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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
asulacrine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
acridine derivatives
252
80841-47-0
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
asulacrine
amsalog
derivative of amsacrine; structure given in first source
Molecular weight: 464.54
Formula: C24H24N4O4S
CLOGP: 4.37
LIPINSKI: 0
HAC: 8
HDO: 3
TPSA: 109.42
ALOGS: -5.06
ROTB: 5
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
34 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)
2.60 mL/min/kg
Lombardo F, Berellini G, Obach RS
t_half (Half-life)
2.40 hours
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.30 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.00 %
Lombardo F, Berellini G, Obach RS
Showing 1 to 5 of 5 entries
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
MeSH PA
D000970
Antineoplastic Agents
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D059005
Topoisomerase II Inhibitors
MeSH PA
D059003
Topoisomerase Inhibitors
Showing 1 to 4 of 4 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.86
acidic
pKa2
11.92
acidic
pKa3
7.74
Basic
Showing 1 to 3 of 3 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
DNA topoisomerase 2-alpha
Enzyme
P11388
TOP2A_HUMAN
WOMBAT-PK
Showing 1 to 1 of 1 entries
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External reference:
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ID
Source
107924
PUBCHEM_CID
C0130561
UMLSCUI
C042315
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135753
CHEBI
CHEMBL48880
ChEMBL_ID
S8P50T62B6
UNII
Showing 1 to 6 of 6 entries
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Pharmaceutical products:
None
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asulacrine