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strychnine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2484	57-24-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: strychnine Strychnidin-10-one (-)-Strychnine strychnin strychnine hydrochloride strychnine sulfate strychnine HCl	An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison. Molecular weight: 334.42 Formula: C21H22N2O2 CLOGP: 1.28 LIPINSKI: 0 HAC: 4 HDO: 0 TPSA: 32.78 ALOGS: -2.29 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

strychnine
Strychnidin-10-one
(-)-Strychnine
strychnin
strychnine hydrochloride
strychnine sulfate
strychnine HCl

An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.

Molecular weight: 334.42
Formula: C21H22N2O2
CLOGP: 1.28
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 32.78
ALOGS: -2.29
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D000697	Central Nervous System Stimulants
MeSH PA	D003292	Convulsants
MeSH PA	D018684	Glycine Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D009676	Noxae
MeSH PA	D011042	Poisons
CHEBI has role	CHEBI:33288	rodenticides
CHEBI has role	CHEBI:33289	avicides
CHEBI has role	CHEBI:35942	neurotransmitter agents
CHEBI has role	CHEBI:48873	acetylcholine receptor antagonist
CHEBI has role	CHEBI:62754	glycine receptor antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.32	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN	ALLOSTERIC MODULATOR	Kd	5	IUPHAR
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN	ALLOSTERIC MODULATOR	Kd	5	IUPHAR
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN	ALLOSTERIC MODULATOR	Kd	5.70	IUPHAR
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN	ALLOSTERIC MODULATOR	Kd	5	IUPHAR
Glycine receptor subunit alpha-1	Ion channel	P23415	GLRA1_HUMAN		IC50	4.70	CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	4.68	CHEMBL
Taste receptor type 2 member 10	GPCR	Q9NYW0	T2R10_HUMAN		EC50	5.30	CHEMBL
Taste receptor type 2 member 46	GPCR	P59540	T2R46_HUMAN	AGONIST	EC50	6.37	SCIENTIFIC LITERATURE
Glycine receptor subunit alpha-1	Ion channel		GLRA1_RAT		Ki	7.92	CHEMBL

External reference:

ID	Source
4019934	VUID
N0000148019	NUI
1421-86-9	SECONDARY_CAS_RN
60-41-3	SECONDARY_CAS_RN
4019131	VANDF
4019934	VANDF
C0202474	UMLSCUI
CHEBI:28973	CHEBI
SY9	PDB_CHEM_ID
CHEMBL227934	ChEMBL_ID
DB15954	DRUGBANK_ID
D013331	MESH_DESCRIPTOR_UI
441071	PUBCHEM_CID
347	IUPHAR_LIGAND_ID
H9Y79VD43J	UNII
236074	RXNORM
NOCODE	MMSL
001377	NDDF
005031	NDDF
005063	NDDF
354051007	SNOMEDCT_US
51200005	SNOMEDCT_US
CHEMBL2165710	ChEMBL_ID
CHEMBL2103753	ChEMBL_ID

Pharmaceutical products:

None