sulfasalazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
phenylazosalicylic acid derivatives antibacterial 2525 599-79-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • salazosulfapyridine
  • salicylazosulfapyridine
  • sulphasalazine
  • azulfidine
  • sulfasalazine
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
  • Molecular weight: 398.39
  • Formula: C18H14N4O5S
  • CLOGP: 4
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 141.31
  • ALOGS: -3.93
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O
2 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 167.34 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.11 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.26 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.60 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKB,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K1,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM1,PIM2,PLK1,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK10,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 80
kinase-selectivity-class ACVR2A,ACVR2B,AURKA,AURKB,AURKC,AXL,BMX,BRAF,CAMK2D,CDK16,CDK4,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FGFR1,GRK2,GSK3A,HIPK2,IKBKB,JAK1,JAK2,MAP2K3,MAP2K6,MAP3K14,MAP3K2,MAP3K7,MAPK1,MAPK12,MAPK7,MAPK8,MARK4,MTOR,PDK4,PIK3CB,PIM3,PRKDC,SGK1,SIK2,STK10,STK33,SYK,TEK,TGFBR1,TTK,UHMK1,ULK1,ULK2,ZAP70 51
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 3.639 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
rat-kpuu-brain Rat brain Kpuu 0.024 % High 1

Approvals:

DateAgencyCompanyOrphan
June 20, 1950 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug intolerance 3633.84 13.89 8397 560465 439194 89620391
Contraindicated product administered 2897.07 13.89 6276 562586 313863 89745722
Synovitis 2848.72 13.89 6345 562517 323407 89736178
Drug ineffective 2602.18 13.89 16154 552708 1368144 88691441
Treatment failure 2549.20 13.89 5781 563081 298147 89761438
Systemic lupus erythematosus 2504.47 13.89 6389 562473 355507 89704078
Joint swelling 2458.22 13.89 7833 561029 495467 89564118
Pemphigus 2405.42 13.89 5908 562954 320956 89738629
Arthropathy 2263.58 13.89 6200 562662 360042 89699543
Glossodynia 2244.37 13.89 5699 563163 316080 89743505
Hand deformity 2184.43 13.89 5361 563501 291001 89768584
Wound 1863.62 13.89 5122 563740 297858 89761727
Abdominal discomfort 1797.14 13.89 6818 562044 470510 89589075
Therapeutic product effect decreased 1794.64 13.89 4780 564082 272791 89786794
Swelling 1692.51 13.89 6124 562738 412934 89646651
Anti-cyclic citrullinated peptide antibody positive 1624.46 13.89 4166 564696 232267 89827318
Pericarditis 1592.60 13.89 4498 564364 265653 89793932
Alopecia 1583.56 13.89 6722 562140 488349 89571236
Musculoskeletal stiffness 1444.52 13.89 4616 564246 291916 89767669
Death 1336.76 13.89 597 568265 455954 89603631
Rheumatoid factor positive 1319.25 13.89 3158 565704 168492 89891093
Acute kidney injury 1298.21 13.89 224 568638 320163 89739422
Discomfort 1273.08 13.89 4201 564661 270134 89789451
Hepatic enzyme increased 1246.17 13.89 5018 563844 355718 89703867
Psoriatic arthropathy 1242.10 13.89 3695 565167 224640 89834945
Anaemia 1220.01 13.89 351 568511 352451 89707134
Duodenal ulcer perforation 1190.38 13.89 3567 565295 217721 89841864
Helicobacter infection 1145.85 13.89 3577 565285 223273 89836312
Toxicity to various agents 1082.43 13.89 241 568621 287605 89771980
Constipation 1072.20 13.89 226 568636 280169 89779416
Drug interaction 1016.52 13.89 243 568619 276210 89783375
Hypotension 1012.45 13.89 388 568474 325009 89734576
Infusion related reaction 988.77 13.89 5192 563670 411588 89647997
C-reactive protein abnormal 982.50 13.89 2348 566514 125081 89934504
Product dose omission issue 928.88 13.89 335 568527 291352 89768233
Hypersensitivity 878.98 13.89 5362 563500 449315 89610270
Completed suicide 860.67 13.89 9 568853 145049 89914536
Folliculitis 782.86 13.89 2939 565923 201414 89858171
Dehydration 757.07 13.89 150 568712 194297 89865288
Drug hypersensitivity 747.35 13.89 5224 563638 458385 89601200
Arthralgia 746.79 13.89 7811 561051 770711 89288874
Febrile neutropenia 733.68 13.89 72 568790 158277 89901308
Product use issue 732.13 13.89 4037 564825 325882 89733703
Sleep disorder due to general medical condition, insomnia type 729.99 13.89 2115 566747 126579 89933006
Fall 724.49 13.89 1193 567669 480617 89578968
Neutropenia 716.37 13.89 258 568604 224646 89834939
Rheumatic fever 714.79 13.89 2351 566511 150770 89908815
Irritable bowel syndrome 708.86 13.89 2878 565984 204570 89855015
Pain 694.91 13.89 9404 559458 986937 89072648
Muscle injury 680.93 13.89 2546 566316 174108 89885477
Seizure 680.08 13.89 80 568782 152549 89907036
Tremor 658.94 13.89 90 568772 153083 89906502
Therapeutic product effect incomplete 656.86 13.89 2683 566179 191213 89868372
C-reactive protein increased 647.27 13.89 2551 566311 178838 89880747
Impaired healing 646.10 13.89 3047 565815 231152 89828433
Type 2 diabetes mellitus 636.79 13.89 2746 566116 200498 89859087
Thrombocytopenia 635.51 13.89 257 568605 208468 89851117
Mobility decreased 626.49 13.89 3171 565691 247563 89812022
Urinary tract infection 624.88 13.89 598 568264 305034 89754551
Somnolence 624.39 13.89 265 568597 208819 89850766
Cough 600.90 13.89 865 567997 368097 89691488
Malignant neoplasm progression 599.18 13.89 15 568847 106855 89952730
Maternal exposure during pregnancy 589.50 13.89 4074 564788 355989 89703596
Hyponatraemia 585.10 13.89 74 568788 133464 89926121
Blister 583.32 13.89 3147 565715 251851 89807734
Red blood cell sedimentation rate increased 577.10 13.89 1466 567396 81129 89978456
Swollen joint count increased 572.26 13.89 1766 567096 109440 89950145
Loss of personal independence in daily activities 567.81 13.89 2013 566849 134092 89925493
Intentional overdose 565.32 13.89 4 568858 93830 89965755
Condition aggravated 559.92 13.89 5954 562908 589591 89469994
Disease progression 555.43 13.89 148 568714 156467 89903118
Ill-defined disorder 532.95 13.89 2437 566425 182454 89877131
Blood cholesterol increased 522.45 13.89 2635 566227 205377 89854208
Inflammation 518.49 13.89 2359 566503 176233 89883352
Cardiac arrest 515.47 13.89 37 568825 104898 89954687
Red blood cell sedimentation rate abnormal 512.43 13.89 694 568168 23510 90036075
Liver injury 507.13 13.89 2269 566593 168298 89891287
Atrial fibrillation 503.65 13.89 111 568751 133500 89926085
Fibromyalgia 493.69 13.89 2578 566284 203691 89855894
Osteoarthritis 492.63 13.89 2481 566381 193249 89866336
Dyspnoea 490.93 13.89 3378 565484 877577 89182008
Drug abuse 480.00 13.89 7 568855 82340 89977245
Rash 469.06 13.89 7301 561561 788799 89270786
Peripheral swelling 456.86 13.89 4273 564589 408833 89650752
Chest discomfort 453.78 13.89 151 568711 138214 89921371
Diarrhoea 446.47 13.89 3764 565098 935426 89124159
Stomatitis 437.96 13.89 3089 565773 271609 89787976
Respiratory failure 433.15 13.89 105 568757 118313 89941272
Vision blurred 427.25 13.89 86 568776 110207 89949378
Infection 422.85 13.89 3790 565072 358304 89701281
Cardiac failure congestive 410.48 13.89 64 568798 98630 89960955
Balance disorder 408.23 13.89 61 568801 97019 89962566
Bone erosion 405.10 13.89 974 567888 52047 90007538
Cardiac failure 404.61 13.89 95 568767 109401 89950184
Platelet count decreased 403.40 13.89 177 568685 136792 89922793
Sepsis 399.62 13.89 325 568537 179489 89880096
Bradycardia 399.37 13.89 34 568828 83813 89975772
Gastrointestinal disorder 397.24 13.89 2866 565996 253821 89805764
Injection site pain 394.75 13.89 307 568555 173392 89886193
Renal failure 392.67 13.89 165 568697 130842 89928743
Joint range of motion decreased 389.32 13.89 1786 567076 133857 89925728
Cerebrovascular accident 387.64 13.89 145 568717 123388 89936197
Suicide attempt 387.03 13.89 21 568841 75378 89984207
Rheumatoid arthritis 383.47 13.89 3716 565146 358898 89700687
Hyperhidrosis 383.08 13.89 188 568674 136117 89923468
Electrocardiogram QT prolonged 382.09 13.89 17 568845 72439 89987146
Depressed level of consciousness 377.61 13.89 19 568843 72765 89986820
Injury 376.77 13.89 2322 566540 195027 89864558
Lower respiratory tract infection 374.28 13.89 2775 566087 247884 89811701
Hyperkalaemia 372.46 13.89 7 568855 64957 89994628
Grip strength decreased 371.29 13.89 1352 567510 91224 89968361
Pulmonary embolism 369.83 13.89 179 568683 130641 89928944
Cognitive disorder 366.95 13.89 16 568846 69391 89990194
Myalgia 361.95 13.89 339 568523 174786 89884799
Blood iron abnormal 357.81 13.89 254 568608 3766 90055819
Knee arthroplasty 354.27 13.89 1239 567623 81943 89977642
Dysphagia 351.94 13.89 132 568730 112146 89947439
Gastrointestinal haemorrhage 350.33 13.89 70 568792 90178 89969407
Cardio-respiratory arrest 349.66 13.89 10 568852 63130 89996455
General physical health deterioration 342.57 13.89 3571 565291 351544 89708041
Musculoskeletal pain 336.38 13.89 2030 566832 169221 89890364
Hypoglycaemia 333.55 13.89 28 568834 69820 89989765
Hypoxia 332.44 13.89 34 568828 72365 89987220
Epistaxis 328.40 13.89 67 568795 85058 89974527
COVID-19 326.94 13.89 346 568516 168497 89891088
Hip arthroplasty 322.70 13.89 1133 567729 75075 89984510
Dry skin 314.54 13.89 82 568780 87991 89971594
White blood cell count decreased 311.91 13.89 353 568509 166756 89892829
Nausea 311.36 13.89 5003 563859 1105313 88954272
Overdose 310.07 13.89 319 568543 157390 89902195
Syncope 308.40 13.89 229 568633 132434 89927151
Coma 304.54 13.89 46 568816 72586 89986999
Asthenia 300.26 13.89 2039 566823 531712 89527873
Pancytopenia 298.93 13.89 193 568669 120070 89939515
Lactic acidosis 295.35 13.89 4 568858 50459 90009126
Chills 295.14 13.89 237 568625 131744 89927841
Intentional product use issue 294.58 13.89 2349 566513 214543 89845042
Sciatica 291.66 13.89 1336 567526 100046 89959539
Neuropathy peripheral 290.31 13.89 259 568603 136711 89922874
Pulmonary fibrosis 289.74 13.89 1390 567472 106113 89953472
Hypokalaemia 287.54 13.89 240 568622 130876 89928709
Feeling abnormal 287.05 13.89 377 568485 166858 89892727
Multiple sclerosis relapse 287.03 13.89 9 568853 52296 90007289
Multiple organ dysfunction syndrome 284.87 13.89 44 568818 68292 89991293
Metabolic acidosis 281.17 13.89 17 568845 55659 90003926
Neutrophil count decreased 280.76 13.89 54 568808 71478 89988107
Agitation 280.17 13.89 43 568819 67055 89992530
Dysarthria 280.17 13.89 15 568847 54467 90005118
Blood glucose increased 275.85 13.89 126 568736 95120 89964465
Wrong technique in product usage process 274.70 13.89 57 568805 71514 89988071
Rheumatoid nodule 274.57 13.89 471 568391 19695 90039890
Hallucination 273.75 13.89 43 568819 65916 89993669
Haemoglobin decreased 269.96 13.89 373 568489 161583 89898002
Back pain 267.32 13.89 1054 567808 316121 89743464
Facet joint syndrome 267.21 13.89 1275 567587 97114 89962471
Joint stiffness 265.60 13.89 1082 567780 76960 89982625
Anxiety 263.23 13.89 1026 567836 308746 89750839
Rhabdomyolysis 260.83 13.89 15 568847 51241 90008344
Neoplasm progression 258.32 13.89 4 568858 44482 90015103
Skin exfoliation 256.74 13.89 56 568806 67857 89991728
Lip dry 250.47 13.89 1275 567587 99680 89959905
Adverse event 249.98 13.89 1422 567440 115996 89943589
Sedation 248.53 13.89 13 568849 48158 90011427
Hyperglycaemia 244.56 13.89 20 568842 50950 90008635
Encephalopathy 241.31 13.89 12 568850 46432 90013153
Sleep disorder 241.23 13.89 2093 566769 195937 89863648
Tachycardia 239.63 13.89 387 568475 157286 89902299
International normalised ratio increased 237.28 13.89 15 568847 47301 90012284
Mental status changes 237.17 13.89 10 568852 44669 90014916
Disability 236.97 13.89 676 568186 40069 90019516
Pulmonary oedema 235.06 13.89 51 568811 62029 89997556
Palpitations 234.86 13.89 308 568554 136420 89923165
Disorientation 233.75 13.89 10 568852 44104 90015481
Flushing 232.49 13.89 133 568729 88358 89971227
Blood pressure increased 230.93 13.89 564 568298 196653 89862932
Breast cancer stage III 227.61 13.89 1092 567770 83355 89976230
Intentional product misuse 223.76 13.89 143 568719 89461 89970124
Deformity 223.49 13.89 326 568536 11844 90047741
Bursitis 223.43 13.89 1504 567358 130150 89929435
Obesity 222.78 13.89 1275 567587 104232 89955353
Dyspnoea exertional 221.52 13.89 88 568774 72200 89987385
Peripheral venous disease 219.57 13.89 1076 567786 82845 89976740
Wound infection 217.62 13.89 1275 567587 105127 89954458
Unresponsive to stimuli 214.99 13.89 5 568857 38116 90021469
Blood parathyroid hormone decreased 213.92 13.89 320 568542 11896 90047689
Granuloma skin 213.66 13.89 298 568564 10382 90049203
Injection site erythema 212.66 13.89 183 568679 98319 89961266
Blood pressure decreased 212.37 13.89 102 568760 74793 89984792
Serotonin syndrome 209.78 13.89 6 568856 37881 90021704
Dislocation of vertebra 209.03 13.89 799 568063 55169 90004416
Dizziness 208.78 13.89 2531 566331 586753 89472832
Erythema 207.93 13.89 739 568123 228507 89831078
Gait inability 206.91 13.89 1601 567261 144855 89914730
Myocardial infarction 205.28 13.89 217 568645 105755 89953830
Disturbance in attention 204.14 13.89 27 568835 47082 90012503
Deep vein thrombosis postoperative 203.53 13.89 933 567929 69876 89989709
Foot deformity 202.94 13.89 827 568035 58824 90000761
Hypercholesterolaemia 202.48 13.89 1203 567659 99689 89959896
Plasma cell myeloma 201.62 13.89 14 568848 40814 90018771
Panniculitis 201.21 13.89 341 568521 14117 90045468
Abdominal pain 200.90 13.89 1556 567306 394165 89665420
Drug tolerance decreased 199.57 13.89 546 568316 31584 90028001
Chronic obstructive pulmonary disease 198.22 13.89 108 568754 73721 89985864
Aphasia 196.82 13.89 20 568842 42792 90016793
Lethargy 196.55 13.89 75 568787 63064 89996521
Haemorrhage 191.37 13.89 98 568764 69271 89990314
Lower limb fracture 191.19 13.89 1045 567817 83968 89975617
Pulmonary hypertension 190.05 13.89 22 568840 42501 90017084
Bone pain 189.04 13.89 76 568786 61907 89997678
Respiratory distress 187.64 13.89 15 568847 38931 90020654
Contusion 187.23 13.89 2404 566458 248812 89810773
Hypervolaemia 185.89 13.89 4 568858 32753 90026832
Ascites 185.32 13.89 37 568825 47703 90011882
Incorrect dose administered 185.03 13.89 135 568727 78795 89980790
Acute respiratory failure 185.01 13.89 25 568837 42893 90016692
Dyskinesia 184.95 13.89 11 568851 36523 90023062
Rash erythematous 184.08 13.89 89 568773 65015 89994570
Blood bilirubin increased 183.45 13.89 27 568835 43443 90016142
Lung disorder 182.40 13.89 1584 567278 148299 89911286
Therapy interrupted 182.09 13.89 45 568817 50063 90009522
Arthritis 181.62 13.89 1725 567137 165590 89893995
Colitis 181.06 13.89 107 568755 69835 89989750
Restlessness 180.09 13.89 11 568851 35709 90023876
Orthostatic hypotension 178.80 13.89 25 568837 41802 90017783
X-ray abnormal 178.36 13.89 659 568203 44765 90014820
Pleural effusion 177.65 13.89 267 568595 111724 89947861
Blood potassium decreased 177.09 13.89 41 568821 47686 90011899
Cellulitis 176.94 13.89 187 568675 91150 89968435
Myelosuppression 176.50 13.89 58 568804 53533 90006052
Dysgeusia 176.45 13.89 55 568807 52505 90007080
Joint destruction 175.22 13.89 306 568556 12981 90046604
Respiratory arrest 175.02 13.89 8 568854 33303 90026282
Pneumonia aspiration 173.77 13.89 25 568837 40915 90018670
Irritability 171.08 13.89 14 568848 35648 90023937
Urinary retention 170.01 13.89 19 568843 37725 90021860
Liver function test increased 169.76 13.89 1011 567851 83844 89975741
Prescribed underdose 168.59 13.89 922 567940 74097 89985488
Dysuria 167.38 13.89 24 568838 39377 90020208
Autoimmune disorder 166.32 13.89 934 567928 75810 89983775
Accidental exposure to product 166.21 13.89 32 568830 42334 90017251
Deep vein thrombosis 166.09 13.89 198 568664 91422 89968163
Haematoma 165.38 13.89 24 568838 39024 90020561
Drug ineffective for unapproved indication 164.16 13.89 108 568754 66536 89993049
Oropharyngeal pain 161.93 13.89 297 568565 114890 89944695
Generalised tonic-clonic seizure 161.25 13.89 16 568846 34887 90024698
Ankylosing spondylitis 161.05 13.89 293 568569 12840 90046745
Liver disorder 161.03 13.89 1307 567555 119962 89939623
Suicidal ideation 160.89 13.89 136 568726 73719 89985866
Exostosis 158.59 13.89 708 568154 52426 90007159
Weight decreased 158.59 13.89 1571 567291 378339 89681246
Inappropriate schedule of product administration 158.57 13.89 451 568411 149482 89910103
Palmar-plantar erythrodysaesthesia syndrome 156.79 13.89 4 568858 28019 90031566
Full blood count decreased 156.41 13.89 7 568855 29682 90029903
Hot flush 155.41 13.89 90 568772 59398 90000187
Hypophagia 154.75 13.89 21 568841 35916 90023669
Oxygen saturation decreased 153.90 13.89 274 568588 107209 89952376
Lupus vulgaris 152.71 13.89 624 568238 44435 90015150
Adjustment disorder with depressed mood 152.26 13.89 733 568129 56020 90003565
Headache 151.79 13.89 4190 564672 858556 89201029
Hepatic failure 151.71 13.89 32 568830 39696 90019889
Drug withdrawal syndrome 150.58 13.89 7 568855 28716 90030869
Hypomagnesaemia 150.42 13.89 22 568840 35566 90024019
Renal impairment 149.82 13.89 270 568592 105151 89954434
Pallor 149.43 13.89 19 568843 34146 90025439
Premature delivery 148.47 13.89 31 568831 38731 90020854
Melaena 148.27 13.89 21 568841 34776 90024809
Psychotic disorder 147.78 13.89 13 568849 31217 90028368
Retinitis 147.71 13.89 554 568308 37904 90021681
Altered state of consciousness 146.87 13.89 14 568848 31518 90028067
Oedema peripheral 146.85 13.89 981 567881 256934 89802651
Arrhythmia 146.28 13.89 42 568820 42290 90017295
Depressed mood 146.09 13.89 66 568796 50156 90009429
Urinary incontinence 146.06 13.89 29 568833 37537 90022048
Cytokine release syndrome 146.05 13.89 7 568855 27966 90031619
Nail disorder 145.07 13.89 744 568118 58323 90001262
Cerebral haemorrhage 144.40 13.89 22 568840 34500 90025085
Osteonecrosis of jaw 144.28 13.89 34 568828 39069 90020516
Obstructive airways disorder 143.58 13.89 4 568858 25865 90033720
Nasopharyngitis 143.52 13.89 3456 565406 403648 89655937
Heart rate increased 143.33 13.89 309 568553 112593 89946992
Influenza 142.83 13.89 425 568437 138839 89920746
Throat irritation 141.64 13.89 64 568798 48631 90010954
Vomiting 141.55 13.89 3817 565045 784476 89275109
Transplant dysfunction 141.06 13.89 170 568692 5112 90054473
Transient ischaemic attack 138.25 13.89 49 568813 43127 90016458
Blood urea increased 137.77 13.89 15 568847 30398 90029187
Night sweats 136.95 13.89 1322 567540 127444 89932141
Clostridium difficile colitis 135.31 13.89 8 568854 26698 90032887
Nasal congestion 135.09 13.89 196 568666 83218 89976367
Onychomadesis 135.09 13.89 610 568252 45388 90014197
Aggression 135.09 13.89 8 568854 26660 90032925
Road traffic accident 134.88 13.89 1145 567717 106481 89953104
Swelling face 134.88 13.89 188 568674 81164 89978421
Vertigo 134.02 13.89 144 568718 69667 89989918
Dysphonia 133.97 13.89 119 568743 62965 89996620
Prescribed overdose 133.86 13.89 1060 567802 96565 89963020
Polyarthritis 133.63 13.89 331 568531 18019 90041566
Dermatitis atopic 132.67 13.89 3 568859 23469 90036116
Macular degeneration 132.45 13.89 37 568825 37933 90021652
Skin necrosis 132.37 13.89 314 568548 16627 90042958
Pulmonary arterial hypertension 132.21 13.89 8 568854 26179 90033406
Metastases to bone 131.20 13.89 7 568855 25498 90034087
Drug level increased 130.17 13.89 12 568850 27750 90031835
Enthesopathy 129.81 13.89 221 568641 9183 90050402
Surgery 128.99 13.89 60 568802 44827 90014758
Musculoskeletal deformity 128.95 13.89 102 568760 1796 90057789
Finger deformity 128.93 13.89 477 568385 32420 90027165
Full blood count abnormal 128.90 13.89 35 568827 36562 90023023
Seronegative arthritis 128.68 13.89 325 568537 17909 90041676
Device dislocation 127.34 13.89 22 568840 31460 90028125
Ventricular tachycardia 126.42 13.89 7 568855 24701 90034884
Vaginal haemorrhage 126.16 13.89 22 568840 31249 90028336
Device issue 125.45 13.89 18 568844 29519 90030066
Chronic kidney disease 125.44 13.89 80 568782 50111 90009474
Abortion spontaneous 124.70 13.89 94 568768 53962 90005623
Paraesthesia oral 124.01 13.89 24 568838 31635 90027950
Therapy cessation 123.95 13.89 37 568825 36324 90023261
Pneumonia 123.89 13.89 3054 565808 635005 89424580
Haematuria 123.83 13.89 33 568829 34904 90024681
Hip fracture 123.55 13.89 28 568834 33049 90026536
Lacrimation increased 123.48 13.89 13 568849 27049 90032536
Hemiparesis 122.80 13.89 25 568837 31794 90027791
Cystitis 122.19 13.89 143 568719 66575 89993010
Fluid retention 122.16 13.89 229 568633 87862 89971723
Cholestasis 121.82 13.89 38 568824 36261 90023324
Cardiac disorder 121.11 13.89 107 568755 56765 90002820
Foetal exposure during pregnancy 121.11 13.89 59 568803 42916 90016669
Angioedema 121.04 13.89 137 568725 64739 89994846
Speech disorder 120.46 13.89 68 568794 45517 90014068
Rhinorrhoea 120.35 13.89 232 568630 88084 89971501
Shock 118.87 13.89 19 568843 28759 90030826
Blood creatinine increased 118.57 13.89 290 568572 101096 89958489
Diplopia 118.51 13.89 19 568843 28695 90030890
Lupus-like syndrome 118.38 13.89 613 568249 48233 90011352
Therapy non-responder 117.81 13.89 1345 567517 135359 89924226
Electrolyte imbalance 117.66 13.89 8 568854 23737 90035848
Muscle twitching 117.50 13.89 9 568853 24193 90035392
Sinusitis 117.07 13.89 2900 565962 340188 89719397
Blood sodium decreased 116.87 13.89 17 568845 27596 90031989
Onychomycosis 116.83 13.89 505 568357 36871 90022714
Lymphocyte count decreased 115.30 13.89 38 568824 35012 90024573
Sinus tachycardia 115.16 13.89 20 568842 28493 90031092
Back injury 114.32 13.89 587 568275 46035 90013550
Tenosynovitis 113.82 13.89 270 568592 14297 90045288
Coordination abnormal 112.62 13.89 5 568857 21351 90038234
Swollen tongue 112.47 13.89 75 568787 45881 90013704
Posterior reversible encephalopathy syndrome 112.25 13.89 7 568855 22332 90037253
Cardiogenic shock 111.01 13.89 12 568850 24456 90035129
Pericardial effusion 110.95 13.89 46 568816 36787 90022798
Pancreatitis acute 110.71 13.89 32 568830 32083 90027502
Blepharospasm 110.49 13.89 660 568202 54785 90004800
Joint dislocation 110.49 13.89 563 568299 44019 90015566
Sinus disorder 110.45 13.89 39 568823 34408 90025177
Withdrawal syndrome 110.42 13.89 8 568854 22516 90037069
Nervousness 110.16 13.89 38 568824 34018 90025567
Chronic sinusitis 109.72 13.89 11 568851 23791 90035794
Haematochezia 109.63 13.89 172 568690 70741 89988844
Bone marrow failure 109.44 13.89 33 568829 32188 90027397
Mucosal inflammation 109.36 13.89 120 568742 57505 90002080
Jaundice 109.19 13.89 34 568828 32483 90027102
Ejection fraction decreased 109.19 13.89 17 568845 26236 90033349
No adverse event 108.85 13.89 161 568701 67821 89991764
Product administration error 107.90 13.89 18 568844 26405 90033180
Head injury 107.66 13.89 31 568831 31157 90028428
Live birth 107.38 13.89 857 568005 78250 89981335
Pollakiuria 106.46 13.89 37 568825 32968 90026617
Adverse drug reaction 106.38 13.89 1161 567701 115540 89944045
Angina pectoris 105.53 13.89 57 568805 39103 90020482
Upper gastrointestinal haemorrhage 104.93 13.89 11 568851 22965 90036620
Flatulence 104.67 13.89 65 568797 41302 90018283
Status epilepticus 104.45 13.89 3 568859 18871 90040714
Lip swelling 104.34 13.89 56 568806 38554 90021031
Blood alkaline phosphatase increased 104.15 13.89 89 568773 47990 90011595
Body height below normal 103.22 13.89 95 568767 2073 90057512
Hallucination, visual 103.06 13.89 12 568850 23080 90036505
Infusion site pain 102.86 13.89 5 568857 19733 90039852
Productive cough 102.79 13.89 205 568657 76858 89982727
Hepatic cytolysis 102.61 13.89 33 568829 30883 90028702
Injection site swelling 102.51 13.89 135 568727 59704 89999881
Toxic epidermal necrolysis 102.31 13.89 38 568824 32490 90027095
Procedural pain 101.56 13.89 41 568821 33319 90026266
Complication associated with device 101.12 13.89 5 568857 19444 90040141
Red blood cell sedimentation rate 100.77 13.89 135 568727 4523 90055062
Human antichimeric antibody positive 100.44 13.89 86 568776 1700 90057885
Hepatitis 100.23 13.89 774 568088 69965 89989620
Cholelithiasis 100.01 13.89 109 568753 52397 90007188
Eye swelling 99.99 13.89 30 568832 29356 90030229
Dry mouth 99.76 13.89 1667 567195 182392 89877193
Haemoptysis 99.74 13.89 42 568820 33278 90026307
Acute myocardial infarction 99.70 13.89 47 568815 34843 90024742
Blood glucose decreased 97.83 13.89 15 568847 23414 90036171
Tachypnoea 97.83 13.89 10 568852 21299 90038286
Loss of consciousness 97.58 13.89 500 568362 139738 89919847
Musculoskeletal disorder 96.77 13.89 329 568533 21440 90038145
Hypersomnia 96.57 13.89 11 568851 21520 90038065
Anti-cyclic citrullinated peptide antibody 96.24 13.89 382 568480 26839 90032746
Bacteraemia 96.09 13.89 13 568849 22287 90037298
Sleep apnoea syndrome 95.06 13.89 40 568822 31707 90027878
Coagulopathy 94.80 13.89 16 568846 23273 90036312
Foetal death 94.43 13.89 10 568852 20713 90038872
Food allergy 94.30 13.89 22 568840 25456 90034129
Premature baby 94.12 13.89 21 568841 25056 90034529
Right ventricular failure 93.64 13.89 7 568855 19198 90040387
Metastases to liver 93.42 13.89 32 568830 28775 90030810
Thrombosis 93.36 13.89 200 568662 73051 89986534
Circulatory collapse 93.18 13.89 21 568841 24883 90034702
Hypothyroidism 92.93 13.89 118 568744 53009 90006576
Sensory loss 92.86 13.89 5 568857 18070 90041515
Hepatocellular injury 92.48 13.89 33 568829 28925 90030660
Emotional distress 92.22 13.89 58 568804 36604 90022981
Product prescribing error 91.85 13.89 37 568825 30108 90029477
C-reactive protein 91.37 13.89 415 568447 30952 90028633
Therapeutic response decreased 91.37 13.89 913 567949 88816 89970769
Eye pruritus 91.14 13.89 34 568828 28993 90030592
Skin haemorrhage 90.87 13.89 13 568849 21367 90038218
Acute hepatic failure 90.74 13.89 16 568846 22545 90037040
Throat tightness 90.15 13.89 36 568826 29448 90030137
Weight increased 90.01 13.89 3338 565524 414589 89644996
Haematemesis 89.56 13.89 50 568812 33676 90025909
Sinus bradycardia 89.29 13.89 4 568858 16948 90042637
Illness 89.29 13.89 243 568619 81726 89977859
Visual acuity reduced 89.09 13.89 19 568843 23391 90036194
Diabetic ketoacidosis 88.52 13.89 22 568840 24385 90035200
Device related infection 88.33 13.89 26 568836 25760 90033825
Respiratory tract infection 87.85 13.89 147 568715 58931 90000654
Presyncope 87.61 13.89 45 568817 31760 90027825
Tinnitus 87.16 13.89 85 568777 43017 90016568
Vaginal discharge 87.16 13.89 10 568852 19454 90040131
Osteoporosis 86.89 13.89 958 567904 95573 89964012
Hepatic cirrhosis 86.80 13.89 687 568175 62566 89997019
Ataxia 86.77 13.89 7 568855 18035 90041550
Blood creatine phosphokinase increased 86.72 13.89 53 568809 33970 90025615
Metastases to central nervous system 86.66 13.89 6 568856 17536 90042049
Device difficult to use 86.56 13.89 6 568856 17519 90042066
Panic attack 86.00 13.89 29 568833 26336 90033249
Wheezing 85.55 13.89 2027 566835 236053 89823532
Extrapyramidal disorder 85.37 13.89 4 568858 16299 90043286
Leukocytosis 85.14 13.89 44 568818 30946 90028639
Acute respiratory distress syndrome 84.53 13.89 37 568825 28649 90030936
Lymphopenia 84.21 13.89 20 568842 22861 90036724
Restless legs syndrome 83.97 13.89 19 568843 22451 90037134
Cytomegalovirus infection 83.79 13.89 31 568831 26571 90033014
Blindness 83.62 13.89 31 568831 26537 90033048
Eating disorder 83.05 13.89 36 568826 28037 90031548
Abdominal distension 82.96 13.89 480 568382 130121 89929464
Eczema 82.91 13.89 127 568735 52743 90006842
Dystonia 82.37 13.89 6 568856 16813 90042772
Ischaemic stroke 82.32 13.89 19 568843 22147 90037438
Cyanosis 82.29 13.89 12 568850 19443 90040142
Eosinophilia 82.20 13.89 38 568824 28495 90031090
Pulmonary congestion 82.16 13.89 12 568850 19421 90040164
Drug tolerance 81.61 13.89 273 568589 17643 90041942
Product substitution issue 81.27 13.89 9 568853 17999 90041586
Skin discolouration 81.13 13.89 95 568767 44220 90015365
Accidental overdose 80.92 13.89 38 568824 28235 90031350
Hyperlipidaemia 80.55 13.89 22 568840 22894 90036691
Dementia 80.03 13.89 25 568837 23836 90035749
Viral infection 79.96 13.89 85 568777 41329 90018256
Hepatic function abnormal 79.73 13.89 104 568758 46184 90013401
Proctitis 79.08 13.89 4 568858 15255 90044330
Drug dependence 78.57 13.89 43 568819 29284 90030301
Ulcer 78.53 13.89 411 568451 32471 90027114
Haemorrhage intracranial 78.50 13.89 4 568858 15158 90044427
Hemiplegia 78.48 13.89 6 568856 16154 90043431
International normalised ratio fluctuation 78.46 13.89 97 568765 2996 90056589
Myoclonus 78.40 13.89 13 568849 19155 90040430
Retching 78.35 13.89 13 568849 19146 90040439
Labelled drug-drug interaction medication error 78.28 13.89 3 568859 14579 90045006
Sinus congestion 78.27 13.89 37 568825 27387 90032198
Injection site pruritus 78.17 13.89 136 568726 53698 90005887
Female genital tract fistula 77.99 13.89 10 568852 17858 90041727
Myelodysplastic syndrome 77.46 13.89 18 568844 20885 90038700
Hospitalisation 77.05 13.89 479 568383 127621 89931964
Schizophrenia 77.01 13.89 4 568858 14910 90044675
Influenza like illness 76.99 13.89 254 568608 80357 89979228
Rhinitis allergic 76.74 13.89 8 568854 16777 90042808
Motor dysfunction 76.55 13.89 14 568848 19216 90040369
Acute myeloid leukaemia 76.04 13.89 18 568844 20622 90038963
Thrombotic microangiopathy 76.02 13.89 6 568856 15737 90043848
Product storage error 75.87 13.89 17 568845 20224 90039361
Cerebral infarction 75.73 13.89 36 568826 26560 90033025
Sneezing 75.47 13.89 47 568815 29822 90029763
Gastritis 74.85 13.89 91 568771 41662 90017923
Product label confusion 74.71 13.89 313 568549 22537 90037048
Skin burning sensation 74.46 13.89 16 568846 19595 90039990
Hyperbilirubinaemia 74.36 13.89 3 568859 13933 90045652
Gamma-glutamyltransferase increased 74.28 13.89 77 568785 37875 90021710
Drug eruption 74.12 13.89 427 568435 34980 90024605
Delusion 73.78 13.89 3 568859 13837 90045748
Hypophosphataemia 73.62 13.89 5 568857 14849 90044736
Hyperthyroidism 73.61 13.89 13 568849 18297 90041288
Coronary artery disease 73.12 13.89 62 568800 33561 90026024
Poisoning 72.92 13.89 6 568856 15211 90044374
Brain oedema 72.89 13.89 11 568851 17374 90042211
Progressive multifocal leukoencephalopathy 72.78 13.89 7 568855 15648 90043937
Injection site haemorrhage 72.33 13.89 44 568818 28274 90031311
Device malfunction 72.13 13.89 21 568841 20956 90038629
Rash macular 71.99 13.89 51 568811 30229 90029356
Maternal exposure timing unspecified 71.98 13.89 306 568556 22177 90037408
Laryngitis 71.71 13.89 555 568307 50198 90009387
Small intestinal obstruction 71.66 13.89 22 568840 21212 90038373
Wheelchair user 71.65 13.89 154 568708 7631 90051954
Subarachnoid haemorrhage 71.35 13.89 13 568849 17891 90041694
Malnutrition 70.75 13.89 15 568847 18543 90041042
Renal disorder 70.56 13.89 80 568782 37779 90021806
Eye pain 70.32 13.89 105 568757 44063 90015522
Joint effusion 70.01 13.89 277 568585 19433 90040152
Respiratory depression 69.74 13.89 8 568854 15567 90044018
Mitral valve incompetence 69.69 13.89 27 568835 22497 90037088
Dermatitis contact 69.10 13.89 4 568858 13591 90045994
Bloody discharge 69.05 13.89 78 568784 2185 90057400
Pyrexia 68.84 13.89 3416 565446 657069 89402516
Multiple sclerosis 68.71 13.89 45 568817 27795 90031790
Anal incontinence 68.67 13.89 10 568852 16220 90043365
Vascular access complication 68.29 13.89 80 568782 2333 90057252
Physical disability 67.88 13.89 103 568759 3878 90055707
Walking aid user 67.78 13.89 418 568444 35088 90024497
Gout 67.71 13.89 12 568850 16847 90042738
Red cell distribution width decreased 67.54 13.89 76 568786 2120 90057465
Left ventricular dysfunction 67.05 13.89 7 568855 14662 90044923
Tricuspid valve incompetence 67.00 13.89 12 568850 16719 90042866
Fatigue 66.86 13.89 8243 560619 1145780 88913805
Antibody test positive 66.77 13.89 88 568774 2901 90056684
Subdural haematoma 66.52 13.89 12 568850 16633 90042952
Abdominal pain lower 66.42 13.89 55 568807 30122 90029463
Inappropriate antidiuretic hormone secretion 66.20 13.89 20 568842 19485 90040100
Staphylococcal infection 66.20 13.89 127 568735 48312 90011273
Diabetes mellitus inadequate control 65.55 13.89 18 568844 18666 90040919
Rash papular 65.34 13.89 23 568839 20332 90039253
Hypovolaemia 65.26 13.89 3 568859 12428 90047157
Metastases to lung 65.06 13.89 11 568851 15980 90043605
Breast cancer stage II 64.97 13.89 412 568450 34922 90024663
Shock haemorrhagic 64.14 13.89 3 568859 12242 90047343
Acute generalised exanthematous pustulosis 64.04 13.89 6 568856 13697 90045888
Injection site bruising 64.04 13.89 146 568716 52161 90007424
Leukopenia 64.03 13.89 370 568492 100340 89959245
Infusion site erythema 63.85 13.89 6 568856 13664 90045921
Femur fracture 63.70 13.89 120 568742 45962 90013623
Skin irritation 63.46 13.89 6 568856 13597 90045988
Pain in extremity 63.04 13.89 3444 565418 447085 89612500
Hallucination, auditory 62.80 13.89 12 568850 15963 90043622
Chromaturia 62.77 13.89 21 568841 19166 90040419
Supraventricular tachycardia 62.70 13.89 13 568849 16323 90043262
Septic shock 62.61 13.89 293 568569 83867 89975718
Breast cancer metastatic 62.48 13.89 10 568852 15122 90044463
Rheumatoid factor negative 62.36 13.89 42 568820 569 90059016
Agranulocytosis 61.99 13.89 77 568785 34925 90024660
Sensory disturbance 61.84 13.89 11 568851 15402 90044183
Caesarean section 61.35 13.89 20 568842 18557 90041028
Neuralgia 60.43 13.89 65 568797 31435 90028150
Hypoalbuminaemia 60.30 13.89 13 568849 15884 90043701
Incontinence 59.91 13.89 7 568855 13428 90046157
Anaphylactic shock 59.81 13.89 66 568796 31551 90028034
Injection site mass 59.75 13.89 32 568830 22058 90037527
Stress cardiomyopathy 59.45 13.89 7 568855 13348 90046237
Hepatic encephalopathy 59.41 13.89 8 568854 13764 90045821
Vascular device infection 59.30 13.89 4 568858 11948 90047637
Feeling cold 59.29 13.89 51 568811 27414 90032171
Mania 59.07 13.89 9 568853 14115 90045470
Mental impairment 58.86 13.89 16 568846 16704 90042881
Ventricular extrasystoles 58.85 13.89 7 568855 13243 90046342
Iron deficiency anaemia 58.73 13.89 38 568824 23624 90035961
Peritonitis 58.72 13.89 25 568837 19680 90039905
Unevaluable event 58.68 13.89 164 568698 54684 90004901
Hiatus hernia 58.62 13.89 44 568818 25317 90034268
Mental disorder 58.39 13.89 70 568792 32248 90027337
Abnormal dreams 58.19 13.89 3 568859 11254 90048331
Basal cell carcinoma 58.14 13.89 384 568478 33005 90026580
Blood urine present 58.13 13.89 18 568844 17260 90042325
Haemodynamic instability 58.03 13.89 4 568858 11735 90047850
Tumour lysis syndrome 57.55 13.89 3 568859 11149 90048436
Upper respiratory tract infection 57.54 13.89 521 568341 127797 89931788
Central nervous system lesion 57.48 13.89 4 568858 11642 90047943
Premature labour 57.16 13.89 8 568854 13368 90046217
Blood triglycerides increased 57.03 13.89 9 568853 13752 90045833
Wrist deformity 56.95 13.89 85 568777 3153 90056432
Eye irritation 56.83 13.89 78 568784 33900 90025685
Chest pain 56.80 13.89 1549 567313 318096 89741489
Troponin increased 56.62 13.89 8 568854 13273 90046312
Cardiac failure acute 56.35 13.89 5 568857 11924 90047661
Infusion site reaction 56.28 13.89 253 568609 18786 90040799
Ulcer haemorrhage 55.47 13.89 318 568544 26003 90033582
Ageusia 55.45 13.89 16 568846 16060 90043525
Cholecystitis 55.13 13.89 19 568843 17021 90042564
Infusion site swelling 55.13 13.89 5 568857 11715 90047870
Hypoaesthesia oral 54.78 13.89 15 568847 15585 90044000
Blood calcium increased 54.48 13.89 6 568856 12052 90047533
Pustular psoriasis 54.42 13.89 246 568616 18310 90041275
Aplastic anaemia 54.27 13.89 9 568853 13260 90046325
Device breakage 54.27 13.89 11 568851 14033 90045552
Arterial occlusive disease 54.24 13.89 7 568855 12439 90047146
Mean platelet volume decreased 54.13 13.89 79 568783 2871 90056714
Respiratory syncytial virus infection 53.52 13.89 3 568859 10477 90049108
Asthma 53.33 13.89 1136 567726 241024 89818561
Sudden death 53.12 13.89 4 568858 10905 90048680
Body temperature increased 52.96 13.89 127 568735 44583 90015002
Intestinal obstruction 52.83 13.89 95 568767 37036 90022549
Arteriosclerosis 52.79 13.89 4 568858 10849 90048736
Neck pain 52.79 13.89 1007 567855 112956 89946629
Radiculopathy 52.76 13.89 25 568837 18480 90041105
Lymphoedema 52.67 13.89 11 568851 13742 90045843
Metastases to lymph nodes 52.35 13.89 6 568856 11683 90047902
Fungal infection 52.28 13.89 119 568743 42542 90017043
Atrial flutter 52.23 13.89 4 568858 10754 90048831
Dactylitis 52.12 13.89 90 568772 3783 90055802
Tuberculin test positive 52.02 13.89 88 568774 3637 90055948
Oesophagitis 51.22 13.89 22 568840 17227 90042358
Gastroenteritis 51.03 13.89 65 568797 29164 90030421
Nephropathy toxic 51.02 13.89 9 568853 12679 90046906
Escherichia infection 50.95 13.89 18 568844 15877 90043708
Mycotic allergy 50.94 13.89 47 568815 1029 90058556
Jaundice cholestatic 50.91 13.89 3 568859 10040 90049545
Pseudomonas infection 50.89 13.89 15 568847 14850 90044735
Faeces discoloured 50.56 13.89 36 568826 21284 90038301
Taste disorder 50.52 13.89 600 568262 60946 89998639
Osteonecrosis 50.50 13.89 54 568808 26187 90033398
Complication of device insertion 50.33 13.89 4 568858 10432 90049153
Faecaloma 50.30 13.89 4 568858 10427 90049158
Disseminated intravascular coagulation 50.26 13.89 37 568825 21501 90038084
Hypertension 50.24 13.89 3424 565438 454108 89605477
Skin ulcer 50.23 13.89 508 568354 49567 90010018
Paranoia 50.11 13.89 10 568852 12898 90046687
Heart rate irregular 50.07 13.89 47 568815 24221 90035364
Acute coronary syndrome 49.83 13.89 5 568857 10808 90048777
Nightmare 49.82 13.89 38 568824 21687 90037898
Hypoacusis 49.60 13.89 61 568801 27789 90031796
Generalised oedema 49.51 13.89 29 568833 19024 90040561
Klebsiella infection 49.51 13.89 4 568858 10293 90049292
Presbyacusis 49.47 13.89 77 568785 2965 90056620
Peripheral coldness 49.46 13.89 13 568849 13879 90045706
Cardiomyopathy 49.41 13.89 33 568829 20173 90039412
Oral candidiasis 49.29 13.89 92 568770 35363 90024222
Adverse reaction 48.91 13.89 337 568525 29375 90030210
Anger 48.54 13.89 13 568849 13707 90045878
Burning sensation 48.33 13.89 219 568643 63233 89996352
Drug-induced liver injury 48.16 13.89 816 568046 89502 89970083
Acute pulmonary oedema 48.14 13.89 3 568859 9577 90050008
Glomerular filtration rate decreased 48.08 13.89 23 568839 16909 90042676
Post procedural complication 48.06 13.89 30 568832 19012 90040573
Neutropenic sepsis 47.96 13.89 27 568835 18103 90041482
Dialysis 47.89 13.89 7 568855 11322 90048263
Eructation 47.72 13.89 6 568856 10876 90048709
Gingival bleeding 47.56 13.89 17 568845 14886 90044699
Pulmonary toxicity 47.55 13.89 170 568692 11361 90048224
Tooth disorder 47.49 13.89 76 568786 31014 90028571
Hypoaesthesia 47.34 13.89 2419 566443 311791 89747794
Bronchitis 47.29 13.89 675 568187 152252 89907333
Limb injury 47.21 13.89 78 568784 31430 90028155
Acidosis 47.13 13.89 11 568851 12725 90046860
Colitis ischaemic 47.02 13.89 10 568852 12336 90047249
Tenosynovitis stenosans 46.96 13.89 87 568775 3866 90055719
Hereditary angioedema 46.86 13.89 3 568859 9362 90050223
Blood magnesium decreased 46.62 13.89 20 568842 15673 90043912
Bacterial infection 46.52 13.89 47 568815 23397 90036188
Thirst 46.48 13.89 22 568840 16273 90043312
Immune thrombocytopenia 46.45 13.89 13 568849 13313 90046272
Ileus 46.19 13.89 23 568839 16523 90043062
Bone swelling 46.18 13.89 56 568806 1695 90057890
Lung infiltration 46.17 13.89 19 568843 15263 90044322
Bronchopulmonary aspergillosis 46.02 13.89 8 568854 11390 90048195
Amenorrhoea 45.67 13.89 9 568853 11713 90047872
Neutrophil count increased 45.65 13.89 33 568829 19357 90040228
Polyuria 45.35 13.89 5 568857 10035 90049550
Device leakage 45.07 13.89 5 568857 9986 90049599
Drug resistance 45.05 13.89 76 568786 30373 90029212
Tenderness 44.97 13.89 306 568556 26562 90033023
Rib fracture 44.91 13.89 60 568802 26375 90033210
Rash maculo-papular 44.83 13.89 121 568741 40812 90018773
Coeliac disease 44.48 13.89 452 568410 44158 90015427
Impaired work ability 44.40 13.89 239 568623 19087 90040498
Product dose omission in error 44.35 13.89 38 568824 20465 90039120
Nocturia 44.14 13.89 6 568856 10249 90049336
Gangrene 44.07 13.89 13 568849 12863 90046722
Blood lactate dehydrogenase increased 43.91 13.89 59 568803 25873 90033712
Kidney infection 43.84 13.89 59 568803 25857 90033728
Respiratory tract congestion 43.79 13.89 65 568797 27345 90032240
Clostridium difficile infection 43.69 13.89 102 568760 36143 90023442
Cold sweat 43.37 13.89 17 568845 14064 90045521
Toxic encephalopathy 42.90 13.89 3 568859 8696 90050889
Spinal fracture 42.71 13.89 45 568817 21971 90037614
Rales 42.70 13.89 23 568839 15804 90043781
Tubulointerstitial nephritis 42.57 13.89 58 568804 25285 90034300
Pleural fibrosis 42.54 13.89 79 568783 3517 90056068
Skin laceration 42.32 13.89 61 568801 25974 90033611
Nervous system disorder 42.04 13.89 44 568818 21549 90038036
Myocardial ischaemia 42.01 13.89 17 568845 13797 90045788
Myocarditis 41.97 13.89 17 568845 13789 90045796
Stevens-Johnson syndrome 41.93 13.89 75 568787 29301 90030284
Mood altered 41.92 13.89 28 568834 17116 90042469
Dental caries 41.86 13.89 10 568852 11387 90048198
Therapy partial responder 41.71 13.89 46 568816 21997 90037588
Eosinophil count increased 41.61 13.89 15 568847 13066 90046519
Face oedema 41.60 13.89 51 568811 23267 90036318
Insurance issue 41.48 13.89 9 568853 10949 90048636
Prothrombin time prolonged 41.39 13.89 6 568856 9766 90049819
Lower gastrointestinal haemorrhage 41.27 13.89 4 568858 8888 90050697
Abdominal tenderness 41.23 13.89 5 568857 9319 90050266
Injection site rash 40.93 13.89 55 568807 24118 90035467
Spondylitis 40.86 13.89 187 568675 13991 90045594
Arthrodesis 40.54 13.89 70 568792 2942 90056643
Pleural thickening 40.51 13.89 73 568789 3175 90056410
Arteriosclerosis coronary artery 40.44 13.89 6 568856 9597 90049988
Lipase increased 40.32 13.89 10 568852 11101 90048484
Product administration interrupted 40.29 13.89 14 568848 12478 90047107
Seasonal allergy 40.24 13.89 51 568811 22932 90036653
Hyperaesthesia 40.09 13.89 9 568853 10693 90048892
Diverticulum 40.07 13.89 13 568849 12100 90047485
Increased appetite 40.05 13.89 12 568850 11753 90047832
Drug specific antibody 40.04 13.89 63 568799 2449 90057136
Pain in jaw 40.00 13.89 160 568702 47825 90011760
Glycosylated haemoglobin increased 40.00 13.89 24 568838 15538 90044047
Disease recurrence 39.97 13.89 113 568749 37540 90022045
Vitamin D deficiency 39.89 13.89 31 568831 17525 90042060
Heavy menstrual bleeding 39.79 13.89 42 568820 20488 90039097
Drug dose omission by device 39.56 13.89 8 568854 10223 90049362
Confusional state 39.55 13.89 2874 565988 383331 89676254
Needle issue 39.46 13.89 19 568843 13915 90045670
Eyelid ptosis 39.41 13.89 5 568857 9001 90050584
Aphonia 39.40 13.89 14 568848 12305 90047280
Apnoea 39.37 13.89 6 568856 9408 90050177
Subcutaneous drug absorption impaired 39.29 13.89 179 568683 13366 90046219
Polyneuropathy 39.27 13.89 38 568824 19303 90040282
Gastric ulcer 39.25 13.89 70 568792 27378 90032207
Aspiration 39.23 13.89 25 568837 15668 90043917
Urticaria 39.13 13.89 2367 566495 310367 89749218
Pneumonitis 38.93 13.89 144 568718 44026 90015559
Facial pain 38.84 13.89 17 568845 13165 90046420
Aspergillus infection 38.78 13.89 10 568852 10813 90048772
Glucose tolerance impaired 38.68 13.89 3 568859 7982 90051603
Extremity contracture 38.49 13.89 44 568818 1249 90058336
Rectal haemorrhage 38.39 13.89 333 568529 82411 89977174
Ovarian cyst 38.32 13.89 212 568650 17106 90042479
Enterococcal infection 38.24 13.89 8 568854 9983 90049602
Heart rate decreased 38.21 13.89 189 568673 53316 90006269
Bundle branch block left 38.09 13.89 3 568859 7882 90051703
Transplant rejection 38.06 13.89 170 568692 12588 90046997
Renal tubular necrosis 38.04 13.89 22 568840 14533 90045052
Ecchymosis 37.75 13.89 15 568847 12308 90047277
Activated partial thromboplastin time prolonged 37.73 13.89 3 568859 7822 90051763
Renal injury 37.60 13.89 9 568853 10234 90049351
Cytomegalovirus infection reactivation 37.58 13.89 3 568859 7797 90051788
Thyroid neoplasm 37.53 13.89 80 568782 3941 90055644
Dizziness postural 37.34 13.89 6 568856 9047 90050538
Affect lability 37.25 13.89 35 568827 18028 90041557
Oedema 37.24 13.89 1575 567287 198720 89860865
Bone density abnormal 37.08 13.89 81 568781 4059 90055526
Injection site induration 36.88 13.89 10 568852 10458 90049127
Mean cell volume decreased 36.82 13.89 85 568777 4421 90055164
Gallbladder disorder 36.74 13.89 42 568820 19761 90039824
Atrioventricular block first degree 36.58 13.89 5 568857 8506 90051079
Mixed liver injury 36.54 13.89 3 568859 7620 90051965
Blood albumin decreased 36.52 13.89 31 568831 16772 90042813
Neck deformity 36.42 13.89 56 568806 2133 90057452
Fear of injection 36.37 13.89 127 568735 8388 90051197
Musculoskeletal chest pain 36.33 13.89 58 568804 23692 90035893
Ocular hyperaemia 36.20 13.89 101 568761 33697 90025888
Hyperthermia 36.18 13.89 10 568852 10325 90049260
Pulmonary haemorrhage 36.17 13.89 4 568858 8009 90051576
Infusion site extravasation 36.14 13.89 10 568852 10318 90049267
Exercise tolerance decreased 36.12 13.89 3 568859 7548 90052037
Neoplasm malignant 36.07 13.89 348 568514 33532 90026053
Sacroiliitis 36.04 13.89 81 568781 4138 90055447
Electrocardiogram abnormal 35.98 13.89 10 568852 10288 90049297
Spinal stenosis 35.73 13.89 209 568653 17215 90042370
Lyme disease 35.49 13.89 81 568781 4181 90055404
Respiratory rate increased 35.42 13.89 29 568833 15972 90043613
Eye haemorrhage 35.35 13.89 10 568852 10170 90049415
Oral herpes 35.30 13.89 101 568761 33423 90026162
Toothache 35.24 13.89 53 568809 22177 90037408
Blood test abnormal 35.14 13.89 48 568814 20904 90038681
Concussion 34.81 13.89 13 568849 11078 90048507
Oral pain 34.76 13.89 98 568764 32585 90027000
Injection site urticaria 34.73 13.89 37 568825 17974 90041611
Synovial fluid analysis 34.72 13.89 63 568799 2755 90056830
Upper limb fracture 34.64 13.89 51 568811 21527 90038058
Hepatotoxicity 34.63 13.89 440 568422 45402 90014183
Major depression 34.59 13.89 10 568852 10025 90049560
Initial insomnia 34.53 13.89 8 568854 9302 90050283
Myopathy 34.53 13.89 21 568841 13497 90046088
Graft versus host disease 34.50 13.89 5 568857 8139 90051446
Urine output decreased 34.46 13.89 18 568844 12585 90047000
Cardiac murmur 34.39 13.89 38 568824 18156 90041429
Gastrointestinal toxicity 34.39 13.89 134 568728 9333 90050252
Intestinal ischaemia 34.23 13.89 7 568855 8876 90050709
Cardiomegaly 34.18 13.89 41 568821 18884 90040701
Pneumothorax 34.11 13.89 42 568820 19125 90040460
Unintended pregnancy 34.00 13.89 4 568858 7633 90051952
Nodule 33.99 13.89 285 568577 26401 90033184
Micturition urgency 33.88 13.89 14 568848 11219 90048366
Visual field defect 33.86 13.89 3 568859 7163 90052422
Appendicitis 33.81 13.89 11 568851 10220 90049365
Ovarian neoplasm 33.68 13.89 35 568827 890 90058695
Anosmia 33.60 13.89 10 568852 9838 90049747
Hydronephrosis 33.49 13.89 18 568844 12384 90047201
Bronchospasm 33.19 13.89 49 568813 20660 90038925
Eye injury 32.99 13.89 147 568715 10873 90048712
Middle insomnia 32.76 13.89 34 568828 16717 90042868
Paraesthesia 32.74 13.89 1262 567600 249064 89810521
Psoriasis 32.66 13.89 1184 567678 146570 89913015
Enteritis 32.55 13.89 12 568850 10309 90049276
Decreased appetite 32.55 13.89 1983 566879 374557 89685028
Coronary artery occlusion 32.43 13.89 7 568855 8547 90051038
COVID-19 pneumonia 32.17 13.89 40 568822 18137 90041448
Tooth extraction 32.14 13.89 16 568846 11497 90048088
Intermenstrual bleeding 32.14 13.89 9 568853 9214 90050371
Head discomfort 32.12 13.89 33 568829 16300 90043285
Rheumatic disorder 32.04 13.89 68 568794 3340 90056245
Blood magnesium increased 32.04 13.89 68 568794 3340 90056245
Therapeutic response unexpected 32.01 13.89 55 568807 21825 90037760
Ankle arthroplasty 32.01 13.89 61 568801 2770 90056815
Dyspepsia 31.77 13.89 1535 567327 196625 89862960
Upper-airway cough syndrome 31.59 13.89 29 568833 15106 90044479
Bladder disorder 31.57 13.89 14 568848 10758 90048827
Infusion site pruritus 31.51 13.89 3 568859 6762 90052823
Paronychia 31.50 13.89 6 568856 8000 90051585
Cerebral ischaemia 31.47 13.89 4 568858 7192 90052393
Breast pain 31.39 13.89 13 568849 10405 90049180
Fear 31.11 13.89 35 568827 16587 90042998
Pregnancy 31.07 13.89 555 568307 61492 89998093
Pain of skin 31.05 13.89 33 568829 16049 90043536
Herpes zoster 30.95 13.89 413 568449 94231 89965354
Asphyxia 30.94 13.89 4 568858 7099 90052486
Haemoglobin abnormal 30.92 13.89 4 568858 7096 90052489
Hyperreflexia 30.89 13.89 3 568859 6654 90052931
Treatment noncompliance 30.79 13.89 194 568668 51533 90008052
Eyelid oedema 30.77 13.89 17 568845 11517 90048068
Staphylococcal bacteraemia 30.69 13.89 5 568857 7464 90052121
Nail operation 30.65 13.89 48 568814 1858 90057727
Pneumonia fungal 30.53 13.89 4 568858 7027 90052558
Injection site warmth 30.53 13.89 39 568823 17476 90042109
Paralysis 30.50 13.89 17 568845 11461 90048124
Hunger 30.34 13.89 3 568859 6560 90053025
Tooth fracture 30.24 13.89 21 568841 12579 90047006
Proteinuria 30.17 13.89 63 568799 23228 90036357
Poor quality sleep 30.16 13.89 69 568793 24624 90034961
Blood thyroid stimulating hormone increased 29.98 13.89 10 568852 9145 90050440
Haemorrhoids 29.95 13.89 78 568784 26624 90032961
Psychomotor hyperactivity 29.91 13.89 22 568840 12791 90046794
Pre-eclampsia 29.89 13.89 16 568846 11032 90048553
Mean cell haemoglobin decreased 29.78 13.89 91 568771 5604 90053981
Device failure 29.77 13.89 4 568858 6893 90052692
Hypercalcaemia 29.52 13.89 337 568525 33903 90025682
Dermatitis allergic 29.39 13.89 198 568664 17129 90042456
Nystagmus 29.34 13.89 5 568857 7222 90052363
Product prescribing issue 29.31 13.89 7 568855 7972 90051613
Ocular discomfort 29.22 13.89 3 568859 6367 90053218
Injection site discolouration 29.12 13.89 11 568851 9309 90050276
Bipolar disorder 29.10 13.89 10 568852 8975 90050610
Carotid artery occlusion 29.05 13.89 3 568859 6339 90053246
Thermal burn 29.00 13.89 4 568858 6758 90052827
Gait disturbance 28.99 13.89 1952 566910 258544 89801041
Essential hypertension 28.90 13.89 3 568859 6312 90053273
Hyperuricaemia 28.75 13.89 4 568858 6715 90052870
Erythema multiforme 28.62 13.89 21 568841 12225 90047360
Hypovolaemic shock 28.60 13.89 5 568857 7089 90052496
Complication of device removal 28.55 13.89 3 568859 6252 90053333
Petechiae 28.54 13.89 34 568828 15707 90043878
Joint space narrowing 28.53 13.89 29 568833 718 90058867
Hypercapnia 28.52 13.89 4 568858 6673 90052912
Abortion induced 28.29 13.89 20 568842 11868 90047717
Pneumonia viral 28.27 13.89 10 568852 8813 90050772
Eye movement disorder 28.22 13.89 3 568859 6195 90053390
Aortic valve incompetence 28.21 13.89 4 568858 6620 90052965
Emphysema 28.21 13.89 21 568841 12134 90047451
Product availability issue 28.19 13.89 6 568856 7398 90052187
Immune reconstitution inflammatory syndrome 28.18 13.89 5 568857 7014 90052571
Post procedural haemorrhage 28.14 13.89 10 568852 8788 90050797
Decubitus ulcer 27.94 13.89 20 568842 11793 90047792
Mass excision 27.92 13.89 21 568841 342 90059243
Bone disorder 27.92 13.89 65 568797 23055 90036530
Menstruation irregular 27.84 13.89 8 568854 8052 90051533
Dermatitis bullous 27.82 13.89 15 568847 10301 90049284
Expired product administered 27.64 13.89 5 568857 6917 90052668
Bone density decreased 27.53 13.89 195 568667 17150 90042435
Joint injury 27.50 13.89 320 568542 32344 90027241
Partial seizures 27.41 13.89 6 568856 7254 90052331
Hypokinesia 27.31 13.89 35 568827 15662 90043923
Orthopnoea 27.16 13.89 5 568857 6830 90052755
Uterine perforation 27.03 13.89 7 568855 7547 90052038
Tension headache 26.79 13.89 7 568855 7502 90052083
Squamous cell carcinoma 26.78 13.89 15 568847 10086 90049499
Gastritis erosive 26.71 13.89 5 568857 6750 90052835
Hypertensive crisis 26.67 13.89 44 568818 17740 90041845
Low birth weight baby 26.67 13.89 13 568849 9454 90050131
Sputum discoloured 26.54 13.89 55 568807 20336 90039249
Epstein-Barr virus infection 26.52 13.89 16 568846 10328 90049257
Squamous cell carcinoma of skin 26.46 13.89 7 568855 7442 90052143
Amylase increased 26.38 13.89 6 568856 7066 90052519
Skin fissures 26.36 13.89 57 568805 20752 90038833
Rebound effect 26.26 13.89 13 568849 9371 90050214
Staphylococcal sepsis 26.26 13.89 13 568849 9370 90050215
Erysipelas 26.16 13.89 12 568850 9040 90050545
Synovial cyst 26.09 13.89 144 568718 11608 90047977
Hepatic enzyme abnormal 26.02 13.89 106 568756 7536 90052049
Forced expiratory volume decreased 25.97 13.89 3 568859 5805 90053780
Congestive cardiomyopathy 25.96 13.89 7 568855 7347 90052238
Fine motor skill dysfunction 25.96 13.89 84 568778 5335 90054250
Off label use 25.92 13.89 6332 562530 1095920 88963665
Protein urine present 25.91 13.89 6 568856 6978 90052607
Paranasal sinus discomfort 25.87 13.89 4 568858 6206 90053379
Ear discomfort 25.84 13.89 16 568846 10184 90049401
Retinal haemorrhage 25.71 13.89 3 568859 5761 90053824
Synovial disorder 25.68 13.89 59 568803 3059 90056526
Dry throat 25.54 13.89 9 568853 7951 90051634
Neoplasm 25.42 13.89 12 568850 8891 90050694
Blood glucose abnormal 25.31 13.89 14 568848 9478 90050107
White blood cells urine positive 25.29 13.89 5 568857 6493 90053092
Hydrocephalus 25.22 13.89 4 568858 6090 90053495
Intestinal sepsis 25.18 13.89 19 568843 311 90059274
Neurological symptom 25.17 13.89 6 568856 6841 90052744
Vitreous floaters 25.16 13.89 8 568854 7541 90052044
Potentiating drug interaction 25.12 13.89 3 568859 5659 90053926
Renal function test abnormal 25.09 13.89 7 568855 7184 90052401
Muscle spasticity 25.09 13.89 125 568737 35197 90024388
Diverticulum intestinal 25.08 13.89 13 568849 9129 90050456
Oesophageal candidiasis 25.07 13.89 6 568856 6823 90052762
Thinking abnormal 25.06 13.89 22 568840 11710 90047875
Post-traumatic stress disorder 25.06 13.89 6 568856 6822 90052763
Drug level decreased 25.02 13.89 15 568847 9715 90049870
Granulocytopenia 24.98 13.89 5 568857 6436 90053149
Peptic ulcer haemorrhage 24.97 13.89 33 568829 1091 90058494
Metabolic disorder 24.74 13.89 8 568854 7462 90052123
Brain natriuretic peptide increased 24.72 13.89 4 568858 6001 90053584
Gingivitis 24.72 13.89 14 568848 9355 90050230
Facial paralysis 24.66 13.89 37 568825 15497 90044088
Femoral neck fracture 24.64 13.89 17 568845 10216 90049369
Porphyria acute 24.53 13.89 195 568667 17780 90041805
Splenomegaly 24.42 13.89 27 568835 12897 90046688
Crying 24.35 13.89 81 568781 25564 90034021
Diabetes mellitus 24.27 13.89 275 568587 64600 89994985
Cystitis haemorrhagic 24.27 13.89 3 568859 5510 90054075
Bone cyst 24.17 13.89 49 568813 2329 90057256
Concomitant disease aggravated 24.13 13.89 22 568840 11496 90048089
Viral upper respiratory tract infection 24.10 13.89 12 568850 8622 90050963
Hallucinations, mixed 24.07 13.89 4 568858 5885 90053700
Choking 24.02 13.89 24 568838 12009 90047576
Procedural complication 24.01 13.89 4 568858 5874 90053711
Intervertebral disc disorder 23.97 13.89 3 568859 5457 90054128
Bundle branch block right 23.93 13.89 3 568859 5450 90054135
Blood pressure abnormal 23.91 13.89 55 568807 19590 90039995
Necrosis 23.89 13.89 6 568856 6604 90052981
Hyperprolactinaemia 23.81 13.89 3 568859 5430 90054155
Eye discharge 23.78 13.89 11 568851 8247 90051338
Oral mucosal blistering 23.68 13.89 7 568855 6917 90052668
Pharyngitis streptococcal 23.66 13.89 27 568835 12715 90046870
Drug level above therapeutic 23.62 13.89 4 568858 5805 90053780
Feeling hot 23.52 13.89 346 568516 77662 89981923
Laryngeal oedema 23.45 13.89 7 568855 6874 90052711
Impaired quality of life 23.45 13.89 71 568791 23073 90036512
Increased tendency to bruise 23.41 13.89 24 568838 11866 90047719
Scleritis 23.40 13.89 79 568783 5129 90054456
Left ventricular hypertrophy 23.35 13.89 5 568857 6139 90053446
Enterocolitis 23.23 13.89 19 568843 10471 90049114
Myasthenia gravis 23.16 13.89 7 568855 6818 90052767
Lymphadenopathy 23.16 13.89 180 568682 45595 90013990
Herpes simplex 23.10 13.89 18 568844 10163 90049422
Malaise 23.09 13.89 3275 565587 582711 89476874
Injection site extravasation 23.05 13.89 14 568848 9005 90050580
Depressive symptom 22.97 13.89 3 568859 5282 90054303
Transaminases increased 22.91 13.89 138 568724 37054 90022531
Aspartate aminotransferase increased 22.90 13.89 482 568380 102455 89957130
Anovulatory cycle 22.88 13.89 14 568848 159 90059426
Supraventricular extrasystoles 22.81 13.89 3 568859 5254 90054331
Extrasystoles 22.78 13.89 4 568858 5653 90053932
Protein total decreased 22.77 13.89 8 568854 7081 90052504
Peripheral sensory neuropathy 22.76 13.89 15 568847 9235 90050350
Blood folate decreased 22.72 13.89 39 568823 1631 90057954
Aortic arteriosclerosis 22.50 13.89 10 568852 7674 90051911
Gastrointestinal inflammation 22.48 13.89 7 568855 6689 90052896
Postoperative wound infection 22.27 13.89 31 568831 13395 90046190
Maternal drugs affecting foetus 22.22 13.89 3 568859 5152 90054433
Feeding disorder 22.15 13.89 48 568814 17464 90042121
Nephrolithiasis 22.12 13.89 199 568663 48886 90010699
Drug effective for unapproved indication 22.11 13.89 11 568851 7907 90051678
Skin swelling 22.06 13.89 7 568855 6607 90052978
Foetal growth restriction 22.03 13.89 16 568846 9364 90050221
Cartilage atrophy 21.95 13.89 14 568848 172 90059413
Hyperkeratosis 21.94 13.89 8 568854 6920 90052665
Injection site haematoma 21.91 13.89 8 568854 6914 90052671
Internal haemorrhage 21.81 13.89 6 568856 6214 90053371
Spinal meningioma benign 21.79 13.89 12 568850 110 90059475
Pharyngitis 21.76 13.89 68 568794 21879 90037706
Skin abrasion 21.75 13.89 23 568839 11212 90048373
Blood culture positive 21.75 13.89 3 568859 5069 90054516
Product dispensing error 21.73 13.89 27 568835 12246 90047339
Vaginal infection 21.71 13.89 13 568849 8427 90051158
Arteriospasm coronary 21.63 13.89 3 568859 5047 90054538
Pathogen resistance 21.59 13.89 12 568850 8103 90051482
Skin hyperpigmentation 21.55 13.89 8 568854 6843 90052742
Cardiovascular disorder 21.55 13.89 32 568830 13460 90046125
Blood phosphorus decreased 21.54 13.89 3 568859 5031 90054554
Muscle atrophy 21.53 13.89 13 568849 8388 90051197
Arthritis enteropathic 21.52 13.89 19 568843 392 90059193
Euphoric mood 21.40 13.89 4 568858 5405 90054180
Substance abuse 21.38 13.89 4 568858 5402 90054183
Gestational diabetes 21.24 13.89 21 568841 10561 90049024
Gastrointestinal motility disorder 21.12 13.89 6 568856 6085 90053500
Papule 21.05 13.89 12 568850 7990 90051595
Scab 21.05 13.89 18 568844 9703 90049882
Large intestine perforation 21.01 13.89 18 568844 9694 90049891
White blood cell count abnormal 20.91 13.89 98 568764 7406 90052179
Hepatomegaly 20.90 13.89 32 568830 13294 90046291
Respiration abnormal 20.86 13.89 12 568850 7951 90051634
Optic neuritis 20.86 13.89 18 568844 9660 90049925
Ischaemia 20.77 13.89 4 568858 5291 90054294
Intentional dose omission 20.68 13.89 51 568811 17732 90041853
Hordeolum 20.65 13.89 3 568859 4875 90054710
Product complaint 20.62 13.89 33 568829 13467 90046118
Abscess 20.57 13.89 56 568806 18835 90040750
Swollen joint count 20.55 13.89 108 568754 8545 90051040
Decreased activity 20.55 13.89 13 568849 8179 90051406
Immobile 20.42 13.89 87 568775 6311 90053274
Oral lichen planus 20.38 13.89 25 568837 766 90058819
Lung neoplasm malignant 20.19 13.89 81 568781 24192 90035393
Toxic skin eruption 20.15 13.89 43 568819 15731 90043854
Venous thrombosis 20.06 13.89 5 568857 5532 90054053
Atypical pneumonia 20.05 13.89 4 568858 5160 90054425
Haematocrit decreased 20.01 13.89 167 568695 41665 90017920
Wound complication 20 13.89 3 568859 4760 90054825
Hyperpyrexia 19.99 13.89 3 568859 4758 90054827
Rash vesicular 19.91 13.89 188 568674 18009 90041576
Overlap syndrome 19.83 13.89 106 568756 8442 90051143
Stress fracture 19.82 13.89 15 568847 8596 90050989
Stillbirth 19.81 13.89 11 568851 7432 90052153
Phlebitis 19.75 13.89 11 568851 7419 90052166
Intracranial pressure increased 19.73 13.89 9 568853 6802 90052783
Thoracic vertebral fracture 19.72 13.89 5 568857 5469 90054116
Poor venous access 19.71 13.89 60 568802 19467 90040118
Cholecystitis acute 19.65 13.89 18 568844 9386 90050199
Fibrin D dimer increased 19.65 13.89 5 568857 5455 90054130
Gastrointestinal infection 19.65 13.89 24 568838 10966 90048619
Menstrual disorder 19.59 13.89 7 568855 6131 90053454
Urosepsis 19.52 13.89 68 568794 21164 90038421
Pelvic pain 19.50 13.89 42 568820 15315 90044270
Muscle tightness 19.46 13.89 34 568828 13405 90046180
Paradoxical drug reaction 19.41 13.89 6 568856 5760 90053825
Weber tuning fork test abnormal 19.33 13.89 11 568851 108 90059477
Hyperventilation 19.32 13.89 9 568853 6719 90052866
Cataract 19.30 13.89 327 568535 71765 89987820
Non-cardiac chest pain 19.28 13.89 9 568853 6712 90052873
Muscle spasms 19.27 13.89 1341 567521 250542 89809043
Hepatitis acute 19.23 13.89 24 568838 10863 90048722
Peripheral arterial occlusive disease 19.20 13.89 3 568859 4618 90054967
SARS-CoV-2 test positive 19.16 13.89 25 568837 11103 90048482
Oral discomfort 19.13 13.89 122 568740 10361 90049224
Nerve injury 19.08 13.89 25 568837 11081 90048504
Hypocalcaemia 18.99 13.89 172 568690 42196 90017389
Blood creatine increased 18.98 13.89 10 568852 6957 90052628
Hepatic enzyme 18.89 13.89 75 568787 5269 90054316
Spinal fusion surgery 18.86 13.89 137 568725 12146 90047439
Heparin-induced thrombocytopenia 18.86 13.89 5 568857 5307 90054278
Paranasal sinus hypersecretion 18.81 13.89 3 568859 4548 90055037
Delirium 18.79 13.89 818 568044 103541 89956044
Cytopenia 18.79 13.89 52 568810 17397 90042188
Pancreatic carcinoma 18.77 13.89 15 568847 8362 90051223
Low density lipoprotein increased 18.72 13.89 14 568848 8071 90051514
Tuberculosis 18.72 13.89 139 568723 12410 90047175
Short stature 18.69 13.89 28 568834 1042 90058543
Urinary tract infection bacterial 18.69 13.89 8 568854 6277 90053308
Spinal cord compression 18.66 13.89 4 568858 4907 90054678
Injection site discomfort 18.58 13.89 7 568855 5933 90053652
Spondyloarthropathy 18.55 13.89 30 568832 1194 90058391
Cachexia 18.55 13.89 10 568852 6868 90052717
Leukoencephalopathy 18.45 13.89 4 568858 4869 90054716
Therapeutic product effect variable 18.45 13.89 34 568828 1505 90058080
Brain injury 18.44 13.89 13 568849 7725 90051860
Blindness unilateral 18.43 13.89 13 568849 7723 90051862
Angina unstable 18.38 13.89 11 568851 7132 90052453
Skin mass 18.35 13.89 12 568850 7418 90052167
Anaphylactoid reaction 18.34 13.89 3 568859 4465 90055120
Autoimmune thyroiditis 18.34 13.89 7 568855 5886 90053699
Alanine aminotransferase abnormal 18.27 13.89 75 568787 5351 90054234
Endocarditis 18.24 13.89 11 568851 7102 90052483
Compression fracture 18.16 13.89 17 568845 8772 90050813
Impaired driving ability 18.12 13.89 5 568857 5168 90054417
Fistula 18.04 13.89 30 568832 12059 90047526
Formication 18.00 13.89 4 568858 4787 90054798
Decreased interest 18.00 13.89 3 568859 4404 90055181
Streptococcal infection 17.90 13.89 12 568850 7321 90052264
Mass 17.86 13.89 45 568817 15532 90044053
Food poisoning 17.83 13.89 5 568857 5113 90054472
Atypical femur fracture 17.81 13.89 9 568853 6412 90053173
General symptom 17.81 13.89 155 568707 14513 90045072
Infusion site bruising 17.80 13.89 3 568859 4369 90055216
Nephropathy 17.78 13.89 19 568843 9216 90050369
Antinuclear antibody positive 17.77 13.89 109 568753 9132 90050453
Hypertonic bladder 17.67 13.89 3 568859 4345 90055240
Pancreatitis 17.64 13.89 320 568542 69506 89990079
International normalised ratio decreased 17.64 13.89 4 568858 4720 90054865
Peroneal nerve palsy 17.60 13.89 7 568855 5741 90053844
Refusal of treatment by patient 17.55 13.89 7 568855 5731 90053854
Incorrect dose administered by device 17.55 13.89 7 568855 5730 90053855
Sensation of foreign body 17.54 13.89 9 568853 6357 90053228
Ventricular septal defect 17.54 13.89 6 568856 5401 90054184
Clostridium test positive 17.51 13.89 6 568856 5395 90054190
Epilepsy 17.49 13.89 656 568206 81550 89978035
Interferon gamma release assay positive 17.42 13.89 10 568852 100 90059485
Pathological fracture 17.37 13.89 21 568841 9639 90049946
Product residue present 17.35 13.89 3 568859 4288 90055297
Oxygen saturation abnormal 17.33 13.89 3 568859 4285 90055300
Pulmonary alveolar haemorrhage 17.26 13.89 8 568854 5990 90053595
Azotaemia 17.24 13.89 6 568856 5342 90054243
Depression 17.09 13.89 1639 567223 298962 89760623
Autoimmune haemolytic anaemia 17.08 13.89 7 568855 5638 90053947
Polydipsia 17.02 13.89 3 568859 4228 90055357
Atrial appendage closure 16.95 13.89 8 568854 51 90059534
Incorrect route of product administration 16.94 13.89 427 568435 50199 90009386
Pemphigoid 16.90 13.89 19 568843 9007 90050578
Onychoclasis 16.89 13.89 13 568849 7386 90052199
Diabetic neuropathy 16.83 13.89 4 568858 4570 90055015
Serum ferritin increased 16.81 13.89 13 568849 7368 90052217
Injection site reaction 16.64 13.89 722 568140 91358 89968227
Type I hypersensitivity 16.59 13.89 3 568859 4152 90055433
Fluid intake reduced 16.58 13.89 3 568859 4149 90055436
Tender joint count 16.54 13.89 31 568831 1390 90058195
Rheumatoid lung 16.50 13.89 60 568802 4043 90055542
Aplasia pure red cell 16.45 13.89 6 568856 5188 90054397
Hepatic necrosis 16.45 13.89 10 568852 6428 90053157
Wound dehiscence 16.39 13.89 8 568854 5814 90053771
Investigation abnormal 16.38 13.89 41 568821 2246 90057339
Tooth loss 16.34 13.89 14 568848 7540 90052045
Trismus 16.26 13.89 5 568857 4816 90054769
Muscle disorder 16.25 13.89 7 568855 5472 90054113
Inflammatory pain 16.22 13.89 26 568836 1027 90058558
Periorbital swelling 16.14 13.89 5 568857 4793 90054792
Aphthous ulcer 16.14 13.89 55 568807 17232 90042353
Tongue oedema 16.12 13.89 7 568855 5447 90054138
Knee operation 16.07 13.89 12 568850 6924 90052661
Tearfulness 16.05 13.89 5 568857 4775 90054810
Renal pain 16.04 13.89 15 568847 7744 90051841
Posthaemorrhagic hydrocephalus 15.99 13.89 8 568854 59 90059526
Escherichia bacteraemia 15.97 13.89 8 568854 5727 90053858
Urine abnormality 15.94 13.89 15 568847 7722 90051863
Oropharyngeal discomfort 15.93 13.89 15 568847 7720 90051865
Cholangitis 15.92 13.89 13 568849 7169 90052416
Intracranial aneurysm 15.88 13.89 4 568858 4394 90055191
Occult blood positive 15.86 13.89 3 568859 4020 90055565
Graft versus host disease in gastrointestinal tract 15.83 13.89 4 568858 4384 90055201
Mycobacterium marinum infection 15.81 13.89 14 568848 290 90059295
Sinus pain 15.80 13.89 7 568855 5382 90054203
Non-small cell lung cancer 15.79 13.89 4 568858 4377 90055208
Blood pressure systolic decreased 15.79 13.89 21 568841 9249 90050336
Heart rate abnormal 15.64 13.89 9 568853 5962 90053623
Respiratory rate decreased 15.64 13.89 3 568859 3980 90055605
Scleroderma 15.61 13.89 10 568852 6251 90053334
Abnormal loss of weight 15.56 13.89 12 568850 6811 90052774
Hair texture abnormal 15.56 13.89 5 568857 4682 90054903
Platelet count abnormal 15.54 13.89 4 568858 4331 90055254
Crepitations 15.53 13.89 102 568760 8750 90050835
Cheilitis 15.49 13.89 6 568856 5001 90054584
Small for dates baby 15.49 13.89 6 568856 5001 90054584
Haemorrhoidal haemorrhage 15.47 13.89 7 568855 5316 90054269
Cardiac operation 15.45 13.89 3 568859 3946 90055639
Adenoiditis 15.32 13.89 7 568855 41 90059544
Deafness neurosensory 15.31 13.89 84 568778 6757 90052828
Uterine leiomyoma 15.27 13.89 28 568834 10836 90048749
Systemic candida 15.25 13.89 6 568856 4953 90054632
Red blood cell count decreased 15.25 13.89 202 568660 46149 90013436
Performance status decreased 15.25 13.89 4 568858 4276 90055309
Elbow deformity 15.20 13.89 31 568831 1480 90058105
Temperature intolerance 15.20 13.89 33 568829 11997 90047588
Colorectal cancer 15.14 13.89 3 568859 3890 90055695
Oral disorder 15.14 13.89 26 568836 10319 90049266
Adrenal insufficiency 15.11 13.89 268 568594 29653 90029932
Nasal discomfort 15.06 13.89 8 568854 5540 90054045
Pseudomembranous colitis 15.01 13.89 3 568859 3865 90055720
Genital abscess 14.97 13.89 14 568848 312 90059273
Rheumatoid factor quantitative increased 14.96 13.89 5 568857 10 90059575
Graft versus host disease in skin 14.92 13.89 3 568859 3850 90055735
Escherichia sepsis 14.91 13.89 9 568853 5807 90053778
Odynophagia 14.88 13.89 21 568841 9022 90050563
Salt craving 14.88 13.89 10 568852 135 90059450
Pulmonary thrombosis 14.86 13.89 24 568838 9758 90049827
Hepatic cancer 14.86 13.89 6 568856 4875 90054710
Ear canal erythema 14.79 13.89 7 568855 45 90059540
Angiopathy 14.73 13.89 8 568854 5472 90054113
Atrial septal defect 14.70 13.89 18 568844 8216 90051369
Blood creatinine abnormal 14.59 13.89 4 568858 4153 90055432
Metastases to peritoneum 14.58 13.89 4 568858 4151 90055434
Candida infection 14.52 13.89 140 568722 33917 90025668
Emotional disorder 14.49 13.89 47 568815 14950 90044635
Tendonitis 14.43 13.89 201 568661 21171 90038414
Pregnancy with implant contraceptive 14.42 13.89 3 568859 3758 90055827
Blood potassium increased 14.41 13.89 74 568788 20675 90038910
Wrist fracture 14.39 13.89 50 568812 15574 90044011
Tachyarrhythmia 14.37 13.89 8 568854 5398 90054187
Tongue disorder 14.37 13.89 117 568745 10743 90048842
Tendon pain 14.35 13.89 3 568859 3745 90055840
Abdominal abscess 14.28 13.89 8 568854 5379 90054206
Parathyroid disorder 14.25 13.89 21 568841 770 90058815
Clear cell renal cell carcinoma 14.25 13.89 31 568831 1549 90058036
Hepatitis toxic 14.22 13.89 3 568859 3722 90055863
Nail psoriasis 14.20 13.89 20 568842 703 90058882
Pharyngeal oedema 14.13 13.89 42 568820 13729 90045856
Cardiac failure chronic 14.10 13.89 9 568853 5637 90053948
Carotid artery stenosis 14.03 13.89 8 568854 5326 90054259
Portal hypertension 13.95 13.89 6 568856 4695 90054890
Gingival swelling 13.95 13.89 7 568855 5006 90054579
Thrombocytosis 13.93 13.89 14 568848 6987 90052598
Poor peripheral circulation 13.89 13.89 4 568858 4021 90055564

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1739.28 14.78 3326 63549 626871 41927589
Joint swelling 1327.73 14.78 990 65885 67032 42487428
Drug intolerance 1245.88 14.78 1021 65854 79403 42475057
Synovitis 954.66 14.78 473 66402 15094 42539366
Contraindicated product administered 703.56 14.78 458 66417 24814 42529646
Pain 632.56 14.78 1265 65610 243583 42310877
Apparent death 621.93 14.78 230 66645 3478 42550982
Treatment failure 616.86 14.78 617 66258 62007 42492453
Arthropathy 612.84 14.78 447 66428 29150 42525310
C-reactive protein abnormal 602.25 14.78 293 66582 8968 42545492
Musculoskeletal stiffness 594.61 14.78 583 66292 57182 42497278
Rheumatoid arthritis 592.27 14.78 508 66367 41932 42512528
Psoriatic arthropathy 564.87 14.78 398 66477 24569 42529891
Therapeutic product effect decreased 512.68 14.78 452 66423 38698 42515762
Arthralgia 472.40 14.78 1012 65863 204226 42350234
C-reactive protein increased 468.23 14.78 537 66338 63023 42491437
Diverticulitis 411.29 14.78 317 66558 22456 42532004
Hand deformity 403.75 14.78 169 66706 3599 42550861
Red blood cell sedimentation rate increased 373.20 14.78 218 66657 9706 42544754
Loss of personal independence in daily activities 365.25 14.78 420 66455 49396 42505064
Arthritis 337.97 14.78 372 66503 41693 42512767
Drug hypersensitivity 335.18 14.78 577 66298 98812 42455648
Impaired work ability 276.24 14.78 194 66681 11897 42542563
Mobility decreased 269.42 14.78 304 66571 35002 42519458
Death 265.85 14.78 211 66664 470974 42083486
Toxicity to various agents 223.85 14.78 44 66831 229092 42325368
Enthesopathy 219.18 14.78 120 66755 4708 42549752
Ankylosing spondylitis 216.32 14.78 136 66739 6920 42547540
Acute kidney injury 210.06 14.78 162 66713 367175 42187285
Red blood cell sedimentation rate abnormal 209.92 14.78 108 66767 3728 42550732
Drug interaction 200.80 14.78 84 66791 266915 42287545
Bone erosion 198.67 14.78 109 66766 4294 42550166
Hypotension 195.43 14.78 80 66795 257551 42296909
Lymphoma 194.62 14.78 169 66706 14152 42540308
Pulmonary thrombosis 186.17 14.78 132 66743 8216 42546244
Deep vein thrombosis 183.86 14.78 386 66489 76571 42477889
Therapeutic product effect incomplete 183.85 14.78 368 66507 70571 42483889
Drug tolerance decreased 178.86 14.78 83 66792 2277 42552183
Psoriasis 177.99 14.78 293 66582 48311 42506149
Tenosynovitis 173.49 14.78 102 66773 4593 42549867
Knee arthroplasty 164.53 14.78 125 66750 8656 42545804
Febrile neutropenia 162.77 14.78 45 66830 185658 42368802
Anaemia 162.10 14.78 122 66753 280156 42274304
Terminal state 157.96 14.78 94 66781 4329 42550131
Inflammation 154.63 14.78 226 66649 33621 42520839
Joint range of motion decreased 148.87 14.78 112 66763 7641 42546819
Alanine aminotransferase abnormal 143.34 14.78 92 66783 4852 42549608
Steroid dependence 135.54 14.78 100 66775 6622 42547838
Malignant neoplasm progression 134.83 14.78 9 66866 108391 42446069
Frequent bowel movements 132.96 14.78 166 66709 21241 42533219
Pain in extremity 131.83 14.78 526 66349 150078 42404382
Gastrointestinal disorder 130.50 14.78 250 66625 46403 42508057
Onychoclasis 128.97 14.78 69 66806 2583 42551877
Osteoarthritis 126.32 14.78 173 66702 24232 42530228
Colitis ulcerative 124.25 14.78 178 66697 25997 42528463
Grip strength decreased 122.29 14.78 74 66801 3514 42550946
Dehydration 121.14 14.78 36 66839 141731 42412729
Joint arthroplasty 118.86 14.78 48 66827 929 42553531
Completed suicide 117.11 14.78 9 66866 96456 42458004
Polyarthritis 116.80 14.78 82 66793 5022 42549438
Intentional product use issue 113.62 14.78 307 66568 71526 42482934
Systemic lupus erythematosus 112.71 14.78 103 66772 9221 42545239
Condition aggravated 109.69 14.78 742 66133 260012 42294448
Thrombocytopenia 108.38 14.78 84 66791 190195 42364265
Dactylitis 108.00 14.78 47 66828 1104 42553356
Impaired quality of life 107.95 14.78 122 66753 14055 42540405
Herpes zoster 105.86 14.78 206 66669 38671 42515789
Burns second degree 103.79 14.78 82 66793 6014 42548446
Catarrh 102.95 14.78 81 66794 5905 42548555
Tooth loss 102.73 14.78 70 66805 4084 42550376
Rheumatoid factor positive 101.93 14.78 41 66834 785 42553675
Uveitis 99.86 14.78 96 66779 9162 42545298
Tongue disorder 99.45 14.78 76 66799 5307 42549153
Joint stiffness 98.91 14.78 109 66766 12213 42542247
Intestinal sepsis 95.18 14.78 38 66837 713 42553747
Joint ankylosis 94.03 14.78 48 66827 1629 42552831
Hyperkalaemia 93.58 14.78 9 66866 80449 42474011
Gastric disorder 93.18 14.78 104 66771 11818 42542642
Bronchiectasis 92.14 14.78 127 66748 17892 42536568
Dyspnoea 91.67 14.78 371 66504 442250 42112210
Bradycardia 90.90 14.78 13 66862 85471 42468989
Anti-cyclic citrullinated peptide antibody positive 90.88 14.78 49 66826 1863 42552597
Disease progression 90.25 14.78 57 66818 143599 42410861
Atrial fibrillation 89.62 14.78 54 66821 139539 42414921
Hypopnoea 89.33 14.78 84 66791 7798 42546662
Swelling 89.22 14.78 237 66638 54648 42499812
Sleep disorder due to general medical condition, insomnia type 88.08 14.78 44 66831 1425 42553035
Musculoskeletal discomfort 86.96 14.78 90 66785 9386 42545074
Musculoskeletal pain 86.34 14.78 173 66702 33167 42521293
Hypokalaemia 86.18 14.78 7 66868 71714 42482746
Parosmia 85.32 14.78 81 66794 7610 42546850
Constipation 83.41 14.78 79 66796 162212 42392248
Pulmonary embolism 83.24 14.78 390 66485 119222 42435238
Photosensitivity reaction 82.89 14.78 101 66774 12601 42541859
Gingival pain 82.17 14.78 83 66792 8411 42546049
Tendonitis 81.98 14.78 89 66786 9805 42544655
Pulmonary fibrosis 80.84 14.78 148 66727 26533 42527927
Liver function test increased 79.22 14.78 125 66750 19873 42534587
Abdominal discomfort 79.17 14.78 279 66596 74976 42479484
Hip arthroplasty 79.00 14.78 66 66809 5239 42549221
Rhabdomyolysis 78.15 14.78 14 66861 78005 42476455
Cardiac arrest 77.91 14.78 37 66838 109283 42445177
Decreased appetite 77.86 14.78 114 66761 193023 42361437
Neutropenia 76.28 14.78 122 66753 199309 42355151
Disability 74.57 14.78 67 66808 5866 42548594
Rhinitis 74.55 14.78 93 66782 11884 42542576
Vomiting 73.89 14.78 222 66653 289501 42264959
Arthritis bacterial 73.23 14.78 66 66809 5802 42548658
Limb discomfort 72.95 14.78 95 66780 12672 42541788
Interstitial lung disease 71.73 14.78 278 66597 78184 42476276
Cytology abnormal 71.71 14.78 26 66849 370 42554090
Seronegative arthritis 71.44 14.78 36 66839 1188 42553272
Blood creatinine increased 69.97 14.78 43 66832 109960 42444500
Hyponatraemia 69.79 14.78 36 66839 101426 42453034
Rheumatoid factor negative 68.66 14.78 33 66842 981 42553479
Overdose 68.56 14.78 40 66835 105224 42449236
Bladder transitional cell carcinoma 68.33 14.78 46 66829 2630 42551830
Localised infection 68.13 14.78 118 66757 20255 42534205
Seizure 67.61 14.78 54 66821 120507 42433953
Cardiac murmur 66.76 14.78 91 66784 12684 42541776
Dizziness 66.43 14.78 187 66688 249067 42305393
Rheumatoid nodule 63.65 14.78 46 66829 2949 42551511
Immobile 63.27 14.78 45 66830 2813 42551647
Foot deformity 63.24 14.78 57 66818 5011 42549449
Alopecia 63.14 14.78 141 66734 29135 42525325
Septic shock 62.35 14.78 33 66842 91639 42462821
Hospitalisation 61.43 14.78 20 66855 74310 42480150
Nodule 60.59 14.78 86 66789 12448 42542012
Axial spondyloarthritis 60.24 14.78 25 66850 520 42553940
Electrocardiogram QT prolonged 59.53 14.78 4 66871 47941 42506519
Agitation 59.32 14.78 14 66861 64300 42490160
Lactic acidosis 58.56 14.78 3 66872 45258 42509202
Hypoxia 57.28 14.78 19 66856 69767 42484693
Joint effusion 55.90 14.78 57 66818 5840 42548620
Peripheral swelling 55.37 14.78 284 66591 89986 42464474
Abdominal pain 54.42 14.78 138 66737 190333 42364127
International normalised ratio increased 54.41 14.78 6 66869 48162 42506298
Hallucination 54.07 14.78 12 66863 57495 42496965
Suicide attempt 54.01 14.78 5 66870 46095 42508365
Cardio-respiratory arrest 53.61 14.78 13 66862 58623 42495837
Fibromyalgia 52.79 14.78 46 66829 3867 42550593
Metabolic acidosis 52.59 14.78 9 66866 51849 42502611
Infection 52.50 14.78 328 66547 111740 42442720
Alcohol poisoning 52.32 14.78 62 66813 7512 42546948
Tenderness 52.15 14.78 67 66808 8816 42545644
Asthenia 52.09 14.78 245 66630 280548 42273912
Oedema peripheral 51.28 14.78 84 66791 135992 42418468
Food intolerance 50.95 14.78 32 66843 1624 42552836
Haematochezia 50.93 14.78 204 66671 58232 42496228
Hepatic enzyme abnormal 50.65 14.78 43 66832 3489 42550971
Tuberculosis 49.86 14.78 70 66805 10029 42544431
Hepatic fibrosis 49.69 14.78 49 66826 4823 42549637
Hypoglycaemia 49.64 14.78 16 66859 59838 42494622
Drug reaction with eosinophilia and systemic symptoms 49.51 14.78 162 66713 41913 42512547
Soft tissue swelling 49.07 14.78 24 66851 742 42553718
Inflammatory bowel disease 48.65 14.78 42 66833 3487 42550973
X-ray abnormal 48.34 14.78 21 66854 491 42553969
Sacroiliitis 48.06 14.78 33 66842 1949 42552511
Multiple organ dysfunction syndrome 47.78 14.78 49 66826 96986 42457474
Coma 46.81 14.78 13 66862 53541 42500919
Oligoarthritis 46.23 14.78 16 66859 197 42554263
Neoplasm malignant 46.22 14.78 107 66768 22636 42531824
Bone cyst 46.08 14.78 30 66845 1621 42552839
Confusional state 45.90 14.78 124 66751 167473 42386987
Stress 45.69 14.78 163 66712 44049 42510411
Mycobacterium tuberculosis complex test positive 45.56 14.78 29 66846 1507 42552953
Rectal haemorrhage 45.51 14.78 176 66699 49430 42505030
Intentional product misuse 44.01 14.78 21 66854 61879 42492581
Platelet count decreased 43.89 14.78 95 66780 138486 42415974
Delirium 43.62 14.78 14 66861 52505 42501955
Muscular weakness 43.62 14.78 40 66835 83458 42471002
Limb deformity 42.75 14.78 20 66855 559 42553901
Arthrodesis 42.68 14.78 20 66855 561 42553899
White blood cell count decreased 42.66 14.78 67 66808 110329 42444131
Renal impairment 42.50 14.78 67 66808 110161 42444299
Liver disorder 41.68 14.78 147 66728 39497 42514963
Cardiogenic shock 41.39 14.78 4 66871 35636 42518824
Red blood cell sedimentation rate 41.31 14.78 24 66851 1056 42553404
Prerenal failure 39.86 14.78 32 66843 2401 42552059
Pneumonia 39.54 14.78 448 66427 421701 42132759
Granuloma skin 39.44 14.78 24 66851 1151 42553309
Abscess 39.37 14.78 76 66799 14172 42540288
Cardiac failure 39.28 14.78 67 66808 106789 42447671
Dysstasia 38.76 14.78 75 66800 14011 42540449
Intervertebral disc annular tear 38.63 14.78 9 66866 20 42554440
Blood creatine phosphokinase increased 38.22 14.78 14 66861 48324 42506136
Ill-defined disorder 37.99 14.78 81 66794 16215 42538245
Pulmonary tuberculosis 37.95 14.78 45 66830 5456 42549004
Abdominal distension 37.90 14.78 34 66841 71701 42482759
Swollen joint count increased 37.84 14.78 15 66860 276 42554184
Syncope 37.77 14.78 61 66814 99345 42455115
Loss of consciousness 37.67 14.78 54 66821 92300 42462160
Bone marrow oedema 37.61 14.78 21 66854 856 42553604
Neutrophil count decreased 37.32 14.78 27 66848 63388 42491072
Blood glucose increased 36.52 14.78 37 66838 73662 42480798
Aggression 36.28 14.78 12 66863 44151 42510309
Epistaxis 36.12 14.78 31 66844 66795 42487665
Angioedema 35.86 14.78 11 66864 42466 42511994
Neck pain 35.70 14.78 116 66759 29898 42524562
Full blood count abnormal 35.65 14.78 3 66872 29873 42524587
Haemorrhage 35.37 14.78 26 66849 60537 42493923
Disseminated strongyloidiasis 35.23 14.78 17 66858 510 42553950
Headache 35.22 14.78 549 66326 238820 42315640
Enzyme abnormality 35.10 14.78 14 66861 262 42554198
Diarrhoea 35.03 14.78 511 66364 460338 42094122
Respiratory distress 35.00 14.78 11 66864 41809 42512651
Respiratory failure 34.91 14.78 95 66780 128037 42426423
Iritis 34.78 14.78 26 66849 1756 42552704
Depressed level of consciousness 34.52 14.78 16 66859 47954 42506506
Tuberculin test positive 34.34 14.78 22 66853 1156 42553304
Pneumonia aspiration 34.08 14.78 18 66857 50060 42504400
Ankle deformity 34.01 14.78 13 66862 216 42554244
Hyperhidrosis 33.96 14.78 56 66819 90456 42464004
Hepatic cirrhosis 33.96 14.78 87 66788 19615 42534845
Fall 33.95 14.78 222 66653 234298 42320162
Inappropriate schedule of product administration 33.86 14.78 262 66613 95640 42458820
Haemoptysis 33.84 14.78 15 66860 46152 42508308
Migraine 33.70 14.78 102 66773 25312 42529148
Mental status changes 33.63 14.78 12 66863 42103 42512357
Dysphagia 33.28 14.78 39 66836 72680 42481780
Myelosuppression 33.22 14.78 11 66864 40450 42514010
Blood pressure fluctuation 32.91 14.78 105 66770 26803 42527657
Swollen tongue 32.79 14.78 90 66785 21141 42533319
Tinnitus 32.77 14.78 110 66765 28828 42525632
Gastrointestinal haemorrhage 32.61 14.78 65 66810 97661 42456799
Dyspepsia 32.59 14.78 140 66735 41212 42513248
Plasma cell myeloma 32.52 14.78 17 66858 47561 42506899
Cognitive disorder 32.38 14.78 7 66868 34165 42520295
Exostosis 32.32 14.78 42 66833 5589 42548871
Panniculitis 32.20 14.78 27 66848 2154 42552306
Blood bilirubin increased 32.14 14.78 13 66862 42239 42512221
Blood parathyroid hormone decreased 32.13 14.78 24 66851 1619 42552841
Lymphadenopathy 31.93 14.78 120 66755 33245 42521215
Cerebral haemorrhage 31.29 14.78 11 66864 38955 42515505
Urticaria 31.17 14.78 211 66664 73825 42480635
Osteolysis 31.06 14.78 33 66842 3547 42550913
Wrong technique in product usage process 31.02 14.78 14 66861 42621 42511839
Urinary tract infection 30.65 14.78 69 66806 99215 42455245
Carbon dioxide abnormal 30.08 14.78 13 66862 300 42554160
Xyphoid retraction 29.99 14.78 11 66864 162 42554298
Cutaneous B-cell lymphoma 29.92 14.78 9 66866 68 42554392
Transient ischaemic attack 29.84 14.78 8 66867 33731 42520729
Ascites 29.78 14.78 27 66848 56651 42497809
Skin injury 29.64 14.78 28 66847 2613 42551847
Stent placement 29.25 14.78 39 66836 5321 42549139
Haematemesis 29.00 14.78 6 66869 30193 42524267
Ventricular fibrillation 28.89 14.78 6 66869 30117 42524343
Pulmonary toxicity 28.76 14.78 50 66825 8605 42545855
Dermatitis psoriasiform 28.73 14.78 25 66850 2097 42552363
Sarcoidosis 28.56 14.78 32 66843 3650 42550810
Hepatic failure 28.53 14.78 12 66863 38088 42516372
Atrial septal defect acquired 28.30 14.78 7 66868 22 42554438
HLA marker study positive 28.18 14.78 11 66864 194 42554266
Synovial cyst 27.86 14.78 27 66848 2602 42551858
Gait inability 27.83 14.78 89 66786 22744 42531716
Restlessness 27.70 14.78 6 66869 29243 42525217
Fine motor skill dysfunction 27.58 14.78 25 66850 2214 42552246
Sensitivity to weather change 27.53 14.78 24 66851 2019 42552441
Neck mass 27.51 14.78 23 66852 1827 42552633
Memory impairment 27.50 14.78 23 66852 50199 42504261
Anaphylactic reaction 26.75 14.78 17 66858 42726 42511734
Adverse drug reaction 26.68 14.78 123 66752 37311 42517149
Wheezing 26.57 14.78 28 66847 54753 42499707
Chondropathy 26.52 14.78 19 66856 1201 42553259
Encephalopathy 26.48 14.78 16 66859 41317 42513143
Thrombocytosis 26.45 14.78 35 66840 4740 42549720
Rash vesicular 26.05 14.78 29 66846 3284 42551176
Generalised tonic-clonic seizure 25.83 14.78 5 66870 26374 42528086
Eczema 25.79 14.78 114 66761 33972 42520488
Epilepsy 25.55 14.78 5 66870 26166 42528294
Lymphoedema 25.48 14.78 35 66840 4913 42549547
Neoplasm progression 25.41 14.78 7 66868 28993 42525467
Nail bed bleeding 25.36 14.78 13 66862 445 42554015
Cholestasis 25.20 14.78 10 66865 32869 42521591
Clonal haematopoiesis 24.98 14.78 10 66865 189 42554271
Treatment noncompliance 24.96 14.78 14 66861 37658 42516802
Medium-chain acyl-coenzyme A dehydrogenase deficiency 24.80 14.78 7 66868 41 42554419
Marginal zone lymphoma 24.76 14.78 9 66866 129 42554331
Diabetic ketoacidosis 24.72 14.78 3 66872 22364 42532096
Pancytopenia 24.67 14.78 98 66777 117645 42436815
Fragile X syndrome 24.52 14.78 7 66868 43 42554417
Chronic kidney disease 24.23 14.78 23 66852 47218 42507242
Nightmare 23.96 14.78 90 66785 24922 42529538
Hyperglycaemia 23.90 14.78 22 66853 45837 42508623
Rheumatoid lung 23.87 14.78 16 66859 908 42553552
Therapeutic response decreased 23.76 14.78 118 66757 36894 42517566
Urinary incontinence 23.72 14.78 3 66872 21665 42532795
Medication error 23.67 14.78 109 66766 33045 42521415
Drug level increased 23.57 14.78 6 66869 26194 42528266
Shoulder operation 23.48 14.78 19 66856 1442 42553018
Disorientation 23.43 14.78 14 66861 36375 42518085
Pyrexia 23.34 14.78 457 66418 393585 42160875
Chest discomfort 23.27 14.78 40 66835 63576 42490884
Erythema 23.21 14.78 267 66608 108526 42445934
Aortic bruit 23.17 14.78 10 66865 230 42554230
Feeling abnormal 23.17 14.78 188 66687 69598 42484862
Neuropathy peripheral 23.14 14.78 82 66793 101771 42452689
Skin laceration 23.12 14.78 61 66814 13997 42540463
Anxiety 22.79 14.78 102 66773 118458 42436002
Hypophosphataemia 22.69 14.78 3 66872 20942 42533518
Inflammatory pain 22.59 14.78 13 66862 562 42553898
Oesophageal infection 22.49 14.78 11 66864 340 42554120
Product dose omission issue 22.37 14.78 146 66729 154219 42400241
Vision blurred 22.28 14.78 31 66844 53668 42500792
Hepatic enzyme increased 22.04 14.78 135 66740 45649 42508811
Blood urea increased 22.00 14.78 12 66863 32781 42521679
Neck deformity 21.93 14.78 8 66867 116 42554344
Ossicle disorder 21.73 14.78 6 66869 32 42554428
Vertigo 21.69 14.78 109 66766 34238 42520222
Tender joint count increased 21.65 14.78 9 66866 188 42554272
Trisomy 8 21.63 14.78 7 66868 69 42554391
Pancreatitis acute 21.49 14.78 13 66862 33551 42520909
Human ehrlichiosis 21.34 14.78 12 66863 496 42553964
Tubulointerstitial nephritis 21.27 14.78 102 66773 31446 42523014
Diaphragmatic injury 21.21 14.78 8 66867 128 42554332
No adverse event 21.20 14.78 18 66857 39003 42515457
Dehiscence 21.18 14.78 13 66862 633 42553827
Hepatic function abnormal 21.17 14.78 30 66845 51537 42502923
Alanine aminotransferase increased 21.17 14.78 222 66653 88184 42466276
Splenic embolism 21.06 14.78 10 66865 289 42554171
Disseminated tuberculosis 20.98 14.78 24 66851 2800 42551660
Acute myocardial infarction 20.88 14.78 37 66838 58128 42496332
Hepatic cytolysis 20.84 14.78 8 66867 26836 42527624
Cutaneous symptom 20.80 14.78 11 66864 402 42554058
Orthostatic hypotension 20.78 14.78 11 66864 30559 42523901
Feeding disorder 20.71 14.78 43 66832 8448 42546012
Tendon disorder 20.59 14.78 26 66849 3363 42551097
Skin ulcer 20.42 14.78 87 66788 25514 42528946
C-reactive protein 20.39 14.78 7 66868 84 42554376
Spondylitis 20.28 14.78 18 66857 1550 42552910
Acute myeloid leukaemia 20.21 14.78 5 66870 22251 42532209
Ischaemic stroke 20.18 14.78 5 66870 22228 42532232
Anti-saccharomyces cerevisiae antibody 20.14 14.78 5 66870 16 42554444
Osteonecrosis of jaw 20.00 14.78 3 66872 19046 42535414
Epstein Barr virus positive mucocutaneous ulcer 19.92 14.78 12 66863 565 42553895
Contraindication to medical treatment 19.84 14.78 14 66861 864 42553596
Oral pustule 19.80 14.78 9 66866 235 42554225
Dry mouth 19.77 14.78 20 66855 39859 42514601
Blood pressure systolic abnormal 19.77 14.78 33 66842 5495 42548965
Respiratory depression 19.74 14.78 3 66872 18865 42535595
Diffuse idiopathic skeletal hyperostosis 19.65 14.78 6 66869 48 42554412
Elbow operation 19.61 14.78 8 66867 159 42554301
Hepatic steatosis 19.58 14.78 76 66799 21372 42533088
Cryopyrin associated periodic syndrome 19.54 14.78 7 66868 96 42554364
Subdural haematoma 19.51 14.78 6 66869 23132 42531328
Lymphoproliferative disorder 19.50 14.78 25 66850 3282 42551178
Bone tuberculosis 19.49 14.78 11 66864 458 42554002
Renal failure 19.36 14.78 325 66550 143401 42411059
Neuralgia 19.33 14.78 8 66867 25639 42528821
Incorrect route of product administration 19.28 14.78 7 66868 24298 42530162
Wrist deformity 19.20 14.78 10 66865 354 42554106
Psychotic disorder 19.14 14.78 11 66864 29197 42525263
Sideroblastic anaemia 19.12 14.78 10 66865 357 42554103
Microcephaly 19.06 14.78 14 66861 920 42553540
Clostridium difficile colitis 18.86 14.78 5 66870 21247 42533213
Basal cell carcinoma 18.71 14.78 78 66797 22655 42531805
Acute respiratory failure 18.69 14.78 20 66855 38838 42515622
Vitamin B1 decreased 18.62 14.78 10 66865 377 42554083
Hallucination, visual 18.56 14.78 5 66870 21015 42533445
Coronary artery disease 18.55 14.78 35 66840 53685 42500775
Muscle spasms 18.41 14.78 71 66804 85973 42468487
Mantle cell lymphoma stage III 18.38 14.78 5 66870 25 42554435
Lacrimal duct neoplasm 18.38 14.78 5 66870 25 42554435
Aspiration 18.36 14.78 3 66872 17883 42536577
Onycholysis 18.15 14.78 14 66861 991 42553469
Acute lung injury 18.13 14.78 17 66858 1572 42552888
Sinus tachycardia 18.07 14.78 5 66870 20648 42533812
Joint space narrowing 17.99 14.78 8 66867 198 42554262
Flushing 17.87 14.78 19 66856 37009 42517451
Chronic obstructive pulmonary disease 17.78 14.78 46 66829 63068 42491392
Intestinal diaphragm disease 17.67 14.78 9 66866 304 42554156
Shock 17.66 14.78 12 66863 29109 42525351
Ventricular tachycardia 17.54 14.78 13 66862 30147 42524313
Drug withdrawal syndrome 17.44 14.78 6 66869 21543 42532917
Inflammatory marker increased 17.41 14.78 35 66840 6721 42547739
Degenerative bone disease 17.33 14.78 6 66869 74 42554386
Somnolence 17.28 14.78 140 66735 140965 42413495
Muscle strain 17.28 14.78 28 66847 4549 42549911
Haematuria 17.16 14.78 41 66834 57758 42496702
Dyspnoea exertional 17.03 14.78 33 66842 50115 42504345
Suicidal ideation 16.96 14.78 31 66844 48130 42506330
Nasopharyngitis 16.96 14.78 204 66671 83792 42470668
Respiratory arrest 16.85 14.78 12 66863 28412 42526048
Hepatitis B virus test positive 16.72 14.78 9 66866 341 42554119
Arthritis enteropathic 16.68 14.78 7 66868 150 42554310
Maternal exposure during pregnancy 16.63 14.78 35 66840 6943 42547517
Dysgeusia 16.57 14.78 101 66774 34088 42520372
Fear of injection 16.56 14.78 18 66857 1985 42552475
Altered state of consciousness 16.52 14.78 13 66862 29246 42525214
Full blood count decreased 16.17 14.78 6 66869 20554 42533906
Back pain 16.06 14.78 312 66563 141464 42412996
Troponin increased 15.97 14.78 5 66870 19057 42535403
Mixed connective tissue disease 15.76 14.78 5 66870 46 42554414
Polychondritis 15.70 14.78 9 66866 386 42554074
Lymphoma transformation 15.67 14.78 10 66865 522 42553938
Clostridium difficile infection 15.63 14.78 8 66867 22651 42531809
Off label use 15.60 14.78 1182 65693 637153 41917307
Joint destruction 15.49 14.78 9 66866 396 42554064
Melaena 15.45 14.78 23 66852 38723 42515737
Granulomatous liver disease 15.40 14.78 11 66864 692 42553768
Rash maculo-papular 15.21 14.78 22 66853 37481 42516979
Hypophagia 15.19 14.78 12 66863 26944 42527516
Labelled drug-drug interaction medication error 15.16 14.78 3 66872 15579 42538881
Cytomegalovirus infection 15.13 14.78 17 66858 32289 42522171
Gastrointestinal infection 15.12 14.78 33 66842 6710 42547750
Product administration error 15.03 14.78 5 66870 18338 42536122
Urinary retention 15.02 14.78 27 66848 42187 42512273
Limb injury 14.99 14.78 53 66822 14252 42540208
Thrombosis 14.99 14.78 169 66706 68342 42486118
Fistula discharge 14.89 14.78 13 66862 1095 42553365
Diabetes mellitus inadequate control 14.89 14.78 3 66872 15387 42539073
Myalgia 14.88 14.78 89 66786 95991 42458469
Tonsillar disorder 14.88 14.78 9 66866 427 42554033
Post infection glomerulonephritis 14.86 14.78 6 66869 116 42554344
Stomatitis 14.81 14.78 132 66743 50197 42504263

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug intolerance 4162.33 14.18 6936 490870 399576 109691917
Synovitis 3611.52 14.18 5256 492550 268836 109822657
Joint swelling 3447.72 14.18 6708 491098 436137 109655356
Contraindicated product administered 2933.79 14.18 4526 493280 243741 109847752
Treatment failure 2645.86 14.18 4589 493217 272645 109818848
Arthropathy 2564.19 14.18 4620 493186 282902 109808591
Drug ineffective 2529.15 14.18 13456 484350 1507084 108584409
Systemic lupus erythematosus 2399.05 14.18 4189 493617 250149 109841344
Therapeutic product effect decreased 2262.68 14.18 3992 493814 240324 109851169
Hand deformity 2225.11 14.18 3724 494082 214782 109876711
Pemphigus 2191.69 14.18 3662 494144 210908 109880585
Glossodynia 2007.08 14.18 3590 494216 218414 109873079
Anti-cyclic citrullinated peptide antibody positive 1867.45 14.18 3113 494693 178871 109912622
Acute kidney injury 1760.50 14.18 360 497446 635070 109456423
Musculoskeletal stiffness 1714.55 14.18 3847 493959 275975 109815518
Abdominal discomfort 1695.28 14.18 4732 493074 389126 109702367
Pericarditis 1689.26 14.18 3310 494496 215804 109875689
Psoriatic arthropathy 1688.11 14.18 3111 494695 193650 109897843
Wound 1633.99 14.18 3396 494410 231041 109860452
Swelling 1624.62 14.18 4332 493474 346709 109744784
C-reactive protein abnormal 1589.82 14.18 2407 495399 127288 109964205
Death 1520.48 14.18 623 497183 698246 109393247
Rheumatoid factor positive 1511.01 14.18 2370 495436 129270 109962223
Alopecia 1499.57 14.18 4311 493495 360442 109731051
Hepatic enzyme increased 1491.64 14.18 3967 493839 316925 109774568
Duodenal ulcer perforation 1423.69 14.18 2729 495077 174971 109916522
Helicobacter infection 1405.68 14.18 2751 495055 179126 109912367
Anaemia 1380.62 14.18 378 497428 546708 109544785
Toxicity to various agents 1343.30 14.18 266 497540 480289 109611204
Drug interaction 1328.67 14.18 311 497495 499872 109591621
Drug hypersensitivity 1250.34 14.18 4683 493123 449407 109642086
Hypotension 1225.87 14.18 415 497391 523434 109568059
Arthralgia 1183.19 14.18 6747 491059 772885 109318608
Hypersensitivity 1166.92 14.18 4232 493574 399766 109691727
Folliculitis 1136.38 14.18 2402 495404 165251 109926242
Discomfort 1117.46 14.18 2771 495035 211936 109879557
Irritable bowel syndrome 1051.24 14.18 2299 495507 161916 109929577
Pain 1047.50 14.18 7612 490194 947343 109144150
Sleep disorder due to general medical condition, insomnia type 1033.51 14.18 1770 496036 103873 109987620
Febrile neutropenia 1025.62 14.18 114 497692 316653 109774840
Infusion related reaction 1019.65 14.18 3896 493910 377266 109714227
Completed suicide 1012.91 14.18 15 497791 242366 109849127
C-reactive protein increased 1012.58 14.18 2695 495111 215224 109876269
Muscle injury 993.35 14.18 2051 495755 138756 109952737
Impaired healing 990.16 14.18 2507 495299 194210 109897283
Mobility decreased 972.44 14.18 2804 495002 234618 109856875
Constipation 917.45 14.18 239 497567 357547 109733946
Red blood cell sedimentation rate increased 901.17 14.18 1412 496394 76890 110014603
Osteoarthritis 855.79 14.18 2266 495540 180357 109911136
Rheumatic fever 853.39 14.18 1776 496030 120803 109970690
Neutropenia 841.37 14.18 317 497489 374303 109717190
Inflammation 825.94 14.18 2318 495488 190920 109900573
Fibromyalgia 812.34 14.18 2132 495674 168777 109922716
Blister 811.90 14.18 2559 495247 224817 109866676
Ill-defined disorder 784.94 14.18 1995 495811 154858 109936635
Dehydration 784.05 14.18 153 497653 279358 109812135
Thrombocytopenia 777.15 14.18 299 497507 348586 109742907
Peripheral swelling 768.69 14.18 3726 494080 400308 109691185
Loss of personal independence in daily activities 759.97 14.18 1917 495889 148103 109943390
Drug abuse 754.40 14.18 8 497798 177403 109914090
Red blood cell sedimentation rate abnormal 750.69 14.18 725 497081 23784 110067709
Type 2 diabetes mellitus 750.50 14.18 2119 495687 175113 109916380
Therapeutic product effect incomplete 727.90 14.18 2440 495366 221365 109870128
Maternal exposure during pregnancy 721.34 14.18 2654 495152 252229 109839264
Malignant neoplasm progression 692.97 14.18 20 497786 174547 109916946
Cardiac arrest 672.99 14.18 57 497749 196696 109894797
Joint range of motion decreased 664.84 14.18 1602 496204 120230 109971263
Gastrointestinal disorder 655.97 14.18 2485 495321 239467 109852026
Hyponatraemia 654.60 14.18 99 497707 217554 109873939
Seizure 653.00 14.18 106 497700 221079 109870414
Atrial fibrillation 651.85 14.18 122 497684 229520 109861973
Stomatitis 638.12 14.18 2658 495148 267584 109823909
Rheumatoid arthritis 637.07 14.18 2855 494951 296758 109794735
Swollen joint count increased 635.46 14.18 1257 496549 82404 110009089
Disease progression 615.91 14.18 168 497638 243866 109847627
Bone erosion 599.71 14.18 883 496923 45488 110046005
Somnolence 594.27 14.18 298 497508 297151 109794342
Grip strength decreased 590.21 14.18 1189 496617 78985 110012508
Infection 588.69 14.18 3197 494609 359003 109732490
Blood cholesterol increased 580.79 14.18 1992 495814 182793 109908700
Product dose omission issue 566.53 14.18 376 497430 321406 109770087
Lower respiratory tract infection 563.61 14.18 2378 495428 240728 109850765
Musculoskeletal pain 554.36 14.18 1949 495857 181074 109910419
Condition aggravated 543.14 14.18 5368 492438 729468 109362025
Bradycardia 540.31 14.18 42 497764 155475 109936018
Hyperkalaemia 533.73 14.18 17 497789 135779 109955714
Fall 531.87 14.18 1208 496598 602274 109489219
Product use issue 531.43 14.18 2788 495018 308907 109782586
Respiratory failure 528.99 14.18 156 497650 215176 109876317
Tremor 518.28 14.18 135 497671 202097 109889396
Cardiac failure 517.06 14.18 107 497699 187519 109903974
Facet joint syndrome 494.03 14.18 1241 496565 95587 109995906
Liver injury 490.65 14.18 1642 496164 148771 109942722
Rash 470.12 14.18 5701 492105 815263 109276230
Lip dry 469.66 14.18 1243 496563 98840 109992653
Dyspnoea 466.56 14.18 2996 494810 1103876 108987617
Knee arthroplasty 458.82 14.18 947 496859 64001 110027492
Platelet count decreased 452.55 14.18 236 497570 230207 109861286
Arthritis 452.10 14.18 1719 496087 165867 109925626
Sepsis 451.65 14.18 484 497322 326862 109764631
Injury 448.68 14.18 1782 496024 175483 109916010
Bursitis 447.67 14.18 1445 496361 128473 109963020
Rhabdomyolysis 446.57 14.18 23 497783 120378 109971115
Cardio-respiratory arrest 446.48 14.18 17 497789 115819 109975674
Sciatica 437.05 14.18 1151 496655 91248 110000245
Multiple organ dysfunction syndrome 436.04 14.18 78 497728 151632 109939861
Gastrointestinal haemorrhage 425.04 14.18 110 497696 165408 109926085
Hip arthroplasty 421.85 14.18 837 496969 54976 110036517
Hypoxia 417.94 14.18 47 497759 129468 109962025
Peripheral venous disease 414.44 14.18 1064 496742 83053 110008440
Cardiac failure congestive 414.21 14.18 87 497719 150913 109940580
Hypoglycaemia 412.93 14.18 28 497778 116076 109975417
Depressed level of consciousness 411.57 14.18 23 497783 112255 109979238
Urinary tract infection 409.70 14.18 520 497286 325762 109765731
Electrocardiogram QT prolonged 403.53 14.18 21 497785 108939 109982554
Breast cancer stage III 395.21 14.18 1006 496800 78111 110013382
Intentional product use issue 387.53 14.18 2166 495640 245740 109845753
Lactic acidosis 382.33 14.18 7 497799 92804 109998689
Hyperhidrosis 380.99 14.18 183 497623 187115 109904378
Suicide attempt 379.55 14.18 21 497785 103373 109988120
Syncope 379.41 14.18 220 497586 202316 109889177
Obesity 378.13 14.18 1247 496559 112104 109979389
Rheumatoid nodule 375.05 14.18 460 497346 19836 110071657
Pancytopenia 367.34 14.18 246 497560 209367 109882126
Sleep disorder 367.07 14.18 1818 495988 196826 109894667
Metabolic acidosis 357.83 14.18 23 497783 99721 109991772
Coma 355.71 14.18 53 497753 117816 109973677
Hypokalaemia 353.54 14.18 190 497616 182258 109909235
Cough 352.20 14.18 994 496812 460647 109630846
Chest discomfort 348.83 14.18 173 497633 173675 109917818
Nasopharyngitis 346.10 14.18 2991 494815 391370 109700123
Adverse event 346.07 14.18 1178 496628 107631 109983862
Vision blurred 340.47 14.18 81 497725 128941 109962552
Renal failure 340.04 14.18 311 497495 226263 109865230
Epistaxis 337.88 14.18 85 497721 130287 109961206
Gait inability 337.03 14.18 1361 496445 135015 109956478
Night sweats 335.82 14.18 1343 496463 132640 109958853
Overdose 334.44 14.18 335 497471 233459 109858034
Agitation 333.96 14.18 54 497752 112997 109978496
Wound infection 330.51 14.18 1071 496735 95394 109996099
Sinusitis 329.43 14.18 2376 495430 294312 109797181
Neutrophil count decreased 324.95 14.18 73 497733 120868 109970625
Joint stiffness 322.41 14.18 842 496964 66401 110025092
Lower limb fracture 316.81 14.18 899 496907 74449 110017044
White blood cell count decreased 315.36 14.18 340 497466 229050 109862443
Cognitive disorder 314.45 14.18 20 497786 87491 110004002
International normalised ratio increased 311.29 14.18 20 497786 86752 110004741
Cerebrovascular accident 309.32 14.18 219 497587 181065 109910428
Deep vein thrombosis postoperative 308.77 14.18 766 497040 58525 110032968
Disability 305.42 14.18 514 497292 29709 110061784
Diarrhoea 302.06 14.18 3480 494326 1136025 108955468
Drug tolerance decreased 300.70 14.18 485 497321 27055 110064438
Hallucination 300.63 14.18 48 497758 101384 109990109
Dislocation of vertebra 297.68 14.18 628 497178 43093 110048400
Contusion 297.08 14.18 1933 495873 231428 109860065
Dysphagia 296.07 14.18 161 497645 153439 109938054
Ankylosing spondylitis 290.35 14.18 355 497451 15257 110076236
Foot deformity 284.43 14.18 656 497150 47824 110043669
Cytokine release syndrome 282.89 14.18 7 497799 70299 110021194
Tachycardia 278.42 14.18 367 497439 226278 109865215
Blood parathyroid hormone decreased 277.10 14.18 318 497488 12771 110078722
Hyperglycaemia 276.74 14.18 30 497776 85060 110006433
Granuloma skin 276.60 14.18 296 497510 10987 110080506
Myalgia 276.36 14.18 357 497449 222024 109869469
Balance disorder 276.20 14.18 90 497716 116470 109975023
Neuropathy peripheral 273.86 14.18 242 497564 179035 109912458
Encephalopathy 270.30 14.18 26 497780 81029 110010464
Sedation 269.31 14.18 10 497796 69673 110021820
Mental status changes 265.94 14.18 20 497786 76102 110015391
Nail disorder 265.11 14.18 713 497093 57222 110034271
Blood creatinine increased 265.06 14.18 259 497547 182630 109908863
Hypercholesterolaemia 262.58 14.18 953 496853 89884 110001609
Autoimmune disorder 262.44 14.18 768 497038 64715 110026778
Pulmonary fibrosis 261.43 14.18 1030 496776 101012 109990481
Unresponsive to stimuli 258.01 14.18 6 497800 63784 110027709
Intentional product misuse 256.59 14.18 139 497667 132765 109958728
Dysarthria 255.73 14.18 37 497769 84084 110007409
Ascites 255.47 14.18 53 497753 92755 109998738
Liver disorder 254.33 14.18 1290 496516 140953 109950540
Renal impairment 253.83 14.18 284 497522 188161 109903332
Liver function test increased 252.59 14.18 925 496881 87623 110003870
Enthesopathy 252.18 14.18 296 497510 12182 110079311
Panniculitis 251.24 14.18 330 497476 15252 110076241
Lung disorder 249.36 14.18 1524 496282 178523 109912970
Pneumonia aspiration 248.65 14.18 35 497771 81198 110010295
Neoplasm progression 247.15 14.18 10 497796 64585 110026908
Disorientation 245.67 14.18 19 497787 70652 110020841
Onychomadesis 245.25 14.18 597 497209 45066 110046427
Blood glucose increased 240.96 14.18 149 497657 132347 109959146
Weight increased 238.79 14.18 2913 494893 416731 109674762
Respiratory distress 238.06 14.18 19 497787 68855 110022638
Serotonin syndrome 237.58 14.18 6 497800 59147 110032346
Exostosis 237.47 14.18 592 497214 45364 110046129
COVID-19 236.83 14.18 465 497341 244595 109846898
Haemorrhage 233.10 14.18 94 497712 106598 109984895
Myelosuppression 232.23 14.18 68 497738 94272 109997221
Pulmonary embolism 231.46 14.18 380 497426 214094 109877399
Dyspnoea exertional 230.10 14.18 90 497716 103970 109987523
Blood bilirubin increased 229.59 14.18 34 497772 75938 110015555
Adjustment disorder with depressed mood 228.54 14.18 567 497239 43316 110048177
Chills 227.58 14.18 315 497491 190265 109901228
Road traffic accident 226.04 14.18 1021 496785 106377 109985116
Blepharospasm 222.38 14.18 646 497160 54205 110037288
Orthostatic hypotension 221.57 14.18 21 497785 66228 110025265
Pulmonary oedema 221.03 14.18 88 497718 100571 109990922
Polyarthritis 220.88 14.18 344 497462 18619 110072874
X-ray abnormal 220.55 14.18 513 497293 37604 110053889
Finger deformity 220.27 14.18 471 497335 32621 110058872
Haemoglobin decreased 217.75 14.18 499 497307 248228 109843265
Pneumonia 215.63 14.18 2720 495086 873994 109217499
Dry mouth 215.31 14.18 1590 496216 198358 109893135
Wrong technique in product usage process 214.94 14.18 63 497743 87285 110004208
Tenosynovitis 214.73 14.18 313 497493 15970 110075523
Retinitis 213.90 14.18 459 497347 31868 110059625
Chronic obstructive pulmonary disease 213.90 14.18 112 497694 109046 109982447
Respiratory arrest 210.42 14.18 13 497793 58286 110033207
General physical health deterioration 210.25 14.18 2877 494929 422418 109669075
Pleural effusion 209.92 14.18 296 497510 177413 109914080
Acute respiratory failure 209.18 14.18 42 497764 75218 110016275
Plasma cell myeloma 205.15 14.18 22 497784 62914 110028579
Cardiogenic shock 203.36 14.18 14 497792 57324 110034169
Hypervolaemia 202.61 14.18 4 497802 49456 110042037
Joint destruction 202.15 14.18 248 497558 10695 110080798
Aggression 200.08 14.18 18 497788 59192 110032301
Cerebral haemorrhage 198.83 14.18 28 497778 64940 110026553
Deformity 198.69 14.18 237 497569 9923 110081570
Blood pressure decreased 196.34 14.18 139 497667 114952 109976541
Onychomycosis 194.52 14.18 492 497314 38039 110053454
Hypomagnesaemia 194.51 14.18 22 497784 60348 110031145
Urinary retention 193.44 14.18 39 497767 69644 110021849
Restlessness 193.11 14.18 16 497790 56243 110035250
Multiple sclerosis relapse 191.46 14.18 8 497798 50232 110041261
Aphasia 191.34 14.18 21 497785 58976 110032517
Live birth 190.76 14.18 717 497089 68767 110022726
Loss of consciousness 190.07 14.18 372 497434 195934 109895559
Melaena 189.79 14.18 39 497767 68718 110022775
Injection site pain 189.40 14.18 318 497488 177604 109913889
Disturbance in attention 189.07 14.18 27 497779 61968 110029525
Haematuria 188.18 14.18 69 497737 82936 110008557
Dry skin 187.65 14.18 127 497679 107526 109983967
Septic shock 186.44 14.18 262 497544 157266 109934227
Hepatic failure 185.63 14.18 41 497765 68698 110022795
Lupus vulgaris 185.17 14.18 446 497360 33437 110058056
Acute myocardial infarction 184.33 14.18 73 497733 83704 110007789
Adverse drug reaction 183.55 14.18 950 496856 104609 109986884
Lethargy 183.36 14.18 96 497710 93480 109998013
Altered state of consciousness 183.17 14.18 22 497784 57604 110033889
Haemoptysis 182.03 14.18 48 497758 71306 110020187
Generalised tonic-clonic seizure 181.11 14.18 18 497788 54662 110036831
Myocardial infarction 180.83 14.18 370 497436 191713 109899780
Prescribed overdose 178.63 14.18 825 496981 86756 110004737
Skin exfoliation 176.12 14.18 87 497719 87564 110003929
C-reactive protein 175.25 14.18 408 497398 29923 110061570
Lupus-like syndrome 174.67 14.18 490 497316 40302 110051191
Abdominal pain 174.63 14.18 1473 496333 511516 109579977
Blood urea increased 172.20 14.18 22 497784 54935 110036558
Asthenia 171.69 14.18 2131 495675 686868 109404625
Neurotoxicity 170.58 14.18 4 497802 42203 110049290
Hypophagia 167.50 14.18 20 497786 52606 110038887
Blood creatine phosphokinase increased 166.93 14.18 60 497746 73017 110018476
Cholestasis 165.35 14.18 43 497763 64475 110027018
Seronegative arthritis 164.70 14.18 247 497559 12930 110078563
Pulmonary hypertension 163.92 14.18 26 497780 55194 110036299
Apparent death 163.65 14.18 122 497684 2780 110088713
Hypoaesthesia 163.59 14.18 2146 495660 312077 109779416
Psychotic disorder 163.01 14.18 19 497787 50918 110040575
Angioedema 162.77 14.18 123 497683 98377 109993116
Palmar-plantar erythrodysaesthesia syndrome 161.66 14.18 5 497801 41020 110050473
Clostridium difficile colitis 160.32 14.18 9 497797 43769 110047724
Pain in extremity 160.06 14.18 3080 494726 484038 109607455
Ventricular tachycardia 159.18 14.18 19 497787 49990 110041503
Flushing 159.17 14.18 142 497664 104594 109986899
Impaired work ability 158.84 14.18 361 497445 26058 110065435
Abnormal behaviour 156.63 14.18 4 497802 39035 110052458
Colitis 156.37 14.18 138 497668 102185 109989308
Hepatic function abnormal 156.09 14.18 105 497701 89190 110002303
Shock 155.14 14.18 27 497779 53561 110037932
Drug level increased 154.72 14.18 17 497789 47702 110043791
Transient ischaemic attack 154.06 14.18 48 497758 63934 110027559
Ventricular fibrillation 152.83 14.18 8 497798 41305 110050188
Full blood count abnormal 152.23 14.18 33 497773 56019 110035474
Haematoma 151.73 14.18 38 497768 58438 110033055
Pancreatitis acute 151.01 14.18 42 497764 60232 110031261
Dyskinesia 150.97 14.18 25 497781 51421 110040072
Dysuria 149.00 14.18 43 497763 60188 110031305
Obstructive airways disorder 148.22 14.18 17 497789 46132 110045361
Prescribed underdose 148.05 14.18 634 497172 64540 110026953
Haematemesis 146.58 14.18 42 497764 59066 110032427
Blood calcium decreased 146.42 14.18 3 497803 35842 110055651
Anxiety 144.61 14.18 934 496872 344144 109747349
Arrhythmia 144.48 14.18 66 497740 69509 110021984
Skin necrosis 144.11 14.18 307 497499 21205 110070288
Drug ineffective for unapproved indication 143.98 14.18 150 497656 102688 109988805
Anti-cyclic citrullinated peptide antibody 143.19 14.18 293 497513 19671 110071822
Maternal exposure timing unspecified 142.06 14.18 301 497505 20712 110070781
Osteonecrosis of jaw 141.65 14.18 23 497783 47994 110043499
Coronary artery disease 141.27 14.18 73 497733 71617 110019876
Pallor 140.26 14.18 40 497766 56427 110035066
Back injury 140.11 14.18 501 497305 46898 110044595
Urinary incontinence 139.53 14.18 25 497781 48562 110042931
Cellulitis 138.99 14.18 220 497586 125796 109965697
Urticaria 138.77 14.18 2110 495696 316747 109774746
Suicidal ideation 138.43 14.18 131 497675 93806 109997687
Chronic kidney disease 138.41 14.18 86 497720 76205 110015288
Oedema peripheral 138.00 14.18 889 496917 327771 109763722
Blood potassium decreased 136.90 14.18 37 497769 54077 110037416
Osteoporosis 135.68 14.18 761 497045 86391 110005102
Therapeutic response decreased 134.91 14.18 819 496987 95680 109995813
Hepatic cirrhosis 133.47 14.18 631 497175 66995 110024498
Wheezing 133.17 14.18 1744 496062 253486 109838007
Hepatic cytolysis 133.10 14.18 41 497765 55012 110036481
Bone marrow failure 131.27 14.18 48 497758 57800 110033693
Psoriasis 131.13 14.18 1078 496728 138915 109952578
Therapy interrupted 130.00 14.18 32 497774 49790 110041703
Nausea 129.93 14.18 4410 493396 1231280 108860213
Sinus tachycardia 129.72 14.18 22 497784 44471 110047022
Hemiparesis 129.58 14.18 21 497785 43882 110047611
Pregnancy 129.57 14.18 514 497292 50553 110040940
Mucosal inflammation 129.30 14.18 145 497661 95996 109995497
Cytomegalovirus infection 129.03 14.18 42 497764 54402 110037091
Presyncope 128.34 14.18 31 497775 48856 110042637
Transplant dysfunction 127.55 14.18 172 497634 8156 110083337
Drug withdrawal syndrome 127.42 14.18 12 497794 38042 110053451
Hypophosphataemia 127.40 14.18 5 497801 33177 110058316
Joint effusion 127.18 14.18 287 497519 20618 110070875
Depressed mood 125.77 14.18 58 497748 60751 110030742
Therapy non-responder 125.36 14.18 1169 496637 156138 109935355
Irritability 124.18 14.18 31 497775 47778 110043715
Posterior reversible encephalopathy syndrome 123.88 14.18 7 497799 33854 110057639
Upper gastrointestinal haemorrhage 123.49 14.18 36 497770 50060 110041433
Subdural haematoma 123.39 14.18 11 497795 36443 110055050
Human antichimeric antibody positive 123.05 14.18 84 497722 1658 110089835
Cerebral infarction 122.84 14.18 40 497766 51798 110039695
Diabetic ketoacidosis 122.17 14.18 21 497785 42037 110049456
Musculoskeletal deformity 121.99 14.18 80 497726 1473 110090020
Oxygen saturation decreased 121.74 14.18 335 497471 156647 109934846
Diplopia 121.51 14.18 21 497785 41873 110049620
Hallucination, visual 121.35 14.18 17 497789 39588 110051905
Vomiting 121.26 14.18 3147 494659 907528 109183965
Electrolyte imbalance 120.54 14.18 13 497793 37015 110054478
Blood pressure increased 120.48 14.18 676 497130 257697 109833796
Status epilepticus 120.40 14.18 5 497801 31566 110059927
Tachypnoea 118.18 14.18 18 497788 39377 110052116
Lymphocyte count decreased 117.78 14.18 55 497751 57188 110034305
Acute myeloid leukaemia 117.62 14.18 16 497790 38094 110053399
Cardiac disorder 117.62 14.18 102 497704 76178 110015315
Acute respiratory distress syndrome 117.61 14.18 46 497760 53152 110038341
Ejection fraction decreased 117.46 14.18 21 497785 40859 110050634
Hyperbilirubinaemia 116.49 14.18 5 497801 30666 110060827
Withdrawal syndrome 116.32 14.18 6 497800 31374 110060119
Pericardial effusion 116.15 14.18 56 497750 57161 110034332
Incorrect dose administered 116.14 14.18 179 497627 103462 109988031
Jaundice 115.71 14.18 61 497745 59175 110032318
Dizziness 115.34 14.18 2333 495473 695860 109395633
Ischaemic stroke 114.72 14.18 23 497783 41240 110050253
Taste disorder 114.71 14.18 590 497216 64797 110026696
Laryngitis 114.21 14.18 435 497371 41976 110049517
Tumour lysis syndrome 113.82 14.18 6 497800 30795 110060698
Circulatory collapse 113.38 14.18 27 497779 42966 110048527
Pulmonary arterial hypertension 112.51 14.18 9 497797 32559 110058934
Haemorrhage intracranial 112.48 14.18 4 497802 28965 110062528
Extrapyramidal disorder 112.04 14.18 4 497802 28863 110062630
Neck pain 111.49 14.18 941 496865 122189 109969304
Eosinophilia 111.21 14.18 61 497745 57875 110033618
Full blood count decreased 110.53 14.18 9 497797 32090 110059403
Body height below normal 109.53 14.18 84 497722 2000 110089493
Product administration error 109.40 14.18 18 497788 37199 110054294
Accidental exposure to product 107.69 14.18 45 497761 49963 110041530
Red blood cell sedimentation rate 107.55 14.18 125 497681 5089 110086404
Respiratory depression 107.39 14.18 10 497796 31991 110059502
Labelled drug-drug interaction medication error 107.37 14.18 6 497800 29296 110062197
Blood sodium decreased 107.29 14.18 21 497785 38298 110053195
Hepatocellular injury 106.78 14.18 47 497759 50595 110040898
Musculoskeletal disorder 106.77 14.18 282 497524 22382 110069111
Thrombotic microangiopathy 106.72 14.18 6 497800 29143 110062350
Product prescribing error 106.10 14.18 49 497757 51282 110040211
Product label confusion 105.66 14.18 281 497525 22396 110069097
Angina pectoris 105.24 14.18 76 497730 62219 110029274
Shock haemorrhagic 104.97 14.18 4 497802 27243 110064250
Blood alkaline phosphatase increased 104.42 14.18 99 497707 70836 110020657
Joint dislocation 104.15 14.18 365 497441 33825 110057668
Ovarian cyst 104.14 14.18 208 497598 13722 110077771
Myoclonus 103.89 14.18 13 497793 32985 110058508
Therapy cessation 103.87 14.18 36 497770 44821 110046672
Bacteraemia 103.50 14.18 31 497775 42359 110049134
Speech disorder 102.86 14.18 76 497730 61493 110030000
Leukocytosis 102.85 14.18 57 497749 53771 110037722
Rash erythematous 101.98 14.18 131 497675 81701 110009792
Coeliac disease 101.87 14.18 425 497381 42762 110048731
Bone pain 101.76 14.18 86 497720 65047 110026446
Coagulopathy 101.57 14.18 29 497777 40882 110050611
Hyperthyroidism 101.32 14.18 8 497798 29253 110062240
Dermatitis atopic 101.05 14.18 3 497803 25538 110065955
Hepatitis 100.81 14.18 723 497083 89331 110002162
Pyrexia 100.80 14.18 3178 494628 895087 109196406
Dactylitis 100.56 14.18 108 497698 4025 110087468
Injection site erythema 100.49 14.18 168 497638 94008 109997485
Fluid retention 99.92 14.18 169 497637 94138 109997355
Hyperlipidaemia 99.63 14.18 20 497786 35828 110055665
Ataxia 99.48 14.18 10 497796 30098 110061395
Lymphopenia 98.77 14.18 29 497777 40141 110051352
Muscle twitching 98.76 14.18 10 497796 29925 110061568
Dystonia 98.70 14.18 4 497802 25801 110065692
Device dislocation 98.58 14.18 13 497793 31691 110059802
Palpitations 98.26 14.18 376 497430 158836 109932657
Toxic epidermal necrolysis 97.41 14.18 68 497738 56659 110034834
Alanine aminotransferase abnormal 97.31 14.18 161 497645 9173 110082320
Metastases to bone 97.23 14.18 13 497793 31359 110060134
Anuria 95.79 14.18 3 497803 24338 110067155
Troponin increased 95.51 14.18 11 497795 29755 110061738
Subarachnoid haemorrhage 95.24 14.18 11 497795 29691 110061802
Hypothermia 94.52 14.18 6 497800 26296 110065197
Device issue 94.46 14.18 20 497786 34515 110056978
Muscle rigidity 94.43 14.18 3 497803 24028 110067465
Migraine 94.17 14.18 1184 496622 170468 109921025
Myelodysplastic syndrome 94.13 14.18 26 497780 37458 110054035
Anaphylactic shock 93.65 14.18 58 497748 51488 110040005
Coordination abnormal 92.96 14.18 5 497801 25223 110066270
Poisoning 92.78 14.18 11 497795 29094 110062399
Device related infection 92.75 14.18 31 497775 39488 110052005
Blood glucose decreased 91.91 14.18 12 497794 29476 110062017
Hot flush 91.67 14.18 97 497709 65939 110025554
Neuralgia 91.67 14.18 52 497754 48426 110043067
Head injury 90.58 14.18 40 497766 42977 110048516
Infusion site reaction 90.52 14.18 227 497579 17455 110074038
Acute hepatic failure 90.27 14.18 26 497780 36442 110055051
Feeling abnormal 90.21 14.18 462 497344 180249 109911244
Right ventricular failure 90.14 14.18 7 497799 25947 110065546
Productive cough 90.06 14.18 242 497564 114063 109977430
Ileus 90.02 14.18 15 497791 30714 110060779
Bloody discharge 89.67 14.18 84 497722 2649 110088844
Tenderness 89.45 14.18 314 497492 29123 110062370
Adverse reaction 89.34 14.18 315 497491 29279 110062214
Lacrimation increased 88.71 14.18 16 497790 30934 110060559
Nephropathy toxic 88.55 14.18 10 497796 27468 110064025
Drug dependence 88.52 14.18 58 497748 49962 110041531
Transfusion 88.10 14.18 7 497799 25465 110066028
Back pain 87.92 14.18 1159 496647 369837 109721656
Brain oedema 87.16 14.18 17 497789 31081 110060412
Activated partial thromboplastin time prolonged 87.16 14.18 3 497803 22365 110069128
Paraesthesia oral 87.12 14.18 22 497784 33649 110057844
International normalised ratio fluctuation 86.15 14.18 99 497707 3981 110087512
Cyanosis 86.06 14.18 15 497791 29726 110061767
Swelling face 85.86 14.18 179 497627 92142 109999351
Hypothyroidism 85.48 14.18 122 497684 72777 110018716
Gamma-glutamyltransferase increased 85.17 14.18 90 497716 61219 110030274
Drug tolerance 84.99 14.18 213 497593 16372 110075121
Torsade de pointes 84.80 14.18 4 497802 22596 110068897
Pulmonary congestion 84.56 14.18 18 497788 30948 110060545
Diabetes mellitus inadequate control 84.04 14.18 16 497790 29759 110061734
Leukopenia 83.90 14.18 364 497442 148427 109943066
Flatulence 83.77 14.18 67 497739 52082 110039411
Nodule 83.23 14.18 329 497477 32302 110059191
Atrial flutter 82.99 14.18 7 497799 24255 110067238
Lip swelling 82.77 14.18 64 497742 50603 110040890
Pollakiuria 82.72 14.18 48 497758 44147 110047346
Left ventricular dysfunction 82.55 14.18 6 497800 23487 110068006
Gout 81.86 14.18 31 497775 36535 110054958
Erythema 81.50 14.18 878 496928 290569 109800924
Rash maculo-papular 81.44 14.18 130 497676 74092 110017401
Arteriosclerosis coronary artery 81.30 14.18 9 497797 25109 110066384
Hypovolaemia 80.80 14.18 4 497802 21670 110069823
Wrist deformity 80.54 14.18 85 497721 3104 110088389
Aplastic anaemia 80.50 14.18 8 497798 24300 110067193
Walking aid user 80.13 14.18 272 497534 24803 110066690
Arteriosclerosis 79.85 14.18 9 497797 24758 110066735
Mydriasis 79.78 14.18 5 497801 22152 110069341
Hypersomnia 79.37 14.18 15 497791 28046 110063447
Bacterial infection 79.29 14.18 55 497751 45981 110045512
Inappropriate antidiuretic hormone secretion 78.67 14.18 27 497779 33824 110057669
Malnutrition 78.41 14.18 14 497792 27265 110064228
Breast cancer stage II 78.06 14.18 286 497520 27089 110064404
Hepatic encephalopathy 78.03 14.18 16 497790 28240 110063253
Heart rate increased 78.01 14.18 357 497449 143477 109948016
Peritonitis 77.54 14.18 25 497781 32582 110058911
Throat irritation 77.36 14.18 76 497730 53476 110038017
Intestinal sepsis 77.12 14.18 51 497755 953 110090540
Cardiac failure acute 77.00 14.18 9 497797 24069 110067424
Hemiplegia 76.77 14.18 7 497799 22775 110068718
Mitral valve incompetence 76.74 14.18 27 497779 33302 110058191
Hip fracture 76.71 14.18 31 497775 35120 110056373
Bronchopulmonary aspergillosis 76.33 14.18 20 497786 29843 110061650
Ulcer 76.29 14.18 390 497416 42726 110048767
Sudden death 75.86 14.18 10 497796 24385 110067108
Tuberculin test positive 75.77 14.18 88 497718 3580 110087913
Weight decreased 75.69 14.18 1569 496237 466488 109625005
Cholelithiasis 75.50 14.18 105 497701 63317 110028176
Schizophrenia 75.48 14.18 6 497800 21820 110069673
Emotional distress 75.38 14.18 55 497751 44792 110046701
Haemodynamic instability 74.59 14.18 8 497798 22880 110068613
Dementia 74.06 14.18 25 497781 31648 110059845
Chronic sinusitis 74.02 14.18 12 497794 25072 110066421
Nasal congestion 73.77 14.18 213 497593 98069 109993424
Respiratory tract infection 73.45 14.18 131 497675 71486 110020007
Delusion 73.24 14.18 10 497796 23745 110067748
Dyspepsia 72.98 14.18 1237 496569 189728 109901765
Small intestinal obstruction 72.63 14.18 27 497779 32186 110059307
Dysphonia 72.50 14.18 145 497661 75784 110015709
Visual acuity reduced 72.49 14.18 27 497779 32146 110059347
Pneumonitis 72.34 14.18 147 497659 76384 110015109
Influenza 72.15 14.18 455 497351 168646 109922847
Hypertension 71.98 14.18 2893 494913 507191 109584302
Nervousness 71.90 14.18 38 497768 36813 110054680
Tricuspid valve incompetence 71.40 14.18 11 497795 23862 110067631
Oliguria 70.99 14.18 3 497803 18654 110072839
Anal incontinence 70.76 14.18 8 497798 21956 110069537
Neutrophil count increased 70.20 14.18 34 497772 34618 110056875
Staphylococcal infection 69.89 14.18 130 497676 69814 110021679
No adverse event 69.65 14.18 142 497664 73697 110017796
Bone swelling 69.63 14.18 61 497745 1760 110089733
Metastases to central nervous system 69.42 14.18 10 497796 22807 110068686
Enterococcal infection 69.32 14.18 6 497800 20360 110071133
Terminal state 69.08 14.18 105 497701 5562 110085931
Skin ulcer 68.94 14.18 507 497299 63138 110028355
Myasthenia gravis 68.89 14.18 8 497798 21503 110069990
Hallucination, auditory 68.78 14.18 17 497789 26380 110065113
Bronchospasm 68.76 14.18 25 497781 30214 110061279
Ventricular extrasystoles 68.71 14.18 10 497796 22631 110068862
Pseudomonas infection 68.68 14.18 20 497786 27833 110063660
Premature delivery 68.52 14.18 26 497780 30606 110060887
Eye pruritus 68.19 14.18 31 497775 32744 110058749
Myocardial ischaemia 67.96 14.18 18 497788 26666 110064827
Disseminated intravascular coagulation 67.63 14.18 52 497754 41234 110050259
Presbyacusis 67.42 14.18 73 497733 2746 110088747
Hypernatraemia 67.42 14.18 3 497803 17830 110073663
Abdominal distension 67.29 14.18 486 497320 174617 109916876
Aspiration 66.52 14.18 27 497779 30506 110060987
Clostridium difficile infection 66.46 14.18 82 497724 52047 110039446
Product quality issue 66.42 14.18 584 497222 76715 110014778
Cardiomyopathy 66.25 14.18 34 497772 33491 110058002
Thyroid neoplasm 66.20 14.18 78 497728 3223 110088270
Gastritis 65.84 14.18 87 497719 53612 110037881
Tendonitis 65.73 14.18 262 497544 25821 110065672
Graft versus host disease 65.51 14.18 5 497801 18801 110072692
Tenosynovitis stenosans 65.50 14.18 81 497725 3522 110087971
Polyneuropathy 65.48 14.18 31 497775 31981 110059512
Paranoia 65.36 14.18 11 497795 22363 110069130
Second primary malignancy 65.29 14.18 4 497802 18064 110073429
Rheumatoid factor negative 65.27 14.18 51 497755 1249 110090244
Blood triglycerides increased 65.15 14.18 14 497792 23912 110067581
Supraventricular tachycardia 65.07 14.18 15 497791 24407 110067086
Hepatic enzyme abnormal 65.01 14.18 139 497667 9624 110081869
Oedema 64.88 14.18 1316 496490 208660 109882833
Escherichia infection 64.71 14.18 14 497792 23802 110067691
Wheelchair user 64.61 14.18 122 497684 7720 110083773
Mental impairment 64.25 14.18 12 497794 22627 110068866
Lower gastrointestinal haemorrhage 64.16 14.18 5 497801 18481 110073012
Injection site reaction 64.09 14.18 648 497158 88422 110003071
Haemodialysis 63.80 14.18 4 497802 17715 110073778
Acute pulmonary oedema 63.80 14.18 3 497803 16993 110074500
Cytomegalovirus infection reactivation 63.51 14.18 5 497801 18328 110073165
Tongue disorder 63.42 14.18 174 497632 14124 110077369
Pulmonary alveolar haemorrhage 63.29 14.18 8 497798 20142 110071351
Throat tightness 63.21 14.18 36 497770 33453 110058040
Myocarditis 63.20 14.18 28 497778 30027 110061466
Hepatitis cholestatic 63.14 14.18 4 497802 17562 110073931
Basal cell carcinoma 63.12 14.18 384 497422 44886 110046607
Complication associated with device 62.97 14.18 8 497798 20065 110071428
Blood iron abnormal 62.83 14.18 53 497753 1451 110090042
Skin haemorrhage 62.75 14.18 17 497789 24810 110066683
Hypoalbuminaemia 62.50 14.18 26 497780 28948 110062545
Sleep apnoea syndrome 62.45 14.18 54 497752 40393 110051100
Appendicitis 62.29 14.18 25 497781 28439 110063054
Blood loss anaemia 62.21 14.18 5 497801 18020 110073473
Exposure during pregnancy 61.97 14.18 1079 496727 166345 109925148
Vaginal haemorrhage 61.83 14.18 18 497788 25056 110066437
Diverticulitis 61.81 14.18 433 497373 53089 110038404
Pustular psoriasis 61.78 14.18 167 497639 13438 110078055
Renal tubular necrosis 61.59 14.18 30 497776 30445 110061048
Intestinal obstruction 61.50 14.18 90 497716 53137 110038356
Pulmonary haemorrhage 61.46 14.18 3 497803 16453 110075040
Hyperthermia 60.96 14.18 11 497795 21261 110070232
Panic attack 60.79 14.18 27 497779 28913 110062580
Chromaturia 60.72 14.18 28 497778 29332 110062161
Dysgeusia 60.71 14.18 141 497665 69844 110021649
Retching 60.29 14.18 14 497792 22668 110068825
Device difficult to use 60.21 14.18 7 497799 18798 110072695
Restless legs syndrome 60.14 14.18 18 497788 24608 110066885
Oesophagitis 59.99 14.18 27 497779 28688 110062805
Blood calcium increased 59.58 14.18 6 497800 18034 110073459
Neoplasm malignant 59.57 14.18 327 497479 36816 110054677
Blood lactate dehydrogenase increased 59.46 14.18 67 497739 44267 110047226
Blindness 59.30 14.18 46 497760 36313 110055180
Erectile dysfunction 59.18 14.18 7 497799 18549 110072944
Dialysis 58.77 14.18 9 497797 19610 110071883
Blood lactic acid increased 58.72 14.18 3 497803 15818 110075675
Metastases to liver 58.69 14.18 44 497762 35342 110056151
Vascular device infection 58.64 14.18 4 497802 16508 110074985
Hypotonia 58.39 14.18 3 497803 15742 110075751
Acute generalised exanthematous pustulosis 58.33 14.18 13 497793 21651 110069842
Polyuria 58.32 14.18 6 497800 17732 110073761
Cystitis 58.13 14.18 132 497674 65904 110025589
Drug eruption 57.86 14.18 427 497379 53232 110038261
Food allergy 57.85 14.18 10 497796 19938 110071555
Sinus disorder 57.84 14.18 38 497768 32690 110058803
Neurological symptom 57.80 14.18 3 497803 15605 110075888
Bone cyst 57.61 14.18 76 497730 3527 110087966
Chest pain 57.52 14.18 1273 496533 375102 109716391
Physical disability 57.21 14.18 91 497715 5015 110086478
Lyme disease 56.96 14.18 83 497723 4233 110087260
Procedural pain 56.74 14.18 46 497760 35519 110055974
Antibody test positive 56.49 14.18 70 497736 3050 110088443
Spondylitis 56.41 14.18 144 497662 11194 110080299
Ulcer haemorrhage 56.30 14.18 226 497580 22345 110069148
Acidosis 55.88 14.18 16 497790 22515 110068978
Bone density abnormal 55.84 14.18 78 497728 3825 110087668
Synovial cyst 55.66 14.18 144 497662 11286 110080207
Sensory loss 55.55 14.18 14 497792 21443 110070050
Off label use 55.26 14.18 5913 491893 1494272 108597221
Porphyria acute 55.06 14.18 198 497608 18582 110072911
Skin burning sensation 55.06 14.18 15 497791 21810 110069683
Rhinorrhoea 54.97 14.18 256 497550 102410 109989083
Proctitis 54.95 14.18 6 497800 16921 110074572
Atrioventricular block 54.74 14.18 6 497800 16871 110074622
Viral infection 54.67 14.18 97 497709 53042 110038451
Oropharyngeal pain 54.65 14.18 370 497436 134906 109956587
Myopathy 54.49 14.18 22 497784 24938 110066555
Acute coronary syndrome 54.47 14.18 18 497788 23094 110068399
Eating disorder 54.31 14.18 36 497770 30822 110060671
Rhinitis allergic 54.19 14.18 8 497798 17914 110073579
Hypertensive crisis 54.00 14.18 21 497785 24351 110067142
Immune thrombocytopenia 53.93 14.18 17 497789 22477 110069016
Prothrombin time prolonged 53.86 14.18 7 497799 17254 110074239
Joint ankylosis 53.42 14.18 61 497745 2436 110089057
COVID-19 pneumonia 53.32 14.18 53 497753 37090 110054403
Female genital tract fistula 53.26 14.18 6 497800 16513 110074980
Benign prostatic hyperplasia 53.19 14.18 9 497797 18225 110073268
Respiratory syncytial virus infection 52.97 14.18 3 497803 14481 110077012
Glycosylated haemoglobin increased 52.91 14.18 20 497786 23599 110067894
Nocturia 52.75 14.18 7 497799 16983 110074510
Spinal stenosis 52.58 14.18 197 497609 18859 110072634
Neck deformity 52.56 14.18 53 497753 1833 110089660
Metastases to lung 52.56 14.18 19 497787 23044 110068449
Eye swelling 52.40 14.18 43 497763 33005 110058488
Steroid dependence 52.33 14.18 117 497689 8352 110083141
Fine motor skill dysfunction 52.18 14.18 98 497708 6176 110085317
Vaginal discharge 51.88 14.18 9 497797 17899 110073594
Faecaloma 51.83 14.18 4 497802 14904 110076589
Hypertriglyceridaemia 51.75 14.18 6 497800 16148 110075345
Faeces discoloured 51.60 14.18 46 497760 33902 110057591
Progressive multifocal leukoencephalopathy 51.30 14.18 24 497782 24932 110066561
Pneumonia fungal 51.18 14.18 4 497802 14750 110076743
Generalised oedema 51.16 14.18 38 497768 30666 110060827
Decubitus ulcer 51.04 14.18 10 497796 18226 110073267
Product substitution issue 50.88 14.18 20 497786 23041 110068452
Ankle arthroplasty 50.69 14.18 60 497746 2491 110089002
Jaundice cholestatic 50.56 14.18 4 497802 14604 110076889
Immobile 50.53 14.18 109 497697 7593 110083900
Stress cardiomyopathy 50.32 14.18 6 497800 15800 110075693
Device occlusion 50.28 14.18 5 497801 15180 110076313
Pleural thickening 50.23 14.18 69 497737 3330 110088163
Pleural fibrosis 49.96 14.18 78 497728 4230 110087263
Infusion site pain 49.93 14.18 9 497797 17410 110074083
Stevens-Johnson syndrome 49.72 14.18 84 497722 46817 110044676
Intestinal ischaemia 49.44 14.18 7 497799 16172 110075321
Transaminases increased 49.33 14.18 135 497671 63255 110028238
Injection site swelling 49.29 14.18 130 497676 61660 110029833
Incontinence 48.99 14.18 8 497798 16627 110074866
Rash papular 48.97 14.18 32 497774 27607 110063886
Electrocardiogram abnormal 48.84 14.18 12 497794 18697 110072796
Lipase increased 48.70 14.18 12 497794 18660 110072833
Lung infiltration 48.63 14.18 25 497781 24603 110066890
Cardiomegaly 48.60 14.18 36 497770 29094 110062399
Drug resistance 48.56 14.18 114 497692 56260 110035233
Agranulocytosis 48.46 14.18 131 497675 61629 110029864
Synovial fluid analysis 48.30 14.18 60 497746 2621 110088872
Ovarian neoplasm 48.11 14.18 32 497774 604 110090889
Sensory disturbance 47.86 14.18 10 497796 17419 110074074
Aspergillus infection 47.68 14.18 28 497778 25588 110065905
Device malfunction 47.49 14.18 28 497778 25530 110065963
Skin discolouration 47.39 14.18 93 497713 48953 110042540
Drug specific antibody 47.31 14.18 61 497745 2767 110088726
Exposure via skin contact 47.24 14.18 3 497803 13144 110078349
Paralysis 47.09 14.18 7 497799 15593 110075900
Central nervous system lesion 46.90 14.18 7 497799 15546 110075947
Pathogen resistance 46.79 14.18 11 497795 17661 110073832
Pneumothorax 46.58 14.18 54 497752 35231 110056262
Iron deficiency anaemia 46.50 14.18 44 497762 31515 110059978
Atrioventricular block first degree 46.29 14.18 5 497801 14220 110077273
Abdominal pain lower 46.12 14.18 60 497746 37223 110054270
Arthrodesis 46.06 14.18 59 497747 2659 110088834
Angina unstable 46.01 14.18 9 497797 16423 110075070
Temperature regulation disorder 45.87 14.18 3 497803 12823 110078670
Bladder cancer 45.76 14.18 17 497789 20275 110071218
Abnormal dreams 45.67 14.18 3 497803 12777 110078716
Skin irritation 45.57 14.18 9 497797 16310 110075183
Sinus congestion 45.43 14.18 42 497764 30417 110061076
Axial spondyloarthritis 45.29 14.18 35 497771 843 110090650
Hypocalcaemia 45.25 14.18 147 497659 65219 110026274
Renal injury 45.12 14.18 14 497792 18699 110072794
Enteritis 45 14.18 15 497791 19141 110072352
Proteinuria 44.94 14.18 69 497737 39949 110051544
Klebsiella infection 44.73 14.18 17 497789 19992 110071501
Abdominal pain upper 44.65 14.18 1960 495846 347151 109744342
Vascular access complication 44.62 14.18 56 497750 2472 110089021
Device leakage 44.50 14.18 9 497797 16039 110075454
Foetal death 44.49 14.18 9 497797 16036 110075457
Blood urine present 44.43 14.18 27 497779 24218 110067275
Mania 44.32 14.18 19 497787 20777 110070716
Rash macular 44.12 14.18 66 497740 38620 110052873
Cold sweat 44.05 14.18 22 497784 22009 110069484
Fatigue 43.89 14.18 6177 491629 1209781 108881712
Influenza like illness 43.56 14.18 227 497579 88185 110003308
Red cell distribution width decreased 43.37 14.18 52 497754 2189 110089304
Toxic encephalopathy 43.31 14.18 8 497798 15206 110076287
Colitis ischaemic 43.30 14.18 13 497793 17737 110073756
Pulseless electrical activity 43.26 14.18 11 497795 16746 110074747
Cystitis haemorrhagic 43.24 14.18 3 497803 12206 110079287
Immune reconstitution inflammatory syndrome 43.16 14.18 10 497796 16216 110075277
Glomerular filtration rate decreased 43.10 14.18 40 497766 28916 110062577
Osteonecrosis 43.09 14.18 53 497753 33688 110057805
Hypovolaemic shock 42.98 14.18 7 497799 14576 110076917
Surgery 42.79 14.18 75 497731 41208 110050285
Feeling cold 42.76 14.18 54 497752 33933 110057560
Peripheral coldness 42.72 14.18 15 497791 18525 110072968
Urine output decreased 42.61 14.18 18 497788 19858 110071635
Deep vein thrombosis 42.54 14.18 413 497393 139474 109952019
Mental disorder 42.50 14.18 68 497738 38723 110052770
Hiatus hernia 42.45 14.18 37 497769 27569 110063924
Hospitalisation 42.37 14.18 423 497383 142070 109949423
Encephalitis 42.12 14.18 16 497790 18823 110072670
Injection site haemorrhage 42.06 14.18 52 497754 32976 110058517
Bone density decreased 41.93 14.18 163 497643 15879 110075614
Vertigo 41.71 14.18 225 497581 86645 110004848
Arterial occlusive disease 41.59 14.18 9 497797 15299 110076194
Congestive cardiomyopathy 41.52 14.18 7 497799 14212 110077281
Thirst 41.45 14.18 23 497783 21684 110069809
Nervous system disorder 41.39 14.18 49 497757 31672 110059821
Staphylococcal bacteraemia 41.11 14.18 12 497794 16676 110074817
Joint arthroplasty 40.96 14.18 64 497742 3473 110088020
Gingival bleeding 40.90 14.18 19 497787 19820 110071673
Enterocolitis 40.88 14.18 17 497789 18932 110072561
Eructation 40.87 14.18 7 497799 14050 110077443
Bundle branch block right 40.82 14.18 4 497802 12287 110079206
Catarrh 40.56 14.18 97 497709 7238 110084255
Pneumocystis jirovecii pneumonia 40.46 14.18 82 497724 42653 110048840
Dermatitis contact 40.45 14.18 7 497799 13946 110077547
Extra dose administered 40.27 14.18 4 497802 12155 110079338
Fear of injection 40.08 14.18 109 497697 8802 110082691
Mixed liver injury 39.94 14.18 4 497802 12075 110079418
Heparin-induced thrombocytopenia 39.90 14.18 3 497803 11421 110080072
Exercise tolerance decreased 39.89 14.18 4 497802 12063 110079430
Squamous cell carcinoma of skin 39.50 14.18 14 497792 17189 110074304
Asphyxia 39.36 14.18 8 497798 14207 110077286
Extremity contracture 39.34 14.18 44 497762 1717 110089776
Apnoea 39.20 14.18 7 497799 13632 110077861
Haematochezia 39.08 14.18 332 497474 115192 109976301
Micturition urgency 39.07 14.18 19 497787 19301 110072192
Sneezing 39.03 14.18 52 497754 31932 110059561
Substance abuse 39.02 14.18 5 497801 12458 110079035
Swollen joint count 38.91 14.18 106 497700 8568 110082925
Staphylococcal sepsis 38.73 14.18 15 497791 17439 110074054
Rhinovirus infection 38.73 14.18 4 497802 11785 110079708
Accidental overdose 38.41 14.18 113 497693 51721 110039772
Metabolic encephalopathy 38.36 14.18 3 497803 11057 110080436
Burns second degree 38.25 14.18 98 497708 7635 110083858
Cholecystitis 38.23 14.18 36 497770 25846 110065647
Eye pain 38.01 14.18 108 497698 49991 110041502
Gastric disorder 38.01 14.18 269 497537 33088 110058405
Ear infection 38.00 14.18 441 497365 62291 110029202
Gastroenteritis 37.98 14.18 73 497733 38727 110052766
Wrong product administered 37.94 14.18 3 497803 10957 110080536
Eosinophil count increased 37.83 14.18 24 497782 21034 110070459
Joint space narrowing 37.78 14.18 31 497775 816 110090677
Left ventricular hypertrophy 37.63 14.18 7 497799 13237 110078256
Cerebral ischaemia 37.55 14.18 5 497801 12099 110079394
Inappropriate schedule of product administration 37.33 14.18 668 497138 202969 109888524
Ageusia 37.24 14.18 21 497785 19624 110071869
Post procedural complication 37.17 14.18 39 497767 26619 110064874
Synovial disorder 37.06 14.18 56 497750 2951 110088542
Dizziness postural 36.93 14.18 10 497796 14599 110076894
Prostatic specific antigen increased 36.88 14.18 6 497800 12505 110078988
Systemic inflammatory response syndrome 36.83 14.18 7 497799 13036 110078457
Pulse absent 36.66 14.18 4 497802 11288 110080205
Injection site mass 36.63 14.18 34 497772 24579 110066914
Hyperuricaemia 36.63 14.18 10 497796 14521 110076972
Psychomotor hyperactivity 36.58 14.18 23 497783 20254 110071239
Respiratory symptom 36.36 14.18 11 497795 14934 110076559
Gangrene 36.34 14.18 14 497792 16327 110075166
Mood altered 36.20 14.18 26 497780 21349 110070144
Hiccups 36.14 14.18 7 497799 12862 110078631
Peritonitis bacterial 36.13 14.18 3 497803 10530 110080963
Pemphigoid 36.04 14.18 22 497784 19685 110071808
Motor dysfunction 35.99 14.18 34 497772 24372 110067121
Drug-induced liver injury 35.91 14.18 749 497057 119318 109972175
Eyelid ptosis 35.88 14.18 8 497798 13319 110078174
Product prescribing issue 35.75 14.18 7 497799 12765 110078728
Epilepsy 35.71 14.18 642 497164 99567 109991926
Potentiating drug interaction 35.66 14.18 5 497801 11638 110079855
Nail operation 35.59 14.18 41 497765 1653 110089840
Hyperaesthesia 35.54 14.18 11 497795 14716 110076777
Rheumatoid lung 35.51 14.18 67 497739 4237 110087256
Erythema multiforme 35.29 14.18 26 497780 21071 110070422
Bone marrow oedema 35.28 14.18 46 497760 2110 110089383
Hydronephrosis 35.18 14.18 25 497781 20640 110070853
Overlap syndrome 35.09 14.18 105 497701 8954 110082539
Product preparation error 34.95 14.18 4 497802 10875 110080618
Gastritis erosive 34.83 14.18 6 497800 11994 110079499
Product storage error 34.79 14.18 28 497778 21700 110069793
Scleritis 34.76 14.18 76 497730 5344 110086149
Blood magnesium increased 34.68 14.18 62 497744 3761 110087732
Acne 34.59 14.18 264 497542 33256 110058237
Partial seizures 34.47 14.18 5 497801 11344 110080149
Rib fracture 34.42 14.18 62 497744 33708 110057785
Blood magnesium decreased 34.29 14.18 24 497782 19972 110071521
Facial paralysis 34.24 14.18 35 497771 24179 110067314
Gastric ulcer 33.93 14.18 81 497725 39746 110051747
Unevaluable event 33.92 14.18 144 497662 59083 110032410
Cardiac failure chronic 33.90 14.18 10 497796 13801 110077692
Therapy change 33.88 14.18 3 497803 9994 110081499
Insurance issue 33.85 14.18 4 497802 10608 110080885
Thrombosis 33.81 14.18 319 497487 108343 109983150
Subcutaneous drug absorption impaired 33.77 14.18 93 497713 7566 110083927
Anger 33.68 14.18 22 497784 18985 110072508
Mean platelet volume decreased 33.17 14.18 56 497750 3244 110088249
Decreased appetite 33.16 14.18 1777 496029 474069 109617424
Nystagmus 33.15 14.18 6 497800 11571 110079922
Cholangitis 33.13 14.18 16 497790 16319 110075174
Drug dose omission by device 33.01 14.18 12 497794 14504 110076989
Oesophageal candidiasis 32.97 14.18 6 497800 11528 110079965
Amylase increased 32.74 14.18 8 497798 12511 110078982
Dermatitis allergic 32.68 14.18 188 497618 21536 110069957
Cytology abnormal 32.61 14.18 20 497786 326 110091167
Pulmonary thrombosis 32.36 14.18 136 497670 13727 110077766
Abortion spontaneous 32.27 14.18 66 497740 34216 110057277
Fear 32.26 14.18 34 497772 23159 110068334
Uveitis 32.09 14.18 187 497619 21523 110069970
Escherichia bacteraemia 32.01 14.18 4 497802 10160 110081333
Coronary artery stenosis 31.92 14.18 11 497795 13747 110077746
Syringe issue 31.90 14.18 3 497803 9522 110081971
Cholecystitis chronic 31.79 14.18 3 497803 9497 110081996
Brain natriuretic peptide increased 31.68 14.18 6 497800 11203 110080290
Mucormycosis 31.55 14.18 5 497801 10623 110080870
Petechiae 31.53 14.18 35 497771 23282 110068211
Peripheral sensory neuropathy 31.38 14.18 18 497788 16662 110074831
Toxic skin eruption 31.32 14.18 47 497759 27468 110064025
Paronychia 31.18 14.18 6 497800 11075 110080418
Peripheral ischaemia 31.08 14.18 6 497800 11052 110080441
Hypoaesthesia oral 31.06 14.18 19 497787 16983 110074510
Sacroiliitis 31.01 14.18 69 497737 4909 110086584
Brain injury 30.88 14.18 11 497795 13465 110078028
Pathological fracture 30.86 14.18 8 497798 12024 110079469
Swollen tongue 30.86 14.18 153 497653 60209 110031284
Rebound effect 30.81 14.18 14 497792 14792 110076701
Mass excision 30.79 14.18 20 497786 362 110091131
Urosepsis 30.65 14.18 57 497749 30618 110060875
Gait disturbance 30.64 14.18 1539 496267 276669 109814824
Pain of skin 30.61 14.18 27 497779 20002 110071491
Blood uric acid increased 30.58 14.18 31 497775 21498 110069995
Leukoencephalopathy 30.52 14.18 3 497803 9192 110082301
Hepatic enzyme 30.42 14.18 70 497736 5093 110086400
Necrosis 30.40 14.18 7 497799 11399 110080094
Multiple fractures 30.37 14.18 99 497707 8841 110082652
Concomitant disease aggravated 30.30 14.18 18 497788 16346 110075147
Treatment noncompliance 30.30 14.18 198 497608 72792 110018701
Device breakage 30.28 14.18 12 497794 13757 110077736
Post procedural haemorrhage 30.25 14.18 16 497790 15496 110075997
Macular degeneration 29.85 14.18 32 497774 21627 110069866
Colitis ulcerative 29.85 14.18 502 497304 76861 110014632
Needle issue 29.82 14.18 22 497784 17818 110073675
Hypoacusis 29.64 14.18 72 497734 35119 110056374
Radiculopathy 29.63 14.18 26 497780 19310 110072183
Blood test abnormal 29.48 14.18 52 497754 28502 110062991
Tender joint count 29.47 14.18 34 497772 1373 110090120
Prostate cancer 29.41 14.18 80 497726 37561 110053932
Retinal haemorrhage 29.29 14.18 4 497802 9497 110081996
Hyperreflexia 29.23 14.18 4 497802 9481 110082012
Retinal detachment 29.21 14.18 7 497799 11093 110080400
Drug level above therapeutic 29.17 14.18 8 497798 11580 110079913
Renal disorder 29.15 14.18 119 497687 49360 110042133
Neck mass 29.11 14.18 66 497740 4755 110086738
Hepatomegaly 29.11 14.18 32 497774 21382 110070111
Hypoxic-ischaemic encephalopathy 29.07 14.18 3 497803 8844 110082649
Spinal fusion surgery 28.97 14.18 99 497707 9057 110082436
Oesophageal carcinoma 28.92 14.18 8 497798 11516 110079977
Orthopnoea 28.90 14.18 7 497799 11014 110080479
Disease recurrence 28.87 14.18 158 497648 60626 110030867
Dermatitis bullous 28.81 14.18 22 497784 17507 110073986
Infusion site swelling 28.54 14.18 5 497801 9872 110081621
Injection site pruritus 28.52 14.18 126 497680 51132 110040361
Muscle atrophy 28.42 14.18 12 497794 13242 110078251
Clostridium test positive 28.41 14.18 7 497799 10886 110080607
Injection site induration 28.39 14.18 8 497798 11375 110080118
Dental caries 28.31 14.18 11 497795 12762 110078731
Blood thyroid stimulating hormone increased 28.26 14.18 10 497796 12291 110079202
Grip strength 28.20 14.18 98 497708 9043 110082450
Ecchymosis 28.19 14.18 22 497784 17316 110074177
Tuberculosis 28.18 14.18 156 497650 17618 110073875
Granulocytopenia 28.10 14.18 11 497795 12704 110078789
Blood potassium increased 28.03 14.18 68 497738 33181 110058312
Hepatitis acute 27.84 14.18 26 497780 18740 110072753
Hypercalcaemia 27.82 14.18 327 497479 46330 110045163
Face oedema 27.78 14.18 69 497737 33400 110058093
Epstein-Barr virus infection 27.75 14.18 26 497780 18712 110072781
Sexual dysfunction 27.75 14.18 3 497803 8527 110082966
Normochromic normocytic anaemia 27.71 14.18 12 497794 13045 110078448
Haematocrit decreased 27.62 14.18 179 497627 65938 110025555
Eosinophilic granulomatosis with polyangiitis 27.61 14.18 7 497799 10679 110080814
Ischaemia 27.59 14.18 4 497802 9079 110082414
Hypercapnia 27.54 14.18 8 497798 11151 110080342
Short stature 27.50 14.18 29 497777 1058 110090435
Rales 27.45 14.18 43 497763 24696 110066797
Pseudomonal sepsis 27.44 14.18 4 497802 9042 110082451
Neutropenic sepsis 27.43 14.18 61 497745 30685 110060808
Aplasia pure red cell 27.34 14.18 5 497801 9573 110081920
Caesarean section 27.32 14.18 14 497792 13803 110077690
Rheumatic disorder 27.30 14.18 54 497752 3537 110087956
Carotid artery occlusion 27.29 14.18 5 497801 9560 110081933
Depressive symptom 27.27 14.18 3 497803 8411 110083082
Multiple sclerosis 27.26 14.18 46 497760 25652 110065841
Hypertonia 27.24 14.18 3 497803 8403 110083090
Procedural complication 27.23 14.18 3 497803 8402 110083091
Anosmia 27.21 14.18 11 497795 12461 110079032
Antinuclear antibody positive 27.17 14.18 97 497709 9071 110082422
Large intestine perforation 27.17 14.18 21 497785 16608 110074885
Pain in jaw 27.16 14.18 128 497678 51049 110040444
Graft versus host disease in gastrointestinal tract 27.12 14.18 4 497802 8964 110082529
Aphonia 27.01 14.18 12 497794 12848 110078645
Increased appetite 27.00 14.18 17 497789 14960 110076533
Cyst 26.97 14.18 146 497660 16350 110075143
Protein urine present 26.96 14.18 9 497797 11475 110080018
Coronary artery occlusion 26.95 14.18 19 497787 15753 110075740
Joint injury 26.89 14.18 287 497519 39707 110051786
Extrasystoles 26.87 14.18 3 497803 8315 110083178
Anovulatory cycle 26.80 14.18 13 497793 129 110091364
Foot operation 26.68 14.18 83 497723 7230 110084263
Heart rate irregular 26.66 14.18 73 497733 34201 110057292
Graft versus host disease in skin 26.61 14.18 3 497803 8251 110083242
Complication of device insertion 26.60 14.18 4 497802 8834 110082659
Illness 26.52 14.18 239 497567 81932 110009561
Respiratory rate increased 26.52 14.18 45 497761 25038 110066455
Haemorrhoids 26.26 14.18 78 497728 35594 110055899
Atrioventricular block complete 26.22 14.18 31 497775 20051 110071442
Paradoxical drug reaction 26.21 14.18 6 497800 9811 110081682
Gastric haemorrhage 26.12 14.18 20 497786 15895 110075598
Cartilage atrophy 26.06 14.18 14 497792 175 110091318
Hallucinations, mixed 26.01 14.18 4 497802 8689 110082804
Supraventricular extrasystoles 25.86 14.18 3 497803 8070 110083423
Cytopenia 25.86 14.18 61 497745 30055 110061438
Breast cancer metastatic 25.84 14.18 9 497797 11172 110080321
Osteopenia 25.83 14.18 180 497626 22029 110069464
Pneumonia viral 25.75 14.18 9 497797 11148 110080345
Hepatic cancer 25.75 14.18 9 497797 11147 110080346
Premature labour 25.73 14.18 5 497801 9167 110082326
Drug effective for unapproved indication 25.65 14.18 16 497790 14151 110077342
Duodenal ulcer 25.61 14.18 30 497776 19484 110072009
Catheter site infection 25.56 14.18 3 497803 7997 110083496
Facial pain 25.53 14.18 19 497787 15320 110076173
Medication error 25.50 14.18 638 497168 104728 109986765
Neoplasm 25.49 14.18 9 497797 11078 110080415
Bacterial test positive 25.46 14.18 3 497803 7974 110083519
Memory impairment 25.44 14.18 1107 496699 195837 109895656
Infusion site erythema 25.37 14.18 11 497795 11948 110079545
Pneumatosis intestinalis 25.35 14.18 4 497802 8525 110082968
Azotaemia 25.31 14.18 7 497799 10078 110081415
Frequent bowel movements 25.30 14.18 457 497349 70933 110020560
Venous thrombosis 25.25 14.18 4 497802 8501 110082992
Personality change 25.18 14.18 9 497797 10993 110080500
Cardiopulmonary failure 25.16 14.18 3 497803 7900 110083593
Metabolic disorder 25.09 14.18 8 497798 10502 110080991
Erysipelas 25.04 14.18 14 497792 13144 110078349
Product dose omission in error 25.02 14.18 42 497764 23470 110068023
Body temperature increased 25.01 14.18 144 497662 54569 110036924
Oral candidiasis 24.92 14.18 110 497696 44650 110046843
Thinking abnormal 24.89 14.18 19 497787 15121 110076372
Fungal infection 24.71 14.18 131 497675 50675 110040818
Initial insomnia 24.64 14.18 8 497798 10381 110081112
Vasculitis 24.60 14.18 81 497725 35792 110055701
Lymphoproliferative disorder 24.58 14.18 80 497726 7138 110084355
Metastases to lymph nodes 24.54 14.18 19 497787 15013 110076480
Therapy partial responder 24.52 14.18 85 497721 36976 110054517
Hypocholesterolaemia 24.47 14.18 74 497732 6347 110085146
Aspartate aminotransferase increased 24.38 14.18 541 497265 159395 109932098
Euphoric mood 24.37 14.18 5 497801 8822 110082671
Glucose tolerance impaired 24.37 14.18 7 497799 9830 110081663
Polydipsia 24.27 14.18 3 497803 7685 110083808
Guillain-Barre syndrome 24.23 14.18 9 497797 10735 110080758
Blood glucose abnormal 24.21 14.18 14 497792 12902 110078591
Peripheral arterial occlusive disease 24.13 14.18 6 497800 9274 110082219
Device related sepsis 24.10 14.18 3 497803 7644 110083849
Blood pressure inadequately controlled 24.05 14.18 3 497803 7630 110083863
Eyelid oedema 24.02 14.18 20 497786 15242 110076251
Spinal meningioma benign 23.99 14.18 11 497795 95 110091398
Eye movement disorder 23.96 14.18 7 497799 9721 110081772
Amenorrhoea 23.94 14.18 6 497800 9225 110082268
Oral lichen planus 23.93 14.18 25 497781 902 110090591
Tinnitus 23.75 14.18 167 497639 60373 110031120
Inflammatory pain 23.67 14.18 32 497774 1521 110089972
Spinal fracture 23.57 14.18 41 497765 22592 110068901
Rotator cuff repair 23.51 14.18 39 497767 2227 110089266
Intracranial pressure increased 23.47 14.18 9 497797 10526 110080967
Blood immunoglobulin E increased 23.43 14.18 3 497803 7479 110084014
Aortic stenosis 23.30 14.18 15 497791 13044 110078449
Aortic arteriosclerosis 23.30 14.18 10 497796 10928 110080565
Cholecystitis acute 23.26 14.18 22 497784 15760 110075733
Protein total decreased 23.13 14.18 10 497796 10880 110080613
Neuritis 23.09 14.18 3 497803 7396 110084097
Refusal of treatment by patient 23.07 14.18 7 497799 9487 110082006
Respiratory tract congestion 23.06 14.18 67 497739 30790 110060703
Hepatitis C 23.04 14.18 14 497792 12559 110078934
Product administration interrupted 23.00 14.18 11 497795 11281 110080212
Blood culture positive 22.96 14.18 6 497800 8970 110082523
Meningitis 22.93 14.18 12 497794 11690 110079803
Sputum discoloured 22.89 14.18 58 497748 27887 110063606
Weber tuning fork test abnormal 22.78 14.18 11 497795 108 110091385
Ventricular hypokinesia 22.72 14.18 11 497795 11203 110080290
Blood folate decreased 22.65 14.18 39 497767 2296 110089197
Parathyroid disorder 22.64 14.18 21 497785 654 110090839
Fibrin D dimer increased 22.62 14.18 8 497798 9837 110081656
Phlebitis 22.61 14.18 8 497798 9833 110081660
Eczema 22.58 14.18 212 497594 72081 110019412
Pancreatitis 22.56 14.18 291 497515 93242 109998251
Multiple-drug resistance 22.54 14.18 16 497790 13219 110078274
Investigation abnormal 22.50 14.18 40 497766 2416 110089077
Tachyarrhythmia 22.16 14.18 5 497801 8256 110083237
Upper respiratory tract infection 22.14 14.18 437 497369 130891 109960602
Mycobacterium tuberculosis complex test positive 22.11 14.18 47 497759 3241 110088252
Skin abrasion 22.11 14.18 24 497782 16127 110075366
Dermatitis acneiform 22.08 14.18 15 497791 12680 110078813
Head discomfort 22.07 14.18 32 497774 18968 110072525
Herpes simplex 22.05 14.18 23 497783 15741 110075752
Long QT syndrome 21.94 14.18 3 497803 7115 110084378
Hereditary angioedema 21.92 14.18 3 497803 7111 110084382
Blood phosphorus decreased 21.89 14.18 4 497802 7661 110083832
Injection site bruising 21.82 14.18 138 497668 51125 110040368
Cachexia 21.79 14.18 16 497790 12989 110078504
Cytomegalovirus colitis 21.70 14.18 3 497803 7058 110084435
Portal hypertension 21.67 14.18 6 497800 8631 110082862
Lung consolidation 21.65 14.18 10 497796 10466 110081027
Antipsychotic drug level increased 21.52 14.18 3 497803 7012 110084481
Sluggishness 21.50 14.18 4 497802 7563 110083930
Bronchitis 21.49 14.18 540 497266 156492 109935001
Femur fracture 21.44 14.18 115 497691 44354 110047139
Hyperpyrexia 21.41 14.18 5 497801 8064 110083429
Elbow deformity 21.34 14.18 30 497776 1480 110090013
White blood cells urine positive 21.33 14.18 4 497802 7520 110083973
Eye irritation 21.28 14.18 78 497728 33374 110058119
Spondyloarthropathy 21.24 14.18 31 497775 1583 110089910
Conjunctivitis allergic 21.18 14.18 3 497803 6928 110084565
Oral herpes 21.11 14.18 87 497719 35993 110055500
Affect lability 21.05 14.18 32 497774 18605 110072888
Renal function test abnormal 21.02 14.18 7 497799 8939 110082554
Bladder disorder 20.98 14.18 12 497794 11125 110080368
Escherichia sepsis 20.93 14.18 10 497796 10262 110081231
Non-small cell lung cancer 20.89 14.18 5 497801 7930 110083563
Granulomatous dermatitis 20.88 14.18 18 497788 508 110090985
Blood creatine increased 20.88 14.18 13 497793 11508 110079985
Blood pressure systolic decreased 20.68 14.18 18 497788 13423 110078070
Cardiovascular disorder 20.43 14.18 45 497761 22715 110068778
Confusional state 20.38 14.18 2409 495397 466271 109625222
Femoral neck fracture 20.37 14.18 16 497790 12551 110078942
Performance status decreased 20.30 14.18 4 497802 7262 110084231
Shoulder arthroplasty 20.27 14.18 48 497758 3559 110087934
Duodenitis 20.25 14.18 8 497798 9188 110082305
Angiopathy 20.22 14.18 7 497799 8723 110082770
Streptococcal infection 20.13 14.18 12 497794 10878 110080615
Bedridden 20.08 14.18 116 497690 13309 110078184
Vitreous floaters 20.02 14.18 8 497798 9126 110082367
Intervertebral disc annular tear 19.91 14.18 8 497798 48 110091445
Arteriospasm coronary 19.90 14.18 8 497798 9092 110082401
Vitamin D deficiency 19.87 14.18 33 497773 18519 110072974
Hunger 19.85 14.18 3 497803 6601 110084892
Amnesia 19.82 14.18 618 497188 104790 109986703
Nail psoriasis 19.78 14.18 20 497786 694 110090799
Heart rate decreased 19.76 14.18 258 497548 82498 110008995
Middle insomnia 19.70 14.18 39 497767 20463 110071030
Smear cervix abnormal 19.68 14.18 40 497766 2672 110088821
Pneumonia pseudomonal 19.39 14.18 5 497801 7541 110083952
Pancreatic carcinoma 19.37 14.18 23 497783 14849 110076644
Embolism 19.35 14.18 27 497779 16262 110075231
Hyperventilation 19.35 14.18 8 497798 8939 110082554
Atrial septal defect acquired 19.34 14.18 7 497799 30 110091463
Anticipatory anxiety 19.32 14.18 26 497780 1230 110090263
Blood albumin decreased 19.27 14.18 62 497744 27590 110063903
Foetal exposure during pregnancy 19.23 14.18 5 497801 7500 110083993
Fluid intake reduced 19.20 14.18 4 497802 6982 110084511
Parainfluenzae virus infection 19.15 14.18 4 497802 6970 110084523
Wound dehiscence 19.12 14.18 6 497800 7956 110083537
Eye haemorrhage 19.07 14.18 15 497791 11759 110079734
Choking 19.02 14.18 24 497782 15086 110076407
Food intolerance 19.00 14.18 54 497752 4473 110087020
Occult blood positive 19.00 14.18 5 497801 7440 110084053
Intermenstrual bleeding 19.00 14.18 4 497802 6930 110084563
Type I hypersensitivity 19.00 14.18 3 497803 6390 110085103
Xyphoid retraction 18.91 14.18 11 497795 162 110091331
Carotid artery stenosis 18.90 14.18 9 497797 9254 110082239
Diabetes mellitus 18.84 14.18 324 497482 99057 109992436
Cardiac tamponade 18.83 14.18 14 497792 11293 110080200
Asthma-chronic obstructive pulmonary disease overlap syndrome 18.80 14.18 3 497803 6341 110085152
Muscle haemorrhage 18.74 14.18 4 497802 6865 110084628
Precancerous cells present 18.74 14.18 26 497780 1267 110090226
Squamous cell carcinoma 18.72 14.18 34 497772 18429 110073064
Cardiac pacemaker insertion 18.62 14.18 3 497803 6298 110085195
Persecutory delusion 18.58 14.18 3 497803 6288 110085205
Heavy menstrual bleeding 18.58 14.18 28 497778 16337 110075156
Platelet count abnormal 18.55 14.18 3 497803 6279 110085214
Pulmonary function test decreased 18.46 14.18 8 497798 8692 110082801
Pulmonary toxicity 18.44 14.18 140 497666 17606 110073887
Systemic candida 18.43 14.18 11 497795 9963 110081530
Brain abscess 18.37 14.18 4 497802 6770 110084723
Posthaemorrhagic hydrocephalus 18.30 14.18 8 497798 61 110091432
Liver abscess 18.28 14.18 6 497800 7733 110083760
Renal cancer 18.25 14.18 19 497787 13015 110078478
Hepatic necrosis 18.25 14.18 11 497795 9911 110081582
Neutrophilia 18.24 14.18 12 497794 10317 110081176
Blood thyroid stimulating hormone decreased 18.21 14.18 5 497801 7234 110084259
Diverticulum 18.18 14.18 26 497780 15500 110075993
Adenoiditis 18.15 14.18 7 497799 37 110091456
Hypopnoea 18.12 14.18 100 497706 11280 110080213
Hepatocellular carcinoma 18.11 14.18 11 497795 9869 110081624
Atrial appendage closure 18.08 14.18 8 497798 63 110091430
Tender joint count increased 18.02 14.18 15 497791 403 110091090
Elbow operation 17.97 14.18 16 497790 472 110091021
Tubulointerstitial nephritis 17.91 14.18 157 497649 54127 110037366
Thoracic vertebral fracture 17.90 14.18 4 497802 6651 110084842
Major depression 17.88 14.18 13 497793 10608 110080885
Laryngeal oedema 17.86 14.18 11 497795 9796 110081697
Ocular discomfort 17.86 14.18 8 497798 8525 110082968
Pneumonia klebsiella 17.81 14.18 4 497802 6628 110084865
Neutropenic colitis 17.78 14.18 7 497799 8058 110083435
Thrombotic thrombocytopenic purpura 17.73 14.18 5 497801 7106 110084387
Seasonal allergy 17.70 14.18 39 497767 19683 110071810
Retroperitoneal haemorrhage 17.68 14.18 3 497803 6062 110085431
Hyperprolactinaemia 17.59 14.18 4 497802 6571 110084922
Spinal cord compression 17.59 14.18 6 497800 7546 110083947
Coronary artery bypass 17.58 14.18 3 497803 6039 110085454
Drug reaction with eosinophilia and systemic symptoms 17.52 14.18 489 497317 81606 110009887
Bone density increased 17.50 14.18 22 497784 973 110090520
Foot fracture 17.49 14.18 184 497622 25362 110066131
Mean cell volume decreased 17.47 14.18 61 497745 5641 110085852
Sensation of foreign body 17.46 14.18 7 497799 7968 110083525
Headache 17.44 14.18 3607 494199 878770 109212723
Haemothorax 17.42 14.18 5 497801 7026 110084467
Kidney infection 17.42 14.18 58 497748 25541 110065952
Ear discomfort 17.39 14.18 15 497791 11234 110080259
Nephropathy 17.36 14.18 21 497785 13446 110078047
Abdominal abscess 17.34 14.18 9 497797 8810 110082683
Dry throat 17.33 14.18 10 497796 9228 110082265
Diabetic neuropathy 17.30 14.18 5 497801 6994 110084499
Faeces soft 17.27 14.18 15 497791 11195 110080298
Psychiatric symptom 17.25 14.18 10 497796 9203 110082290
Upper-airway cough syndrome 17.18 14.18 28 497778 15829 110075664
Product availability issue 17.15 14.18 7 497799 7883 110083610
Crepitations 17.11 14.18 95 497711 10740 110080753
Expired product administered 17.10 14.18 8 497798 8312 110083181
Concussion 17.10 14.18 16 497790 11522 110079971
Methaemoglobinaemia 17.10 14.18 10 497796 9158 110082335
Renal cyst 17.09 14.18 35 497771 18137 110073356
Coronary arterial stent insertion 17.08 14.18 3 497803 5912 110085581
Solar urticaria 17.07 14.18 9 497797 108 110091385
Atypical pneumonia 17.05 14.18 7 497799 7855 110083638
Distributive shock 17.03 14.18 3 497803 5901 110085592
Hypogammaglobulinaemia 16.97 14.18 41 497765 20035 110071458
Rheumatoid vasculitis 16.95 14.18 17 497789 584 110090909
Skin hyperpigmentation 16.92 14.18 9 497797 8687 110082806
Pseudomembranous colitis 16.88 14.18 4 497802 6387 110085106
Pneumonia bacterial 16.86 14.18 61 497745 26200 110065293
International normalised ratio decreased 16.81 14.18 8 497798 8228 110083265
Disseminated strongyloidiasis 16.76 14.18 17 497789 592 110090901
Low density lipoprotein increased 16.76 14.18 14 497792 10652 110080841
Injection site rash 16.67 14.18 52 497754 23367 110068126
Musculoskeletal chest pain 16.60 14.18 70 497736 28777 110062716
Ureterocele 16.59 14.18 5 497801 10 110091483
Rheumatoid factor quantitative increased 16.59 14.18 5 497801 10 110091483
Oligoarthritis 16.57 14.18 19 497787 762 110090731
Normal newborn 16.57 14.18 161 497645 21735 110069758
Ear pain 16.56 14.18 334 497472 52892 110038601
Abdominal tenderness 16.51 14.18 19 497787 12438 110079055
Non-cardiac chest pain 16.51 14.18 13 497793 10185 110081308
Multiple allergies 16.45 14.18 103 497703 12160 110079333
Sputum increased 16.42 14.18 3 497803 5748 110085745
Respiratory rate decreased 16.36 14.18 4 497802 6254 110085239
Splenomegaly 16.33 14.18 56 497750 24442 110067051
Papule 16.30 14.18 13 497793 10120 110081373
Skin swelling 16.26 14.18 8 497798 8072 110083421
Bilirubin conjugated increased 16.23 14.18 4 497802 6220 110085273
Emphysema 16.19 14.18 41 497765 19715 110071778
Clonal haematopoiesis 16.15 14.18 10 497796 166 110091327
Electrocardiogram T wave inversion 16.14 14.18 3 497803 5677 110085816
Sleep disorder due to general medical condition, hypersomnia type 16.13 14.18 31 497775 1988 110089505
White blood cell count increased 16.10 14.18 323 497483 96519 109994974
Purpura 16.09 14.18 56 497750 24332 110067161
Electroencephalogram abnormal 16.04 14.18 4 497802 6169 110085324
Cytomegalovirus chorioretinitis 16.03 14.18 6 497800 7122 110084371
Skin infection 16.01 14.18 50 497756 22459 110069034
Postoperative wound infection 15.98 14.18 29 497777 15724 110075769
Transplant failure 15.96 14.18 3 497803 5632 110085861
Hyperkeratosis 15.96 14.18 11 497795 9228 110082265
Hypokinesia 15.87 14.18 48 497758 21778 110069715
Oxygen saturation abnormal 15.87 14.18 3 497803 5608 110085885
Post-traumatic stress disorder 15.79 14.18 5 497801 6591 110084902
Trismus 15.79 14.18 5 497801 6591 110084902
Limb discomfort 15.72 14.18 265 497541 40589 110050904
Dyspnoea at rest 15.71 14.18 9 497797 8337 110083156
Fungaemia 15.70 14.18 4 497802 6082 110085411
Juvenile idiopathic arthritis 15.67 14.18 61 497745 5946 110085547
Proctalgia 15.62 14.18 22 497784 13200 110078293
Arthritis enteropathic 15.61 14.18 14 497792 417 110091076
Lymphoma 15.60 14.18 149 497657 20022 110071471
Drug level decreased 15.58 14.18 38 497768 18510 110072983
Skin fissures 15.58 14.18 57 497749 24401 110067092
Cutaneous B-cell lymphoma 15.56 14.18 9 497797 131 110091362
Haemophagocytic lymphohistiocytosis 15.56 14.18 81 497725 31478 110060015
Ossicle disorder 15.52 14.18 6 497800 32 110091461
Increased tendency to bruise 15.52 14.18 18 497788 11740 110079753
Ear canal erythema 15.42 14.18 7 497799 59 110091434
Gastrointestinal inflammation 15.42 14.18 12 497794 9457 110082036
Tongue oedema 15.40 14.18 9 497797 8247 110083246
Mouth haemorrhage 15.39 14.18 23 497783 13465 110078028
Burning sensation 15.36 14.18 219 497587 68993 110022500
Staphylococcus test positive 15.29 14.18 7 497799 7363 110084130
Red blood cell sedimentation rate decreased 15.26 14.18 24 497782 1310 110090183
Troponin I increased 15.24 14.18 3 497803 5449 110086044
Bipolar disorder 15.20 14.18 11 497795 8996 110082497
Autoimmune thyroiditis 15.18 14.18 5 497801 6429 110085064
Hypoproteinaemia 15.16 14.18 4 497802 5941 110085552
Bone disorder 15.13 14.18 47 497759 21145 110070348
Blood pressure abnormal 15.12 14.18 51 497755 22373 110069120
Libido decreased 15.12 14.18 4 497802 5931 110085562
Paranasal sinus discomfort 15.07 14.18 5 497801 6400 110085093
Toothache 14.98 14.18 55 497751 23520 110067973
Anti-saccharomyces cerevisiae antibody 14.94 14.18 5 497801 16 110091477
Incorrect dose administered by device 14.88 14.18 6 497800 6808 110084685
Nephrolithiasis 14.88 14.18 209 497597 66003 110025490
Ganglioneuroma 14.88 14.18 9 497797 143 110091350
Haemorrhoidal haemorrhage 14.85 14.18 9 497797 8084 110083409
Scleroderma 14.83 14.18 5 497801 6336 110085157
Jugular vein thrombosis 14.82 14.18 3 497803 5342 110086151
Metastases to spine 14.81 14.18 3 497803 5340 110086153
Lung neoplasm 14.79 14.18 9 497797 8067 110083426
Panic reaction 14.72 14.18 3 497803 5319 110086174
Injection site urticaria 14.68 14.18 35 497771 17180 110074313
Mite allergy 14.62 14.18 4 497802 5799 110085694
Transplant rejection 14.56 14.18 172 497634 24395 110067098
General physical condition abnormal 14.55 14.18 8 497798 7582 110083911
Oropharyngeal discomfort 14.52 14.18 15 497791 10312 110081181
Rash pustular 14.52 14.18 22 497784 12807 110078686
Venous thrombosis limb 14.50 14.18 3 497803 5262 110086231
Superinfection 14.46 14.18 4 497802 5759 110085734
Poor quality sleep 14.45 14.18 71 497735 28006 110063487
Drug use disorder 14.43 14.18 38 497768 18036 110073457
Coronavirus infection 14.43 14.18 13 497793 9532 110081961
Injection site warmth 14.35 14.18 36 497770 17369 110074124
Diverticulum intestinal 14.35 14.18 19 497787 11700 110079793
Congestive hepatopathy 14.32 14.18 3 497803 5217 110086276
Abnormal loss of weight 14.31 14.18 15 497791 10242 110081251
Allergy to chemicals 14.29 14.18 40 497766 3285 110088208
Extrapulmonary tuberculosis 14.25 14.18 15 497791 546 110090947
Urine abnormality 14.22 14.18 12 497794 9084 110082409
Human anti-human antibody test 14.20 14.18 13 497793 398 110091095
Mean cell haemoglobin decreased 14.19 14.18 67 497739 7107 110084386

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07EC01 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Aminosalicylic acid and similar agents
FDA CS M0000971 Aminosalicylic Acids
MeSH PA D000700 Analgesics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
FDA EPC N0000175781 Aminosalicylate
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:55324 gastrointestinal drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:76797 EC 2.5.1.18 (glutathione transferase) inhibitor
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:173085 ferroptosis inducer

Related Drugs by ATC class:

A07EC Aminosalicylic acid and similar agents 3 drugs
balsalazidemesalazineolsalazine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Juvenile rheumatoid arthritis indication 410795001
Collagenous colitis off-label use 19311003 DOID:0060183
Psoriasis with arthropathy off-label use 33339001
Crohn's disease off-label use 34000006
Systemic sclerosis off-label use 89155008 DOID:418
Urinary tract obstruction contraindication 7163005 DOID:5200
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Gastrointestinal obstruction contraindication 126765001
Asthma contraindication 195967001 DOID:2841
Disease of liver contraindication 235856003 DOID:409
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449
Porphyria contraindication 418470004
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.28 acidic
pKa2 8.93 acidic
pKa3 11.45 acidic
pKa4 1.48 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cyclooxygenase Enzyme INHIBITOR CHEMBL CHEMBL
Arachidonate 5-lipoxygenase Enzyme INHIBITOR WOMBAT-PK CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 6.34 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 5.16 CHEMBL
Acetyl-CoA acetyltransferase, mitochondrial Enzyme WOMBAT-PK
Cystine/glutamate transporter Transporter IC50 4.52 CHEMBL
Caspase-1 Enzyme IC50 4.54 DRUG MATRIX
Flavin reductase (NADPH) Enzyme Kd 6.36 CHEMBL
Thromboxane-A synthase Enzyme IC50 4.71 DRUG MATRIX
Interstitial collagenase Enzyme IC50 4.63 DRUG MATRIX
Proton-coupled folate transporter Transporter INHIBITOR IC50 4.20 IUPHAR
Mitogen-activated protein kinase 1 Kinase IC50 5.20 DRUG MATRIX
Sodium/bile acid cotransporter Transporter IC50 5.02 CHEMBL
Multidrug resistance protein 1 Transporter EC50 6.04 CHEMBL
Bifunctional purine biosynthesis protein PURH Enzyme Ki 4.66 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.06 CHEMBL
Androgen receptor Transcription factor Ki 4.53 DRUG MATRIX
Aldose reductase Enzyme IC50 4.77 DRUG MATRIX
Replicase polyprotein 1ab Enzyme Kd 5.12 CHEMBL

External reference:

IDSource
4017897 VUID
N0000146249 NUI
D00448 KEGG_DRUG
4017897 VANDF
4019494 VANDF
C0036078 UMLSCUI
CHEBI:9334 CHEBI
SAS PDB_CHEM_ID
CHEMBL421 ChEMBL_ID
D012460 MESH_DESCRIPTOR_UI
DB00795 DRUGBANK_ID
5339 PUBCHEM_CID
4840 IUPHAR_LIGAND_ID
2210 INN_ID
3XC8GUZ6CB UNII
202770 RXNORM
2061 MMSL
37855 MMSL
37856 MMSL
3946 MMSL
5056 MMSL
5528 MMSL
663 MMSL
d00379 MMSL
d01031 MMSL
001600 NDDF
002832 NDDF
387248006 SNOMEDCT_US
387501005 SNOMEDCT_US
45844004 SNOMEDCT_US
86977007 SNOMEDCT_US
C0127615 UMLSCUI
DB00244 DRUGBANK_ID
4075 PUBCHEM_CID
CHEBI:6775 CHEBI
3XC8GUZ6CB INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Azulfidine HUMAN PRESCRIPTION DRUG LABEL 1 0013-0101 TABLET 500 mg ORAL NDA 25 sections
AzulfidineEN-tabs HUMAN PRESCRIPTION DRUG LABEL 1 0013-0102 TABLET, DELAYED RELEASE 500 mg ORAL NDA 24 sections
AzulfidineEN-tabs HUMAN PRESCRIPTION DRUG LABEL 1 0013-0102 TABLET, DELAYED RELEASE 500 mg ORAL NDA 24 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3234 TABLET 500 mg ORAL ANDA 23 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 10544-288 TABLET 500 mg ORAL ANDA 29 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 11534-200 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 11534-201 TABLET, DELAYED RELEASE 500 mg ORAL ANDA 26 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 16571-261 TABLET 500 mg ORAL ANDA 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 33261-756 TABLET 500 mg ORAL ANDA 29 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 43353-495 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 27 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-0086 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 50090-6936 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 59762-0104 TABLET, DELAYED RELEASE 500 mg ORAL NDA AUTHORIZED GENERIC 26 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 59762-5000 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 26 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 60687-932 TABLET 500 mg ORAL ANDA 14 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 62135-960 TABLET 500 mg ORAL ANDA 14 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 63629-9715 TABLET 500 mg ORAL ANDA 23 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 70518-1829 TABLET 500 mg ORAL NDA authorized generic 25 sections
Sulfasalazine HUMAN PRESCRIPTION DRUG LABEL 1 71610-706 TABLET 500 mg ORAL NDA AUTHORIZED GENERIC 26 sections