors
FDA EPC	N0000175746	Phenothiazine
CHEBI has role	CHEBI:176497	geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Treatment-Resistant Schizophrenia	indication
Hyperkalemia	contraindication	14140009
Neuroleptic malignant syndrome	contraindication	15244003	DOID:14464
Senile dementia	contraindication	15662003
Orthostatic hypotension	contraindication	28651003
Hypokalemia	contraindication	43339004
Epilepsy	contraindication	84757009	DOID:1826
Stupor	contraindication	89458003
Tardive dyskinesia	contraindication	102449007
Prolonged QT interval	contraindication	111975006
Disease of blood AND/OR blood-forming organ	contraindication	191124002	DOID:74
Coma	contraindication	371632003
Breastfeeding (mother)	contraindication	413712001
Congenital long QT syndrome	contraindication	442917000
Predisposed to Torsades de Pointes Cardiac Arrhythmias	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.22	Basic
pKa2	3.45	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	ANTAGONIST	IC50	7.40		WOMBAT-PK	CHEMBL
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		IC50	7.10		WOMBAT-PK
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	6.87		PDSP
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	6.82		DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	7		WOMBAT-PK
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	5.90		PDSP
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.81		DRUG MATRIX
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN	ANTAGONIST	Ki	7.10		IUPHAR
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST	EC50	8		WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	7.09		DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN	ANTAGONIST	Ki	7.30		IUPHAR
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN	ANTAGONIST	Ki	7.20		IUPHAR
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	7.15		CHEMBL
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		IC50	7.90		WOMBAT-PK
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.47		PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN	ANTAGONIST	IC50	7.30		WOMBAT-PK
D(1B) dopamine receptor	GPCR	P21918	DRD5_HUMAN	ANTAGONIST	Ki	5.60		IUPHAR
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	7.70		IUPHAR
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	6.87		PDSP
Histamine H4 receptor	GPCR	Q9H3N8	HRH4_HUMAN		Ki	5.62		PDSP
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	8.57		PDSP
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	7.85		PDSP
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	7.60		PDSP
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	8.05		PDSP
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	7.89		PDSP
Aldehyde oxidase	Enzyme	Q06278	AOXA_HUMAN		IC50	6.80		WOMBAT-PK
5-hydroxytryptamine receptor 1B	GPCR	P28222	5HT1B_HUMAN		Ki	6.96		PDSP
5-hydroxytryptamine receptor 1D	GPCR	P28221	5HT1D_HUMAN		Ki	6.24		PDSP
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	7.13		PDSP
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	5.77		PDSP
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	5.75		DRUG MATRIX
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN	ANTAGONIST	Ki	7.98		PDSP
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	8.69		DRUG MATRIX
Alpha-1B adrenergic receptor	GPCR	P35368	ADA1B_HUMAN		Ki	8.62		PDSP
Kappa-type opioid receptor	GPCR	P41145	OPRK_HUMAN		Ki	6.00		DRUG MATRIX
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN		IC50	5.18		CHEMBL
5-hydroxytryptamine receptor 5A	GPCR	P47898	5HT5A_HUMAN		Ki	6.44		PDSP
Cytochrome P450 1A2	Enzyme	P05177	CP1A2_HUMAN		IC50	5.03		DRUG MATRIX
5-hydroxytryptamine receptor 1E	GPCR	P28566	5HT1E_HUMAN		Ki	6.71		PDSP
Epidermal growth factor receptor	Kinase	P00533	EGFR_HUMAN		IC50	5.53		DRUG MATRIX
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	5.20		DRUG MATRIX
Tyrosine-protein kinase Fyn	Kinase	P06241	FYN_HUMAN		IC50	5.30		DRUG MATRIX
Serine/threonine-protein kinase pim-1	Kinase	P11309	PIM1_HUMAN		IC50	5.16		CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	5.19		CHEMBL
Nuclear receptor subfamily 1 group I member 3	Nuclear hormone receptor	Q14994	NR1I3_HUMAN					WOMBAT-PK
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Enzyme	Q9UDY8	MALT1_HUMAN		IC50	5.46		CHEMBL
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	8.59		DRUG MATRIX
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		Ki	6.28		DRUG MATRIX
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		IC50	8.29		CHEMBL
D(2) dopamine receptor	GPCR		DRD2_RAT		IC50	8.55		CHEMBL
5-hydroxytryptamine receptor 7	GPCR		5HT7R_RAT	ANTAGONIST	Ki	7.20		IUPHAR
D(1A) dopamine receptor	GPCR		DRD1_RAT		IC50	7.76		CHEMBL
Histamine H1 receptor	GPCR		HRH1_RAT		IC50	7		CHEMBL
5-hydroxytryptamine receptor 6	GPCR		5HT6R_RAT	ANTAGONIST	Ki	8.20		IUPHAR
Pleiotropic ABC efflux transporter of multiple drugs	Transporter		PDR5_YEAST		IC50	5.89		CHEMBL
Muscarinic acetylcholine receptor	GPCR		ACM1_RAT ACM3_RAT ACM4_RAT ACM5_RAT ACM2_RAT		IC50	8.70		CHEMBL
Serotonin 1 (5-HT1) receptor	GPCR		5HT1A_RAT 5HT1B_RAT 5HT1D_RAT 5HT1F_RAT		IC50	5.06		CHEMBL
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		IC50	5.89		CHEMBL
Dopamine receptor	GPCR		DRD1_RAT DRD3_RAT DRD5_RAT DRD4_RAT DRD2_RAT		IC50	7.07		CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2C_RAT 5HT2A_RAT 5HT2B_RAT		IC50	7.74		CHEMBL
G protein-activated inward rectifier potassium channel 2	Ion channel		KCNJ6_MOUSE	GATING INHIBITOR	EC50	4.20		IUPHAR

External reference:

ID	Source
4019946	VUID
N0000148031	NUI
D00373	KEGG_DRUG
130-61-0	SECONDARY_CAS_RN
4017892	VANDF
4019946	VANDF
C0039943	UMLSCUI
CHEBI:9566	CHEBI
LZU	PDB_CHEM_ID
CHEMBL479	ChEMBL_ID
DB00679	DRUGBANK_ID
CHEMBL1200916	ChEMBL_ID
D013881	MESH_DESCRIPTOR_UI
5452	PUBCHEM_CID
100	IUPHAR_LIGAND_ID
818	INN_ID
N3D6TG58NI	UNII
10502	RXNORM
1788	MMSL
2125	MMSL
5571	MMSL
5572	MMSL
d00389	MMSL
001482	NDDF
004591	NDDF
18550006	SNOMEDCT_US
33588000	SNOMEDCT_US
372706001	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0612	TABLET, FILM COATED	10 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0614	TABLET, FILM COATED	25 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0616	TABLET, FILM COATED	50 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0618	TABLET, FILM COATED	100 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	51079-565	TABLET, FILM COATED	10 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	51079-566	TABLET, FILM COATED	25 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	51079-567	TABLET, FILM COATED	50 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	51079-580	TABLET, FILM COATED	100 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	53489-148	TABLET, FILM COATED	10 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	53489-149	TABLET, FILM COATED	25 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	53489-150	TABLET, FILM COATED	50 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	53489-500	TABLET, FILM COATED	100 mg	ORAL	ANDA	18 sections
Thioridazine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	70518-1706	TABLET, FILM COATED	100 mg	ORAL	ANDA	15 sections