spironolactone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonists 2475 52-01-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • spironolactone
  • abbolactone
  • aldactone
  • aldopur
  • berlactone
  • euteberol
  • quimolactona
  • spirolactone
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
  • Molecular weight: 416.58
  • Formula: C24H32O4S
  • CLOGP: 2.84
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 60.44
  • ALOGS: -5.32
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 13.72 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
May 26, 2023 EMA Nova Laboratories Ireland Limited
Jan. 21, 1960 FDA GD SEARLE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 2277.46 9.98 1560 170635 52643 63264184
Acute kidney injury 1346.32 9.98 2493 169702 260922 63055905
Cardiac failure 1040.13 9.98 1245 170950 87897 63228930
Hyponatraemia 821.26 9.98 1247 170948 110653 63206174
Drug ineffective 635.94 9.98 1171 171024 1043594 62273233
Pulmonary arterial hypertension 599.17 9.98 494 171701 22083 63294744
Right ventricular failure 521.90 9.98 407 171788 16781 63300046
Synovitis 454.54 9.98 11 172184 186907 63129920
Pemphigus 453.87 9.98 9 172186 183717 63133110
Hepatic encephalopathy 420.23 9.98 302 171893 10980 63305847
Arthropathy 415.40 9.98 69 172126 234723 63082104
Ascites 407.42 9.98 527 171668 40201 63276626
Hand deformity 405.71 9.98 5 172190 159452 63157375
Pulmonary hypertension 404.06 9.98 501 171694 36622 63280205
Drug interaction 390.97 9.98 1437 170758 227694 63089133
Hypotension 384.49 9.98 1610 170585 270994 63045833
Systemic lupus erythematosus 384.11 9.98 55 172140 208863 63107964
Renal impairment 383.39 9.98 782 171413 87573 63229254
Glossodynia 372.25 9.98 30 172165 178846 63137981
Joint swelling 371.33 9.98 214 171981 327452 62989375
Drug intolerance 346.30 9.98 204 171991 308457 63008370
Dyspnoea 344.17 9.98 3006 169189 658307 62658520
Cardiac failure congestive 337.69 9.98 763 171432 91670 63225157
Therapeutic product effect decreased 326.02 9.98 64 172131 193123 63123704
Contraindicated product administered 324.31 9.98 94 172101 217554 63099273
Infusion related reaction 322.74 9.98 131 172064 245390 63071437
Renal failure 321.59 9.98 869 171326 116783 63200044
Maternal exposure during pregnancy 308.36 9.98 106 172089 219956 63096871
Bradycardia 308.07 9.98 640 171555 72587 63244240
Rheumatoid arthritis 303.14 9.98 155 172040 253664 63063163
Treatment failure 294.63 9.98 87 172108 198956 63117871
Oedema peripheral 292.09 9.98 1151 171044 188360 63128467
Alopecia 279.64 9.98 302 171893 337234 62979593
Dehydration 268.82 9.98 1055 171140 172299 63144528
Wound 265.31 9.98 59 172136 163204 63153623
Pain 262.96 9.98 1077 171118 739551 62577276
Fluid retention 252.59 9.98 523 171672 59163 63257664
International normalised ratio increased 246.82 9.98 448 171747 45977 63270850
Discomfort 246.14 9.98 74 172121 167300 63149527
Hypersensitivity 244.45 9.98 260 171935 292425 63024402
Atrial fibrillation 242.71 9.98 782 171413 115854 63200973
Blood creatinine increased 235.11 9.98 644 171551 87200 63229627
Abdominal discomfort 225.05 9.98 326 171869 320559 62996268
Pericarditis 221.05 9.98 44 172151 131535 63185292
Helicobacter infection 216.24 9.98 8 172187 92777 63224050
Hypervolaemia 214.25 9.98 321 171874 28092 63288735
Duodenal ulcer perforation 205.04 9.98 7 172188 87202 63229625
Musculoskeletal stiffness 199.90 9.98 127 172068 184491 63132336
Hepatic enzyme increased 196.99 9.98 156 172039 202172 63114655
Arthralgia 195.27 9.98 839 171356 568871 62747956
Blood potassium increased 187.88 9.98 240 171955 18069 63298758
Sensitisation 179.84 9.98 113 172082 3273 63313554
Rash 177.80 9.98 850 171345 560021 62756806
Cardiac failure chronic 170.81 9.98 121 172074 4297 63312530
Polycystic ovaries 169.51 9.98 121 172074 4350 63312477
Folliculitis 160.68 9.98 7 172188 70310 63246517
Exposure during pregnancy 158.98 9.98 114 172081 155433 63161394
Blood urea increased 156.27 9.98 267 171928 26112 63290715
Anaemia 155.40 9.98 1341 170854 292089 63024738
Off label use 154.45 9.98 1134 171061 673328 62643499
Swelling 152.81 9.98 324 171871 275054 63041773
Ejection fraction 150.09 9.98 89 172106 2317 63314510
Hepatic cirrhosis 150.03 9.98 253 171942 24481 63292346
Product use issue 148.69 9.98 230 171965 220290 63096537
Lower respiratory tract infection 145.97 9.98 89 172106 132218 63184609
Dyspnoea exertional 140.80 9.98 421 171774 59881 63256946
Completed suicide 138.39 9.98 115 172080 145558 63171269
Drug hypersensitivity 136.39 9.98 412 171783 310275 63006552
Melaena 128.32 9.98 266 171929 30099 63286728
Renal disorder 127.96 9.98 279 171916 32695 63284132
Product prescribing error 127.57 9.98 244 171951 26045 63290782
N-terminal prohormone brain natriuretic peptide increased 127.19 9.98 77 172118 2084 63314743
Impaired healing 123.20 9.98 62 172133 102480 63214347
Syncope 118.63 9.98 630 171565 116755 63200072
Psoriatic arthropathy 118.22 9.98 50 172145 91470 63225357
Gastrointestinal haemorrhage 116.83 9.98 483 171712 80693 63236134
Oedema 115.63 9.98 548 171647 97074 63219753
Irritable bowel syndrome 114.79 9.98 40 172155 82372 63234455
Hepatic failure 112.35 9.98 278 171917 35378 63281449
Stomatitis 107.21 9.98 131 172064 138594 63178233
Ill-defined disorder 105.06 9.98 45 172150 81710 63235117
Drug abuse 104.85 9.98 33 172162 72485 63244342
Cardiac failure acute 104.34 9.98 129 172066 9394 63307433
Cardiac disorder 104.05 9.98 339 171856 50477 63266350
Hypokalaemia 101.40 9.98 552 171643 103252 63213575
Orthopnoea 99.67 9.98 103 172092 6158 63310669
Ejection fraction abnormal 98.41 9.98 61 172134 1724 63315103
Blood pressure decreased 97.61 9.98 392 171803 64630 63252197
Glomerular filtration rate decreased 93.07 9.98 146 172049 13295 63303532
Mobility decreased 93.00 9.98 115 172080 121044 63195783
Brain natriuretic peptide increased 92.59 9.98 91 172104 5122 63311705
Cardioactive drug level increased 91.46 9.98 63 172132 2137 63314690
Blood bilirubin increased 89.25 9.98 262 171933 36878 63279949
Sinusitis 88.04 9.98 317 171878 226336 63090491
Blood cholesterol increased 87.12 9.98 76 172119 93956 63222871
Product monitoring error 86.17 9.98 82 172113 4434 63312393
Labelled drug-drug interaction medication error 85.19 9.98 140 172055 13259 63303568
Transfusion 84.88 9.98 150 172045 15067 63301760
Rhinitis allergic 84.86 9.98 130 172065 11597 63305230
Fall 84.57 9.98 1514 170681 390820 62926007
Nasopharyngitis 84.02 9.98 379 171816 253878 63062949
Pulmonary oedema 83.31 9.98 332 171863 54541 63262286
Ventricular tachycardia 83.22 9.98 174 172021 19805 63297022
Hepatocellular carcinoma 82.31 9.98 59 172136 2135 63314692
Congestive cardiomyopathy 79.71 9.98 91 172104 6091 63310736
Atrial flutter 78.84 9.98 114 172081 9658 63307169
Sleep disorder due to general medical condition, insomnia type 78.70 9.98 22 172173 52195 63264632
Infection 78.50 9.98 337 171858 228836 63087991
Pain in jaw 78.34 9.98 278 171917 43218 63273609
Chronic kidney disease 78.24 9.98 286 171909 45112 63271715
Atrioventricular block 78.07 9.98 100 172095 7547 63309280
Febrile neutropenia 76.50 9.98 127 172068 118322 63198505
Toxicity to various agents 76.15 9.98 378 171817 246872 63069955
Intentional product use issue 75.52 9.98 145 172050 127747 63189080
Cardiomegaly 75.24 9.98 155 172040 17459 63299368
Arthritis 74.21 9.98 125 172070 115796 63201031
Hip arthroplasty 73.84 9.98 19 172176 47627 63269200
Sleep apnoea syndrome 73.36 9.98 209 171986 28924 63287903
Blood test abnormal 73.30 9.98 143 172052 15486 63301341
Pleural effusion 73.16 9.98 468 171727 92742 63224085
Hepatic function abnormal 72.65 9.98 244 171951 36898 63279929
Blister 71.68 9.98 153 172042 129661 63187166
Knee arthroplasty 70.98 9.98 29 172166 54177 63262650
Pulmonary arterial pressure increased 69.98 9.98 66 172129 3529 63313298
Sputum culture positive 69.44 9.98 53 172142 2114 63314713
Gastrointestinal disorder 68.93 9.98 159 172036 131080 63185747
Abdominal distension 68.66 9.98 436 171759 86179 63230648
Vital capacity decreased 68.36 9.98 48 172147 1680 63315147
Urticaria 67.65 9.98 227 171968 165575 63151252
Concomitant disease aggravated 67.33 9.98 102 172093 9010 63307817
Hypothyroidism 65.56 9.98 259 171936 42373 63274454
Blood sodium decreased 64.02 9.98 177 172018 24075 63292752
Left ventricular failure 63.86 9.98 78 172117 5609 63311218
Liver injury 63.59 9.98 43 172152 60477 63256350
Reversible airways obstruction 63.35 9.98 47 172148 1795 63315032
Arrhythmia 62.98 9.98 237 171958 37903 63278924
Body tinea 62.39 9.98 47 172148 1838 63314989
Catheter management 62.32 9.98 57 172138 2930 63313897
Generalised oedema 61.54 9.98 134 172061 15684 63301143
Palpitations 61.43 9.98 519 171676 112251 63204576
Cardiogenic shock 60.97 9.98 144 172051 17788 63299039
Ischaemic stroke 60.84 9.98 144 172051 17813 63299014
Haematemesis 60.56 9.98 201 171994 30211 63286616
Atrioventricular block complete 60.45 9.98 92 172103 8159 63308668
Respiratory failure 60.45 9.98 478 171717 101380 63215447
Osteoarthritis 59.93 9.98 104 172091 95239 63221588
Injection site reaction 59.61 9.98 43 172152 58481 63258346
Electrolyte imbalance 58.52 9.98 152 172043 19924 63296903
Red blood cell sedimentation rate increased 58.46 9.98 23 172172 43959 63272868
General physical health deterioration 57.56 9.98 815 171380 200587 63116240
Epistaxis 56.97 9.98 365 171830 72360 63244467
Inhibitory drug interaction 56.79 9.98 53 172142 2796 63314031
Paraesthesia 56.72 9.98 226 171969 156740 63160087
Injection site pain 56.23 9.98 173 172022 129627 63187200
Catheter site infection 56.15 9.98 68 172127 4846 63311981
Paracentesis 55.64 9.98 34 172161 936 63315891
Prothrombin time prolonged 55.58 9.98 96 172099 9468 63307359
Type 2 diabetes mellitus 55.17 9.98 55 172140 63813 63253014
Tricuspid valve incompetence 54.78 9.98 122 172073 14499 63302328
Haematoma 53.91 9.98 212 171983 34608 63282219
Anaphylactic reaction 53.64 9.98 60 172135 66040 63250787
Shock haemorrhagic 53.21 9.98 96 172099 9799 63307028
Abortion spontaneous 53.07 9.98 31 172164 47164 63269663
Nephrectomy 53.04 9.98 39 172156 1469 63315358
Injection site erythema 52.02 9.98 91 172104 83083 63233744
Pericardial effusion 51.48 9.98 189 172006 29869 63286958
Device related infection 51.47 9.98 160 172035 23232 63293595
Upper gastrointestinal haemorrhage 51.17 9.98 139 172056 18713 63298114
Fatigue 51.04 9.98 1933 170262 886095 62430732
Oesophageal varices haemorrhage 50.51 9.98 35 172160 1199 63315628
Cor pulmonale 50.45 9.98 43 172152 2011 63314816
Adverse drug reaction 50.05 9.98 87 172108 79627 63237200
Congestive hepatopathy 49.74 9.98 50 172145 2892 63313935
Sleep disorder due to a general medical condition 49.43 9.98 105 172090 12083 63304744
Varices oesophageal 48.70 9.98 51 172144 3097 63313730
Bronchial secretion retention 48.49 9.98 48 172147 2725 63314102
Bursitis 48.20 9.98 20 172175 37021 63279806
Inappropriate antidiuretic hormone secretion 48.12 9.98 120 172075 15342 63301485
Hypoxia 48.01 9.98 302 171893 59490 63257337
Oxygen saturation decreased 47.87 9.98 407 171788 88178 63228649
Atrial tachycardia 47.36 9.98 58 172137 4182 63312645
Joint range of motion decreased 46.44 9.98 15 172180 32413 63284414
Carpal tunnel syndrome 46.37 9.98 143 172052 20674 63296153
Ammonia increased 46.14 9.98 60 172135 4596 63312231
Cardiomyopathy 46.08 9.98 128 172067 17456 63299371
Sleep disorder 45.97 9.98 95 172100 81471 63235356
Sinoatrial block 45.57 9.98 29 172166 859 63315968
Hypoaesthesia 45.42 9.98 269 171926 168124 63148703
Anuria 45.09 9.98 103 172092 12448 63304379
Portal hypertension 43.89 9.98 53 172142 3766 63313061
Intentional overdose 43.82 9.98 84 172111 74068 63242759
Hypovolaemia 43.34 9.98 92 172103 10581 63306246
Hypertrichosis 43.22 9.98 31 172164 1123 63315704
Hypochloraemia 43.21 9.98 39 172156 1970 63314857
Therapeutic drug monitoring analysis not performed 43.18 9.98 33 172162 1319 63315508
Chest pain 42.12 9.98 821 171374 215138 63101689
Ejection fraction decreased 41.30 9.98 144 172051 22188 63294639
Electrocardiogram QRS complex prolonged 40.42 9.98 64 172131 5874 63310953
Acute respiratory failure 40.37 9.98 193 172002 34292 63282535
Live birth 40.14 9.98 10 172185 25620 63291207
Ventricular fibrillation 40.02 9.98 95 172100 11772 63305055
Product use in unapproved indication 39.82 9.98 303 171892 178777 63138050
Sinus node dysfunction 39.77 9.98 56 172139 4629 63312198
Hypovolaemic shock 39.39 9.98 65 172130 6176 63310651
Metabolic alkalosis 39.36 9.98 45 172150 3016 63313811
Subdural haematoma 39.24 9.98 106 172089 14222 63302605
Multiple organ dysfunction syndrome 39.14 9.98 276 171919 56476 63260351
Infection susceptibility increased 39.06 9.98 48 172147 3473 63313354
Haemoptysis 39.03 9.98 168 172027 28558 63288269
Grip strength decreased 38.36 9.98 7 172188 22280 63294547
Aspartate aminotransferase increased 38.34 9.98 394 171801 89883 63226944
Blood alkaline phosphatase increased 38.29 9.98 223 171972 42744 63274083
Purpura 38.24 9.98 91 172104 11294 63305533
Therapeutic response decreased 37.85 9.98 68 172127 61457 63255370
Pregnancy 37.60 9.98 27 172168 36809 63280018
Diffuse large B-cell lymphoma refractory 37.05 9.98 29 172166 1201 63315626
Oliguria 36.44 9.98 78 172117 9023 63307804
Pulmonary congestion 36.36 9.98 117 172078 17301 63299526
Gamma-glutamyltransferase increased 35.96 9.98 185 172010 33846 63282981
Night sweats 35.71 9.98 48 172147 48766 63268061
Concomitant disease progression 35.59 9.98 36 172159 2098 63314729
Jaundice 35.18 9.98 165 172030 29086 63287741
Blood aldosterone increased 35.12 9.98 15 172180 188 63316639
Acute pulmonary oedema 35.09 9.98 72 172123 8086 63308741
Hepatorenal syndrome 34.82 9.98 34 172161 1898 63314929
Catheterisation cardiac 34.68 9.98 52 172143 4551 63312276
Sudden death 34.54 9.98 83 172112 10366 63306461
Foetal exposure during pregnancy 34.53 9.98 22 172173 31940 63284887
Mitral valve incompetence 34.22 9.98 124 172071 19470 63297357
Multiple sclerosis relapse 34.14 9.98 49 172146 48429 63268398
Cardiac output decreased 33.88 9.98 25 172170 947 63315880
Lung transplant 33.67 9.98 42 172153 3086 63313741
Bundle branch block left 33.60 9.98 65 172130 6994 63309833
Catheter placement 33.55 9.98 36 172159 2248 63314579
Rhabdomyolysis 33.44 9.98 219 171976 43732 63273095
Shock 33.25 9.98 139 172056 23324 63293503
Abdominal cavity drainage 32.94 9.98 18 172177 399 63316428
Joint stiffness 32.89 9.98 39 172156 41830 63274997
Neutropenia 32.67 9.98 310 171885 174695 63142132
Blood potassium decreased 32.33 9.98 210 171985 41816 63275011
Orthostatic hypotension 31.79 9.98 187 172008 35973 63280854
Bone erosion 31.74 9.98 5 172190 17712 63299115
Lactic acidosis 31.74 9.98 195 172000 38092 63278735
Bundle branch block right 31.47 9.98 52 172143 4946 63311881
Injury 31.44 9.98 98 172097 73149 63243678
Hospitalisation 31.36 9.98 361 171834 84720 63232107
Muscle spasticity 31.35 9.98 10 172185 21784 63295043
Urine output decreased 31.02 9.98 84 172111 11286 63305541
Haemoglobin decreased 30.72 9.98 560 171635 144925 63171902
Hypertrophic cardiomyopathy 30.63 9.98 29 172166 1558 63315269
Waist circumference increased 30.41 9.98 23 172172 905 63315922
Cardioversion 30.18 9.98 26 172169 1234 63315593
Polyuria 29.48 9.98 69 172126 8473 63308354
Jugular vein distension 29.17 9.98 23 172172 963 63315864
Macular degeneration 28.87 9.98 15 172180 24361 63292466
Decreased appetite 28.84 9.98 888 171307 250164 63066663
Cyanosis 28.59 9.98 106 172089 16829 63299998
Lip dry 28.56 9.98 4 172191 15466 63301361
N-terminal prohormone brain natriuretic peptide abnormal 28.55 9.98 9 172186 43 63316784
Injection site pruritus 28.54 9.98 49 172146 45067 63271760
Dizziness 28.46 9.98 1432 170763 428493 62888334
Intra-abdominal fluid collection 28.39 9.98 34 172161 2395 63314432
Poor quality sleep 28.17 9.98 118 172077 19817 63297010
Vascular resistance pulmonary decreased 28.05 9.98 10 172185 74 63316753
Injection site bruising 27.92 9.98 44 172151 41866 63274961
Catheter site erythema 27.62 9.98 45 172150 4231 63312596
Drug resistance 27.33 9.98 14 172181 22919 63293908
Atrial enlargement 27.15 9.98 15 172180 340 63316487
Thermohypoaesthesia 26.95 9.98 11 172184 122 63316705
Neuropathy peripheral 26.85 9.98 189 172006 113478 63203349
Left-to-right cardiac shunt 26.72 9.98 11 172184 125 63316702
Multiple allergies 26.39 9.98 90 172105 13712 63303115
Left ventricular dysfunction 26.38 9.98 82 172113 11906 63304921
Platelet count decreased 26.30 9.98 452 171743 115670 63201157
Sight disability 26.18 9.98 11 172184 132 63316695
Device stimulation issue 26.17 9.98 9 172186 59 63316768
Renin increased 26.05 9.98 12 172183 182 63316645
Inability to afford medication 26.04 9.98 32 172163 2315 63314512
Glucose tolerance impaired 25.91 9.98 56 172139 6521 63310306
Dyspnoea paroxysmal nocturnal 25.81 9.98 21 172174 920 63315907
Hyperthyroidism 25.75 9.98 93 172102 14580 63302247
Hidradenitis 25.63 9.98 35 172160 2811 63314016
Hyperbilirubinaemia 25.46 9.98 78 172117 11236 63305591
Bradyarrhythmia 25.37 9.98 30 172165 2085 63314742
Metabolic acidosis 25.36 9.98 209 171986 44860 63271967
Therapeutic product effect incomplete 25.30 9.98 217 171978 124839 63191988
Foot deformity 25.20 9.98 23 172172 27830 63288997
Inflammation 25.16 9.98 126 172069 82147 63234680
Iron deficiency anaemia 25.02 9.98 114 172081 19855 63296972
Cardiorenal syndrome 25.00 9.98 20 172175 855 63315972
Pemphigoid 24.99 9.98 59 172136 7285 63309542
Catheter site discharge 24.89 9.98 29 172166 1984 63314843
Sedation complication 24.54 9.98 4 172191 13818 63303009
Cortisol increased 24.51 9.98 15 172180 414 63316413
Tenosynovitis 24.48 9.98 4 172191 13791 63303036
Renal function test abnormal 24.35 9.98 39 172156 3614 63313213
Pulmonary arterial pressure abnormal 24.19 9.98 16 172179 507 63316320
Tachypnoea 24.13 9.98 102 172093 17200 63299627
Upper-airway cough syndrome 24.11 9.98 77 172118 11341 63305486
Gait inability 24.06 9.98 69 172126 52890 63263937
Hepatomegaly 24.04 9.98 79 172116 11810 63305017
Sinus bradycardia 23.67 9.98 90 172105 14461 63302366
Cirrhosis alcoholic 23.53 9.98 12 172183 230 63316597
Eosinophil count increased 23.35 9.98 74 172121 10854 63305973
Incorrect route of product administration 23.29 9.98 24 172171 27428 63289399
Fear of eating 23.15 9.98 14 172181 378 63316449
Ischaemic cardiomyopathy 23.12 9.98 31 172164 2446 63314381
Foreign body in reproductive tract 23.05 9.98 18 172177 743 63316084
Exercise tolerance decreased 23.04 9.98 48 172147 5449 63311378
Drug dispensed to wrong patient 22.98 9.98 13 172182 309 63316518
Haemorrhage subcutaneous 22.91 9.98 34 172161 2949 63313878
Full blood count abnormal 22.90 9.98 156 172039 31561 63285266
Portopulmonary hypertension 22.82 9.98 10 172185 134 63316693
Bilirubin conjugated increased 22.77 9.98 33 172162 2801 63314026
Calcium deficiency 22.74 9.98 21 172174 1093 63315734
C-reactive protein increased 22.60 9.98 157 172038 94550 63222277
Oxygen consumption increased 22.59 9.98 39 172156 3845 63312982
Right ventricular dilatation 22.56 9.98 23 172172 1353 63315474
Multimorbidity 22.34 9.98 16 172179 578 63316249
Cellulitis 22.32 9.98 329 171866 81629 63235198
Intentional self-injury 22.32 9.98 22 172173 25665 63291162
Hepatic cancer 22.20 9.98 42 172153 4445 63312382
Hypoglycaemia 22.19 9.98 255 171940 59810 63257017
Cardiac hypertrophy 21.91 9.98 20 172175 1025 63315802
Liver transplant 21.89 9.98 29 172166 2262 63314565
Vascular access site thrombosis 21.78 9.98 7 172188 36 63316791
Portal vein thrombosis 21.68 9.98 31 172164 2599 63314228
Transplant evaluation 21.45 9.98 21 172174 1176 63315651
Aortic valve calcification 21.39 9.98 15 172180 524 63316303
Premature labour 21.37 9.98 4 172191 12500 63304327
Peripheral circulatory failure 21.23 9.98 19 172176 949 63315878
Psychotic disorder 21.23 9.98 23 172172 25689 63291138
Dyspnoea at rest 21.20 9.98 39 172156 4040 63312787
Haemorrhagic disorder 21.19 9.98 18 172177 838 63315989
Blood loss anaemia 21.14 9.98 63 172132 8938 63307889
Stress 21.03 9.98 102 172093 67065 63249762
Poor peripheral circulation 20.96 9.98 37 172158 3712 63313115
Peritonitis bacterial 20.91 9.98 43 172152 4836 63311991
Colitis ulcerative 20.82 9.98 24 172171 26067 63290760
Metastases to central nervous system 20.74 9.98 5 172190 13100 63303727
Brain natriuretic peptide abnormal 20.73 9.98 13 172182 375 63316452
Cytomegalovirus infection 20.55 9.98 16 172179 20936 63295891
Walking distance test abnormal 20.54 9.98 15 172180 559 63316268
Bile acid malabsorption 20.53 9.98 10 172185 173 63316654
Vessel puncture site haemorrhage 20.51 9.98 9 172186 121 63316706
Dystonia 20.49 9.98 6 172189 13813 63303014
Torsade de pointes 20.43 9.98 81 172114 13270 63303557
Occult blood positive 20.24 9.98 36 172159 3634 63313193
Chronic hepatic failure 20.15 9.98 15 172180 576 63316251
Cardiac dysfunction 20.14 9.98 28 172167 2287 63314540
Catheter removal 20.08 9.98 13 172182 397 63316430
Pulmonary arterial wedge pressure increased 19.95 9.98 12 172183 321 63316506
Haemorrhoidal haemorrhage 19.88 9.98 39 172156 4240 63312587
Viral diarrhoea 19.83 9.98 10 172185 187 63316640
Myelosuppression 19.80 9.98 21 172174 23682 63293145
Pyrexia 19.74 9.98 1059 171136 469419 62847408
Pulmonary hypertensive crisis 19.58 9.98 12 172183 332 63316495
Asthenia 19.58 9.98 1248 170947 382356 62934471
Blood pressure systolic abnormal 19.51 9.98 6 172189 13380 63303447
Electrocardiogram abnormal 19.47 9.98 62 172133 9117 63307710
Joint effusion 19.47 9.98 11 172184 17049 63299778
Gastrooesophageal reflux disease 19.44 9.98 366 171829 95273 63221554
Marasmus 19.42 9.98 14 172181 511 63316316
Sputum culture 19.39 9.98 11 172184 263 63316564
Vascular access site infection 19.27 9.98 7 172188 55 63316772
Hyperuricaemia 19.21 9.98 44 172151 5326 63311501
Immunodeficiency 19.20 9.98 16 172179 20238 63296589
Multiple drug therapy 19.13 9.98 35 172160 3611 63313216
Gout 19.10 9.98 79 172116 13192 63303635
Dementia 19.05 9.98 101 172094 18693 63298134
Red cell distribution width abnormal 19.00 9.98 9 172186 146 63316681
Peripartum cardiomyopathy 19.00 9.98 9 172186 146 63316681
Gastric varices haemorrhage 18.94 9.98 9 172186 147 63316680
Cough 18.91 9.98 973 171222 291770 63025057
Right ventricular dysfunction 18.90 9.98 24 172171 1795 63315032
Device alarm issue 18.85 9.98 22 172173 1508 63315319
Electrocardiogram T wave amplitude increased 18.81 9.98 6 172189 30 63316797
Systemic infection 18.73 9.98 40 172155 4620 63312207
Neonatal respiratory failure 18.70 9.98 11 172184 282 63316545
Prerenal failure 18.62 9.98 23 172172 1673 63315154
Brain stem stroke 18.58 9.98 12 172183 365 63316462
Sciatica 18.48 9.98 41 172154 34283 63282544
Right atrial dilatation 18.34 9.98 15 172180 662 63316165
Suicidal ideation 18.29 9.98 97 172098 62324 63254503
Cardiac murmur 18.17 9.98 83 172112 14469 63302358
Adverse event 18.16 9.98 108 172087 67451 63249376
Altered state of consciousness 18.15 9.98 124 172071 25106 63291721
Diet noncompliance 18.12 9.98 12 172183 381 63316446
Nodal rhythm 18.12 9.98 23 172172 1720 63315107
Sedation 18.05 9.98 50 172145 38759 63278068
Accidental exposure to product 18.04 9.98 29 172166 27376 63289451
Vasodilatation 17.96 9.98 27 172168 2368 63314459
Oesophageal variceal ligation 17.93 9.98 5 172190 14 63316813
Anxiety 17.90 9.98 451 171744 217090 63099737
Activated partial thromboplastin time prolonged 17.89 9.98 50 172145 6843 63309984
Myocardial infarction 17.86 9.98 375 171820 99518 63217309
Pneumonia 17.82 9.98 1454 170741 455313 62861514
Foetal death 17.75 9.98 4 172191 10976 63305851
Hypercholesterolaemia 17.71 9.98 19 172176 21315 63295512
Central venous catheterisation 17.67 9.98 28 172167 2571 63314256
Chronic obstructive pulmonary disease 17.60 9.98 253 171942 62433 63254394
Back pain 17.57 9.98 564 171631 263581 63053246
Deformity 17.46 9.98 5 172190 11679 63305148
Peripheral swelling 17.41 9.98 569 171626 265373 63051454
Schizophrenia 17.40 9.98 3 172192 9949 63306878
Heart valve incompetence 17.35 9.98 29 172166 2785 63314042
Ear pain 17.20 9.98 46 172149 36072 63280755
Atrioventricular block first degree 17.17 9.98 51 172144 7222 63309605
Catheter site pain 17.17 9.98 39 172156 4696 63312131
Urine output increased 17.11 9.98 20 172175 1373 63315454
Acidosis 17.07 9.98 68 172127 11165 63305662
Aspiration pleural cavity 17.03 9.98 16 172179 851 63315976
Blood parathyroid hormone decreased 17.02 9.98 3 172192 9788 63307039
Gastric polyps 17.00 9.98 32 172163 3373 63313454
Female sexual arousal disorder 16.99 9.98 6 172189 43 63316784
Hyperglycaemia 16.95 9.98 181 172014 41686 63275141
Progressive multifocal leukoencephalopathy 16.88 9.98 7 172188 12964 63303863
Injection site swelling 16.85 9.98 69 172126 47503 63269324
Hypercapnia 16.74 9.98 42 172153 5389 63311438
Aortic stenosis 16.73 9.98 40 172155 4980 63311847
Seizure 16.68 9.98 256 171939 132378 63184449
Product odour abnormal 16.58 9.98 19 172176 1277 63315550
Leukaemic infiltration renal 16.57 9.98 5 172190 20 63316807
Oropharyngeal pain 16.52 9.98 170 172025 94317 63222510
Parkinsonism 16.51 9.98 64 172131 10375 63306452
Nodal arrhythmia 16.50 9.98 18 172177 1145 63315682
Erysipelas 16.41 9.98 53 172142 7852 63308975
Disseminated intravascular coagulation 16.41 9.98 98 172097 18953 63297874
Blood potassium abnormal 16.38 9.98 27 172168 2563 63314264
Device related sepsis 16.29 9.98 35 172160 4059 63312768
Incision site impaired healing 16.17 9.98 9 172186 207 63316620
Sinus arrest 16.11 9.98 23 172172 1926 63314901
Aortic valve incompetence 16.10 9.98 44 172151 5944 63310883
Venous pressure jugular increased 16.09 9.98 13 172182 564 63316263
Catheter site swelling 16.08 9.98 20 172175 1465 63315362
Cardiac ablation 16.08 9.98 20 172175 1465 63315362
Vascular device infection 16.07 9.98 50 172145 7262 63309565
Primary biliary cholangitis 16.05 9.98 18 172177 1181 63315646
Gouty arthritis 16.01 9.98 13 172182 568 63316259
Ventricular failure 15.97 9.98 11 172184 373 63316454
Ulcer 15.93 9.98 29 172166 26078 63290749
Blood creatine increased 15.91 9.98 42 172153 5559 63311268
Blood cholesterol decreased 15.88 9.98 16 172179 928 63315899
Cerebral infarction 15.77 9.98 115 172080 23778 63293049
Cardiac arrest 15.77 9.98 345 171850 92200 63224627
Migraine 15.68 9.98 192 172003 103154 63213673
Bleeding varicose vein 15.66 9.98 10 172185 298 63316529
Drug therapeutic incompatibility 15.52 9.98 6 172189 57 63316770
Amaurosis 15.47 9.98 13 172182 596 63316231
Akathisia 15.47 9.98 3 172192 9143 63307684
Left atrial dilatation 15.44 9.98 22 172173 1839 63314988
Blood albumin decreased 15.41 9.98 80 172115 14686 63302141
Musculoskeletal disorder 15.41 9.98 20 172175 20624 63296203
Pulmonary veno-occlusive disease 15.30 9.98 17 172178 1104 63315723
Mixed hepatocellular cholangiocarcinoma 15.28 9.98 4 172191 8 63316819
Renin decreased 15.21 9.98 7 172188 106 63316721
Malignant neoplasm progression 15.08 9.98 146 172049 81975 63234852
Low cardiac output syndrome 15.06 9.98 11 172184 410 63316417
Therapeutic embolisation 15.03 9.98 8 172187 168 63316659
Renal artery stenosis 15.01 9.98 22 172173 1887 63314940
Alanine aminotransferase increased 14.97 9.98 378 171817 103392 63213435
Splenomegaly 14.96 9.98 65 172130 11092 63305735
Hypernatraemia 14.89 9.98 50 172145 7559 63309268
Mucosal inflammation 14.85 9.98 71 172124 46857 63269970
Blood pressure systolic decreased 14.82 9.98 49 172146 7348 63309479
Gamma-glutamyltransferase abnormal 14.79 9.98 10 172185 329 63316498
Left ventricular enlargement 14.75 9.98 6 172189 66 63316761
Blood calcium decreased 14.73 9.98 31 172164 26420 63290407
Exostosis 14.72 9.98 16 172179 17846 63298981
Circulatory collapse 14.72 9.98 106 172089 21832 63294995
Embolic stroke 14.70 9.98 32 172163 3744 63313083
Product quality issue 14.68 9.98 49 172146 35816 63281011
Chronic respiratory failure 14.68 9.98 22 172173 1925 63314902
Supraventricular tachycardia 14.67 9.98 77 172118 14194 63302633
Presyncope 14.65 9.98 127 172068 27658 63289169
Tendonitis 14.64 9.98 19 172176 19596 63297231
Malignant ascites 14.59 9.98 15 172180 891 63315936
Premature baby 14.56 9.98 21 172174 20714 63296113
Suicide attempt 14.53 9.98 101 172094 60817 63256010
Pruritus 14.51 9.98 817 171378 360636 62956191
Pain in extremity 14.28 9.98 744 171451 330742 62986085
Alcoholic liver disease 14.27 9.98 7 172188 123 63316704
Upper respiratory tract inflammation 14.24 9.98 25 172170 2498 63314329
Azotaemia 14.23 9.98 35 172160 4436 63312391
Subchorionic haematoma 14.22 9.98 7 172188 124 63316703
Coagulopathy 14.21 9.98 100 172095 20444 63296383
Pericarditis constrictive 14.17 9.98 10 172185 353 63316474
Blood urea abnormal 14.17 9.98 13 172182 671 63316156
Cortisol free urine increased 14.14 9.98 5 172190 36 63316791
Pulmonary aplasia 14.14 9.98 4 172191 12 63316815
Electrocardiogram QT shortened 14.12 9.98 7 172188 126 63316701
Sepsis 14.11 9.98 528 171667 152595 63164232
Metastases to bone 14.06 9.98 22 172173 20997 63295830
Acute myocardial infarction 14.01 9.98 141 172054 31983 63284844
Hepatorenal failure 14.01 9.98 13 172182 681 63316146
Throat tightness 14.00 9.98 29 172166 24858 63291969
Blood uric acid increased 13.99 9.98 39 172156 5328 63311499
Pulmonary fibrosis 13.94 9.98 58 172137 39751 63277076
Brain natriuretic peptide 13.91 9.98 5 172190 38 63316789
Neuroglycopenia 13.82 9.98 11 172184 467 63316360
Asterixis 13.82 9.98 18 172177 1381 63315446
Urinary retention 13.70 9.98 134 172061 30167 63286660
Postpericardiotomy syndrome 13.67 9.98 4 172191 14 63316813
Blood catecholamines decreased 13.67 9.98 4 172191 14 63316813
Inferior vena cava dilatation 13.65 9.98 6 172189 81 63316746
Angina pectoris 13.60 9.98 133 172062 29945 63286882
Oligohydramnios 13.50 9.98 43 172152 6323 63310504
Panniculitis 13.49 9.98 7 172188 11378 63305449
No adverse event 13.48 9.98 62 172133 41343 63275484
Toxic epidermal necrolysis 13.47 9.98 116 172079 25218 63291609
Disability 13.46 9.98 18 172177 18329 63298498
Hypophosphataemia 13.41 9.98 64 172131 11362 63305465
Encephalopathy 13.40 9.98 162 172033 38458 63278369
Respiratory distress 13.39 9.98 146 172049 33805 63283022
Colitis 13.35 9.98 77 172118 48451 63268376
Cardiac failure high output 13.31 9.98 9 172186 296 63316531
Drug monitoring procedure not performed 13.30 9.98 12 172183 606 63316221
Blood bilirubin abnormal 13.28 9.98 15 172180 992 63315835
Catheter site pruritus 13.27 9.98 22 172173 2098 63314729
Urine potassium increased 13.26 9.98 4 172191 16 63316811
Photophobia 13.25 9.98 17 172178 17618 63299209
Haptoglobin decreased 13.16 9.98 13 172182 736 63316091
Dizziness postural 13.15 9.98 47 172148 7329 63309498
Injection site haemorrhage 13.12 9.98 29 172166 24285 63292542
Intentional product misuse 13.09 9.98 104 172091 60813 63256014
Prescribed overdose 13.08 9.98 48 172147 34105 63282722
Basal cell carcinoma 13.06 9.98 36 172159 27955 63288872
X-ray abnormal 13.02 9.98 3 172192 8107 63308720
Injection site mass 12.99 9.98 19 172176 18637 63298190
Localised oedema 12.97 9.98 38 172157 5340 63311487
Depression 12.95 9.98 420 171775 196072 63120755
Mucocutaneous haemorrhage 12.91 9.98 6 172189 93 63316734
Haemorrhage 12.91 9.98 235 171960 60787 63256040
Epstein-Barr virus infection 12.88 9.98 3 172192 8047 63308780
Electrocardiogram QT prolonged 12.85 9.98 230 171965 59300 63257527
Blood culture negative 12.74 9.98 7 172188 157 63316670
Bronchiectasis 12.72 9.98 15 172180 16127 63300700
Toxic neuropathy 12.70 9.98 10 172185 418 63316409
Haemodynamic instability 12.68 9.98 54 172141 9136 63307691
Haemodialysis 12.67 9.98 53 172142 8894 63307933
Stevens-Johnson syndrome 12.62 9.98 113 172082 24837 63291990
Blood pressure systolic increased 12.61 9.98 76 172119 47321 63269506
Scleroderma 12.61 9.98 38 172157 5424 63311403
Ear infection 12.57 9.98 57 172138 38156 63278671
Visual acuity reduced transiently 12.54 9.98 7 172188 162 63316665
Right ventricular systolic pressure increased 12.52 9.98 11 172184 536 63316291
Bone density decreased 12.48 9.98 75 172120 14537 63302290
Neonatal hyponatraemia 12.45 9.98 5 172190 53 63316774
Glaucoma 12.45 9.98 20 172175 18885 63297942
Electrocardiogram change 12.41 9.98 12 172183 662 63316165
Multiple sclerosis 12.41 9.98 30 172165 24342 63292485
Atrial septal defect repair 12.39 9.98 8 172187 243 63316584
Ventricular hypokinesia 12.36 9.98 34 172161 4610 63312217
Respiratory tract infection 12.28 9.98 169 172026 41314 63275513
Lupus-like syndrome 12.28 9.98 14 172181 15281 63301546
Psoriasis 12.28 9.98 164 172031 86793 63230034
Device difficult to use 12.26 9.98 10 172185 12786 63304041
Tachyarrhythmia 12.26 9.98 33 172162 4417 63312410
Dilatation ventricular 12.24 9.98 23 172172 2422 63314405
Right-to-left cardiac shunt 12.22 9.98 8 172187 249 63316578
Ventricular arrhythmia 12.22 9.98 30 172165 3798 63313029
Blood antidiuretic hormone increased 12.21 9.98 3 172192 4 63316823
Labelled drug-drug interaction issue 12.20 9.98 15 172180 1086 63315741
Platelet dysfunction 12.15 9.98 6 172189 107 63316720
Coma hepatic 12.13 9.98 12 172183 681 63316146
Food allergy 12.11 9.98 8 172187 11393 63305434
Neurodevelopmental disorder 12.09 9.98 7 172188 174 63316653
Diarrhoea infectious 12.09 9.98 15 172180 1096 63315731
Catastrophic reaction 12.08 9.98 4 172191 23 63316804
Walking disability 12.03 9.98 17 172178 1410 63315417
Blood pressure diastolic abnormal 12.02 9.98 13 172182 14529 63302298
Hepatitis fulminant 11.97 9.98 28 172167 3436 63313391
Vascular stenosis 11.97 9.98 9 172186 351 63316476
Glomerular filtration rate abnormal 11.93 9.98 13 172182 826 63316001
Cardiac flutter 11.92 9.98 31 172164 4065 63312762
Renal injury 11.91 9.98 54 172141 9385 63307442
Nasal congestion 11.90 9.98 247 171948 65413 63251414
Gastrointestinal angiectasia 11.83 9.98 5 172190 61 63316766
Sudden cardiac death 11.81 9.98 21 172174 2119 63314708
Ventricular assist device insertion 11.80 9.98 4 172191 25 63316802
Chronic right ventricular failure 11.80 9.98 4 172191 25 63316802
Cardiac pacemaker insertion 11.78 9.98 31 172164 4095 63312732
Gastrointestinal arteriovenous malformation 11.77 9.98 11 172184 581 63316246
Posterior reversible encephalopathy syndrome 11.75 9.98 18 172177 17327 63299500
International normalised ratio abnormal 11.74 9.98 27 172168 3277 63313550
Hypoosmolar state 11.71 9.98 7 172188 185 63316642
Urogenital haemorrhage 11.68 9.98 8 172187 269 63316558
Conduction disorder 11.67 9.98 17 172178 1450 63315377
Extensor plantar response 11.62 9.98 16 172179 1295 63315532
Catheter site inflammation 11.56 9.98 13 172182 856 63315971
Hepatitis C 11.53 9.98 36 172159 5238 63311589
Blood bilirubin unconjugated increased 11.49 9.98 9 172186 373 63316454
Fibrinous bronchitis 11.46 9.98 3 172192 6 63316821
Lower limb fracture 11.42 9.98 31 172164 24190 63292637
Human metapneumovirus test positive 11.41 9.98 5 172190 67 63316760
Lower gastrointestinal haemorrhage 11.38 9.98 47 172148 7843 63308984
Blood chloride decreased 11.36 9.98 37 172158 5505 63311322
Haematocrit abnormal 11.34 9.98 13 172182 874 63315953
Hypertonic bladder 11.32 9.98 28 172167 3560 63313267
Burning sensation 11.32 9.98 209 171986 54198 63262629
Left ventricular dilatation 11.32 9.98 10 172185 491 63316336
Neuromyelitis optica spectrum disorder 11.32 9.98 14 172181 1020 63315807
Premature delivery 11.31 9.98 43 172152 30238 63286589
Thyroxine increased 11.21 9.98 11 172184 618 63316209
Cardiac valve disease 11.19 9.98 31 172164 4221 63312606
Secretion discharge 11.18 9.98 10 172185 12221 63304606
Diabetic metabolic decompensation 11.05 9.98 18 172177 1692 63315135
Catheter site rash 11.03 9.98 12 172183 761 63316066
Duodenal ulcer 11.03 9.98 46 172149 7710 63309117
Tachycardia 11.02 9.98 408 171787 117748 63199079
White blood cell count decreased 11.00 9.98 290 171905 138814 63178013
Bradykinesia 10.97 9.98 35 172160 5153 63311674
Listeraemia 10.96 9.98 5 172190 74 63316753
Toxic skin eruption 10.91 9.98 66 172129 12819 63304008
Cardiac cirrhosis 10.86 9.98 6 172189 136 63316691
Nephrocalcinosis 10.85 9.98 14 172181 1064 63315763
Total bile acids increased 10.82 9.98 6 172189 137 63316690
Angina unstable 10.82 9.98 43 172152 7052 63309775
Erythema 10.80 9.98 379 171816 175372 63141455
Haematotoxicity 10.77 9.98 6 172189 9370 63307457
Electrocardiogram T wave peaked 10.75 9.98 7 172188 216 63316611
Volume blood decreased 10.74 9.98 6 172189 139 63316688
Ballismus 10.74 9.98 6 172189 139 63316688
Cardiac operation 10.69 9.98 26 172169 3272 63313555
Cardio-respiratory arrest 10.69 9.98 225 171970 59734 63257093
Bone marrow failure 10.68 9.98 42 172153 29248 63287579
Ventricular extrasystoles 10.63 9.98 61 172134 11626 63305201
Osteonecrosis of jaw 10.61 9.98 54 172141 35069 63281758
Pancreatic enzymes decreased 10.60 9.98 3 172192 9 63316818
CREST syndrome 10.58 9.98 10 172185 536 63316291
QRS axis abnormal 10.58 9.98 14 172181 1091 63315736
Loss of consciousness 10.56 9.98 406 171789 117715 63199112
Endocarditis 10.56 9.98 37 172158 5713 63311114
Drug withdrawal syndrome 10.56 9.98 38 172157 27156 63289671
Balloon atrial septostomy 10.56 9.98 5 172190 81 63316746
Labelled drug-disease interaction medication error 10.55 9.98 6 172189 144 63316683
Respiratory depression 10.53 9.98 13 172182 13702 63303125
Blood pressure fluctuation 10.46 9.98 78 172117 46239 63270588
Palliative care 10.41 9.98 10 172185 547 63316280
Therapy non-responder 10.41 9.98 144 172051 75757 63241070
Wound infection 10.40 9.98 27 172168 21383 63295444
Gastrointestinal toxicity 10.36 9.98 4 172191 7737 63309090
Gastritis erosive 10.36 9.98 38 172157 6001 63310826
Senile dementia 10.33 9.98 7 172188 231 63316596
Gastroenteritis 10.32 9.98 114 172081 26476 63290351
Blood pressure increased 10.30 9.98 348 171847 161714 63155113
Systemic scleroderma 10.28 9.98 13 172182 968 63315859
Breast cancer female 10.26 9.98 13 172182 13546 63303281
Synovial cyst 10.19 9.98 8 172187 10425 63306402
Right ventricular hypertrophy 10.19 9.98 11 172184 692 63316135
Gastrointestinal endoscopic therapy 10.17 9.98 4 172191 40 63316787
Dependence on oxygen therapy 10.17 9.98 9 172186 443 63316384
Strabismus 10.15 9.98 19 172176 1995 63314832
Flatulence 10.12 9.98 141 172054 34561 63282266
Blood corticotrophin decreased 10.10 9.98 8 172187 337 63316490
Pharyngitis 10.09 9.98 25 172170 20118 63296709
Hyperlipidaemia 10.08 9.98 89 172106 19482 63297345
Herpes zoster 10.08 9.98 160 172035 82302 63234525
Chronic sinusitis 10.05 9.98 12 172183 12831 63303996
Percutaneous coronary intervention 10.05 9.98 7 172188 242 63316585
Intervertebral disc degeneration 10.03 9.98 17 172178 15715 63301112
Chondrocalcinosis 10.01 9.98 12 172183 846 63315981
Hypocalvaria 10.00 9.98 4 172191 42 63316785

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 2475.73 10.86 2038 125688 67351 34761854
Acute kidney injury 940.20 10.86 2837 124889 302151 34527054
Cardiac failure 704.37 10.86 1224 126502 90024 34739181
Hepatic encephalopathy 606.47 10.86 471 127255 14214 34814991
Ascites 390.87 10.86 649 127077 45922 34783283
Cardiac failure chronic 343.39 10.86 261 127465 7618 34821587
Drug ineffective 302.58 10.86 775 126951 455976 34373229
Hypotension 292.20 10.86 1586 126140 220063 34609142
Hyponatraemia 288.97 10.86 807 126919 81884 34747321
Cardiac failure congestive 288.39 10.86 810 126916 82460 34746745
Oedema peripheral 269.24 10.86 1005 126721 118807 34710398
Hepatic cirrhosis 260.63 10.86 319 127407 16995 34812210
Drug abuse 245.72 10.86 35 127691 99061 34730144
Hepatic failure 239.95 10.86 443 127283 34088 34795117
Gynaecomastia 228.20 10.86 231 127495 9949 34819256
Dyspnoea 225.15 10.86 2230 125496 374552 34454653
Renal impairment 216.54 10.86 798 126928 93715 34735490
Completed suicide 200.92 10.86 55 127671 98113 34731092
Right ventricular failure 196.30 10.86 199 127527 8585 34820620
Off label use 191.34 10.86 837 126889 418687 34410518
Pulmonary hypertension 188.15 10.86 301 127425 20623 34808582
Blood potassium increased 171.80 10.86 254 127472 16241 34812964
Ejection fraction decreased 170.12 10.86 274 127452 18880 34810325
Dehydration 164.73 10.86 921 126805 129048 34700157
Renal failure 154.21 10.86 908 126818 129649 34699556
N-terminal prohormone brain natriuretic peptide increased 152.69 10.86 105 127621 2610 34826595
Febrile neutropenia 143.83 10.86 173 127553 136676 34692529
Blood creatinine increased 142.95 10.86 706 127020 94270 34734935
Toxicity to various agents 138.98 10.86 331 127395 200031 34629174
Pulmonary arterial hypertension 137.99 10.86 165 127561 8574 34820631
Oesophageal varices haemorrhage 136.59 10.86 104 127622 3042 34826163
Neutropenia 135.26 10.86 228 127498 156550 34672655
Congestive cardiomyopathy 134.00 10.86 151 127575 7359 34821846
Ventricular tachycardia 132.27 10.86 297 127429 26282 34802923
Hepatorenal syndrome 131.14 10.86 95 127631 2571 34826634
Brain natriuretic peptide increased 118.84 10.86 124 127602 5535 34823670
International normalised ratio increased 118.84 10.86 412 127314 46915 34782290
Bradycardia 117.29 10.86 566 127160 74852 34754353
Hepatocellular carcinoma 115.65 10.86 140 127586 7369 34821836
Orthopnoea 114.73 10.86 116 127610 4987 34824218
Arthralgia 111.54 10.86 289 127437 169752 34659453
Oedema 109.51 10.86 392 127334 45349 34783856
Blood urea increased 108.52 10.86 299 127427 30065 34799140
Mitral valve incompetence 106.64 10.86 194 127532 14749 34814456
Drug interaction 102.47 10.86 1268 126458 224678 34604527
General physical health deterioration 101.21 10.86 808 126918 127461 34701744
Hepatic cancer 100.28 10.86 137 127589 8138 34821067
Syncope 90.39 10.86 608 127118 90843 34738362
Intentional overdose 90.18 10.86 24 127702 43650 34785555
Ischaemic cardiomyopathy 90.16 10.86 114 127612 6275 34822930
Therapeutic product effect incomplete 86.68 10.86 38 127688 50503 34778702
Varices oesophageal 85.59 10.86 86 127640 3669 34825536
Orthostatic hypotension 85.54 10.86 248 127478 25671 34803534
Cardiac failure acute 82.86 10.86 143 127583 10427 34818778
Atrial fibrillation 81.76 10.86 743 126983 121650 34707555
Foetal exposure during pregnancy 78.55 10.86 21 127705 38080 34791125
Atrioventricular block complete 78.25 10.86 130 127596 9189 34820016
Fluid retention 75.40 10.86 243 127483 26644 34802561
Arrhythmia 74.16 10.86 293 127433 35515 34793690
Dyspnoea exertional 73.24 10.86 333 127393 42946 34786259
Chronic kidney disease 71.17 10.86 319 127407 40891 34788314
Suicide attempt 69.33 10.86 28 127698 39088 34790117
Tricuspid valve incompetence 68.73 10.86 126 127600 9634 34819571
Blood pressure decreased 67.07 10.86 368 127358 51147 34778058
Breast tenderness 66.31 10.86 39 127687 732 34828473
Glomerular filtration rate decreased 65.78 10.86 146 127580 12815 34816390
Pain 65.11 10.86 459 127267 204216 34624989
Melaena 64.99 10.86 279 127447 35101 34794104
Treatment failure 64.39 10.86 46 127680 46651 34782554
Pyrexia 63.12 10.86 848 126878 332165 34497040
Bundle branch block left 62.14 10.86 92 127634 5887 34823318
Electrolyte imbalance 61.83 10.86 152 127574 14260 34814945
Product dose omission issue 61.69 10.86 227 127499 119484 34709721
Concomitant disease aggravated 61.10 10.86 89 127637 5612 34823593
Rash 60.82 10.86 521 127205 222231 34606974
Rheumatoid arthritis 60.60 10.86 32 127694 38206 34790999
Intentional product misuse 60.22 10.86 47 127679 45564 34783641
Urticaria 60.15 10.86 84 127642 62293 34766912
Ammonia increased 60.14 10.86 77 127649 4292 34824913
Infusion related reaction 60.12 10.86 63 127663 52994 34776211
Anaemia 58.49 10.86 1186 126540 232149 34597056
Product use in unapproved indication 58.47 10.86 226 127500 117273 34711932
Electrocardiogram abnormal 58.45 10.86 114 127612 9133 34820072
Depression 57.66 10.86 173 127553 96925 34732280
Intentional product use issue 57.23 10.86 81 127645 59735 34769470
Blood bilirubin increased 57.04 10.86 284 127442 38012 34791193
Gastrointestinal haemorrhage 55.96 10.86 531 127195 87946 34741259
Hypokalaemia 55.07 10.86 383 127343 57831 34771374
COVID-19 54.53 10.86 127 127599 77423 34751782
Hypervolaemia 54.23 10.86 177 127549 19532 34809673
Neuropathy peripheral 52.62 10.86 144 127582 83119 34746086
Brain natriuretic peptide abnormal 52.23 10.86 26 127700 344 34828861
Blood cholesterol 51.14 10.86 22 127704 203 34829002
Suicidal ideation 50.37 10.86 44 127682 40344 34788861
Nipple pain 49.79 10.86 35 127691 902 34828303
Anxiety 48.33 10.86 193 127533 99235 34729970
Chronic obstructive pulmonary disease 47.54 10.86 324 127402 48594 34780611
Fall 47.46 10.86 1021 126705 201864 34627341
Musculoskeletal stiffness 45.87 10.86 62 127664 46618 34782587
Joint swelling 45.46 10.86 94 127632 59796 34769409
Electrocardiogram T wave peaked 44.72 10.86 28 127698 591 34828614
Cytomegalovirus infection 44.25 10.86 20 127706 26115 34803090
Bradyarrhythmia 44.20 10.86 47 127679 2144 34827061
Cardiomegaly 43.70 10.86 140 127586 15298 34813907
Drug dependence 43.46 10.86 17 127709 24200 34805005
Injection site pain 43.42 10.86 47 127679 38958 34790247
Ventricular internal diameter abnormal 43.36 10.86 19 127707 184 34829021
Therapeutic product effect decreased 43.14 10.86 38 127688 34705 34794500
Headache 43.13 10.86 497 127229 200138 34629067
Congestive hepatopathy 42.72 10.86 43 127683 1838 34827367
Left ventricular dilatation 41.57 10.86 29 127697 738 34828467
Overdose 41.01 10.86 182 127544 90877 34738328
Leukopenia 41.00 10.86 107 127619 62749 34766456
Jaundice 40.98 10.86 227 127499 31655 34797550
Sinusitis 40.66 10.86 55 127671 41347 34787858
Mucosal inflammation 40.32 10.86 49 127677 38573 34790632
BRASH syndrome 40.20 10.86 25 127701 521 34828684
Cardiomyopathy 40.16 10.86 144 127582 16664 34812541
Synovitis 39.88 10.86 3 127723 14063 34815142
Hypersensitivity 39.73 10.86 104 127622 60931 34768274
Therapeutic drug monitoring analysis not performed 39.42 10.86 25 127701 540 34828665
White blood cell count decreased 39.32 10.86 197 127529 95248 34733957
Chronic hepatic failure 39.03 10.86 24 127702 490 34828715
Intentional self-injury 38.87 10.86 3 127723 13768 34815437
Portal hypertension 38.66 10.86 60 127666 4002 34825203
Seizure 38.47 10.86 225 127501 104632 34724573
Polyuria 38.45 10.86 92 127634 8482 34820723
Left ventricular dysfunction 38.20 10.86 101 127625 9906 34819299
Hypovolaemia 38.14 10.86 96 127630 9138 34820067
Arthropathy 37.75 10.86 26 127700 26881 34802324
Blood sodium decreased 36.94 10.86 137 127589 16114 34813091
Breast pain 36.84 10.86 35 127691 1393 34827812
Cardioactive drug level increased 36.73 10.86 38 127688 1679 34827526
Premature baby 36.54 10.86 13 127713 19620 34809585
Systemic infection 36.34 10.86 67 127659 5145 34824060
Low cardiac output syndrome 35.34 10.86 24 127702 584 34828621
Hyperhidrosis 34.86 10.86 150 127576 75542 34753663
Product monitoring error 33.98 10.86 59 127667 4322 34824883
Pulmonary oedema 33.98 10.86 293 127433 47236 34781969
Liver transplant 33.84 10.86 44 127682 2490 34826715
Generalised oedema 33.75 10.86 111 127615 12297 34816908
Pneumonitis 33.27 10.86 45 127681 33833 34795372
Neuroleptic malignant syndrome 33.17 10.86 12 127714 17922 34811283
Pulmonary congestion 32.94 10.86 118 127608 13647 34815558
Pulmonary arterial pressure abnormal 32.87 10.86 16 127710 201 34829004
Ventricular hypokinesia 32.16 10.86 66 127660 5486 34823719
Loss of personal independence in daily activities 31.66 10.86 45 127681 33134 34796071
Hepatic function abnormal 31.46 10.86 273 127453 44090 34785115
Troponin T increased 31.40 10.86 41 127685 2330 34826875
Nodal rhythm 30.98 10.86 32 127694 1411 34827794
Cytokine release syndrome 30.92 10.86 23 127703 22854 34806351
Accidental exposure to product 30.60 10.86 5 127721 12797 34816408
Cardiogenic shock 30.60 10.86 184 127542 26434 34802771
Drug ineffective for unapproved indication 30.59 10.86 25 127701 23690 34805515
Abdominal cavity drainage 30.55 10.86 19 127707 396 34828809
Faecal volume decreased 30.50 10.86 13 127713 117 34829088
Atrioventricular block 30.39 10.86 81 127645 7982 34821223
Pleural effusion 30.35 10.86 442 127284 81104 34748101
Lactic acidosis 30.11 10.86 224 127502 34548 34794657
Abdominal distension 29.80 10.86 336 127390 58156 34771049
Anaphylactic reaction 29.65 10.86 45 127681 32256 34796949
Ejection fraction 29.48 10.86 12 127714 95 34829110
Oliguria 29.41 10.86 82 127644 8298 34820907
Insomnia 29.21 10.86 241 127485 103666 34725539
Subarachnoid haemorrhage 29.12 10.86 107 127619 12528 34816677
Death 29.05 10.86 1175 126551 396874 34432331
Waist circumference increased 28.86 10.86 25 127701 881 34828324
Inability to afford medication 28.72 10.86 31 127695 1439 34827766
Amyloidosis 28.57 10.86 37 127689 2086 34827119
Cirrhosis alcoholic 28.38 10.86 24 127702 818 34828387
Dyspnoea paroxysmal nocturnal 28.22 10.86 31 127695 1468 34827737
Peritonitis bacterial 27.87 10.86 66 127660 6044 34823161
Glomerular filtration rate abnormal 27.87 10.86 24 127702 839 34828366
Multiple sclerosis relapse 27.52 10.86 7 127719 13126 34816079
Keratoconus 27.50 10.86 12 127714 115 34829090
Tremor 27.29 10.86 183 127543 82404 34746801
Gastric varices 27.26 10.86 20 127706 552 34828653
Sudden death 27.23 10.86 119 127607 15082 34814123
Appendicitis 27.23 10.86 10 127716 14797 34814408
Quadriparesis 27.06 10.86 31 127695 1538 34827667
Metabolic acidosis 27.01 10.86 261 127465 43419 34785786
Neutrophil count decreased 26.89 10.86 96 127630 51008 34778197
Gastrointestinal disorder 26.85 10.86 52 127674 33896 34795309
Adverse drug reaction 26.82 10.86 41 127685 29301 34799904
Hepatitis C 26.79 10.86 88 127638 9742 34819463
Sopor 26.35 10.86 6 127720 12130 34817075
Left ventricular failure 26.16 10.86 58 127668 5086 34824119
Paraesthesia 26.10 10.86 133 127593 64039 34765166
Anuria 25.69 10.86 90 127636 10295 34818910
Urine output decreased 25.65 10.86 88 127638 9961 34819244
Rales 25.62 10.86 87 127639 9796 34819409
Hallucination 25.62 10.86 99 127627 51399 34777806
Prostate cancer 25.46 10.86 68 127658 39581 34789624
Adrenal adenoma 25.40 10.86 18 127708 470 34828735
Stress 25.32 10.86 45 127681 30302 34798903
Pulmonary embolism 25.29 10.86 208 127518 89538 34739667
Diaphragmatic spasm 25.24 10.86 11 127715 105 34829100
Localised oedema 25.23 10.86 46 127680 3502 34825703
Nasopharyngitis 25.19 10.86 151 127575 69817 34759388
Iron deficiency anaemia 25.11 10.86 89 127637 10240 34818965
Basal cell carcinoma 25.01 10.86 21 127705 19637 34809568
Pain in extremity 25.01 10.86 319 127407 126194 34703011
Therapeutic response decreased 24.88 10.86 43 127683 29270 34799935
Neutrophil count increased 24.82 10.86 16 127710 17130 34812075
Torsade de pointes 24.77 10.86 70 127656 7139 34822066
Therapy partial responder 24.76 10.86 3 127723 9613 34819592
Blood loss anaemia 24.75 10.86 76 127650 8118 34821087
N-terminal prohormone brain natriuretic peptide abnormal 24.61 10.86 13 127713 196 34829009
Jugular vein distension 24.56 10.86 20 127706 646 34828559
Drug intolerance 24.49 10.86 123 127603 59447 34769758
Thrombosis 24.46 10.86 98 127628 50360 34778845
Malignant neoplasm progression 24.38 10.86 205 127521 87841 34741364
Osteonecrosis of jaw 24.16 10.86 18 127708 17871 34811334
Therapeutic drug monitoring analysis incorrectly performed 24.11 10.86 15 127711 313 34828892
Bundle branch block right 23.91 10.86 71 127655 7445 34821760
Sudden cardiac death 23.84 10.86 46 127680 3655 34825550
Cardiac arrest 23.75 10.86 488 127238 95671 34733534
Sedation 23.72 10.86 25 127701 20981 34808224
Memory impairment 23.72 10.86 80 127646 43238 34785967
Neck pain 23.57 10.86 35 127691 25314 34803891
5-alpha-reductase deficiency 23.56 10.86 6 127720 6 34829199
Embolic stroke 23.53 10.86 51 127675 4403 34824802
Portal hypertensive gastropathy 23.49 10.86 19 127707 608 34828597
Scrotal oedema 23.29 10.86 31 127695 1795 34827410
Circulatory collapse 23.28 10.86 144 127582 20894 34808311
Blood aldosterone increased 23.19 10.86 7 127719 19 34829186
Pancytopenia 23.12 10.86 229 127497 94928 34734277
Protein-losing gastroenteropathy 23.06 10.86 15 127711 339 34828866
Oxygen saturation increased 22.89 10.86 14 127712 283 34828922
Pneumonia 22.80 10.86 1088 126638 361539 34467666
Platelet count normal 22.68 10.86 7 127719 21 34829184
Back pain 22.64 10.86 311 127415 121478 34707727
Type 2 diabetes mellitus 22.53 10.86 117 127609 15915 34813290
Feeling abnormal 22.48 10.86 137 127589 63098 34766107
Ventricular fibrillation 22.27 10.86 152 127574 22802 34806403
Invasive ductal breast carcinoma 21.96 10.86 8 127718 45 34829160
Ejection fraction abnormal 21.96 10.86 22 127704 935 34828270
Hypoaesthesia 21.91 10.86 133 127593 61311 34767894
Portal vein thrombosis 21.90 10.86 45 127681 3743 34825462
Psoriatic arthropathy 21.87 10.86 24 127702 19774 34809431
Myasthenic syndrome 21.84 10.86 17 127709 514 34828691
Cardiac disorder 21.63 10.86 247 127479 42879 34786326
Graft versus host disease 21.45 10.86 6 127720 10563 34818642
Diplopia 21.42 10.86 18 127708 16825 34812380
Oesophageal variceal ligation 21.41 10.86 9 127717 78 34829127
Bone marrow failure 21.28 10.86 47 127679 29206 34799999
Coma hepatic 21.28 10.86 16 127710 459 34828746
Fractured coccyx 21.18 10.86 11 127715 160 34829045
Prothrombin time prolonged 21.13 10.86 79 127647 9327 34819878
Respiratory depression 21.11 10.86 17 127709 16228 34812977
Periarthritis calcarea 21.02 10.86 9 127717 82 34829123
Articular calcification 20.74 10.86 9 127717 85 34829120
Aggression 20.63 10.86 73 127653 38891 34790314
Vision blurred 20.60 10.86 92 127634 45871 34783334
Hydrothorax 20.41 10.86 16 127710 489 34828716
Spur cell anaemia 20.26 10.86 8 127718 58 34829147
Immature granulocyte count increased 20.24 10.86 10 127716 130 34829075
Paracentesis 20.11 10.86 15 127711 425 34828780
Blood ketone body increased 20.02 10.86 15 127711 428 34828777
Electrocardiogram QRS complex abnormal 20.01 10.86 14 127712 358 34828847
Azotaemia 19.85 10.86 51 127675 4916 34824289
Dyskinesia 19.83 10.86 32 127694 22381 34806824
Liver disorder 19.83 10.86 196 127530 32801 34796404
Akathisia 19.76 10.86 3 127723 8106 34821099
Poisoning 19.71 10.86 10 127716 12216 34816989
Subdural haematoma 19.68 10.86 135 127591 20286 34808919
Somnolence 19.50 10.86 287 127439 110829 34718376
Product prescribing error 19.45 10.86 147 127579 22780 34806425
Colitis ulcerative 19.41 10.86 19 127707 16501 34812704
Apparent mineralocorticoid excess 19.27 10.86 7 127719 39 34829166
Acute myeloid leukaemia 19.26 10.86 23 127703 18247 34810958
Angina pectoris 19.19 10.86 187 127539 31176 34798029
Colitis 19.14 10.86 72 127654 37678 34791527
Drug level decreased 18.90 10.86 3 127723 7843 34821362
Transplant rejection 18.90 10.86 7 127719 10304 34818901
Blood potassium abnormal 18.88 10.86 24 127702 1328 34827877
Drug withdrawal syndrome 18.82 10.86 27 127699 19807 34809398
Cardiac amyloidosis 18.74 10.86 23 127703 1228 34827977
Primary hyperaldosteronism 18.58 10.86 8 127718 74 34829131
Weight increased 18.53 10.86 458 127268 92575 34736630
Aspergillus infection 18.34 10.86 11 127715 12243 34816962
Bronchopulmonary aspergillosis 18.24 10.86 16 127710 14643 34814562
Genitalia external ambiguous 18.09 10.86 11 127715 220 34828985
Upper gastrointestinal haemorrhage 18.07 10.86 157 127569 25361 34803844
Generalised tonic-clonic seizure 18.02 10.86 31 127695 21143 34808062
Dizziness 17.95 10.86 973 126753 217548 34611657
Stomatitis 17.92 10.86 87 127639 42427 34786778
Injection site erythema 17.86 10.86 19 127707 15880 34813325
Disease recurrence 17.81 10.86 32 127694 21458 34807747
Oropharyngeal pain 17.79 10.86 68 127658 35417 34793788
Arthritis 17.77 10.86 57 127669 31289 34797916
Enteritis 17.73 10.86 4 127722 8138 34821067
Bladder cancer 17.69 10.86 20 127706 16258 34812947
Infection 17.68 10.86 230 127496 90685 34738520
Diabetic ketoacidosis 17.66 10.86 24 127702 18008 34811197
Encephalopathy 17.58 10.86 202 127524 35117 34794088
Hepatomegaly 17.58 10.86 80 127646 10316 34818889
Exercise tolerance decreased 17.40 10.86 50 127676 5148 34824057
Haematemesis 17.34 10.86 166 127560 27545 34801660
Pancreatitis 17.33 10.86 78 127648 38813 34790392
Nephrolithiasis 17.31 10.86 55 127671 30278 34798927
Creatinine renal clearance decreased 17.06 10.86 38 127688 3343 34825862
Cardioversion 17.02 10.86 19 127707 916 34828289
Alopecia 17.01 10.86 40 127686 24315 34804890
Electrolyte depletion 16.94 10.86 10 127716 189 34829016
Influenza 16.93 10.86 109 127617 49557 34779648
Metabolic alkalosis 16.91 10.86 24 127702 1477 34827728
Epistaxis 16.89 10.86 303 127423 57948 34771257
Irritability 16.89 10.86 41 127685 24649 34804556
International normalised ratio fluctuation 16.83 10.86 22 127704 1252 34827953
Renin increased 16.68 10.86 8 127718 97 34829108
Herpes zoster 16.55 10.86 67 127659 34332 34794873
Hypoalbuminaemia 16.53 10.86 88 127638 12086 34817119
Erysipelas 16.49 10.86 47 127679 4816 34824389
Injection site reaction 16.49 10.86 14 127712 13019 34816186
Exposure during pregnancy 16.48 10.86 6 127720 8928 34820277
Xanthopsia 16.46 10.86 9 127717 146 34829059
Haemophagocytic lymphohistiocytosis 16.33 10.86 14 127712 12959 34816246
Diastolic dysfunction 16.30 10.86 55 127671 6172 34823033
Atrioventricular block second degree 16.29 10.86 40 127686 3748 34825457
Resting tremor 16.25 10.86 16 127710 666 34828539
Endometriosis male 16.20 10.86 5 127721 15 34829190
Transplant evaluation 16.19 10.86 14 127712 492 34828713
Chills 16.13 10.86 204 127522 80839 34748366
Atrioventricular block first degree 16.12 10.86 54 127672 6038 34823167
Epstein-Barr virus infection 16.11 10.86 4 127722 7624 34821581
Adrenal cyst 16.04 10.86 9 127717 154 34829051
Transfusion 15.99 10.86 68 127658 8517 34820688
Tooth disorder 15.96 10.86 10 127716 10872 34818333
Oesophageal carcinoma 15.94 10.86 7 127719 9297 34819908
Base excess decreased 15.93 10.86 10 127716 212 34828993
Troponin increased 15.93 10.86 83 127643 11306 34817899
Bladder irrigation 15.87 10.86 7 127719 69 34829136
Potentiating drug interaction 15.82 10.86 47 127679 4930 34824275
Blood cholesterol increased 15.79 10.86 32 127694 20511 34808694
Labelled drug-drug interaction medication error 15.75 10.86 101 127625 14838 34814367
Hypertensive cardiomyopathy 15.73 10.86 9 127717 160 34829045
Agitation 15.72 10.86 134 127592 57265 34771940
Blood urea abnormal 15.71 10.86 17 127709 791 34828414
Neoplasm progression 15.70 10.86 39 127687 23261 34805944
Psychotic disorder 15.65 10.86 42 127684 24410 34804795
Left atrial dilatation 15.64 10.86 27 127699 1969 34827236
Plasma cell myeloma 15.51 10.86 90 127636 41947 34787258
Hyperbilirubinaemia 15.44 10.86 110 127616 16733 34812472
Eosinophilia 15.39 10.86 155 127571 26067 34803138
International normalised ratio abnormal 15.19 10.86 36 127690 3299 34825906
Influenza like illness 15.15 10.86 51 127675 27583 34801622
Low birth weight baby 15.12 10.86 5 127721 7900 34821305
Child-Pugh-Turcotte score increased 15.10 10.86 5 127721 20 34829185
Hydrocholecystis 15.03 10.86 13 127713 457 34828748
Withdrawal syndrome 15.01 10.86 14 127712 12441 34816764
Blood thyroid stimulating hormone abnormal 14.99 10.86 12 127714 378 34828827
Angina unstable 14.99 10.86 83 127643 11570 34817635
Nephrogenic anaemia 14.88 10.86 28 127698 2183 34827022
Haematoma 14.86 10.86 151 127575 25454 34803751
Transferrin saturation decreased 14.82 10.86 13 127713 466 34828739
Electrocardiogram T wave amplitude increased 14.79 10.86 6 127720 47 34829158
Fluid intake reduced 14.79 10.86 38 127688 3663 34825542
Concomitant disease progression 14.66 10.86 30 127696 2488 34826717
Oral lichen planus 14.62 10.86 9 127717 184 34829021
Atrial enlargement 14.60 10.86 15 127711 657 34828548
Thrombocytopenia 14.60 10.86 447 127279 155800 34673405
Diffuse vasculitis 14.59 10.86 7 127719 85 34829120
Rash erythematous 14.45 10.86 45 127681 24932 34804273
Electrocardiogram change 14.42 10.86 15 127711 667 34828538
Lung diffusion test abnormal 14.37 10.86 6 127720 51 34829154
Haematotoxicity 14.30 10.86 6 127720 8188 34821017
Sinus arrest 14.24 10.86 24 127702 1716 34827489
Prothrombin level decreased 14.16 10.86 19 127707 1109 34828096
Schizophrenia 14.10 10.86 7 127719 8659 34820546
Hyperthyroidism 14.09 10.86 76 127650 10490 34818715
Left ventricular false tendon 14.08 10.86 6 127720 54 34829151
Pneumocystis jirovecii pneumonia 14.07 10.86 32 127694 19678 34809527
Thrombotic microangiopathy 13.97 10.86 11 127715 10619 34818586
Secondary sexual characteristics absence 13.85 10.86 3 127723 0 34829205
Injection site swelling 13.84 10.86 13 127713 11514 34817691
Blood pressure systolic decreased 13.82 10.86 42 127684 4461 34824744
Therapy non-responder 13.81 10.86 85 127641 39061 34790144
Preternatural anus 13.71 10.86 7 127719 98 34829107
Acute myocardial infarction 13.71 10.86 274 127452 53445 34775760
Glomerular filtration rate increased 13.71 10.86 12 127714 429 34828776
Hypoparathyroidism secondary 13.70 10.86 8 127718 148 34829057
Migraine 13.62 10.86 27 127699 17451 34811754
Therapeutic response shortened 13.61 10.86 5 127721 7399 34821806
Pulmonary veno-occlusive disease 13.59 10.86 13 127713 522 34828683
Middle insomnia 13.55 10.86 55 127671 6747 34822458
Dependence on oxygen therapy 13.51 10.86 9 127717 212 34828993
Tricuspid valve replacement 13.46 10.86 5 127721 30 34829175
Burning feet syndrome 13.40 10.86 7 127719 103 34829102
Red cell distribution width increased 13.40 10.86 51 127675 6072 34823133
Breast mass 13.39 10.86 14 127712 626 34828579
Squamous cell carcinoma of skin 13.39 10.86 12 127714 10869 34818336
Inferior vena cava syndrome 13.35 10.86 6 127720 62 34829143
Left ventricular hypertrophy 13.33 10.86 62 127664 8068 34821137
Percussion test abnormal 13.32 10.86 5 127721 31 34829174
Atrial flutter 13.29 10.86 100 127626 15474 34813731
Blood creatine increased 13.20 10.86 44 127682 4907 34824298
Scrotal swelling 13.20 10.86 21 127705 1431 34827774
Intracranial aneurysm 13.15 10.86 23 127703 1695 34827510
Eye pain 13.10 10.86 18 127708 13444 34815761
Blood chloride increased 13.01 10.86 31 127695 2850 34826355
Haematuria 12.99 10.86 256 127470 49810 34779395
Dyspnoea at rest 12.98 10.86 37 127689 3791 34825414
Rectosigmoid cancer metastatic 12.96 10.86 4 127722 12 34829193
Fungal infection 12.96 10.86 24 127702 15911 34813294
Pulmonary hypertensive crisis 12.94 10.86 8 127718 165 34829040
Device inappropriate shock delivery 12.93 10.86 5 127721 34 34829171
Ear infection 12.93 10.86 11 127715 10220 34818985
Nocturnal dyspnoea 12.91 10.86 13 127713 556 34828649
Upper respiratory tract inflammation 12.90 10.86 23 127703 1721 34827484
Tachycardia 12.85 10.86 225 127501 84547 34744658
Acute pulmonary oedema 12.79 10.86 57 127669 7286 34821919
Coordination abnormal 12.70 10.86 6 127720 7638 34821567
Substance abuse 12.70 10.86 6 127720 7635 34821570
Hormone receptor positive breast cancer 12.69 10.86 5 127721 36 34829169
Acquired haemophilia 12.66 10.86 17 127709 993 34828212
Performance enhancing product use 12.64 10.86 6 127720 71 34829134
Condition aggravated 12.60 10.86 839 126887 191357 34637848
Haemodynamic test abnormal 12.57 10.86 5 127721 37 34829168
Product storage error 12.57 10.86 7 127719 8115 34821090
Activated partial thromboplastin time shortened 12.56 10.86 12 127714 481 34828724
International normalised ratio decreased 12.55 10.86 41 127685 4526 34824679
Pulmonary renal syndrome 12.52 10.86 8 127718 175 34829030
Tuberculosis 12.42 10.86 8 127718 8569 34820636
Left ventricular enlargement 12.33 10.86 14 127712 688 34828517
Pulmonary vein stenosis 12.24 10.86 5 127721 40 34829165
Asthma-chronic obstructive pulmonary disease overlap syndrome 12.23 10.86 19 127707 1268 34827937
Hyperuricaemia 12.22 10.86 60 127666 7983 34821222
Large intestine perforation 12.22 10.86 8 127718 8495 34820710
Oxygen consumption decreased 12.16 10.86 9 127717 252 34828953
Abdominal discomfort 12.14 10.86 150 127576 59685 34769520
Lymphopenia 12.08 10.86 26 127700 16309 34812896
Respiratory arrest 12.04 10.86 57 127669 27986 34801219
Diffuse large B-cell lymphoma 11.92 10.86 6 127720 7364 34821841
Hepatic calcification 11.92 10.86 10 127716 337 34828868
Syringe issue 11.90 10.86 3 127723 5661 34823544
Double hit lymphoma 11.89 10.86 4 127722 17 34829188
Ultrasound abdomen abnormal 11.89 10.86 4 127722 17 34829188
Conjunctival scar 11.87 10.86 7 127719 132 34829073
Feeling hot 11.86 10.86 34 127692 19338 34809867
Myocardial fibrosis 11.84 10.86 18 127708 1179 34828026
Restless legs syndrome 11.81 10.86 8 127718 8346 34820859
Erythema 11.80 10.86 241 127485 88539 34740666
Poisoning deliberate 11.80 10.86 7 127719 7837 34821368
Abnormal behaviour 11.78 10.86 49 127677 24920 34804285
Hypophagia 11.78 10.86 137 127589 23885 34805320
Pacemaker generated arrhythmia 11.78 10.86 3 127723 3 34829202
Ectopic ACTH syndrome 11.71 10.86 4 127722 18 34829187
Gouty arthritis 11.70 10.86 17 127709 1069 34828136
Hepatic pain 11.69 10.86 20 127706 1448 34827757
Breath sounds abnormal 11.67 10.86 53 127673 6828 34822377
Perineal infection 11.66 10.86 13 127713 626 34828579
Urine osmolarity decreased 11.63 10.86 5 127721 46 34829159
Deep vein thrombosis 11.62 10.86 168 127558 65080 34764125
Sepsis 11.59 10.86 494 127232 166067 34663138
Haemarthrosis 11.54 10.86 32 127694 3227 34825978
Hepatotoxicity 11.54 10.86 40 127686 21445 34807760
Portal shunt procedure 11.54 10.86 4 127722 19 34829186
Dilatation ventricular 11.51 10.86 28 127698 2608 34826597
Stasis dermatitis 11.47 10.86 16 127710 969 34828236
Postrenal failure 11.45 10.86 11 127715 444 34828761
Nightmare 11.42 10.86 22 127704 14369 34814836
Cataract 11.38 10.86 53 127673 26133 34803072
Apheresis related complication 11.37 10.86 4 127722 20 34829185
Muscle rigidity 11.34 10.86 13 127713 10505 34818700
Lichenoid keratosis 11.34 10.86 27 127699 2481 34826724
Dyspepsia 11.33 10.86 83 127643 36649 34792556
Enteropathy-associated T-cell lymphoma 11.32 10.86 3 127723 4 34829201
Blood pressure abnormal 11.28 10.86 59 127667 8047 34821158
Myalgia 11.28 10.86 228 127498 83882 34745323
Parkinsonism 11.23 10.86 8 127718 8130 34821075
Prerenal failure 11.17 10.86 24 127702 2060 34827145
Hypertension 11.16 10.86 397 127329 136046 34693159
Miosis 11.16 10.86 11 127715 9524 34819681
Infected dermal cyst 11.13 10.86 15 127711 879 34828326
Joint stiffness 11.13 10.86 14 127712 10859 34818346
Rhabdomyolysis 11.12 10.86 327 127399 67836 34761369
Product quality issue 11.10 10.86 29 127697 17006 34812199
Prescribed underdose 11.07 10.86 63 127663 8870 34820335
Cardiac output decreased 11.05 10.86 15 127711 885 34828320
Acute abdomen 11.04 10.86 23 127703 1932 34827273
Acute respiratory distress syndrome 11.03 10.86 53 127673 25916 34803289
Metamyelocyte count increased 11.00 10.86 10 127716 376 34828829
Left atrial enlargement 10.99 10.86 15 127711 890 34828315
Clostridium difficile infection 10.97 10.86 34 127692 18864 34810341
Conduction disorder 10.97 10.86 24 127702 2086 34827119
Crepitations 10.95 10.86 31 127695 3165 34826040
Testicular swelling 10.92 10.86 21 127705 1664 34827541
Shock haemorrhagic 10.90 10.86 75 127651 11279 34817926
Paranoia 10.89 10.86 17 127709 12051 34817154
Tongue disorder 10.89 10.86 3 127723 5336 34823869
Cardiac asthma 10.87 10.86 8 127718 222 34828983

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 4549.22 9.77 3424 257327 110974 79372663
Acute kidney injury 2210.85 9.77 5084 255667 514320 78969317
Cardiac failure 1424.34 9.77 2118 258633 152724 79330913
Hyponatraemia 977.51 9.77 1936 258815 175912 79307725
Hepatic encephalopathy 963.99 9.77 726 260025 23440 79460197
Drug ineffective 701.99 9.77 1565 259186 1079348 78404289
Ascites 682.99 9.77 1026 259725 74536 79409101
Pulmonary arterial hypertension 626.57 9.77 607 260144 27759 79455878
Right ventricular failure 582.43 9.77 536 260215 22961 79460676
Hypotension 577.38 9.77 2904 257847 437413 79046224
Renal impairment 563.90 9.77 1448 259303 156335 79327302
Cardiac failure congestive 522.47 9.77 1320 259431 141082 79342555
Oedema peripheral 505.64 9.77 1892 258859 250396 79233241
Pulmonary hypertension 488.33 9.77 690 260061 47390 79436247
Dyspnoea 485.38 9.77 4594 256157 852431 78631206
Cardiac failure chronic 456.19 9.77 340 260411 10795 79472842
Renal failure 442.21 9.77 1554 259197 199414 79284223
Synovitis 440.50 9.77 11 260740 150723 79332914
Drug interaction 421.00 9.77 2555 258196 412628 79071009
Dehydration 416.54 9.77 1761 258990 246426 79237211
Completed suicide 373.45 9.77 168 260583 245599 79238038
Bradycardia 372.60 9.77 1131 259620 134426 79349211
Arthropathy 372.47 9.77 65 260686 177046 79306591
Joint swelling 367.99 9.77 246 260505 288400 79195237
Blood creatinine increased 344.38 9.77 1203 259548 153854 79329783
Drug abuse 339.29 9.77 61 260690 162630 79321007
Off label use 336.75 9.77 1676 259075 905539 78578098
Infusion related reaction 335.02 9.77 167 260584 230070 79253567
Rheumatoid arthritis 317.47 9.77 142 260609 208328 79275309
Hand deformity 313.92 9.77 5 260746 103914 79379723
Hepatic failure 312.64 9.77 647 260104 60565 79423072
Hepatic cirrhosis 309.59 9.77 470 260281 34436 79449201
Therapeutic product effect decreased 307.90 9.77 78 260673 163785 79319852
International normalised ratio increased 304.96 9.77 780 259971 83941 79399696
Arthralgia 292.64 9.77 929 259822 570874 78912763
Drug intolerance 288.62 9.77 263 260488 263856 79219781
Pemphigus 284.51 9.77 9 260742 99573 79384064
Atrial fibrillation 284.22 9.77 1341 259410 196545 79287092
Treatment failure 282.62 9.77 102 260649 170384 79313253
Blood potassium increased 280.88 9.77 409 260342 28866 79454771
Pain 273.05 9.77 1279 259472 702523 78781114
Fluid retention 258.81 9.77 650 260101 69159 79414478
Hypersensitivity 251.54 9.77 292 260459 261947 79221690
Maternal exposure during pregnancy 250.77 9.77 68 260683 136470 79347167
Gynaecomastia 242.22 9.77 201 260550 7480 79476157
Musculoskeletal stiffness 241.19 9.77 136 260615 174872 79308765
N-terminal prohormone brain natriuretic peptide increased 240.32 9.77 165 260586 4590 79479047
Toxicity to various agents 237.79 9.77 654 260097 420886 79062751
Blood urea increased 236.67 9.77 505 260246 48285 79435352
Glossodynia 235.43 9.77 30 260721 103307 79380330
Systemic lupus erythematosus 232.77 9.77 55 260696 121094 79362543
Alopecia 210.85 9.77 268 260483 231087 79252550
Hypervolaemia 201.48 9.77 437 260314 42253 79441384
Febrile neutropenia 200.90 9.77 277 260474 230722 79252915
Syncope 199.19 9.77 1132 259619 178317 79305320
Pericarditis 196.96 9.77 49 260702 104187 79379450
Rash 195.75 9.77 1101 259650 577257 78906380
Ventricular tachycardia 191.92 9.77 424 260327 41511 79442126
Orthopnoea 190.14 9.77 198 260553 9875 79473762
Dyspnoea exertional 186.67 9.77 668 260083 86405 79397232
Anaemia 186.54 9.77 2249 258502 442766 79040871
Brain natriuretic peptide increased 186.32 9.77 185 260566 8715 79474922
Hepatocellular carcinoma 186.05 9.77 186 260565 8835 79474802
Contraindicated product administered 185.31 9.77 146 260605 157392 79326245
Oedema 177.15 9.77 818 259933 118762 79364875
Duodenal ulcer perforation 172.80 9.77 11 260740 66200 79417437
Helicobacter infection 172.19 9.77 15 260736 69689 79413948
Cardiac failure acute 168.00 9.77 255 260496 18674 79464963
Wound 166.30 9.77 86 260665 116093 79367544
Oesophageal varices haemorrhage 166.07 9.77 126 260625 4110 79479527
Hepatic enzyme increased 164.83 9.77 213 260538 182397 79301240
Melaena 164.31 9.77 505 260246 60385 79423252
Congestive cardiomyopathy 163.08 9.77 197 260554 11583 79472054
General physical health deterioration 161.34 9.77 1489 259262 273749 79209888
Abdominal discomfort 159.06 9.77 366 260385 250361 79233276
Hepatorenal syndrome 154.80 9.77 121 260630 4128 79479509
Discomfort 154.68 9.77 111 260640 125506 79358131
Ejection fraction decreased 151.94 9.77 344 260407 34233 79449404
Chronic kidney disease 145.62 9.77 512 260239 65642 79417995
Gastrointestinal haemorrhage 142.84 9.77 899 259852 146820 79336817
Folliculitis 142.18 9.77 10 260741 55370 79428267
Sinusitis 142.06 9.77 264 260487 195237 79288400
Muscle injury 140.11 9.77 4 260747 48557 79435080
Drug hypersensitivity 138.70 9.77 506 260245 298410 79185227
Atrioventricular block complete 137.94 9.77 217 260534 16393 79467244
Sensitisation 137.63 9.77 102 260649 3209 79480428
Exposure during pregnancy 137.27 9.77 80 260671 101052 79382585
Glomerular filtration rate decreased 135.22 9.77 256 260495 22446 79461191
Ejection fraction 134.61 9.77 87 260664 2182 79481455
Polycystic ovaries 134.19 9.77 106 260645 3673 79479964
Psoriatic arthropathy 133.81 9.77 44 260707 77955 79405682
Neutropenia 132.85 9.77 488 260263 287222 79196415
Intentional product use issue 130.60 9.77 184 260567 151928 79331709
Blood pressure decreased 130.40 9.77 657 260094 98809 79384828
Arrhythmia 127.85 9.77 466 260285 60806 79422831
Lower respiratory tract infection 126.93 9.77 141 260610 129079 79354558
Blood bilirubin increased 126.80 9.77 490 260261 65742 79417895
Hypokalaemia 125.49 9.77 854 259897 143186 79340451
Product prescribing error 122.14 9.77 373 260378 44440 79439197
Mitral valve incompetence 121.97 9.77 281 260470 28284 79455353
Impaired healing 120.88 9.77 68 260683 87587 79396050
Cardiac disorder 120.63 9.77 480 260271 65277 79418360
Intentional overdose 118.64 9.77 103 260648 105857 79377780
Stomatitis 117.75 9.77 186 260565 146571 79337066
Varices oesophageal 117.11 9.77 120 260631 5871 79477766
Cardioactive drug level increased 116.83 9.77 97 260654 3612 79480025
Urticaria 116.09 9.77 272 260479 184929 79298708
Concomitant disease aggravated 114.90 9.77 176 260575 12991 79470646
Tricuspid valve incompetence 114.59 9.77 220 260531 19492 79464145
Fall 112.65 9.77 2228 258523 485401 78998236
Product use in unapproved indication 111.42 9.77 431 260320 249928 79233709
Nasopharyngitis 109.22 9.77 443 260308 253438 79230199
Product monitoring error 108.97 9.77 140 260611 8766 79474871
Ischaemic cardiomyopathy 108.67 9.77 130 260621 7565 79476072
Electrolyte imbalance 108.66 9.77 282 260469 30599 79453038
Arthritis 107.81 9.77 130 260621 114750 79368887
Atrioventricular block 107.79 9.77 177 260574 13864 79469773
Orthostatic hypotension 107.08 9.77 415 260336 55749 79427888
C-reactive protein abnormal 105.54 9.77 16 260735 48351 79435286
Irritable bowel syndrome 103.49 9.77 37 260714 62204 79421433
Injection site pain 101.86 9.77 167 260584 129671 79353966
Cardiomegaly 101.45 9.77 249 260502 26103 79457534
Ejection fraction abnormal 101.04 9.77 75 260676 2365 79481272
Swelling 98.40 9.77 370 260381 216341 79267296
Hepatic cancer 97.94 9.77 145 260606 10384 79473253
Blood cholesterol increased 96.65 9.77 79 260672 83641 79399996
Mobility decreased 95.98 9.77 157 260594 122018 79361619
Product use issue 95.42 9.77 358 260393 209464 79274173
Bundle branch block left 93.65 9.77 149 260602 11364 79472273
Blood sodium decreased 93.63 9.77 280 260471 32975 79450662
Gastrointestinal disorder 88.75 9.77 165 260586 122040 79361597
Renal disorder 87.63 9.77 320 260431 41785 79441852
Ammonia increased 85.64 9.77 115 260636 7520 79476117
Pulmonary oedema 85.19 9.77 537 260214 87717 79395920
Labelled drug-drug interaction medication error 82.81 9.77 238 260513 27412 79456225
Infection 82.68 9.77 458 260293 241254 79242383
Pyrexia 82.33 9.77 1645 259106 677064 78806573
Pleural effusion 81.56 9.77 779 259972 144483 79339154
Transfusion 81.53 9.77 201 260550 21129 79462508
Ill-defined disorder 81.35 9.77 58 260693 65817 79417820
Injection site erythema 80.50 9.77 82 260669 78115 79405522
Hepatic function abnormal 80.24 9.77 460 260291 72647 79410990
Generalised oedema 79.84 9.77 213 260538 23496 79460141
Abdominal distension 79.68 9.77 666 260085 118984 79364653
Therapeutic product effect incomplete 79.49 9.77 220 260531 141425 79342212
Anaphylactic reaction 79.38 9.77 94 260657 83649 79399988
Sleep disorder due to general medical condition, insomnia type 79.36 9.77 22 260729 43534 79440103
Paraesthesia 78.76 9.77 303 260448 176020 79307617
Hypovolaemia 77.71 9.77 176 260575 17515 79466122
Cardiogenic shock 77.70 9.77 307 260444 41607 79442030
Therapeutic drug monitoring analysis not performed 76.81 9.77 58 260693 1878 79481759
Electrocardiogram abnormal 75.18 9.77 168 260583 16569 79467068
Cardiomyopathy 73.32 9.77 234 260517 28540 79455097
Intentional product misuse 70.43 9.77 127 260624 95038 79388599
Jaundice 69.62 9.77 352 260399 52997 79430640
Injection site reaction 69.29 9.77 47 260704 54738 79428899
Osteoarthritis 68.75 9.77 112 260639 87197 79396440
Atrial flutter 68.54 9.77 190 260561 21435 79462202
Congestive hepatopathy 67.83 9.77 79 260672 4468 79479169
Left ventricular failure 67.19 9.77 116 260635 9465 79474172
Portal hypertension 66.28 9.77 98 260653 7010 79476627
Joint range of motion decreased 66.13 9.77 14 260737 33268 79450369
Prothrombin time prolonged 65.39 9.77 160 260591 16739 79466898
Knee arthroplasty 64.92 9.77 30 260721 43218 79440419
Haematemesis 64.15 9.77 339 260412 51925 79431712
Hypoaesthesia 63.43 9.77 336 260415 179016 79304621
Polyuria 62.23 9.77 146 260605 14868 79468769
Paracentesis 61.74 9.77 44 260707 1301 79482336
Blister 61.65 9.77 193 260558 119283 79364354
Brain natriuretic peptide abnormal 61.13 9.77 36 260715 761 79482876
Chronic obstructive pulmonary disease 60.93 9.77 483 260268 84936 79398701
Inability to afford medication 60.57 9.77 59 260692 2714 79480923
Cytomegalovirus infection 60.36 9.77 32 260719 42612 79441025
Bursitis 60.11 9.77 21 260730 35823 79447814
Epistaxis 59.62 9.77 592 260159 110923 79372714
Pulmonary arterial pressure increased 59.53 9.77 74 260677 4481 79479156
Adverse drug reaction 59.29 9.77 78 260673 66314 79417323
Pain in jaw 59.16 9.77 303 260448 45848 79437789
Pulmonary congestion 58.98 9.77 209 260542 26891 79456746
Anxiety 57.98 9.77 526 260225 247986 79235651
Red blood cell sedimentation rate increased 57.32 9.77 40 260711 45902 79437735
Suicidal ideation 57.28 9.77 101 260650 76239 79407398
Anuria 56.66 9.77 174 260577 20789 79462848
Subdural haematoma 56.47 9.77 228 260523 31206 79452431
Oliguria 56.42 9.77 148 260603 16161 79467476
Neuropathy peripheral 55.56 9.77 255 260496 141050 79342587
Sudden death 55.49 9.77 181 260570 22330 79461307
Upper gastrointestinal haemorrhage 55.38 9.77 275 260476 41105 79442532
Bradyarrhythmia 55.22 9.77 68 260683 4078 79479559
Hip arthroplasty 54.93 9.77 24 260727 35732 79447905
Electrocardiogram T wave peaked 54.46 9.77 36 260715 939 79482698
Vital capacity decreased 54.12 9.77 46 260705 1770 79481867
Systemic infection 53.23 9.77 106 260645 9646 79473991
Grip strength decreased 53.22 9.77 5 260746 21864 79461773
Mucosal inflammation 53.16 9.77 104 260647 75476 79408161
Haematoma 53.13 9.77 322 260429 51873 79431764
Therapeutic response decreased 52.40 9.77 86 260665 66767 79416870
Suicide attempt 51.77 9.77 122 260629 82810 79400827
Rhinitis allergic 51.61 9.77 120 260631 12149 79471488
Lactic acidosis 51.36 9.77 400 260351 69959 79413678
Intentional self-injury 51.02 9.77 21 260730 32398 79451239
Metabolic alkalosis 50.94 9.77 68 260683 4421 79479216
Bundle branch block right 50.61 9.77 113 260638 11138 79472499
Pulmonary arterial pressure abnormal 50.41 9.77 31 260720 711 79482926
Catheter management 50.28 9.77 61 260690 3602 79480035
Liver transplant 50.19 9.77 67 260684 4356 79479281
Blood aldosterone increased 49.85 9.77 21 260730 207 79483430
Left ventricular dysfunction 49.83 9.77 158 260593 19203 79464434
Abdominal cavity drainage 49.67 9.77 32 260719 798 79482839
Depression 49.63 9.77 461 260290 216329 79267308
Body tinea 49.28 9.77 44 260707 1810 79481827
Shock haemorrhagic 49.18 9.77 161 260590 19899 79463738
Urine output decreased 49.09 9.77 150 260601 17872 79465765
Stress 48.99 9.77 118 260633 79494 79404143
Multiple sclerosis relapse 48.80 9.77 48 260703 46485 79437152
Ventricular fibrillation 48.42 9.77 220 260531 31706 79451931
Sleep disorder 48.11 9.77 133 260618 85544 79398093
Dyspnoea paroxysmal nocturnal 47.91 9.77 47 260704 2181 79481456
Peritonitis bacterial 47.50 9.77 100 260651 9467 79474170
Sputum culture positive 47.15 9.77 60 260691 3721 79479916
Metabolic acidosis 47.00 9.77 444 260307 82085 79401552
COVID-19 46.94 9.77 312 260439 157362 79326275
N-terminal prohormone brain natriuretic peptide abnormal 46.07 9.77 21 260730 254 79483383
Ischaemic stroke 45.64 9.77 222 260529 32909 79450728
Cor pulmonale 45.37 9.77 46 260705 2222 79481415
Low cardiac output syndrome 45.25 9.77 33 260718 1012 79482625
Renin increased 45.23 9.77 20 260731 224 79483413
Reversible airways obstruction 45.12 9.77 45 260706 2131 79481506
Ventricular internal diameter abnormal 44.61 9.77 20 260731 232 79483405
Iron deficiency anaemia 44.37 9.77 184 260567 25488 79458149
Hyperbilirubinaemia 44.17 9.77 178 260573 24340 79459297
Nipple pain 44.14 9.77 31 260720 895 79482742
Myelosuppression 44.09 9.77 40 260711 40256 79443381
Inflammation 43.88 9.77 158 260593 93595 79390042
Night sweats 43.71 9.77 64 260687 52031 79431606
Sleep apnoea syndrome 43.67 9.77 235 260516 36243 79447394
Bone erosion 43.64 9.77 4 260747 17843 79465794
Rhabdomyolysis 42.93 9.77 521 260230 102610 79381027
White blood cell count decreased 42.83 9.77 401 260350 187887 79295750
Waist circumference increased 42.76 9.77 39 260712 1650 79481987
Muscle spasticity 42.74 9.77 9 260742 21466 79462171
Progressive multifocal leukoencephalopathy 42.32 9.77 8 260743 20592 79463045
Accidental exposure to product 42.18 9.77 25 260726 31297 79452340
Oropharyngeal pain 42.00 9.77 199 260552 109154 79374483
Chronic hepatic failure 41.48 9.77 31 260720 988 79482649
Sedation 41.38 9.77 66 260685 51829 79431808
Live birth 41.35 9.77 6 260745 18738 79464899
Blood loss anaemia 41.29 9.77 128 260623 15370 79468267
Hypothyroidism 41.13 9.77 303 260448 52089 79431548
Pain in extremity 40.98 9.77 894 259857 363644 79119993
Inhibitory drug interaction 40.95 9.77 61 260690 4392 79479245
Injury 40.81 9.77 124 260627 77372 79406265
Nephrectomy 40.68 9.77 42 260709 2073 79481564
Abortion spontaneous 40.51 9.77 23 260728 29484 79454153
Cirrhosis alcoholic 40.41 9.77 31 260720 1028 79482609
Hepatitis C 40.01 9.77 107 260644 11818 79471819
Circulatory collapse 40.01 9.77 235 260516 37433 79446204
Sinoatrial block 39.81 9.77 34 260717 1317 79482320
Catheter site infection 39.69 9.77 76 260675 6719 79476918
Torsade de pointes 39.53 9.77 146 260605 19166 79464471
Poisoning deliberate 39.35 9.77 7 260744 18821 79464816
Left ventricular dilatation 39.35 9.77 31 260720 1070 79482567
BRASH syndrome 39.32 9.77 30 260721 987 79482650
Cardioversion 39.16 9.77 41 260710 2057 79481580
Hypovolaemic shock 39.04 9.77 108 260643 12168 79471469
Joint stiffness 38.51 9.77 46 260705 40784 79442853
Concomitant disease progression 38.48 9.77 52 260699 3421 79480216
Pericardial effusion 38.37 9.77 271 260480 45966 79437671
Chest pain 38.06 9.77 1200 259551 281104 79202533
Embolic stroke 37.93 9.77 81 260670 7745 79475892
Nodal rhythm 37.91 9.77 49 260702 3086 79480551
Acute pulmonary oedema 37.42 9.77 117 260634 14113 79469524
Injection site pruritus 37.42 9.77 50 260701 42233 79441404
Electrocardiogram QRS complex prolonged 37.16 9.77 98 260653 10735 79472902
Azotaemia 37.09 9.77 83 260668 8193 79475444
Overdose 37.05 9.77 404 260347 183802 79299835
Generalised tonic-clonic seizure 36.79 9.77 54 260697 43856 79439781
Dizziness 36.60 9.77 2087 258664 524354 78959283
Sinus node dysfunction 36.51 9.77 79 260672 7622 79476015
Hypochloraemia 36.36 9.77 43 260708 2472 79481165
Schizophrenia 36.35 9.77 4 260747 15436 79468201
Blood test abnormal 36.34 9.77 134 260617 17576 79466061
Portal vein thrombosis 36.31 9.77 67 260684 5760 79477877
Exercise tolerance decreased 36.29 9.77 87 260664 8984 79474653
Cardiac output decreased 36.26 9.77 37 260714 1801 79481836
Purpura 36.16 9.77 143 260608 19384 79464253
Seizure 36.07 9.77 419 260332 188415 79295222
Back pain 35.92 9.77 740 260011 303440 79180197
Cytokine release syndrome 35.64 9.77 39 260712 35959 79447678
Electrocardiogram T wave amplitude increased 35.58 9.77 12 260739 59 79483578
Blood pressure systolic increased 35.40 9.77 107 260644 66879 79416758
Blood potassium decreased 35.38 9.77 267 260484 46245 79437392
Inappropriate antidiuretic hormone secretion 35.30 9.77 175 260576 26138 79457499
Colitis ulcerative 35.11 9.77 37 260714 34705 79448932
Blood pressure fluctuation 34.96 9.77 108 260643 67037 79416600
Injection site bruising 34.77 9.77 50 260701 40952 79442685
Sedation complication 34.60 9.77 5 260746 15664 79467973
Neuroleptic malignant syndrome 34.37 9.77 24 260727 27535 79456102
Oesophageal variceal ligation 34.34 9.77 14 260737 126 79483511
Basal cell carcinoma 34.31 9.77 43 260708 37332 79446305
Glomerular filtration rate abnormal 34.02 9.77 34 260717 1614 79482023
Drug ineffective for unapproved indication 33.91 9.77 73 260678 51165 79432472
Jugular vein distension 33.47 9.77 32 260719 1438 79482199
Drug resistance 33.37 9.77 54 260697 42159 79441478
Respiratory depression 33.24 9.77 25 260726 27605 79456032
Hepatomegaly 33.18 9.77 136 260615 18738 79464899
Breast tenderness 33.16 9.77 39 260712 2229 79481408
Palpitations 33.07 9.77 590 260161 126020 79357617
Blood alkaline phosphatase increased 33.06 9.77 336 260415 63328 79420309
Hyperhidrosis 33.02 9.77 326 260425 151166 79332471
Injection site swelling 33.01 9.77 65 260686 47067 79436570
Bone marrow failure 32.85 9.77 74 260677 51033 79432604
Pregnancy 32.68 9.77 24 260727 26827 79456810
Osteonecrosis of jaw 32.59 9.77 57 260694 43169 79440468
Atrial tachycardia 32.49 9.77 72 260679 7061 79476576
Atrial enlargement 32.27 9.77 27 260724 1016 79482621
Adrenal adenoma 31.58 9.77 29 260722 1238 79482399
Drug tolerance decreased 31.49 9.77 3 260748 12975 79470662
Neoplasm progression 31.48 9.77 77 260674 51605 79432032
Transplant evaluation 31.39 9.77 33 260718 1664 79481973
Foot deformity 31.32 9.77 20 260731 24054 79459583
Fatigue 31.10 9.77 2618 258133 927109 78556528
Cardiac murmur 31.03 9.77 118 260633 15706 79467931
Liver injury 30.96 9.77 89 260662 56525 79427112
Epstein-Barr virus infection 30.92 9.77 5 260746 14411 79469226
Hyperthyroidism 30.72 9.77 149 260602 22060 79461577
Haemoglobin decreased 30.67 9.77 947 259804 221172 79262465
Bronchial secretion retention 30.51 9.77 51 260700 4053 79479584
Blood cholesterol 30.50 9.77 22 260729 663 79482974
Musculoskeletal disorder 30.49 9.77 16 260735 21432 79462205
Localised oedema 30.46 9.77 75 260676 7877 79475760
Sopor 30.28 9.77 38 260713 32972 79450665
Device related infection 30.23 9.77 204 260547 34090 79449547
Poisoning 30.23 9.77 23 260728 25249 79458388
Infection susceptibility increased 30.05 9.77 48 260703 3673 79479964
Asthenia 29.88 9.77 1998 258753 509691 78973946
Akathisia 29.83 9.77 4 260747 13255 79470382
Blood pressure increased 29.66 9.77 499 260252 210861 79272776
Scrotal oedema 29.63 9.77 31 260720 1554 79482083
Therapy partial responder 29.51 9.77 10 260741 17387 79466250
Hypocalvaria 29.44 9.77 9 260742 30 79483607
Psoriasis 29.38 9.77 172 260579 89415 79394222
Spur cell anaemia 29.34 9.77 12 260739 109 79483528
Ear infection 29.18 9.77 42 260709 34390 79449247
Catheter placement 29.17 9.77 42 260709 2932 79480705
Gastric varices 28.96 9.77 22 260729 719 79482918
Blood creatine increased 28.91 9.77 82 260669 9373 79474264
Prerenal failure 28.90 9.77 47 260704 3651 79479986
Pneumonitis 28.85 9.77 102 260649 60758 79422879
Catheterisation cardiac 28.59 9.77 60 260691 5668 79477969
Erythema 28.53 9.77 536 260215 222754 79260883
Colitis 28.38 9.77 133 260618 73174 79410463
Erysipelas 28.34 9.77 89 260662 10761 79472876
Pemphigoid 28.24 9.77 112 260639 15203 79468434
Angiotensin converting enzyme inhibitor foetopathy 28.17 9.77 9 260742 36 79483601
Migraine 28.15 9.77 169 260582 87324 79396313
Gamma-glutamyltransferase increased 28.11 9.77 288 260463 54392 79429245
Tendonitis 28.10 9.77 22 260729 23808 79459829
Gouty arthritis 28.08 9.77 29 260722 1432 79482205
Tenosynovitis 28.07 9.77 8 260743 15546 79468091
Sinus bradycardia 27.78 9.77 159 260592 25088 79458549
Lip dry 27.69 9.77 8 260743 15410 79468227
Decreased appetite 27.67 9.77 1377 259374 341041 79142596
Platelet count normal 27.58 9.77 8 260743 21 79483616
Hypertrichosis 27.49 9.77 27 260724 1255 79482382
Leukopenia 27.41 9.77 246 260505 116267 79367370
Shock 27.18 9.77 239 260512 43309 79440328
Haemorrhage subcutaneous 27.13 9.77 53 260698 4756 79478881
Acute respiratory failure 27.08 9.77 306 260445 59235 79424402
Apparent mineralocorticoid excess 27.06 9.77 9 260742 42 79483595
Portal hypertensive gastropathy 27.05 9.77 28 260723 1386 79482251
Dyspnoea at rest 27.05 9.77 68 260683 7234 79476403
Ventricular hypokinesia 26.95 9.77 79 260672 9200 79474437
Walking distance test abnormal 26.85 9.77 21 260730 717 79482920
Cardiac arrest 26.83 9.77 745 260006 171351 79312286
Faecal volume decreased 26.77 9.77 13 260738 183 79483454
Left-to-right cardiac shunt 26.70 9.77 11 260740 102 79483535
Malignant neoplasm progression 26.64 9.77 300 260451 135690 79347947
Troponin T increased 26.50 9.77 44 260707 3478 79480159
Sudden cardiac death 26.39 9.77 55 260696 5170 79478467
Incorrect route of product administration 26.39 9.77 46 260705 34883 79448754
Rales 26.11 9.77 132 260619 19869 79463768
Atrioventricular block first degree 26.04 9.77 95 260656 12396 79471241
Ulcer 25.96 9.77 36 260715 29936 79453701
Neutrophil count decreased 25.95 9.77 190 260561 93769 79389868
Left atrial dilatation 25.91 9.77 41 260710 3112 79480525
Vascular resistance pulmonary decreased 25.88 9.77 10 260741 77 79483560
Oxygen consumption increased 25.84 9.77 53 260698 4926 79478711
Electrocardiogram change 25.83 9.77 26 260725 1245 79482392
Herpes zoster 25.82 9.77 188 260563 92895 79390742
Diaphragmatic spasm 25.80 9.77 11 260740 112 79483525
Psychotic disorder 25.76 9.77 61 260690 41341 79442296
Pruritus 25.74 9.77 1042 259709 393606 79090031
Hyperuricaemia 25.67 9.77 91 260660 11708 79471929
Aortic valve incompetence 25.66 9.77 79 260672 9451 79474186
Sinus arrest 25.59 9.77 44 260707 3578 79480059
Carpal tunnel syndrome 25.58 9.77 129 260622 19399 79464238
Fear of eating 25.30 9.77 17 260734 456 79483181
Keratoconus 25.29 9.77 11 260740 118 79483519
Protein-losing gastroenteropathy 25.27 9.77 19 260732 611 79483026
Insomnia 25.06 9.77 610 260141 244560 79239077
Dilatation ventricular 25.01 9.77 47 260704 4097 79479540
Blood urea abnormal 24.89 9.77 26 260725 1301 79482336
Joint effusion 24.79 9.77 14 260737 18000 79465637
Hypoglycaemia 24.64 9.77 468 260283 101126 79382511
Blood pressure systolic decreased 24.60 9.77 86 260665 10990 79472647
Bronchopulmonary aspergillosis 24.55 9.77 22 260729 22272 79461365
Haematotoxicity 24.51 9.77 10 260741 15509 79468128
Intra-abdominal fluid collection 24.37 9.77 40 260711 3132 79480505
Ventricular extrasystoles 24.31 9.77 128 260623 19576 79464061
Cytomegalovirus viraemia 24.26 9.77 6 260745 12815 79470822
Lung transplant 24.20 9.77 49 260702 4512 79479125
Blood parathyroid hormone decreased 24.13 9.77 3 260748 10533 79473104
Female sexual arousal disorder 23.74 9.77 6 260745 7 79483630
Glaucoma 23.61 9.77 18 260733 19743 79463894
Hospitalisation 23.50 9.77 436 260315 93800 79389837
Therapy non-responder 23.45 9.77 191 260560 92114 79391523
Tremor 23.39 9.77 403 260348 169680 79313957
Immunodeficiency 23.35 9.77 22 260729 21746 79461891
Hypophagia 23.35 9.77 239 260512 45128 79438509
Endocarditis 23.29 9.77 82 260669 10515 79473122
Calcium deficiency 23.23 9.77 21 260730 878 79482759
Graft versus host disease 23.22 9.77 10 260741 15016 79468621
Subarachnoid haemorrhage 23.06 9.77 148 260603 24317 79459320
Activated partial thromboplastin time prolonged 23.05 9.77 100 260651 14128 79469509
Coma hepatic 23.05 9.77 23 260728 1090 79482547
Acute myocardial infarction 23.04 9.77 367 260384 76669 79406968
Dry mouth 22.88 9.77 181 260570 87838 79395799
Pericarditis constrictive 22.78 9.77 18 260733 624 79483013
International normalised ratio abnormal 22.73 9.77 55 260696 5713 79477924
Cardiac dysfunction 22.72 9.77 45 260706 4079 79479558
Cardiorenal syndrome 22.69 9.77 27 260724 1562 79482075
Thermohypoaesthesia 22.62 9.77 10 260741 112 79483525
Product dose omission issue 22.36 9.77 627 260124 246910 79236727
Catheter removal 22.32 9.77 18 260733 643 79482994
Portopulmonary hypertension 22.21 9.77 11 260740 162 79483475
Upper respiratory tract inflammation 22.19 9.77 44 260707 3991 79479646
Multiple allergies 22.19 9.77 80 260671 10380 79473257
C-reactive protein increased 22.10 9.77 293 260458 128734 79354903
Neck pain 22.05 9.77 150 260601 75267 79408370
Asterixis 21.97 9.77 35 260716 2672 79480965
Pulmonary veno-occlusive disease 21.90 9.77 27 260724 1621 79482016
Prescribed overdose 21.87 9.77 58 260693 37825 79445812
Catheter site erythema 21.77 9.77 51 260700 5189 79478448
Dizziness postural 21.73 9.77 85 260666 11464 79472173
Drug withdrawal syndrome 21.72 9.77 51 260700 34667 79448970
Gout 21.68 9.77 147 260604 24602 79459035
Periarthritis calcarea 21.61 9.77 9 260742 86 79483551
Ear pain 21.61 9.77 47 260704 32822 79450815
Hypertension 21.55 9.77 874 259877 330118 79153519
Urine potassium increased 21.48 9.77 6 260745 13 79483624
Acute myeloid leukaemia 21.28 9.77 43 260708 30842 79452795
Conduction disorder 21.24 9.77 39 260712 3340 79480297
Device alarm issue 21.23 9.77 30 260721 2059 79481578
Bleeding varicose vein 21.20 9.77 17 260734 602 79483035
Haemoptysis 21.20 9.77 278 260473 55721 79427916
Venous pressure jugular increased 21.20 9.77 24 260727 1316 79482321
Rash pruritic 21.17 9.77 142 260609 71487 79412150
Cyanosis 21.13 9.77 148 260603 25034 79458603
Sight disability 21.10 9.77 10 260741 133 79483504
Aortic stenosis 20.99 9.77 63 260688 7432 79476205
Thrombotic microangiopathy 20.92 9.77 21 260730 20148 79463489
Cerebral infarction 20.89 9.77 235 260516 45441 79438196
Throat tightness 20.86 9.77 37 260714 27870 79455767
Haemorrhoidal haemorrhage 20.84 9.77 59 260692 6736 79476901
Gastric polyps 20.78 9.77 41 260710 3706 79479931
Influenza like illness 20.78 9.77 143 260608 71564 79412073
Hypernatraemia 20.75 9.77 98 260653 14353 79469284
Aspiration pleural cavity 20.70 9.77 26 260725 1591 79482046
Intervertebral disc degeneration 20.69 9.77 13 260738 15772 79467865
Amyloidosis 20.62 9.77 34 260717 2672 79480965
Cardiac hypertrophy 20.54 9.77 26 260725 1604 79482033
Gait inability 20.46 9.77 111 260640 58806 79424831
Vascular access site thrombosis 20.34 9.77 7 260744 37 79483600
Respiratory failure 20.31 9.77 753 259998 180158 79303479
Primary hyperaldosteronism 20.27 9.77 10 260741 146 79483491
Full blood count abnormal 20.25 9.77 212 260539 40262 79443375
Hypoalbuminaemia 20.17 9.77 129 260622 21168 79462469
Aggression 19.99 9.77 92 260659 50866 79432771
Ventricular arrhythmia 19.94 9.77 69 260682 8771 79474866
Disability 19.94 9.77 16 260735 17104 79466533
Dyskinesia 19.93 9.77 77 260674 44696 79438941
Right ventricular dysfunction 19.93 9.77 33 260718 2602 79481035
Therapeutic embolisation 19.80 9.77 15 260736 488 79483149
Encephalopathy 19.75 9.77 320 260431 67077 79416560
Withdrawal syndrome 19.71 9.77 36 260715 26818 79456819
Angina pectoris 19.66 9.77 257 260494 51475 79432162
Influenza 19.50 9.77 302 260449 129304 79354333
Panniculitis 19.49 9.77 8 260743 12363 79471274
Pulmonary hypertensive crisis 19.40 9.77 13 260738 347 79483290
Exostosis 19.33 9.77 16 260735 16842 79466795
Coma 19.33 9.77 223 260528 100426 79383211
Catheter site discharge 19.32 9.77 31 260720 2381 79481256
Transplant rejection 19.30 9.77 21 260730 19416 79464221
Uveitis 19.27 9.77 16 260735 16814 79466823
ECG signs of myocardial ischaemia 19.21 9.77 13 260738 353 79483284
Sleep disorder due to a general medical condition 19.18 9.77 95 260656 14182 79469455
Respiratory arrest 19.13 9.77 110 260641 57440 79426197
Injection site haemorrhage 19.04 9.77 39 260712 27831 79455806
Device difficult to use 19.01 9.77 10 260741 13375 79470262
Peripheral circulatory failure 18.94 9.77 21 260730 1125 79482512
Diffuse large B-cell lymphoma 18.91 9.77 8 260743 12141 79471496
Eosinophilia 18.83 9.77 229 260522 45116 79438521
Angina unstable 18.79 9.77 105 260646 16422 79467215
Acute graft versus host disease 18.77 9.77 5 260746 10162 79473475
Haematuria 18.76 9.77 323 260428 68513 79415124
Cytomegalovirus infection reactivation 18.75 9.77 3 260748 8713 79474924
Cortisol increased 18.74 9.77 15 260736 530 79483107
Hyperaldosteronism 18.74 9.77 14 260737 446 79483191
Hypertrophic cardiomyopathy 18.64 9.77 30 260721 2310 79481327
Drug tolerance 18.63 9.77 3 260748 8672 79474965
Right ventricular dilatation 18.60 9.77 27 260724 1899 79481738
Photophobia 18.44 9.77 24 260727 20504 79463133
Bladder cancer 18.41 9.77 22 260729 19504 79464133
Inappropriate schedule of product administration 18.25 9.77 317 260434 133311 79350326
Dystonia 18.24 9.77 26 260725 21373 79462264
Oxygen saturation increased 18.22 9.77 15 260736 552 79483085
Stevens-Johnson syndrome 18.13 9.77 202 260549 38964 79444673
Chronic sinusitis 18.10 9.77 10 260741 13016 79470621
Cardiac amyloidosis 18.07 9.77 26 260725 1814 79481823
Lower limb fracture 18.06 9.77 30 260721 23185 79460452
Altered state of consciousness 18.06 9.77 221 260530 43601 79440036
Renal function test abnormal 17.95 9.77 46 260705 4952 79478685
Ectopic ACTH syndrome 17.93 9.77 10 260741 190 79483447
Dyspepsia 17.83 9.77 249 260502 108438 79375199
Fungal infection 17.82 9.77 73 260678 41675 79441962
Premature labour 17.80 9.77 3 260748 8387 79475250
Posterior reversible encephalopathy syndrome 17.76 9.77 37 260714 26244 79457393
Wound infection 17.76 9.77 32 260719 23959 79459678
Fluid intake reduced 17.75 9.77 53 260698 6235 79477402
Oesophageal carcinoma 17.73 9.77 7 260744 11077 79472560
Poor quality sleep 17.60 9.77 131 260620 22591 79461046
Drug dependence 17.59 9.77 71 260680 40698 79442939
Loss of personal independence in daily activities 17.55 9.77 233 260518 102347 79381290
Oxygen saturation decreased 17.48 9.77 549 260202 128498 79355139
Upper-airway cough syndrome 17.30 9.77 80 260671 11613 79472024
Marasmus 17.27 9.77 19 260732 1009 79482628
Memory impairment 17.27 9.77 259 260492 111475 79372162
Agranulocytosis 17.24 9.77 224 260527 44806 79438831
Vision blurred 17.23 9.77 243 260508 105655 79377982
Multiple sclerosis 17.15 9.77 29 260722 22253 79461384
Breast cancer female 17.12 9.77 8 260743 11453 79472184
Appendicitis 17.00 9.77 26 260725 20768 79462869
Hepatorenal failure 16.99 9.77 21 260730 1264 79482373
Gastric varices haemorrhage 16.95 9.77 13 260738 431 79483206
Foetal death 16.79 9.77 3 260748 8041 79475596
Electrocardiogram QRS complex abnormal 16.76 9.77 15 260736 619 79483018
Endometriosis male 16.75 9.77 5 260746 15 79483622
Hypoparathyroidism secondary 16.71 9.77 10 260741 218 79483419
Myasthenic syndrome 16.70 9.77 17 260734 825 79482812
Product quality issue 16.68 9.77 56 260695 33884 79449753
Troponin increased 16.65 9.77 114 260637 19141 79464496
Nodal arrhythmia 16.64 9.77 26 260725 1952 79481685
Vasodilatation 16.60 9.77 34 260717 3157 79480480
Adrenal cyst 16.57 9.77 9 260742 162 79483475
International normalised ratio decreased 16.51 9.77 61 260690 8009 79475628
Mouth ulceration 16.48 9.77 67 260684 38327 79445310
Neurotoxicity 16.43 9.77 53 260698 32465 79451172
Catheter site swelling 16.42 9.77 25 260726 1835 79481802
Urogenital haemorrhage 16.32 9.77 18 260733 959 79482678
Anal haemorrhage 16.29 9.77 40 260711 4194 79479443
Sciatica 16.20 9.77 55 260696 33167 79450470
Condition aggravated 16.13 9.77 1873 258878 499251 78984386
Cystitis haemorrhagic 16.04 9.77 5 260746 9167 79474470
Foreign body in reproductive tract 16.03 9.77 15 260736 656 79482981
Neutropenic sepsis 15.96 9.77 41 260710 27023 79456614
Diet noncompliance 15.95 9.77 14 260737 563 79483074
Therapeutic response shortened 15.91 9.77 17 260734 15846 79467791
Nephrocalcinosis 15.90 9.77 22 260729 1480 79482157
Premature delivery 15.89 9.77 33 260718 23434 79460203
Eye pain 15.86 9.77 66 260685 37512 79446125
Eye irritation 15.84 9.77 27 260724 20654 79462983
Loss of consciousness 15.83 9.77 686 260065 167257 79316380
Injection site mass 15.78 9.77 26 260725 20158 79463479
Encephalitis 15.74 9.77 15 260736 14745 79468892
Diabetic ketoacidosis 15.63 9.77 58 260693 34064 79449573
Nephrolithiasis 15.57 9.77 106 260645 53185 79430452
Quadriparesis 15.56 9.77 35 260716 3466 79480171
Affective disorder 15.54 9.77 4 260747 8315 79475322
Toxic epidermal necrolysis 15.52 9.77 218 260533 44363 79439274
Left ventricular hypertrophy 15.42 9.77 75 260676 11116 79472521
Mitral valve disease 15.39 9.77 33 260718 3164 79480473
Left ventricular false tendon 15.33 9.77 6 260745 48 79483589
Aspartate aminotransferase increased 15.30 9.77 576 260175 138065 79345572
Leukaemic infiltration renal 15.27 9.77 5 260746 22 79483615
Bone pain 15.25 9.77 113 260638 55629 79428008
Therapeutic drug monitoring analysis incorrectly performed 15.20 9.77 15 260736 701 79482936
Secretion discharge 15.18 9.77 16 260735 15006 79468631
Gastritis erosive 15.16 9.77 73 260678 10774 79472863
Somnolence 15.13 9.77 633 260118 238348 79245289
Gender dysphoria 15.12 9.77 6 260745 50 79483587
Mass 15.12 9.77 21 260730 17451 79466186
Testicular swelling 15.10 9.77 20 260731 1290 79482347
Vessel puncture site haemorrhage 15.09 9.77 9 260742 195 79483442
Synovial cyst 15.08 9.77 7 260744 10058 79473579
Hepatotoxicity 15.08 9.77 102 260649 51250 79432387
Fibromyalgia 15.06 9.77 136 260615 64204 79419433
Bilirubin conjugated increased 14.99 9.77 46 260705 5493 79478144
Hepatic neoplasm 14.95 9.77 34 260717 3392 79480245
Drug level decreased 14.93 9.77 15 260736 14387 79469250
Peripartum cardiomyopathy 14.88 9.77 8 260743 141 79483496
Hydrocholecystis 14.87 9.77 13 260738 520 79483117
Osteonecrosis 14.81 9.77 52 260699 31043 79452594
Tricuspid valve replacement 14.75 9.77 5 260746 25 79483612
Ataxia 14.71 9.77 38 260713 25001 79458636
Blood albumin decreased 14.59 9.77 132 260619 24111 79459526
Prostatomegaly 14.58 9.77 34 260717 3449 79480188
Feeling hot 14.54 9.77 125 260626 59609 79424028
Device inappropriate shock delivery 14.53 9.77 6 260745 56 79483581
Blood culture negative 14.50 9.77 9 260742 210 79483427
Scrotal swelling 14.47 9.77 18 260733 1091 79482546
Articular calcification 14.46 9.77 9 260742 211 79483426
Preternatural anus 14.45 9.77 7 260744 98 79483539
Myasthenia gravis 14.43 9.77 8 260743 10391 79473246
Atrial septal defect repair 14.43 9.77 12 260739 448 79483189
Prothrombin level decreased 14.38 9.77 22 260729 1622 79482015
Haemothorax 14.37 9.77 45 260706 5433 79478204
Illness 14.36 9.77 91 260660 46420 79437217
Brain oedema 14.34 9.77 39 260712 25224 79458413
Mood swings 14.28 9.77 27 260724 19853 79463784
Hypoglycaemic coma 14.28 9.77 41 260710 4719 79478918
Caesarean section 14.25 9.77 12 260739 12523 79471114
Sputum culture 14.24 9.77 9 260742 217 79483420
Bulbospinal muscular atrophy congenital 14.22 9.77 4 260747 9 79483628
Adverse event 14.22 9.77 127 260624 60087 79423550
Secondary sexual characteristics absence 14.18 9.77 3 260748 0 79483637
Chills 14.17 9.77 407 260344 159827 79323810
Cardiac ablation 14.16 9.77 26 260725 2227 79481410
Squamous cell carcinoma of skin 14.12 9.77 15 260736 14018 79469619
Pulmonary vein stenosis 14.11 9.77 8 260743 157 79483480
Multiple drug therapy 14.10 9.77 37 260714 4041 79479596
Pulmonary capillary haemangiomatosis 14.08 9.77 6 260745 61 79483576
Food allergy 14.07 9.77 9 260742 10815 79472822
Muscle haemorrhage 14.06 9.77 49 260702 6251 79477386
Sinus disorder 14.05 9.77 33 260718 22431 79461206
Rhinorrhoea 14.05 9.77 170 260581 75904 79407733
Kidney transplant rejection 14.05 9.77 8 260743 10238 79473399
Blood calcium decreased 13.99 9.77 55 260696 31764 79451873
Red cell distribution width abnormal 13.99 9.77 9 260742 224 79483413
Blood creatinine abnormal 13.98 9.77 41 260710 4776 79478861
Serotonin syndrome 13.95 9.77 88 260663 44939 79438698
Renal injury 13.92 9.77 99 260652 16828 79466809
Bladder irrigation 13.91 9.77 6 260745 63 79483574
Deformity 13.90 9.77 7 260744 9598 79474039
Therapeutic response increased 13.86 9.77 13 260738 570 79483067
Chronic coronary syndrome 13.84 9.77 7 260744 108 79483529
Partial seizures 13.83 9.77 6 260745 8972 79474665
Coordination abnormal 13.82 9.77 22 260729 17290 79466347
Tenderness 13.80 9.77 36 260715 23606 79460031
Aspergillus infection 13.79 9.77 26 260725 19135 79464502
Subchorionic haematoma 13.79 9.77 7 260744 109 79483528
Haemophagocytic lymphohistiocytosis 13.72 9.77 32 260719 21805 79461832
Injection site urticaria 13.71 9.77 13 260738 12813 79470824
Second primary malignancy 13.71 9.77 16 260735 14334 79469303
Blood pressure systolic abnormal 13.69 9.77 22 260729 17225 79466412
Injection site warmth 13.63 9.77 17 260734 14790 79468847
Hypercholesterolaemia 13.61 9.77 35 260716 23060 79460577
Renal artery stenosis 13.50 9.77 33 260718 3449 79480188
Labelled drug-disease interaction medication error 13.48 9.77 10 260741 315 79483322
Paranoia 13.44 9.77 27 260724 19405 79464232
Urinary retention 13.43 9.77 260 260491 56370 79427267
Pancytopenia 13.43 9.77 426 260325 165319 79318318
Hypomania 13.39 9.77 4 260747 7540 79476097
BK virus infection 13.38 9.77 6 260745 8798 79474839
Diplopia 13.38 9.77 60 260691 33406 79450231
Multiple organ dysfunction syndrome 13.37 9.77 500 260251 119746 79363891
Substance abuse 13.35 9.77 9 260742 10517 79473120
Hydrothorax 13.34 9.77 20 260731 1448 79482189
Lymphopenia 13.32 9.77 53 260698 30504 79453133
Diffuse vasculitis 13.29 9.77 7 260744 118 79483519
Blood ketone body increased 13.28 9.77 14 260737 708 79482929
Joint injury 13.25 9.77 55 260696 31280 79452357
Renin decreased 13.24 9.77 7 260744 119 79483518
Glucose tolerance impaired 13.24 9.77 57 260694 8027 79475610
Hypoaesthesia oral 13.22 9.77 16 260735 14108 79469529
Presyncope 13.20 9.77 198 260553 40856 79442781
Incision site impaired healing 13.13 9.77 10 260741 328 79483309
Electrolyte depletion 13.12 9.77 11 260740 415 79483222
Visual impairment 13.08 9.77 217 260534 91914 79391723
Cerebral haemorrhage 13.07 9.77 263 260488 57410 79426227
Pulmonary arterial wedge pressure increased 13.05 9.77 12 260739 513 79483124
Tricuspid valve disease 12.99 9.77 11 260740 421 79483216
Vascular access site infection 12.99 9.77 7 260744 124 79483513
Thrombosis 12.98 9.77 195 260556 83905 79399732
Catheter site pain 12.95 9.77 43 260708 5353 79478284
Demyelination 12.95 9.77 5 260746 8018 79475619
Blood catecholamines decreased 12.94 9.77 4 260747 14 79483623
Tongue disorder 12.91 9.77 16 260735 13959 79469678
Left ventricular enlargement 12.90 9.77 14 260737 732 79482905
Urine output increased 12.89 9.77 25 260726 2231 79481406
Blood chloride decreased 12.89 9.77 57 260694 8120 79475517
Child-Pugh-Turcotte score increased 12.89 9.77 5 260746 39 79483598
Drug specific antibody present 12.81 9.77 3 260748 6649 79476988
Resting tremor 12.81 9.77 20 260731 1501 79482136
Neutrophil count increased 12.80 9.77 51 260700 29345 79454292
Nasal polyps 12.80 9.77 4 260747 7323 79476314
Emotional disorder 12.74 9.77 17 260734 14370 79469267
Liver carcinoma ruptured 12.72 9.77 8 260743 191 79483446
Ventricular dyssynchrony 12.71 9.77 6 260745 79 79483558
Lymphadenopathy 12.70 9.77 112 260639 53135 79430502
Cytopenia 12.70 9.77 30 260721 20353 79463284
Glycosylated haemoglobin increased 12.70 9.77 107 260644 19153 79464484
Xanthopsia 12.70 9.77 10 260741 345 79483292
Cardiac pacemaker evaluation 12.69 9.77 7 260744 130 79483507
Body temperature increased 12.66 9.77 89 260662 44331 79439306
Blood potassium abnormal 12.63 9.77 30 260721 3080 79480557
Product storage error 12.60 9.77 21 260730 16205 79467432
Dry eye 12.59 9.77 70 260681 36861 79446776
Device occlusion 12.58 9.77 74 260677 11792 79471845
Fibrinous bronchitis 12.57 9.77 5 260746 42 79483595
Catheter site inflammation 12.51 9.77 17 260734 1124 79482513
Hepatitis fulminant 12.51 9.77 52 260699 7210 79476427
Diastolic dysfunction 12.50 9.77 69 260682 10742 79472895
Prostate cancer 12.50 9.77 61 260690 33207 79450430
Atrial thrombosis 12.46 9.77 33 260718 3623 79480014
Performance enhancing product use 12.45 9.77 6 260745 83 79483554
Walking aid user 12.44 9.77 9 260742 10139 79473498
Occult blood positive 12.42 9.77 50 260701 6833 79476804
Tooth disorder 12.41 9.77 44 260707 26189 79457448
Lymphocyte count decreased 12.40 9.77 97 260654 47192 79436445
Oxygen consumption decreased 12.39 9.77 11 260740 449 79483188
Bronchiectasis 12.38 9.77 35 260716 22351 79461286
Primary biliary cholangitis 12.35 9.77 17 260734 1138 79482499
Atrioventricular block second degree 12.31 9.77 52 260699 7260 79476377
Obesity 12.29 9.77 66 260685 35059 79448578
Heart sounds abnormal 12.29 9.77 19 260732 1414 79482223
Hepatic calcification 12.28 9.77 10 260741 362 79483275
Disease recurrence 12.27 9.77 89 260662 44020 79439617
Right atrial dilatation 12.23 9.77 14 260737 777 79482860
Postrenal failure 12.23 9.77 13 260738 664 79482973
Pulmonary artery dilatation 12.21 9.77 11 260740 458 79483179
Road traffic accident 12.19 9.77 88 260663 43576 79440061
Blood pressure diastolic abnormal 12.18 9.77 28 260723 19174 79464463
Enteritis 12.15 9.77 18 260733 14565 79469072
Persistent foetal circulation 12.11 9.77 3 260748 3 79483634
Chronic respiratory failure 12.11 9.77 29 260722 2993 79480644
Prothrombin time ratio increased 12.09 9.77 9 260742 285 79483352
Nephrogenic anaemia 12.08 9.77 34 260717 3868 79479769
Cortisol free urine increased 12.08 9.77 5 260746 47 79483590
Bundle branch block 12.05 9.77 20 260731 1580 79482057
Internal haemorrhage 12.03 9.77 59 260692 8774 79474863
Bile acid malabsorption 12.02 9.77 8 260743 211 79483426
Headache 12.01 9.77 1916 258835 651856 78831781
Liver disorder 11.99 9.77 316 260435 72101 79411536
Alpha 1 foetoprotein increased 11.99 9.77 14 260737 794 79482843
Percussion test abnormal 11.98 9.77 5 260746 48 79483589
Graft versus host disease in gastrointestinal tract 11.98 9.77 3 260748 6353 79477284
Metastases to central nervous system 11.98 9.77 22 260729 16353 79467284
Colon cancer 11.98 9.77 85 260666 14438 79469199
Alcoholic liver disease 11.97 9.77 12 260739 572 79483065
Base excess decreased 11.96 9.77 10 260741 376 79483261
Nodule 11.95 9.77 37 260714 22957 79460680
Neuroglycopenia 11.91 9.77 11 260740 473 79483164
Cardiac pacemaker insertion 11.90 9.77 44 260707 5778 79477859
Infected skin ulcer 11.90 9.77 31 260720 3370 79480267
Blood pressure orthostatic 11.90 9.77 6 260745 92 79483545
Viral diarrhoea 11.89 9.77 10 260741 379 79483258
Poor venous access 11.89 9.77 26 260725 18123 79465514
QRS axis abnormal 11.87 9.77 23 260728 2051 79481586
Cardiac ventricular thrombosis 11.83 9.77 21 260730 1752 79481885
Nightmare 11.82 9.77 44 260707 25817 79457820
Apheresis related complication 11.80 9.77 4 260747 20 79483617
Optic nerve operation 11.79 9.77 11 260740 479 79483158
Frequent bowel movements 11.78 9.77 53 260698 29486 79454151
Fistula 11.76 9.77 15 260736 12925 79470712
Duplicate therapy error 11.74 9.77 9 260742 298 79483339
Meningitis aseptic 11.72 9.77 4 260747 6924 79476713
Foot fracture 11.69 9.77 35 260716 21946 79461691
Drug dose omission by device 11.68 9.77 3 260748 6247 79477390
Macroangiopathy 11.68 9.77 7 260744 153 79483484
Candida infection 11.67 9.77 75 260676 38139 79445498
Ventricular assist device insertion 11.63 9.77 5 260746 52 79483585
Blood thyroid stimulating hormone abnormal 11.60 9.77 15 260736 945 79482692
Gamma-glutamyltransferase abnormal 11.59 9.77 12 260739 594 79483043
Brain stem stroke 11.58 9.77 13 260738 706 79482931
Infective pulmonary exacerbation of cystic fibrosis 11.57 9.77 15 260736 12836 79470801
Alkalosis hypochloraemic 11.53 9.77 11 260740 493 79483144
Tuberculosis 11.49 9.77 20 260731 15178 79468459
Portal shunt procedure 11.49 9.77 4 260747 22 79483615
Scrotal infection 11.48 9.77 12 260739 601 79483036
Brain natriuretic peptide 11.47 9.77 5 260746 54 79483583
Insurance issue 11.45 9.77 43 260708 5690 79477947
Macular degeneration 11.45 9.77 12 260739 11284 79472353
Movement disorder 11.43 9.77 48 260703 27211 79456426
Adrenomegaly 11.41 9.77 10 260741 401 79483236
Hypoxia 11.41 9.77 429 260322 102814 79380823
Inferior vena cava syndrome 11.40 9.77 6 260745 101 79483536
Exposure to toxic agent 11.39 9.77 8 260743 9150 79474487
Osteomyelitis 11.37 9.77 62 260689 32803 79450834
Catastrophic reaction 11.34 9.77 4 260747 23 79483614
Cardiotoxicity 11.32 9.77 14 260737 12225 79471412
Aspiration bone marrow 11.31 9.77 5 260746 56 79483581
Stasis dermatitis 11.29 9.77 18 260733 1375 79482262
Hepatitis B reactivation 11.29 9.77 3 260748 6105 79477532
Upper respiratory tract infection 11.28 9.77 220 260531 90948 79392689
Toxic skin eruption 11.26 9.77 117 260634 22176 79461461
Ankylosing spondylitis 11.24 9.77 14 260737 12191 79471446
Infected dermal cyst 11.24 9.77 17 260734 1241 79482396
Dilatation atrial 11.20 9.77 32 260719 3672 79479965
Haematocrit abnormal 11.19 9.77 19 260732 1529 79482108
Product administration error 11.19 9.77 156 260595 31690 79451947
Haemorrhagic stroke 11.14 9.77 68 260683 10978 79472659
Peripheral arterial occlusive disease 11.13 9.77 55 260696 8203 79475434
Bradypnoea 11.13 9.77 3 260748 6049 79477588
Hyperglycaemia 11.10 9.77 305 260446 70030 79413607
Swelling face 11.03 9.77 165 260586 71047 79412590
Adenovirus infection 11.01 9.77 7 260744 8440 79475197
Tardive dyskinesia 10.97 9.77 11 260740 10560 79473077
Haemodialysis 10.97 9.77 99 260652 18069 79465568
Creatinine renal clearance abnormal 10.94 9.77 11 260740 526 79483111
Bronchial hyperreactivity 10.94 9.77 28 260723 3012 79480625
Hypertensive cardiomyopathy 10.93 9.77 9 260742 331 79483306
Haemorrhagic disorder 10.93 9.77 19 260732 1559 79482078
Cryoglobulins present 10.90 9.77 3 260748 6 79483631
Pneumocystis jirovecii pneumonia 10.88 9.77 62 260689 32446 79451191
Tooth fracture 10.86 9.77 13 260738 11517 79472120
Forced expiratory volume decreased 10.86 9.77 6 260745 7808 79475829
Inguinal hernia 10.82 9.77 46 260705 6442 79477195
Haemorrhagic infarction 10.80 9.77 13 260738 761 79482876
Activated partial thromboplastin time shortened 10.79 9.77 14 260737 885 79482752
Pulmonary embolism 10.79 9.77 455 260296 171199 79312438
Hypoosmolar state 10.77 9.77 9 260742 338 79483299
Extrapyramidal disorder 10.75 9.77 38 260713 22641 79460996
Osteoporosis 10.74 9.77 119 260632 53993 79429644
Alanine aminotransferase abnormal 10.69 9.77 8 260743 8859 79474778
Osteopenia 10.69 9.77 28 260723 18336 79465301
Congenital arterial malformation 10.68 9.77 4 260747 28 79483609
Venous pressure increased 10.68 9.77 4 260747 28 79483609
Blood bilirubin abnormal 10.62 9.77 18 260733 1447 79482190
Hyperandrogenism 10.59 9.77 3 260748 7 79483630
Idiopathic angioedema 10.58 9.77 5 260746 66 79483571
Device use error 10.54 9.77 5 260746 7096 79476541
Costal cartilage fracture 10.54 9.77 8 260743 261 79483376
Central venous catheterisation 10.52 9.77 29 260722 3260 79480377
Dependence on oxygen therapy 10.52 9.77 11 260740 551 79483086
Nocturnal dyspnoea 10.52 9.77 19 260732 1607 79482030
Amaurosis 10.50 9.77 16 260735 1175 79482462
Prolactin-producing pituitary tumour 10.48 9.77 6 260745 120 79483517
Skin infection 10.48 9.77 28 260723 18217 79465420
Coeliac disease 10.48 9.77 13 260738 11338 79472299
Time perception altered 10.48 9.77 7 260744 186 79483451
Heart transplant 10.48 9.77 18 260733 1463 79482174
Blood sodium increased 10.44 9.77 37 260714 4761 79478876
Subcutaneous haematoma 10.43 9.77 26 260725 2751 79480886
Pulmonary fibrosis 10.43 9.77 93 260658 44019 79439618
Craniocerebral injury 10.40 9.77 39 260712 5157 79478480
Left atrial enlargement 10.38 9.77 16 260735 1187 79482450
Perineal infection 10.37 9.77 13 260738 794 79482843
Hypertrophy 10.33 9.77 13 260738 797 79482840
Lower gastrointestinal haemorrhage 10.32 9.77 89 260662 16036 79467601
Gastric ulcer 10.31 9.77 162 260589 33743 79449894
Arteriovenous fistula 10.30 9.77 17 260734 1337 79482300
Intervertebral disc protrusion 10.27 9.77 41 260710 23580 79460057
Depressed mood 10.27 9.77 105 260646 48375 79435262
Craniotomy 10.27 9.77 10 260741 460 79483177
Eosinophil count increased 10.22 9.77 93 260658 17012 79466625
Tachycardia induced cardiomyopathy 10.22 9.77 7 260744 194 79483443
Somnambulism 10.22 9.77 3 260748 5718 79477919
Testicular mass 10.20 9.77 5 260746 72 79483565
Ovarian cyst 10.18 9.77 16 260735 12639 79470998
Acute left ventricular failure 10.16 9.77 20 260731 1804 79481833
Electrocardiogram P wave abnormal 10.15 9.77 9 260742 367 79483270
Burning feet syndrome 10.12 9.77 7 260744 197 79483440
Intracardiac thrombus 10.12 9.77 34 260717 4259 79479378
Blood albumin abnormal 10.12 9.77 12 260739 692 79482945
Acidosis 10.11 9.77 104 260647 19658 79463979
Procedural pain 10.08 9.77 40 260711 23044 79460593
Cerebral haematoma 10.08 9.77 52 260699 7890 79475747
Hypocoagulable state 10.07 9.77 22 260729 2137 79481500
Monocyte count increased 10.06 9.77 12 260739 10649 79472988
Right ventricular systolic pressure increased 10.05 9.77 14 260737 948 79482689
Sensitivity to weather change 10.04 9.77 7 260744 8040 79475597
Intestinal obstruction 10.04 9.77 91 260660 42929 79440708
Cryptogenic cirrhosis 10.01 9.77 5 260746 75 79483562
Fat intolerance 10.01 9.77 4 260747 34 79483603
Injection site rash 9.98 9.77 28 260723 17926 79465711
Blood antidiuretic hormone increased 9.96 9.77 5 260746 76 79483561
Lymphoproliferative disorder 9.93 9.77 3 260748 5612 79478025
Autoimmune disorder 9.92 9.77 25 260726 16587 79467050
Collateral circulation 9.90 9.77 5 260746 77 79483560
Glucose tolerance decreased 9.90 9.77 5 260746 77 79483560
Suspected suicide 9.88 9.77 12 260739 10564 79473073
Splinter haemorrhages 9.86 9.77 6 260745 135 79483502
Pathogen resistance 9.85 9.77 20 260731 14322 79469315
Plasma cell myeloma 9.84 9.77 119 260632 53140 79430497
Cardiac asthma 9.84 9.77 8 260743 289 79483348
CSF volume increased 9.81 9.77 4 260747 36 79483601
Cheilosis 9.81 9.77 3 260748 10 79483627
Lupus-like syndrome 9.80 9.77 19 260732 13838 79469799
Amnesia 9.80 9.77 146 260605 62911 79420726

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Generalised tonic-clonic seizure 29.91 24.02 9 73 131 89579

Pharmacologic Action:

SourceCodeDescription
ATC C03DA01 CARDIOVASCULAR SYSTEM
DIURETICS
ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
Aldosterone antagonists
FDA MoA N0000011310 Aldosterone Antagonists
FDA EPC N0000175557 Aldosterone Antagonist
MeSH PA D004232 Diuretics
MeSH PA D006727 Hormone Antagonists
MeSH PA D000451 Mineralocorticoid Receptor Antagonists
MeSH PA D045283 Natriuretic Agents
CHEBI has role CHEBI:35498 diuretics
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Aldosteronism indication 88213004 DOID:446
Edema indication 267038008
Ascites indication 389026000
Diagnostic Test for Primary Aldosteronism indication
Hypokalemia Prevention indication
Peripheral Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Edema due to Nephrotic Syndrome indication
Pulmonary Edema due to Chronic Heart Failure indication
Acne off-label use 11381005 DOID:6543
Polycystic ovaries off-label use 69878008
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Neonatal hyperbilirubinemia contraindication 281610001
Azotemia contraindication 445009001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
Cardalis Ceva Sante Animale 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
25MG/5ML CAROSPIR CMP DEV LLC N209478 Aug. 4, 2017 RX SUSPENSION ORAL 11395828 Oct. 28, 2036 CAROSPIR IS INDICATED AS AN ADD-ON THERAPY FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULT PATIENTS WHO ARE NOT ADEQUATELY CONTROLLED ON OTHER AGENTS
25MG/5ML CAROSPIR CMP DEV LLC N209478 Aug. 4, 2017 RX SUSPENSION ORAL 11395828 Oct. 28, 2036 CAROSPIR IS INDICATED FOR THE MANAGEMENT OF EDEMA IN ADULT CIRRHOTIC PATIENTS WHEN EDEMA IS NOT RESPONSIVE TO FLUID AND SODIUM RESTRICTION
25MG/5ML CAROSPIR CMP DEV LLC N209478 Aug. 4, 2017 RX SUSPENSION ORAL 11395828 Oct. 28, 2036 CAROSPIR IS INDICATED FOR TREATMENT OF NYHA CLASS III-IV HEART FAILURE AND REDUCED EJECTION FRACTION TO INCREASE SURVIVAL, MANAGE EDEMA, AND TO REDUCE THE NEED FOR HOSPITALIZATION FOR HEART FAILURE
25MG/5ML CAROSPIR CMP DEV LLC N209478 Aug. 4, 2017 RX SUSPENSION ORAL 9757394 Oct. 28, 2036 CAROSPIR IS INDICATED FOR TREATMENT OF NYHA CLASS III-IV HEART FAILURE AND REDUCED EJECTION FRACTION TO INCREASE SURVIVAL, MANAGE EDEMA, AND TO REDUCE THE NEED FOR HOSPITALIZATION FOR HEART FAILURE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mineralocorticoid receptor Nuclear hormone receptor ANTAGONIST IC50 9.88 WOMBAT-PK CHEMBL
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor WOMBAT-PK
Androgen receptor Nuclear hormone receptor Ki 7.40 CHEMBL
Progesterone receptor Nuclear hormone receptor EC50 6.03 WOMBAT-PK
Estrogen receptor beta Nuclear hormone receptor EC50 5.48 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 5.52 DRUG MATRIX
Glucocorticoid receptor Nuclear hormone receptor IC50 6.23 WOMBAT-PK
Multidrug and toxin extrusion protein 1 Transporter IC50 4.73 CHEMBL
Androgen receptor Transcription factor IC50 6.17 CHEMBL
Progesterone receptor Transcription factor Ki 6.66 DRUG MATRIX

External reference:

IDSource
4017881 VUID
N0000146234 NUI
D00443 KEGG_DRUG
4017881 VANDF
C0037982 UMLSCUI
CHEBI:9241 CHEBI
SNL PDB_CHEM_ID
CHEMBL1393 ChEMBL_ID
D013148 MESH_DESCRIPTOR_UI
DB00421 DRUGBANK_ID
5833 PUBCHEM_CID
2875 IUPHAR_LIGAND_ID
987 INN_ID
27O7W4T232 UNII
151317 RXNORM
1558 MMSL
1587 MMSL
5506 MMSL
d00373 MMSL
002211 NDDF
13929005 SNOMEDCT_US
387078006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Aldactone HUMAN PRESCRIPTION DRUG LABEL 1 0025-1001 TABLET, FILM COATED 25 mg ORAL NDA 26 sections
Aldactone HUMAN PRESCRIPTION DRUG LABEL 1 0025-1001 TABLET, FILM COATED 25 mg ORAL NDA 26 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1011 TABLET, FILM COATED 25 mg ORAL NDA 24 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1011 TABLET, FILM COATED 25 mg ORAL NDA 24 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1021 TABLET, FILM COATED 50 mg ORAL NDA 24 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1021 TABLET, FILM COATED 50 mg ORAL NDA 24 sections
Aldactone HUMAN PRESCRIPTION DRUG LABEL 1 0025-1031 TABLET, FILM COATED 100 mg ORAL NDA 26 sections
Aldactone HUMAN PRESCRIPTION DRUG LABEL 1 0025-1031 TABLET, FILM COATED 100 mg ORAL NDA 26 sections
Aldactone HUMAN PRESCRIPTION DRUG LABEL 1 0025-1041 TABLET, FILM COATED 50 mg ORAL NDA 26 sections
Aldactone HUMAN PRESCRIPTION DRUG LABEL 1 0025-1041 TABLET, FILM COATED 50 mg ORAL NDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0243 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0243 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Spironolactone and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0403 TABLET 25 mg ORAL ANDA 25 sections
Spironolactone and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0403 TABLET 25 mg ORAL ANDA 25 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0437 TABLET, FILM COATED 100 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0437 TABLET, FILM COATED 100 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0378-2146 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0378-2146 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8178 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8178 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8221 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8221 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8451 TABLET 25 mg ORAL ANDA 25 sections
SPIRONOLACTONE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8452 TABLET 50 mg ORAL ANDA 25 sections
spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6927 TABLET 25 mg ORAL ANDA 24 sections
spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6927 TABLET 25 mg ORAL ANDA 24 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 10544-499 TABLET 25 mg ORAL ANDA 16 sections
Spironolactone HUMAN PRESCRIPTION DRUG LABEL 1 10544-523 TABLET 25 mg ORAL ANDA 16 sections
SPIRONOLACTONE HUMAN PRESCRIPTION DRUG LABEL 1 16714-084 TABLET 25 mg ORAL ANDA 25 sections
SPIRONOLACTONE HUMAN PRESCRIPTION DRUG LABEL 1 16714-084 TABLET 25 mg ORAL ANDA 25 sections