atomoxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 256 | 83015-26-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 80 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 27.80 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 1.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 8.39 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 94 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.85 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 9.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 5.20 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 26, 2002 | FDA | LILLY |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blepharospasm | 266.99 | 16.91 | 81 | 11804 | 5915 | 63471222 |
| Suicidal ideation | 247.91 | 16.91 | 151 | 11734 | 62270 | 63414867 |
| Taste disorder | 194.81 | 16.91 | 79 | 11806 | 13583 | 63463554 |
| Epilepsy | 154.41 | 16.91 | 83 | 11802 | 26982 | 63450155 |
| Tic | 110.06 | 16.91 | 30 | 11855 | 1490 | 63475647 |
| Memory impairment | 108.87 | 16.91 | 115 | 11770 | 104143 | 63372994 |
| Irritability | 101.51 | 16.91 | 67 | 11818 | 31627 | 63445510 |
| Aggression | 98.70 | 16.91 | 59 | 11826 | 23439 | 63453698 |
| Myocarditis | 98.66 | 16.91 | 45 | 11840 | 10280 | 63466857 |
| Abnormal behaviour | 98.41 | 16.91 | 57 | 11828 | 21369 | 63455768 |
| Prescribed overdose | 94.61 | 16.91 | 66 | 11819 | 34087 | 63443050 |
| Paraesthesia | 88.68 | 16.91 | 127 | 11758 | 156839 | 63320298 |
| Gastrooesophageal reflux disease | 88.48 | 16.91 | 99 | 11786 | 95540 | 63381597 |
| Agitation | 84.85 | 16.91 | 78 | 11807 | 59679 | 63417458 |
| Disturbance in attention | 81.38 | 16.91 | 63 | 11822 | 38126 | 63439011 |
| Hypoaesthesia | 76.34 | 16.91 | 123 | 11762 | 168270 | 63308867 |
| Product tampering | 74.57 | 16.91 | 17 | 11868 | 401 | 63476736 |
| Suicide attempt | 74.09 | 16.91 | 73 | 11812 | 60845 | 63416292 |
| Pulse abnormal | 72.31 | 16.91 | 24 | 11861 | 2340 | 63474797 |
| Mood swings | 71.94 | 16.91 | 44 | 11841 | 18204 | 63458933 |
| Depression | 68.75 | 16.91 | 128 | 11757 | 196364 | 63280773 |
| Crying | 66.72 | 16.91 | 46 | 11839 | 23297 | 63453840 |
| Adulterated product | 65.43 | 16.91 | 14 | 11871 | 244 | 63476893 |
| Intentional self-injury | 65.03 | 16.91 | 47 | 11838 | 25640 | 63451497 |
| Claustrophobia | 64.07 | 16.91 | 18 | 11867 | 1000 | 63476137 |
| Overdose | 60.42 | 16.91 | 90 | 11795 | 114988 | 63362149 |
| Liver injury | 60.01 | 16.91 | 65 | 11820 | 60455 | 63416682 |
| Congestive hepatopathy | 59.70 | 16.91 | 22 | 11863 | 2920 | 63474217 |
| Attention deficit hyperactivity disorder | 58.74 | 16.91 | 22 | 11863 | 3054 | 63474083 |
| Intentional overdose | 57.27 | 16.91 | 70 | 11815 | 74082 | 63403055 |
| Tachycardia | 57.22 | 16.91 | 89 | 11796 | 118067 | 63359070 |
| Somnolence | 57.06 | 16.91 | 112 | 11773 | 178573 | 63298564 |
| Somatic symptom disorder | 50.71 | 16.91 | 19 | 11866 | 2641 | 63474496 |
| Loss of consciousness | 50.39 | 16.91 | 84 | 11801 | 118037 | 63359100 |
| Impulsive behaviour | 48.13 | 16.91 | 16 | 11869 | 1567 | 63475570 |
| Brain injury | 46.98 | 16.91 | 24 | 11861 | 7019 | 63470118 |
| Seizure | 45.83 | 16.91 | 86 | 11799 | 132548 | 63344589 |
| Paranoia | 45.61 | 16.91 | 28 | 11857 | 11651 | 63465486 |
| Neurological symptom | 45.36 | 16.91 | 22 | 11863 | 5761 | 63471376 |
| Abdominal pain upper | 44.98 | 16.91 | 111 | 11774 | 206333 | 63270804 |
| Amenorrhoea | 44.51 | 16.91 | 26 | 11859 | 9888 | 63467249 |
| Raynaud's phenomenon | 43.81 | 16.91 | 14 | 11871 | 1210 | 63475927 |
| Hyperreflexia | 41.86 | 16.91 | 21 | 11864 | 5913 | 63471224 |
| Completed suicide | 41.35 | 16.91 | 87 | 11798 | 145586 | 63331551 |
| Vomiting | 39.88 | 16.91 | 208 | 11677 | 559409 | 62917728 |
| Anxiety | 39.24 | 16.91 | 109 | 11776 | 217432 | 63259705 |
| Mania | 39.22 | 16.91 | 26 | 11859 | 12341 | 63464796 |
| Anger | 39.05 | 16.91 | 26 | 11859 | 12430 | 63464707 |
| Trichotillomania | 37.91 | 16.91 | 8 | 11877 | 130 | 63477007 |
| Psychomotor hyperactivity | 37.70 | 16.91 | 24 | 11861 | 10639 | 63466498 |
| Supine hypertension | 37.18 | 16.91 | 7 | 11878 | 61 | 63477076 |
| Feeling abnormal | 34.66 | 16.91 | 82 | 11803 | 148310 | 63328827 |
| Diarrhoea | 33.97 | 16.91 | 51 | 11834 | 715315 | 62761822 |
| Oppositional defiant disorder | 33.29 | 16.91 | 6 | 11879 | 40 | 63477097 |
| Hepatic failure | 33.08 | 16.91 | 37 | 11848 | 35619 | 63441518 |
| Hepatitis | 33.06 | 16.91 | 39 | 11846 | 39749 | 63437388 |
| Dystonia | 32.07 | 16.91 | 24 | 11861 | 13795 | 63463342 |
| Hepatic encephalopathy | 31.68 | 16.91 | 22 | 11863 | 11260 | 63465877 |
| Hyperhidrosis | 31.28 | 16.91 | 65 | 11820 | 107771 | 63369366 |
| Pneumonia | 31.17 | 16.91 | 24 | 11861 | 456743 | 63020394 |
| Bipolar I disorder | 30.59 | 16.91 | 12 | 11873 | 1887 | 63475250 |
| Palpitations | 30.43 | 16.91 | 66 | 11819 | 112704 | 63364433 |
| Electrocardiogram QT prolonged | 30.41 | 16.91 | 46 | 11839 | 59484 | 63417653 |
| Withdrawal syndrome | 30.11 | 16.91 | 27 | 11858 | 19970 | 63457167 |
| Psychotic disorder | 29.74 | 16.91 | 30 | 11855 | 25682 | 63451455 |
| Educational problem | 29.33 | 16.91 | 8 | 11877 | 398 | 63476739 |
| Encephalopathy | 29.06 | 16.91 | 36 | 11849 | 38584 | 63438553 |
| Drug screen positive | 29.05 | 16.91 | 14 | 11871 | 3615 | 63473522 |
| Renal tubular acidosis | 28.35 | 16.91 | 11 | 11874 | 1681 | 63475456 |
| Electrocardiogram ST segment elevation | 28.00 | 16.91 | 14 | 11871 | 3913 | 63473224 |
| Obsessive-compulsive disorder | 27.56 | 16.91 | 14 | 11871 | 4046 | 63473091 |
| Acute kidney injury | 26.83 | 16.91 | 8 | 11877 | 263407 | 63213730 |
| Treatment failure | 26.75 | 16.91 | 3 | 11882 | 199040 | 63278097 |
| Mydriasis | 26.05 | 16.91 | 20 | 11865 | 11936 | 63465201 |
| Thinking abnormal | 25.85 | 16.91 | 19 | 11866 | 10624 | 63466513 |
| Aspartate aminotransferase increased | 25.69 | 16.91 | 54 | 11831 | 90223 | 63386914 |
| Treatment noncompliance | 25.25 | 16.91 | 33 | 11852 | 37292 | 63439845 |
| Piloerection | 25.11 | 16.91 | 7 | 11878 | 378 | 63476759 |
| Dysmenorrhoea | 24.94 | 16.91 | 13 | 11872 | 3960 | 63473177 |
| Hypomania | 24.27 | 16.91 | 15 | 11870 | 6315 | 63470822 |
| Face oedema | 24.14 | 16.91 | 24 | 11861 | 20188 | 63456949 |
| Heart rate increased | 24.11 | 16.91 | 54 | 11831 | 94184 | 63382953 |
| Contraindicated product administered | 23.30 | 16.91 | 6 | 11879 | 217642 | 63259495 |
| Euphoric mood | 22.42 | 16.91 | 13 | 11872 | 4874 | 63472263 |
| Arthropathy | 22.38 | 16.91 | 8 | 11877 | 234784 | 63242353 |
| Social avoidant behaviour | 22.33 | 16.91 | 11 | 11874 | 2977 | 63474160 |
| Arthralgia | 22.12 | 16.91 | 46 | 11839 | 569664 | 62907473 |
| Infection | 21.52 | 16.91 | 8 | 11877 | 229165 | 63247972 |
| Joint swelling | 21.35 | 16.91 | 18 | 11867 | 327648 | 63149489 |
| Dermatitis atopic | 20.61 | 16.91 | 16 | 11869 | 9708 | 63467429 |
| Anaemia | 20.53 | 16.91 | 15 | 11870 | 293415 | 63183722 |
| Death | 20.45 | 16.91 | 24 | 11861 | 374357 | 63102780 |
| Mood altered | 20.43 | 16.91 | 19 | 11866 | 14724 | 63462413 |
| Emotional disorder | 20.02 | 16.91 | 18 | 11867 | 13361 | 63463776 |
| Hypertensive crisis | 19.84 | 16.91 | 19 | 11866 | 15267 | 63461870 |
| Toxicity to various agents | 18.98 | 16.91 | 94 | 11791 | 247156 | 63229981 |
| Bipolar disorder | 18.86 | 16.91 | 14 | 11871 | 7946 | 63469191 |
| Lymphocytic hypophysitis | 18.69 | 16.91 | 5 | 11880 | 231 | 63476906 |
| Personality change | 18.19 | 16.91 | 13 | 11872 | 6960 | 63470177 |
| Peripheral swelling | 18.08 | 16.91 | 14 | 11871 | 265928 | 63211209 |
| Merycism | 17.83 | 16.91 | 5 | 11880 | 276 | 63476861 |
| Abnormal dreams | 17.44 | 16.91 | 15 | 11870 | 10501 | 63466636 |
| Affective disorder | 17.29 | 16.91 | 12 | 11873 | 6134 | 63471003 |
| Generalised tonic-clonic seizure | 17.11 | 16.91 | 24 | 11861 | 28992 | 63448145 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Suicidal ideation | 674.51 | 22.10 | 335 | 14823 | 40053 | 34901720 |
| Tic | 564.24 | 22.10 | 139 | 15019 | 1919 | 34939854 |
| Aggression | 545.23 | 22.10 | 287 | 14871 | 38677 | 34903096 |
| Prescribed overdose | 477.69 | 22.10 | 178 | 14980 | 10469 | 34931304 |
| Abnormal behaviour | 349.07 | 22.10 | 184 | 14974 | 24785 | 34916988 |
| Anger | 266.50 | 22.10 | 121 | 15037 | 11763 | 34930010 |
| Irritability | 238.95 | 22.10 | 143 | 15015 | 24547 | 34917226 |
| Crying | 205.60 | 22.10 | 82 | 15076 | 5780 | 34935993 |
| Intentional self-injury | 199.46 | 22.10 | 104 | 15054 | 13667 | 34928106 |
| Psychomotor hyperactivity | 175.59 | 22.10 | 85 | 15073 | 9537 | 34932236 |
| Testicular pain | 174.97 | 22.10 | 60 | 15098 | 2758 | 34939015 |
| Oppositional defiant disorder | 155.05 | 22.10 | 38 | 15120 | 511 | 34941262 |
| Agitation | 148.46 | 22.10 | 152 | 15006 | 57247 | 34884526 |
| Ejaculation disorder | 145.64 | 22.10 | 41 | 15117 | 968 | 34940805 |
| Suicide attempt | 132.10 | 22.10 | 120 | 15038 | 38996 | 34902777 |
| Homicidal ideation | 131.81 | 22.10 | 48 | 15110 | 2634 | 34939139 |
| Mood swings | 129.85 | 22.10 | 65 | 15093 | 7836 | 34933937 |
| Urinary hesitation | 126.09 | 22.10 | 47 | 15111 | 2755 | 34939018 |
| Anxiety | 116.69 | 22.10 | 177 | 14981 | 99251 | 34842522 |
| Disturbance in attention | 114.91 | 22.10 | 93 | 15065 | 25852 | 34915921 |
| Impulsive behaviour | 114.89 | 22.10 | 41 | 15117 | 2121 | 34939652 |
| Heart rate increased | 107.76 | 22.10 | 116 | 15042 | 46227 | 34895546 |
| Psychotic disorder | 106.91 | 22.10 | 87 | 15071 | 24365 | 34917408 |
| Depressed mood | 104.58 | 22.10 | 78 | 15080 | 19239 | 34922534 |
| Mood altered | 100.12 | 22.10 | 57 | 15101 | 8895 | 34932878 |
| Death | 100.02 | 22.10 | 25 | 15133 | 398024 | 34543749 |
| Acute kidney injury | 99.57 | 22.10 | 9 | 15149 | 304979 | 34636794 |
| Hallucination, auditory | 97.33 | 22.10 | 62 | 15096 | 11855 | 34929918 |
| Pneumonia | 96.63 | 22.10 | 20 | 15138 | 362607 | 34579166 |
| Depression | 93.50 | 22.10 | 158 | 15000 | 96940 | 34844833 |
| Insomnia | 93.41 | 22.10 | 164 | 14994 | 103743 | 34838030 |
| Somnolence | 93.01 | 22.10 | 170 | 14988 | 110946 | 34830827 |
| Attention deficit hyperactivity disorder | 90.41 | 22.10 | 36 | 15122 | 2523 | 34939250 |
| Decreased eye contact | 89.44 | 22.10 | 24 | 15134 | 471 | 34941302 |
| Product substitution issue | 86.14 | 22.10 | 54 | 15104 | 10041 | 34931732 |
| Bruxism | 85.06 | 22.10 | 31 | 15127 | 1704 | 34940069 |
| Drug screen positive | 84.72 | 22.10 | 39 | 15119 | 3904 | 34937869 |
| Mania | 83.99 | 22.10 | 52 | 15106 | 9459 | 34932314 |
| Seizure | 80.96 | 22.10 | 155 | 15003 | 104702 | 34837071 |
| Alanine aminotransferase increased | 73.15 | 22.10 | 128 | 15030 | 80687 | 34861086 |
| Palpitations | 72.45 | 22.10 | 88 | 15070 | 39898 | 34901875 |
| Self-injurious ideation | 71.23 | 22.10 | 27 | 15131 | 1657 | 34940116 |
| Tachycardia | 69.99 | 22.10 | 129 | 15029 | 84643 | 34857130 |
| Feeling abnormal | 67.69 | 22.10 | 108 | 15050 | 63127 | 34878646 |
| Mydriasis | 67.55 | 22.10 | 41 | 15117 | 7196 | 34934577 |
| Suicidal behaviour | 66.94 | 22.10 | 25 | 15133 | 1472 | 34940301 |
| Aspartate aminotransferase increased | 66.11 | 22.10 | 111 | 15047 | 67672 | 34874101 |
| Penile discharge | 64.25 | 22.10 | 13 | 15145 | 66 | 34941707 |
| Educational problem | 64.03 | 22.10 | 19 | 15139 | 543 | 34941230 |
| Dystonia | 63.66 | 22.10 | 46 | 15112 | 10799 | 34930974 |
| Sepsis | 59.84 | 22.10 | 3 | 15155 | 166558 | 34775215 |
| Dysuria | 59.64 | 22.10 | 66 | 15092 | 27086 | 34914687 |
| Diarrhoea | 58.63 | 22.10 | 50 | 15108 | 389862 | 34551911 |
| Generalised tonic-clonic seizure | 58.17 | 22.10 | 58 | 15100 | 21116 | 34920657 |
| Anaemia | 57.79 | 22.10 | 15 | 15143 | 233320 | 34708453 |
| Dyskinesia | 57.21 | 22.10 | 59 | 15099 | 22354 | 34919419 |
| Blood alkaline phosphatase increased | 57.10 | 22.10 | 69 | 15089 | 31106 | 34910667 |
| Choreoathetosis | 55.86 | 22.10 | 20 | 15138 | 1044 | 34940729 |
| Electrocardiogram QT prolonged | 55.31 | 22.10 | 78 | 15080 | 40874 | 34900899 |
| Nervousness | 53.28 | 22.10 | 44 | 15114 | 12562 | 34929211 |
| Manic symptom | 53.15 | 22.10 | 12 | 15146 | 110 | 34941663 |
| Emotional disorder | 52.37 | 22.10 | 32 | 15126 | 5684 | 34936089 |
| Retching | 52.29 | 22.10 | 34 | 15124 | 6727 | 34935046 |
| Headache | 48.96 | 22.10 | 194 | 14964 | 200441 | 34741332 |
| Trismus | 48.40 | 22.10 | 23 | 15135 | 2472 | 34939301 |
| Affect lability | 42.65 | 22.10 | 24 | 15134 | 3659 | 34938114 |
| Febrile neutropenia | 42.07 | 22.10 | 5 | 15153 | 136844 | 34804929 |
| Gilbert's syndrome | 41.71 | 22.10 | 8 | 15150 | 29 | 34941744 |
| Coordination abnormal | 41.65 | 22.10 | 31 | 15127 | 7613 | 34934160 |
| Social avoidant behaviour | 40.76 | 22.10 | 22 | 15136 | 3092 | 34938681 |
| Screaming | 39.31 | 22.10 | 17 | 15141 | 1467 | 34940306 |
| Growth retardation | 38.82 | 22.10 | 18 | 15140 | 1830 | 34939943 |
| Panic attack | 37.95 | 22.10 | 32 | 15126 | 9400 | 34932373 |
| Sexual dysfunction | 37.59 | 22.10 | 27 | 15131 | 6276 | 34935497 |
| Thrombocytopenia | 36.86 | 22.10 | 11 | 15147 | 156236 | 34785537 |
| Hepatic enzyme increased | 36.74 | 22.10 | 63 | 15095 | 39017 | 34902756 |
| Loss of consciousness | 36.54 | 22.10 | 98 | 15060 | 82569 | 34859204 |
| Blood bilirubin increased | 36.35 | 22.10 | 62 | 15096 | 38234 | 34903539 |
| Obsessive-compulsive disorder | 35.88 | 22.10 | 25 | 15133 | 5539 | 34936234 |
| Disease progression | 35.68 | 22.10 | 3 | 15155 | 108074 | 34833699 |
| Trichotillomania | 35.56 | 22.10 | 8 | 15150 | 72 | 34941701 |
| General physical health deterioration | 34.19 | 22.10 | 7 | 15151 | 128262 | 34813511 |
| Thinking abnormal | 33.68 | 22.10 | 25 | 15133 | 6112 | 34935661 |
| Physical assault | 33.25 | 22.10 | 14 | 15144 | 1131 | 34940642 |
| Paranoia | 33.03 | 22.10 | 33 | 15125 | 12035 | 34929738 |
| Personality change | 32.93 | 22.10 | 23 | 15135 | 5116 | 34936657 |
| Pallor | 32.14 | 22.10 | 47 | 15111 | 25433 | 34916340 |
| Enuresis | 31.85 | 22.10 | 17 | 15141 | 2336 | 34939437 |
| Fight in school | 31.37 | 22.10 | 5 | 15153 | 3 | 34941770 |
| Renal failure | 31.14 | 22.10 | 9 | 15149 | 130548 | 34811225 |
| Apathy | 30.98 | 22.10 | 25 | 15133 | 6907 | 34934866 |
| Hyperkinesia | 30.38 | 22.10 | 15 | 15143 | 1753 | 34940020 |
| Negativism | 30.27 | 22.10 | 10 | 15148 | 409 | 34941364 |
| Tearfulness | 29.86 | 22.10 | 17 | 15141 | 2650 | 34939123 |
| Hyperhidrosis | 29.76 | 22.10 | 86 | 15072 | 75606 | 34866167 |
| Scrotal pain | 29.43 | 22.10 | 12 | 15146 | 894 | 34940879 |
| Repetitive speech | 29.37 | 22.10 | 7 | 15151 | 83 | 34941690 |
| Erectile dysfunction | 28.88 | 22.10 | 40 | 15118 | 20597 | 34921176 |
| Cardiac failure | 28.87 | 22.10 | 3 | 15155 | 91245 | 34850528 |
| Abdominal pain upper | 28.85 | 22.10 | 82 | 15076 | 71408 | 34870365 |
| Urinary retention | 28.37 | 22.10 | 54 | 15104 | 36234 | 34905539 |
| Sleep disorder | 28.37 | 22.10 | 50 | 15108 | 31638 | 34910135 |
| Restlessness | 27.89 | 22.10 | 44 | 15114 | 25438 | 34916335 |
| Decreased appetite | 27.83 | 22.10 | 144 | 15014 | 166248 | 34775525 |
| Syncope | 27.75 | 22.10 | 95 | 15063 | 91356 | 34850417 |
| Speech disorder | 27.62 | 22.10 | 44 | 15114 | 25642 | 34916131 |
| Spontaneous ejaculation | 27.61 | 22.10 | 5 | 15153 | 12 | 34941761 |
| Pyromania | 26.98 | 22.10 | 6 | 15152 | 51 | 34941722 |
| Pyrexia | 26.93 | 22.10 | 66 | 15092 | 332947 | 34608826 |
| Respiratory failure | 26.79 | 22.10 | 7 | 15151 | 108565 | 34833208 |
| Hostility | 26.75 | 22.10 | 11 | 15147 | 837 | 34940936 |
| Chest pain | 26.48 | 22.10 | 117 | 15041 | 126645 | 34815128 |
| Dyspnoea | 25.77 | 22.10 | 81 | 15077 | 376701 | 34565072 |
| Hyponatraemia | 25.45 | 22.10 | 3 | 15155 | 82688 | 34859085 |
| Raynaud's phenomenon | 25.22 | 22.10 | 8 | 15150 | 287 | 34941486 |
| Tourette's disorder | 25.11 | 22.10 | 6 | 15152 | 72 | 34941701 |
| Asthenia | 24.54 | 22.10 | 43 | 15115 | 245208 | 34696565 |
| Abdominal discomfort | 24.50 | 22.10 | 69 | 15089 | 59766 | 34882007 |
| Pain | 24.22 | 22.10 | 32 | 15126 | 204643 | 34737130 |
| Hallucination, visual | 24.17 | 22.10 | 34 | 15124 | 17757 | 34924016 |
| Dysphoria | 23.98 | 22.10 | 14 | 15144 | 2288 | 34939485 |
| Oedema peripheral | 23.93 | 22.10 | 11 | 15147 | 119801 | 34821972 |
| Drooling | 23.71 | 22.10 | 16 | 15142 | 3366 | 34938407 |
| Pulmonary embolism | 23.69 | 22.10 | 5 | 15153 | 89741 | 34852032 |
| Semen analysis abnormal | 23.46 | 22.10 | 5 | 15153 | 34 | 34941739 |
| Drug abuse | 23.31 | 22.10 | 7 | 15151 | 99089 | 34842684 |
| Amphetamines positive | 23.14 | 22.10 | 7 | 15151 | 214 | 34941559 |
| Sedation | 22.61 | 22.10 | 36 | 15122 | 20970 | 34920803 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Suicidal ideation | 747.13 | 16.17 | 385 | 22266 | 75955 | 79645782 |
| Tic | 685.04 | 16.17 | 161 | 22490 | 2825 | 79718912 |
| Aggression | 568.49 | 16.17 | 281 | 22370 | 50677 | 79671060 |
| Prescribed overdose | 483.06 | 16.17 | 229 | 22422 | 37654 | 79684083 |
| Abnormal behaviour | 403.50 | 16.17 | 200 | 22451 | 36221 | 79685516 |
| Irritability | 313.60 | 16.17 | 176 | 22475 | 40968 | 79680769 |
| Anger | 302.07 | 16.17 | 130 | 22521 | 17032 | 79704705 |
| Psychomotor hyperactivity | 246.16 | 16.17 | 112 | 22539 | 16737 | 79705000 |
| Intentional self-injury | 207.92 | 16.17 | 124 | 22527 | 32295 | 79689442 |
| Crying | 204.35 | 16.17 | 109 | 22542 | 22934 | 79698803 |
| Agitation | 200.54 | 16.17 | 190 | 22461 | 99525 | 79622212 |
| Mood swings | 190.38 | 16.17 | 99 | 22552 | 19781 | 79701956 |
| Disturbance in attention | 186.11 | 16.17 | 137 | 22514 | 50664 | 79671073 |
| Oppositional defiant disorder | 186.04 | 16.17 | 40 | 22611 | 457 | 79721280 |
| Blepharospasm | 171.41 | 16.17 | 64 | 22587 | 5787 | 79715950 |
| Suicide attempt | 162.86 | 16.17 | 156 | 22495 | 82776 | 79638961 |
| Ejaculation disorder | 149.88 | 16.17 | 34 | 22617 | 505 | 79721232 |
| Homicidal ideation | 143.63 | 16.17 | 49 | 22602 | 3408 | 79718329 |
| Impulsive behaviour | 135.89 | 16.17 | 45 | 22606 | 2855 | 79718882 |
| Depression | 132.65 | 16.17 | 228 | 22423 | 216562 | 79505175 |
| Somnolence | 127.84 | 16.17 | 237 | 22414 | 238744 | 79482993 |
| Testicular pain | 125.30 | 16.17 | 39 | 22612 | 2026 | 79719711 |
| Anxiety | 124.93 | 16.17 | 240 | 22411 | 248272 | 79473465 |
| Mania | 122.69 | 16.17 | 72 | 22579 | 18188 | 79703549 |
| Seizure | 119.98 | 16.17 | 202 | 22449 | 188632 | 79533105 |
| Psychotic disorder | 109.15 | 16.17 | 92 | 22559 | 41310 | 79680427 |
| Educational problem | 109.12 | 16.17 | 25 | 22626 | 389 | 79721348 |
| Urinary hesitation | 108.16 | 16.17 | 42 | 22609 | 4224 | 79717513 |
| Attention deficit hyperactivity disorder | 107.27 | 16.17 | 39 | 22612 | 3270 | 79718467 |
| Acute kidney injury | 105.83 | 16.17 | 12 | 22639 | 519392 | 79202345 |
| Heart rate increased | 104.47 | 16.17 | 149 | 22502 | 120575 | 79601162 |
| Tachycardia | 100.94 | 16.17 | 181 | 22470 | 177587 | 79544150 |
| Hallucination, auditory | 99.58 | 16.17 | 66 | 22585 | 20627 | 79701110 |
| Product substitution issue | 96.01 | 16.17 | 64 | 22587 | 20192 | 79701545 |
| Taste disorder | 94.90 | 16.17 | 58 | 22593 | 15765 | 79705972 |
| Dystonia | 92.82 | 16.17 | 64 | 22587 | 21335 | 79700402 |
| Pneumonia | 92.63 | 16.17 | 36 | 22615 | 660210 | 79061527 |
| Decreased eye contact | 90.82 | 16.17 | 25 | 22626 | 840 | 79720897 |
| Trichotillomania | 86.64 | 16.17 | 18 | 22633 | 172 | 79721565 |
| Aspartate aminotransferase increased | 84.94 | 16.17 | 146 | 22505 | 138495 | 79583242 |
| Feeling abnormal | 82.67 | 16.17 | 156 | 22495 | 159043 | 79562694 |
| Epilepsy | 82.31 | 16.17 | 78 | 22573 | 40782 | 79680955 |
| Insomnia | 79.96 | 16.17 | 199 | 22452 | 244971 | 79476766 |
| Mood altered | 78.87 | 16.17 | 54 | 22597 | 17793 | 79703944 |
| Alanine aminotransferase increased | 77.92 | 16.17 | 154 | 22497 | 162416 | 79559321 |
| Depressed mood | 74.63 | 16.17 | 80 | 22571 | 48400 | 79673337 |
| Generalised tonic-clonic seizure | 73.91 | 16.17 | 76 | 22575 | 43834 | 79677903 |
| Bruxism | 72.46 | 16.17 | 31 | 22620 | 3995 | 79717742 |
| Loss of consciousness | 70.93 | 16.17 | 151 | 22500 | 167792 | 79553945 |
| Diarrhoea | 70.77 | 16.17 | 88 | 22563 | 880401 | 78841336 |
| Mydriasis | 70.07 | 16.17 | 50 | 22601 | 17593 | 79704144 |
| Dyskinesia | 69.12 | 16.17 | 74 | 22577 | 44699 | 79677038 |
| Death | 68.41 | 16.17 | 38 | 22613 | 566476 | 79155261 |
| Paranoia | 67.97 | 16.17 | 51 | 22600 | 19381 | 79702356 |
| Product tampering | 67.12 | 16.17 | 17 | 22634 | 411 | 79721326 |
| Obsessive-compulsive disorder | 66.90 | 16.17 | 33 | 22618 | 5894 | 79715843 |
| Anaemia | 66.18 | 16.17 | 22 | 22629 | 444993 | 79276744 |
| Electrocardiogram QT prolonged | 65.90 | 16.17 | 103 | 22548 | 90283 | 79631454 |
| Palpitations | 65.62 | 16.17 | 124 | 22527 | 126486 | 79595251 |
| Self-injurious ideation | 65.43 | 16.17 | 28 | 22623 | 3610 | 79718127 |
| Drug screen positive | 63.25 | 16.17 | 32 | 22619 | 6031 | 79715706 |
| Suicidal behaviour | 58.43 | 16.17 | 25 | 22626 | 3222 | 79718515 |
| Hyperhidrosis | 58.04 | 16.17 | 131 | 22520 | 151361 | 79570376 |
| Adulterated product | 57.79 | 16.17 | 14 | 22637 | 280 | 79721457 |
| Emotional disorder | 57.66 | 16.17 | 41 | 22610 | 14346 | 79707391 |
| Manic symptom | 57.08 | 16.17 | 12 | 22639 | 122 | 79721615 |
| Choreoathetosis | 56.52 | 16.17 | 20 | 22631 | 1550 | 79720187 |
| Penile discharge | 55.00 | 16.17 | 10 | 22641 | 43 | 79721694 |
| Social avoidant behaviour | 54.92 | 16.17 | 27 | 22624 | 4787 | 79716950 |
| Retching | 54.85 | 16.17 | 43 | 22608 | 17424 | 79704313 |
| Sepsis | 52.89 | 16.17 | 7 | 22644 | 269421 | 79452316 |
| Claustrophobia | 52.75 | 16.17 | 18 | 22633 | 1252 | 79720485 |
| Intentional overdose | 51.49 | 16.17 | 101 | 22550 | 105859 | 79615878 |
| Somatic symptom disorder | 50.55 | 16.17 | 21 | 22630 | 2516 | 79719221 |
| Blood alkaline phosphatase increased | 49.84 | 16.17 | 75 | 22576 | 63589 | 79658148 |
| Nervousness | 49.42 | 16.17 | 54 | 22597 | 33361 | 79688376 |
| Growth retardation | 48.80 | 16.17 | 19 | 22632 | 1924 | 79719813 |
| Pulse abnormal | 47.84 | 16.17 | 22 | 22629 | 3362 | 79718375 |
| Febrile neutropenia | 47.82 | 16.17 | 5 | 22646 | 230994 | 79490743 |
| Completed suicide | 47.81 | 16.17 | 166 | 22485 | 245601 | 79476136 |
| Bipolar I disorder | 47.11 | 16.17 | 19 | 22632 | 2110 | 79719627 |
| Memory impairment | 46.61 | 16.17 | 100 | 22551 | 111634 | 79610103 |
| Personality change | 45.47 | 16.17 | 31 | 22620 | 10139 | 79711598 |
| Thinking abnormal | 44.82 | 16.17 | 34 | 22617 | 13127 | 79708610 |
| Thrombocytopenia | 43.27 | 16.17 | 11 | 22640 | 265248 | 79456489 |
| Affect lability | 42.63 | 16.17 | 31 | 22620 | 11228 | 79710509 |
| Arthralgia | 41.91 | 16.17 | 61 | 22590 | 571742 | 79149995 |
| Overdose | 41.69 | 16.17 | 131 | 22520 | 184075 | 79537662 |
| Myocarditis | 40.95 | 16.17 | 40 | 22611 | 21693 | 79700044 |
| Disease progression | 40.84 | 16.17 | 3 | 22648 | 184359 | 79537378 |
| Coordination abnormal | 40.61 | 16.17 | 36 | 22615 | 17276 | 79704461 |
| Amenorrhoea | 40.59 | 16.17 | 26 | 22625 | 7666 | 79714071 |
| Brain injury | 39.77 | 16.17 | 30 | 22621 | 11487 | 79710250 |
| Infection | 39.47 | 16.17 | 10 | 22641 | 241702 | 79480035 |
| Gilbert's syndrome | 38.71 | 16.17 | 7 | 22644 | 29 | 79721708 |
| Nightmare | 38.60 | 16.17 | 42 | 22609 | 25819 | 79695918 |
| Hyperreflexia | 38.54 | 16.17 | 26 | 22625 | 8359 | 79713378 |
| Abdominal pain upper | 38.28 | 16.17 | 145 | 22506 | 223674 | 79498063 |
| Trismus | 37.88 | 16.17 | 22 | 22629 | 5445 | 79716292 |
| Physical assault | 37.81 | 16.17 | 15 | 22636 | 1596 | 79720141 |
| Neurological symptom | 37.45 | 16.17 | 26 | 22625 | 8757 | 79712980 |
| Peripheral swelling | 37.21 | 16.17 | 15 | 22636 | 269602 | 79452135 |
| Scrotal pain | 35.96 | 16.17 | 11 | 22640 | 539 | 79721198 |
| Pancytopenia | 35.86 | 16.17 | 3 | 22648 | 165742 | 79555995 |
| Decreased appetite | 35.36 | 16.17 | 191 | 22460 | 342227 | 79379510 |
| Dysuria | 34.29 | 16.17 | 56 | 22595 | 50895 | 79670842 |
| Speech disorder | 34.17 | 16.17 | 58 | 22593 | 54387 | 79667350 |
| Pain in extremity | 34.08 | 16.17 | 32 | 22619 | 364506 | 79357231 |
| Joint swelling | 33.86 | 16.17 | 20 | 22631 | 288626 | 79433111 |
| General physical health deterioration | 33.83 | 16.17 | 18 | 22633 | 275220 | 79446517 |
| Enuresis | 33.82 | 16.17 | 17 | 22634 | 3159 | 79718578 |
| Pyrexia | 33.70 | 16.17 | 91 | 22560 | 678618 | 79043119 |
| Hyperkinesia | 33.22 | 16.17 | 16 | 22635 | 2713 | 79719024 |
| Raynaud's phenomenon | 32.77 | 16.17 | 12 | 22639 | 1026 | 79720711 |
| Tourette's disorder | 32.63 | 16.17 | 7 | 22644 | 79 | 79721658 |
| Paraesthesia | 32.46 | 16.17 | 117 | 22534 | 176206 | 79545531 |
| School refusal | 31.78 | 16.17 | 6 | 22645 | 33 | 79721704 |
| Vomiting | 31.65 | 16.17 | 308 | 22343 | 665520 | 79056217 |
| Restlessness | 31.15 | 16.17 | 51 | 22600 | 46441 | 79675296 |
| Bipolar disorder | 30.96 | 16.17 | 22 | 22629 | 7685 | 79714052 |
| Chest pain | 30.86 | 16.17 | 160 | 22491 | 282144 | 79439593 |
| Treatment noncompliance | 30.61 | 16.17 | 54 | 22597 | 52214 | 79669523 |
| Liver injury | 29.99 | 16.17 | 56 | 22595 | 56558 | 79665179 |
| Spontaneous ejaculation | 29.72 | 16.17 | 5 | 22646 | 12 | 79721725 |
| Renal failure | 29.71 | 16.17 | 10 | 22641 | 200958 | 79520779 |
| Dyspnoea | 29.70 | 16.17 | 134 | 22517 | 856891 | 78864846 |
| Arthropathy | 29.54 | 16.17 | 7 | 22644 | 177104 | 79544633 |
| Neuropathy peripheral | 29.39 | 16.17 | 3 | 22648 | 141302 | 79580435 |
| Petit mal epilepsy | 29.33 | 16.17 | 19 | 22632 | 5708 | 79716029 |
| Panic attack | 28.84 | 16.17 | 35 | 22616 | 24181 | 79697556 |
| Distractibility | 28.77 | 16.17 | 10 | 22641 | 735 | 79721002 |
| Feeling jittery | 28.72 | 16.17 | 26 | 22625 | 12815 | 79708922 |
| Drooling | 28.72 | 16.17 | 19 | 22632 | 5915 | 79715822 |
| Euphoric mood | 28.63 | 16.17 | 21 | 22630 | 7705 | 79714032 |
| Fall | 28.45 | 16.17 | 60 | 22591 | 487569 | 79234168 |
| Blood bilirubin increased | 28.44 | 16.17 | 60 | 22591 | 66172 | 79655565 |
| Gastrooesophageal reflux disease | 28.19 | 16.17 | 79 | 22572 | 104167 | 79617570 |
| Congestive hepatopathy | 28.11 | 16.17 | 17 | 22634 | 4530 | 79717207 |
| Rheumatoid arthritis | 28.11 | 16.17 | 12 | 22639 | 208458 | 79513279 |
| Treatment failure | 27.93 | 16.17 | 7 | 22644 | 170479 | 79551258 |
| Hyponatraemia | 27.81 | 16.17 | 8 | 22643 | 177840 | 79543897 |
| Hypoaesthesia | 27.26 | 16.17 | 112 | 22539 | 179240 | 79542497 |
| Pyromania | 27.05 | 16.17 | 5 | 22646 | 24 | 79721713 |
| Infusion related reaction | 26.93 | 16.17 | 16 | 22635 | 230221 | 79491516 |
| Sinus tachycardia | 26.80 | 16.17 | 42 | 22609 | 36866 | 79684871 |
| Renal impairment | 26.79 | 16.17 | 6 | 22645 | 157777 | 79563960 |
| Hostility | 26.48 | 16.17 | 13 | 22638 | 2297 | 79719440 |
| Tearfulness | 26.02 | 16.17 | 18 | 22633 | 6027 | 79715710 |
| Drug hypersensitivity | 25.92 | 16.17 | 28 | 22623 | 298888 | 79422849 |
| Headache | 25.66 | 16.17 | 291 | 22360 | 653481 | 79068256 |
| Sleep disorder | 25.23 | 16.17 | 67 | 22584 | 85610 | 79636127 |
| Urinary retention | 25.13 | 16.17 | 52 | 22599 | 56578 | 79665159 |
| Screaming | 25.08 | 16.17 | 15 | 22636 | 3918 | 79717819 |
| Cardiac failure congestive | 25.02 | 16.17 | 5 | 22646 | 142397 | 79579340 |
| Hypotension | 24.99 | 16.17 | 55 | 22596 | 440262 | 79281475 |
| Staring | 24.82 | 16.17 | 13 | 22638 | 2632 | 79719105 |
| Viral infection | 24.62 | 16.17 | 44 | 22607 | 42972 | 79678765 |
| Hypomania | 24.61 | 16.17 | 19 | 22632 | 7525 | 79714212 |
| Erectile dysfunction | 23.98 | 16.17 | 25 | 22626 | 14639 | 79707098 |
| Medication error | 23.68 | 16.17 | 57 | 22594 | 68585 | 79653152 |
| Negativism | 23.68 | 16.17 | 9 | 22642 | 854 | 79720883 |
| Sedation | 23.43 | 16.17 | 48 | 22603 | 51847 | 79669890 |
| Synovitis | 23.17 | 16.17 | 7 | 22644 | 150727 | 79571010 |
| Apathy | 22.81 | 16.17 | 23 | 22628 | 12954 | 79708783 |
| Dysphoria | 22.53 | 16.17 | 15 | 22636 | 4719 | 79717018 |
| Drug abuse | 22.52 | 16.17 | 9 | 22642 | 162682 | 79559055 |
| Gastrointestinal haemorrhage | 22.45 | 16.17 | 7 | 22644 | 147712 | 79574025 |
| Penile pain | 22.29 | 16.17 | 9 | 22642 | 1002 | 79720735 |
| Gastric hypomotility | 22.26 | 16.17 | 6 | 22645 | 186 | 79721551 |
| Infectious mononucleosis | 21.95 | 16.17 | 11 | 22640 | 2031 | 79719706 |
| Vision blurred | 21.84 | 16.17 | 73 | 22578 | 105825 | 79615912 |
| Cyanosis | 21.63 | 16.17 | 31 | 22620 | 25151 | 79696586 |
| Supine hypertension | 21.56 | 16.17 | 7 | 22644 | 417 | 79721320 |
| Dysphemia | 21.47 | 16.17 | 13 | 22638 | 3471 | 79718266 |
| Pulmonary embolism | 21.41 | 16.17 | 11 | 22640 | 171643 | 79550094 |
| Haemoglobin decreased | 21.33 | 16.17 | 19 | 22632 | 222100 | 79499637 |
| Blood creatinine increased | 20.78 | 16.17 | 9 | 22642 | 155048 | 79566689 |
| Electrocardiogram ST segment elevation | 20.77 | 16.17 | 18 | 22633 | 8379 | 79713358 |
| Hallucination | 20.32 | 16.17 | 62 | 22589 | 85683 | 79636054 |
| Arthritis | 20.25 | 16.17 | 4 | 22647 | 114876 | 79606861 |
| Rash | 20.24 | 16.17 | 90 | 22561 | 578268 | 79143469 |
| Withdrawal syndrome | 20.11 | 16.17 | 31 | 22620 | 26823 | 79694914 |
| Contraindicated product administered | 19.79 | 16.17 | 10 | 22641 | 157528 | 79564209 |
| Wolff-Parkinson-White syndrome | 19.55 | 16.17 | 6 | 22645 | 297 | 79721440 |
| Fight in school | 19.42 | 16.17 | 3 | 22648 | 3 | 79721734 |
| Male genital atrophy | 19.42 | 16.17 | 3 | 22648 | 3 | 79721734 |
| Prostatic pain | 18.82 | 16.17 | 4 | 22647 | 43 | 79721694 |
| Sinus arrhythmia | 18.75 | 16.17 | 10 | 22641 | 2100 | 79719637 |
| Urinary tract infection | 18.43 | 16.17 | 31 | 22620 | 274481 | 79447256 |
| Priapism | 18.42 | 16.17 | 13 | 22638 | 4492 | 79717245 |
| Electroencephalogram abnormal | 18.42 | 16.17 | 14 | 22637 | 5420 | 79716317 |
| Hypokalaemia | 18.31 | 16.17 | 9 | 22642 | 144031 | 79577706 |
| Chromaturia | 18.28 | 16.17 | 29 | 22622 | 25717 | 79696020 |
| Streptococcal infection | 18.05 | 16.17 | 17 | 22634 | 8813 | 79712924 |
| Sexual dysfunction | 17.92 | 16.17 | 16 | 22635 | 7747 | 79713990 |
| Urethral discharge | 17.89 | 16.17 | 3 | 22648 | 7 | 79721730 |
| Syncope | 17.74 | 16.17 | 99 | 22552 | 179350 | 79542387 |
| Pallor | 17.72 | 16.17 | 42 | 22609 | 50020 | 79671717 |
| Thalassaemia | 17.66 | 16.17 | 4 | 22647 | 59 | 79721678 |
| Iron metabolism disorder | 17.66 | 16.17 | 4 | 22647 | 59 | 79721678 |
| Eye movement disorder | 17.49 | 16.17 | 16 | 22635 | 7995 | 79713742 |
| Growth hormone-producing pituitary tumour | 17.29 | 16.17 | 4 | 22647 | 65 | 79721672 |
| Peripheral coldness | 17.28 | 16.17 | 22 | 22629 | 15948 | 79705789 |
| Back pain | 17.24 | 16.17 | 38 | 22613 | 304142 | 79417595 |
| Semen analysis abnormal | 17.10 | 16.17 | 3 | 22648 | 10 | 79721727 |
| Hypertensive crisis | 17.01 | 16.17 | 25 | 22626 | 20745 | 79700992 |
| Dizziness | 17.01 | 16.17 | 226 | 22425 | 526215 | 79195522 |
| Laryngeal pain | 16.96 | 16.17 | 14 | 22637 | 6100 | 79715637 |
| Tremor | 16.93 | 16.17 | 94 | 22557 | 169989 | 79551748 |
| Postictal state | 16.92 | 16.17 | 9 | 22642 | 1880 | 79719857 |
| Respiratory failure | 16.75 | 16.17 | 16 | 22635 | 180895 | 79540842 |
| Dehydration | 16.68 | 16.17 | 28 | 22623 | 248159 | 79473578 |
| Piloerection | 16.58 | 16.17 | 6 | 22645 | 496 | 79721241 |
| Flat affect | 16.26 | 16.17 | 9 | 22642 | 2032 | 79719705 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06BA09 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Centrally acting sympathomimetics |
| FDA MoA | N0000000102 | Norepinephrine Uptake Inhibitors |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018759 | Adrenergic Uptake Inhibitors |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
| FDA EPC | N0000175695 | Norepinephrine Reuptake Inhibitor |
| CHEBI has role | CHEBI:35469 | antidepressants |
| CHEBI has role | CHEBI:35640 | adrenergic uptake inhibitors |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Attention deficit hyperactivity disorder | indication | 406506008 | |
| Delay when starting to pass urine | contraindication | 5972002 | |
| Priapism | contraindication | 6273006 | DOID:9286 |
| Suicidal thoughts | contraindication | 6471006 | |
| Sinus tachycardia | contraindication | 11092001 | |
| Bipolar disorder | contraindication | 13746004 | DOID:3312 |
| Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Feeling agitated | contraindication | 24199005 | |
| Orthostatic hypotension | contraindication | 28651003 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Low blood pressure | contraindication | 45007003 | |
| Chronic heart failure | contraindication | 48447003 | |
| Feeling irritable | contraindication | 55929007 | |
| Aggressive behavior | contraindication | 61372001 | |
| Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
| Psychotic disorder | contraindication | 69322001 | |
| Cardiomyopathy | contraindication | 85898001 | DOID:0050700 |
| Structural disorder of heart | contraindication | 128599005 | |
| Seizure disorder | contraindication | 128613002 | |
| Liver function tests abnormal | contraindication | 166603001 | |
| Cerebrovascular accident | contraindication | 230690007 | |
| Mania | contraindication | 231494001 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Raynaud's phenomenon | contraindication | 266261006 | |
| Retention of urine | contraindication | 267064002 | |
| Pheochromocytoma | contraindication | 302835009 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Disorder of coronary artery | contraindication | 414024009 | |
| Myocardial infarction in recovery phase | contraindication | 418044006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.32 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Kd | 8.69 | CHEMBL | CHEMBL | |||
| Sodium-dependent serotonin transporter | Transporter | Kd | 8.05 | CHEMBL | |||||
| Sodium-dependent dopamine transporter | Transporter | Kd | 5.97 | CHEMBL | |||||
| Cytochrome P450 2D6 | Enzyme | Ki | 4.77 | WOMBAT-PK | |||||
| G protein-activated inward rectifier potassium channel 2 | Ion channel | IC50 | 4.28 | WOMBAT-PK | |||||
| Kir3.1/Kir3.2 | Ion channel | IC50 | 4.48 | WOMBAT-PK | |||||
| Kir3.1/Kir3.4 | Ion channel | IC50 | 4.85 | WOMBAT-PK | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.68 | CHEMBL | |||||
| Krueppel-like factor 10 | Nuclear other | IC50 | 4 | CHEMBL | |||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 7.37 | CHEMBL | |||||
| Sodium-dependent dopamine transporter | Transporter | Ki | 5.85 | CHEMBL | |||||
| Transporter | Transporter | Ki | 9.15 | CHEMBL | |||||
| Transporter | Transporter | Ki | 8.40 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02574 | KEGG_DRUG |
| 82248-59-7 | SECONDARY_CAS_RN |
| 353103 | RXNORM |
| C0076823 | UMLSCUI |
| CHEBI:331697 | CHEBI |
| CHEMBL641 | ChEMBL_ID |
| CHEMBL1702 | ChEMBL_ID |
| DB00289 | DRUGBANK_ID |
| D000069445 | MESH_DESCRIPTOR_UI |
| 54841 | PUBCHEM_CID |
| 7118 | IUPHAR_LIGAND_ID |
| 5354 | INN_ID |
| ASW034S0B8 | UNII |
| 17042 | MMSL |
| 192105 | MMSL |
| 45567 | MMSL |
| d04827 | MMSL |
| 407037005 | SNOMEDCT_US |
| 407038000 | SNOMEDCT_US |
| 412577007 | SNOMEDCT_US |
| 4021364 | VANDF |
| 4024296 | VANDF |
| 009862 | NDDF |
| 009863 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3227 | CAPSULE | 10 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3228 | CAPSULE | 25 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3229 | CAPSULE | 40 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3238 | CAPSULE | 18 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3239 | CAPSULE | 60 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3250 | CAPSULE | 80 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3251 | CAPSULE | 100 mg | ORAL | NDA | 38 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3542 | CAPSULE | 10 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3542 | CAPSULE | 10 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3542 | CAPSULE | 10 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3543 | CAPSULE | 18 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3543 | CAPSULE | 18 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3543 | CAPSULE | 18 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3544 | CAPSULE | 25 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3544 | CAPSULE | 25 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3544 | CAPSULE | 25 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3545 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3545 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3545 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3546 | CAPSULE | 60 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3546 | CAPSULE | 60 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3546 | CAPSULE | 60 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3547 | CAPSULE | 80 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3547 | CAPSULE | 80 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3547 | CAPSULE | 80 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3548 | CAPSULE | 100 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3548 | CAPSULE | 100 mg | ORAL | ANDA | 33 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3548 | CAPSULE | 100 mg | ORAL | ANDA | 33 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2260 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2261 | CAPSULE | 18 mg | ORAL | ANDA | 32 sections |