talipexole Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2558 101626-70-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • talipexole hydrochloride
  • talipexole HCl
  • domin
  • talipexole
dopamine receptor agonist; structure given in first source
  • Molecular weight: 209.31
  • Formula: C10H15N3S
  • CLOGP: 1.14
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 42.15
  • ALOGS: -2.50
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018491 Dopamine Agonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Parkinson's disease indication 49049000 DOID:14330

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.59 Basic
pKa2 4.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(3) dopamine receptor GPCR Ki 7.48 PDSP
Alpha-1B adrenergic receptor GPCR Ki 5.41 PDSP
Alpha-1D adrenergic receptor GPCR Ki 5.90 PDSP
D(1B) dopamine receptor GPCR Ki 5.46 PDSP
D(4) dopamine receptor GPCR Ki 6.48 PDSP
Alpha-2C adrenergic receptor GPCR Ki 6.70 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.69 PDSP
D(2) dopamine receptor GPCR Ki 6.31 PDSP
Alpha-2A adrenergic receptor GPCR Ki 6.91 PDSP
5-hydroxytryptamine receptor 1A GPCR Ki 5.77 PDSP
Adrenergic receptor alpha-2 GPCR IC50 7.60 CHEMBL
D(2) dopamine receptor GPCR Ki 8.24 CHEMBL

External reference:

IDSource
D08558 KEGG_DRUG
7AM2J46Z1Y UNII
5973 INN_ID
5374 PUBCHEM_CID
CHEBI:93327 CHEBI
CHEMBL279085 ChEMBL_ID
C024763 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL1504869 ChEMBL_ID
5442 IUPHAR_LIGAND_ID

Pharmaceutical products:

None