spironolactone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonists 2475 52-01-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • spironolactone
  • abbolactone
  • aldactone
  • aldopur
  • berlactone
  • euteberol
  • quimolactona
  • spirolactone
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
  • Molecular weight: 416.58
  • Formula: C24H32O4S
  • CLOGP: 2.84
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 60.44
  • ALOGS: -5.32
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 13.72 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
May 26, 2023 EMA Nova Laboratories Ireland Limited
Jan. 21, 1960 FDA GD SEARLE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 2277.46 9.98 1560 170635 52643 63264184
Acute kidney injury 1346.32 9.98 2493 169702 260922 63055905
Cardiac failure 1040.13 9.98 1245 170950 87897 63228930
Hyponatraemia 821.26 9.98 1247 170948 110653 63206174
Drug ineffective 635.94 9.98 1171 171024 1043594 62273233
Pulmonary arterial hypertension 599.17 9.98 494 171701 22083 63294744
Right ventricular failure 521.90 9.98 407 171788 16781 63300046
Synovitis 454.54 9.98 11 172184 186907 63129920
Pemphigus 453.87 9.98 9 172186 183717 63133110
Hepatic encephalopathy 420.23 9.98 302 171893 10980 63305847
Arthropathy 415.40 9.98 69 172126 234723 63082104
Ascites 407.42 9.98 527 171668 40201 63276626
Hand deformity 405.71 9.98 5 172190 159452 63157375
Pulmonary hypertension 404.06 9.98 501 171694 36622 63280205
Drug interaction 390.97 9.98 1437 170758 227694 63089133
Hypotension 384.49 9.98 1610 170585 270994 63045833
Systemic lupus erythematosus 384.11 9.98 55 172140 208863 63107964
Renal impairment 383.39 9.98 782 171413 87573 63229254
Glossodynia 372.25 9.98 30 172165 178846 63137981
Joint swelling 371.33 9.98 214 171981 327452 62989375
Drug intolerance 346.30 9.98 204 171991 308457 63008370
Dyspnoea 344.17 9.98 3006 169189 658307 62658520
Cardiac failure congestive 337.69 9.98 763 171432 91670 63225157
Therapeutic product effect decreased 326.02 9.98 64 172131 193123 63123704
Contraindicated product administered 324.31 9.98 94 172101 217554 63099273
Infusion related reaction 322.74 9.98 131 172064 245390 63071437
Renal failure 321.59 9.98 869 171326 116783 63200044
Maternal exposure during pregnancy 308.36 9.98 106 172089 219956 63096871
Bradycardia 308.07 9.98 640 171555 72587 63244240
Rheumatoid arthritis 303.14 9.98 155 172040 253664 63063163
Treatment failure 294.63 9.98 87 172108 198956 63117871
Oedema peripheral 292.09 9.98 1151 171044 188360 63128467
Alopecia 279.64 9.98 302 171893 337234 62979593
Dehydration 268.82 9.98 1055 171140 172299 63144528
Wound 265.31 9.98 59 172136 163204 63153623
Pain 262.96 9.98 1077 171118 739551 62577276
Fluid retention 252.59 9.98 523 171672 59163 63257664
International normalised ratio increased 246.82 9.98 448 171747 45977 63270850
Discomfort 246.14 9.98 74 172121 167300 63149527
Hypersensitivity 244.45 9.98 260 171935 292425 63024402
Atrial fibrillation 242.71 9.98 782 171413 115854 63200973
Blood creatinine increased 235.11 9.98 644 171551 87200 63229627
Abdominal discomfort 225.05 9.98 326 171869 320559 62996268
Pericarditis 221.05 9.98 44 172151 131535 63185292
Helicobacter infection 216.24 9.98 8 172187 92777 63224050
Hypervolaemia 214.25 9.98 321 171874 28092 63288735
Duodenal ulcer perforation 205.04 9.98 7 172188 87202 63229625
Musculoskeletal stiffness 199.90 9.98 127 172068 184491 63132336
Hepatic enzyme increased 196.99 9.98 156 172039 202172 63114655
Arthralgia 195.27 9.98 839 171356 568871 62747956
Blood potassium increased 187.88 9.98 240 171955 18069 63298758
Sensitisation 179.84 9.98 113 172082 3273 63313554
Rash 177.80 9.98 850 171345 560021 62756806
Cardiac failure chronic 170.81 9.98 121 172074 4297 63312530
Polycystic ovaries 169.51 9.98 121 172074 4350 63312477
Folliculitis 160.68 9.98 7 172188 70310 63246517
Exposure during pregnancy 158.98 9.98 114 172081 155433 63161394
Blood urea increased 156.27 9.98 267 171928 26112 63290715
Anaemia 155.40 9.98 1341 170854 292089 63024738
Off label use 154.45 9.98 1134 171061 673328 62643499
Swelling 152.81 9.98 324 171871 275054 63041773
Ejection fraction 150.09 9.98 89 172106 2317 63314510
Hepatic cirrhosis 150.03 9.98 253 171942 24481 63292346
Product use issue 148.69 9.98 230 171965 220290 63096537
Lower respiratory tract infection 145.97 9.98 89 172106 132218 63184609
Dyspnoea exertional 140.80 9.98 421 171774 59881 63256946
Completed suicide 138.39 9.98 115 172080 145558 63171269
Drug hypersensitivity 136.39 9.98 412 171783 310275 63006552
Melaena 128.32 9.98 266 171929 30099 63286728
Renal disorder 127.96 9.98 279 171916 32695 63284132
Product prescribing error 127.57 9.98 244 171951 26045 63290782
N-terminal prohormone brain natriuretic peptide increased 127.19 9.98 77 172118 2084 63314743
Impaired healing 123.20 9.98 62 172133 102480 63214347
Syncope 118.63 9.98 630 171565 116755 63200072
Psoriatic arthropathy 118.22 9.98 50 172145 91470 63225357
Gastrointestinal haemorrhage 116.83 9.98 483 171712 80693 63236134
Oedema 115.63 9.98 548 171647 97074 63219753
Irritable bowel syndrome 114.79 9.98 40 172155 82372 63234455
Hepatic failure 112.35 9.98 278 171917 35378 63281449
Stomatitis 107.21 9.98 131 172064 138594 63178233
Ill-defined disorder 105.06 9.98 45 172150 81710 63235117
Drug abuse 104.85 9.98 33 172162 72485 63244342
Cardiac failure acute 104.34 9.98 129 172066 9394 63307433
Cardiac disorder 104.05 9.98 339 171856 50477 63266350
Hypokalaemia 101.40 9.98 552 171643 103252 63213575
Orthopnoea 99.67 9.98 103 172092 6158 63310669
Ejection fraction abnormal 98.41 9.98 61 172134 1724 63315103
Blood pressure decreased 97.61 9.98 392 171803 64630 63252197
Glomerular filtration rate decreased 93.07 9.98 146 172049 13295 63303532
Mobility decreased 93.00 9.98 115 172080 121044 63195783
Brain natriuretic peptide increased 92.59 9.98 91 172104 5122 63311705
Cardioactive drug level increased 91.46 9.98 63 172132 2137 63314690
Blood bilirubin increased 89.25 9.98 262 171933 36878 63279949
Sinusitis 88.04 9.98 317 171878 226336 63090491
Blood cholesterol increased 87.12 9.98 76 172119 93956 63222871
Product monitoring error 86.17 9.98 82 172113 4434 63312393
Labelled drug-drug interaction medication error 85.19 9.98 140 172055 13259 63303568
Transfusion 84.88 9.98 150 172045 15067 63301760
Rhinitis allergic 84.86 9.98 130 172065 11597 63305230
Fall 84.57 9.98 1514 170681 390820 62926007
Nasopharyngitis 84.02 9.98 379 171816 253878 63062949
Pulmonary oedema 83.31 9.98 332 171863 54541 63262286
Ventricular tachycardia 83.22 9.98 174 172021 19805 63297022
Hepatocellular carcinoma 82.31 9.98 59 172136 2135 63314692
Congestive cardiomyopathy 79.71 9.98 91 172104 6091 63310736
Atrial flutter 78.84 9.98 114 172081 9658 63307169
Sleep disorder due to general medical condition, insomnia type 78.70 9.98 22 172173 52195 63264632
Infection 78.50 9.98 337 171858 228836 63087991
Pain in jaw 78.34 9.98 278 171917 43218 63273609
Chronic kidney disease 78.24 9.98 286 171909 45112 63271715
Atrioventricular block 78.07 9.98 100 172095 7547 63309280
Febrile neutropenia 76.50 9.98 127 172068 118322 63198505
Toxicity to various agents 76.15 9.98 378 171817 246872 63069955
Intentional product use issue 75.52 9.98 145 172050 127747 63189080
Cardiomegaly 75.24 9.98 155 172040 17459 63299368
Arthritis 74.21 9.98 125 172070 115796 63201031
Hip arthroplasty 73.84 9.98 19 172176 47627 63269200
Sleep apnoea syndrome 73.36 9.98 209 171986 28924 63287903
Blood test abnormal 73.30 9.98 143 172052 15486 63301341
Pleural effusion 73.16 9.98 468 171727 92742 63224085
Hepatic function abnormal 72.65 9.98 244 171951 36898 63279929
Blister 71.68 9.98 153 172042 129661 63187166
Knee arthroplasty 70.98 9.98 29 172166 54177 63262650
Pulmonary arterial pressure increased 69.98 9.98 66 172129 3529 63313298
Sputum culture positive 69.44 9.98 53 172142 2114 63314713
Gastrointestinal disorder 68.93 9.98 159 172036 131080 63185747
Abdominal distension 68.66 9.98 436 171759 86179 63230648
Vital capacity decreased 68.36 9.98 48 172147 1680 63315147
Urticaria 67.65 9.98 227 171968 165575 63151252
Concomitant disease aggravated 67.33 9.98 102 172093 9010 63307817
Hypothyroidism 65.56 9.98 259 171936 42373 63274454
Blood sodium decreased 64.02 9.98 177 172018 24075 63292752
Left ventricular failure 63.86 9.98 78 172117 5609 63311218
Liver injury 63.59 9.98 43 172152 60477 63256350
Reversible airways obstruction 63.35 9.98 47 172148 1795 63315032
Arrhythmia 62.98 9.98 237 171958 37903 63278924
Body tinea 62.39 9.98 47 172148 1838 63314989
Catheter management 62.32 9.98 57 172138 2930 63313897
Generalised oedema 61.54 9.98 134 172061 15684 63301143
Palpitations 61.43 9.98 519 171676 112251 63204576
Cardiogenic shock 60.97 9.98 144 172051 17788 63299039
Ischaemic stroke 60.84 9.98 144 172051 17813 63299014
Haematemesis 60.56 9.98 201 171994 30211 63286616
Atrioventricular block complete 60.45 9.98 92 172103 8159 63308668
Respiratory failure 60.45 9.98 478 171717 101380 63215447
Osteoarthritis 59.93 9.98 104 172091 95239 63221588
Injection site reaction 59.61 9.98 43 172152 58481 63258346
Electrolyte imbalance 58.52 9.98 152 172043 19924 63296903
Red blood cell sedimentation rate increased 58.46 9.98 23 172172 43959 63272868
General physical health deterioration 57.56 9.98 815 171380 200587 63116240
Epistaxis 56.97 9.98 365 171830 72360 63244467
Inhibitory drug interaction 56.79 9.98 53 172142 2796 63314031
Paraesthesia 56.72 9.98 226 171969 156740 63160087
Injection site pain 56.23 9.98 173 172022 129627 63187200
Catheter site infection 56.15 9.98 68 172127 4846 63311981
Paracentesis 55.64 9.98 34 172161 936 63315891
Prothrombin time prolonged 55.58 9.98 96 172099 9468 63307359
Type 2 diabetes mellitus 55.17 9.98 55 172140 63813 63253014
Tricuspid valve incompetence 54.78 9.98 122 172073 14499 63302328
Haematoma 53.91 9.98 212 171983 34608 63282219
Anaphylactic reaction 53.64 9.98 60 172135 66040 63250787
Shock haemorrhagic 53.21 9.98 96 172099 9799 63307028
Abortion spontaneous 53.07 9.98 31 172164 47164 63269663
Nephrectomy 53.04 9.98 39 172156 1469 63315358
Injection site erythema 52.02 9.98 91 172104 83083 63233744
Pericardial effusion 51.48 9.98 189 172006 29869 63286958
Device related infection 51.47 9.98 160 172035 23232 63293595
Upper gastrointestinal haemorrhage 51.17 9.98 139 172056 18713 63298114
Fatigue 51.04 9.98 1933 170262 886095 62430732
Oesophageal varices haemorrhage 50.51 9.98 35 172160 1199 63315628
Cor pulmonale 50.45 9.98 43 172152 2011 63314816
Adverse drug reaction 50.05 9.98 87 172108 79627 63237200
Congestive hepatopathy 49.74 9.98 50 172145 2892 63313935
Sleep disorder due to a general medical condition 49.43 9.98 105 172090 12083 63304744
Varices oesophageal 48.70 9.98 51 172144 3097 63313730
Bronchial secretion retention 48.49 9.98 48 172147 2725 63314102
Bursitis 48.20 9.98 20 172175 37021 63279806
Inappropriate antidiuretic hormone secretion 48.12 9.98 120 172075 15342 63301485
Hypoxia 48.01 9.98 302 171893 59490 63257337
Oxygen saturation decreased 47.87 9.98 407 171788 88178 63228649
Atrial tachycardia 47.36 9.98 58 172137 4182 63312645
Joint range of motion decreased 46.44 9.98 15 172180 32413 63284414
Carpal tunnel syndrome 46.37 9.98 143 172052 20674 63296153
Ammonia increased 46.14 9.98 60 172135 4596 63312231
Cardiomyopathy 46.08 9.98 128 172067 17456 63299371
Sleep disorder 45.97 9.98 95 172100 81471 63235356
Sinoatrial block 45.57 9.98 29 172166 859 63315968
Hypoaesthesia 45.42 9.98 269 171926 168124 63148703
Anuria 45.09 9.98 103 172092 12448 63304379
Portal hypertension 43.89 9.98 53 172142 3766 63313061
Intentional overdose 43.82 9.98 84 172111 74068 63242759
Hypovolaemia 43.34 9.98 92 172103 10581 63306246
Hypertrichosis 43.22 9.98 31 172164 1123 63315704
Hypochloraemia 43.21 9.98 39 172156 1970 63314857
Therapeutic drug monitoring analysis not performed 43.18 9.98 33 172162 1319 63315508
Chest pain 42.12 9.98 821 171374 215138 63101689
Ejection fraction decreased 41.30 9.98 144 172051 22188 63294639
Electrocardiogram QRS complex prolonged 40.42 9.98 64 172131 5874 63310953
Acute respiratory failure 40.37 9.98 193 172002 34292 63282535
Live birth 40.14 9.98 10 172185 25620 63291207
Ventricular fibrillation 40.02 9.98 95 172100 11772 63305055
Product use in unapproved indication 39.82 9.98 303 171892 178777 63138050
Sinus node dysfunction 39.77 9.98 56 172139 4629 63312198
Hypovolaemic shock 39.39 9.98 65 172130 6176 63310651
Metabolic alkalosis 39.36 9.98 45 172150 3016 63313811
Subdural haematoma 39.24 9.98 106 172089 14222 63302605
Multiple organ dysfunction syndrome 39.14 9.98 276 171919 56476 63260351
Infection susceptibility increased 39.06 9.98 48 172147 3473 63313354
Haemoptysis 39.03 9.98 168 172027 28558 63288269
Grip strength decreased 38.36 9.98 7 172188 22280 63294547
Aspartate aminotransferase increased 38.34 9.98 394 171801 89883 63226944
Blood alkaline phosphatase increased 38.29 9.98 223 171972 42744 63274083
Purpura 38.24 9.98 91 172104 11294 63305533
Therapeutic response decreased 37.85 9.98 68 172127 61457 63255370
Pregnancy 37.60 9.98 27 172168 36809 63280018
Diffuse large B-cell lymphoma refractory 37.05 9.98 29 172166 1201 63315626
Oliguria 36.44 9.98 78 172117 9023 63307804
Pulmonary congestion 36.36 9.98 117 172078 17301 63299526
Gamma-glutamyltransferase increased 35.96 9.98 185 172010 33846 63282981
Night sweats 35.71 9.98 48 172147 48766 63268061
Concomitant disease progression 35.59 9.98 36 172159 2098 63314729
Jaundice 35.18 9.98 165 172030 29086 63287741
Blood aldosterone increased 35.12 9.98 15 172180 188 63316639
Acute pulmonary oedema 35.09 9.98 72 172123 8086 63308741
Hepatorenal syndrome 34.82 9.98 34 172161 1898 63314929
Catheterisation cardiac 34.68 9.98 52 172143 4551 63312276
Sudden death 34.54 9.98 83 172112 10366 63306461
Foetal exposure during pregnancy 34.53 9.98 22 172173 31940 63284887
Mitral valve incompetence 34.22 9.98 124 172071 19470 63297357
Multiple sclerosis relapse 34.14 9.98 49 172146 48429 63268398
Cardiac output decreased 33.88 9.98 25 172170 947 63315880
Lung transplant 33.67 9.98 42 172153 3086 63313741
Bundle branch block left 33.60 9.98 65 172130 6994 63309833
Catheter placement 33.55 9.98 36 172159 2248 63314579
Rhabdomyolysis 33.44 9.98 219 171976 43732 63273095
Shock 33.25 9.98 139 172056 23324 63293503
Abdominal cavity drainage 32.94 9.98 18 172177 399 63316428
Joint stiffness 32.89 9.98 39 172156 41830 63274997
Neutropenia 32.67 9.98 310 171885 174695 63142132
Blood potassium decreased 32.33 9.98 210 171985 41816 63275011
Orthostatic hypotension 31.79 9.98 187 172008 35973 63280854
Bone erosion 31.74 9.98 5 172190 17712 63299115
Lactic acidosis 31.74 9.98 195 172000 38092 63278735
Bundle branch block right 31.47 9.98 52 172143 4946 63311881
Injury 31.44 9.98 98 172097 73149 63243678
Hospitalisation 31.36 9.98 361 171834 84720 63232107
Muscle spasticity 31.35 9.98 10 172185 21784 63295043
Urine output decreased 31.02 9.98 84 172111 11286 63305541
Haemoglobin decreased 30.72 9.98 560 171635 144925 63171902
Hypertrophic cardiomyopathy 30.63 9.98 29 172166 1558 63315269
Waist circumference increased 30.41 9.98 23 172172 905 63315922
Cardioversion 30.18 9.98 26 172169 1234 63315593
Polyuria 29.48 9.98 69 172126 8473 63308354
Jugular vein distension 29.17 9.98 23 172172 963 63315864
Macular degeneration 28.87 9.98 15 172180 24361 63292466
Decreased appetite 28.84 9.98 888 171307 250164 63066663
Cyanosis 28.59 9.98 106 172089 16829 63299998
Lip dry 28.56 9.98 4 172191 15466 63301361
N-terminal prohormone brain natriuretic peptide abnormal 28.55 9.98 9 172186 43 63316784
Injection site pruritus 28.54 9.98 49 172146 45067 63271760
Dizziness 28.46 9.98 1432 170763 428493 62888334
Intra-abdominal fluid collection 28.39 9.98 34 172161 2395 63314432
Poor quality sleep 28.17 9.98 118 172077 19817 63297010
Vascular resistance pulmonary decreased 28.05 9.98 10 172185 74 63316753
Injection site bruising 27.92 9.98 44 172151 41866 63274961
Catheter site erythema 27.62 9.98 45 172150 4231 63312596
Drug resistance 27.33 9.98 14 172181 22919 63293908
Atrial enlargement 27.15 9.98 15 172180 340 63316487
Thermohypoaesthesia 26.95 9.98 11 172184 122 63316705
Neuropathy peripheral 26.85 9.98 189 172006 113478 63203349
Left-to-right cardiac shunt 26.72 9.98 11 172184 125 63316702
Multiple allergies 26.39 9.98 90 172105 13712 63303115
Left ventricular dysfunction 26.38 9.98 82 172113 11906 63304921
Platelet count decreased 26.30 9.98 452 171743 115670 63201157
Sight disability 26.18 9.98 11 172184 132 63316695
Device stimulation issue 26.17 9.98 9 172186 59 63316768
Renin increased 26.05 9.98 12 172183 182 63316645
Inability to afford medication 26.04 9.98 32 172163 2315 63314512
Glucose tolerance impaired 25.91 9.98 56 172139 6521 63310306
Dyspnoea paroxysmal nocturnal 25.81 9.98 21 172174 920 63315907
Hyperthyroidism 25.75 9.98 93 172102 14580 63302247
Hidradenitis 25.63 9.98 35 172160 2811 63314016
Hyperbilirubinaemia 25.46 9.98 78 172117 11236 63305591
Bradyarrhythmia 25.37 9.98 30 172165 2085 63314742
Metabolic acidosis 25.36 9.98 209 171986 44860 63271967
Therapeutic product effect incomplete 25.30 9.98 217 171978 124839 63191988
Foot deformity 25.20 9.98 23 172172 27830 63288997
Inflammation 25.16 9.98 126 172069 82147 63234680
Iron deficiency anaemia 25.02 9.98 114 172081 19855 63296972
Cardiorenal syndrome 25.00 9.98 20 172175 855 63315972
Pemphigoid 24.99 9.98 59 172136 7285 63309542
Catheter site discharge 24.89 9.98 29 172166 1984 63314843
Sedation complication 24.54 9.98 4 172191 13818 63303009
Cortisol increased 24.51 9.98 15 172180 414 63316413
Tenosynovitis 24.48 9.98 4 172191 13791 63303036
Renal function test abnormal 24.35 9.98 39 172156 3614 63313213
Pulmonary arterial pressure abnormal 24.19 9.98 16 172179 507 63316320
Tachypnoea 24.13 9.98 102 172093 17200 63299627
Upper-airway cough syndrome 24.11 9.98 77 172118 11341 63305486
Gait inability 24.06 9.98 69 172126 52890 63263937
Hepatomegaly 24.04 9.98 79 172116 11810 63305017
Sinus bradycardia 23.67 9.98 90 172105 14461 63302366
Cirrhosis alcoholic 23.53 9.98 12 172183 230 63316597
Eosinophil count increased 23.35 9.98 74 172121 10854 63305973
Incorrect route of product administration 23.29 9.98 24 172171 27428 63289399
Fear of eating 23.15 9.98 14 172181 378 63316449
Ischaemic cardiomyopathy 23.12 9.98 31 172164 2446 63314381
Foreign body in reproductive tract 23.05 9.98 18 172177 743 63316084
Exercise tolerance decreased 23.04 9.98 48 172147 5449 63311378
Drug dispensed to wrong patient 22.98 9.98 13 172182 309 63316518
Haemorrhage subcutaneous 22.91 9.98 34 172161 2949 63313878
Full blood count abnormal 22.90 9.98 156 172039 31561 63285266
Portopulmonary hypertension 22.82 9.98 10 172185 134 63316693
Bilirubin conjugated increased 22.77 9.98 33 172162 2801 63314026
Calcium deficiency 22.74 9.98 21 172174 1093 63315734
C-reactive protein increased 22.60 9.98 157 172038 94550 63222277
Oxygen consumption increased 22.59 9.98 39 172156 3845 63312982
Right ventricular dilatation 22.56 9.98 23 172172 1353 63315474
Multimorbidity 22.34 9.98 16 172179 578 63316249
Cellulitis 22.32 9.98 329 171866 81629 63235198
Intentional self-injury 22.32 9.98 22 172173 25665 63291162
Hepatic cancer 22.20 9.98 42 172153 4445 63312382
Hypoglycaemia 22.19 9.98 255 171940 59810 63257017
Cardiac hypertrophy 21.91 9.98 20 172175 1025 63315802
Liver transplant 21.89 9.98 29 172166 2262 63314565
Vascular access site thrombosis 21.78 9.98 7 172188 36 63316791
Portal vein thrombosis 21.68 9.98 31 172164 2599 63314228
Transplant evaluation 21.45 9.98 21 172174 1176 63315651
Aortic valve calcification 21.39 9.98 15 172180 524 63316303
Premature labour 21.37 9.98 4 172191 12500 63304327
Peripheral circulatory failure 21.23 9.98 19 172176 949 63315878
Psychotic disorder 21.23 9.98 23 172172 25689 63291138
Dyspnoea at rest 21.20 9.98 39 172156 4040 63312787
Haemorrhagic disorder 21.19 9.98 18 172177 838 63315989
Blood loss anaemia 21.14 9.98 63 172132 8938 63307889
Stress 21.03 9.98 102 172093 67065 63249762
Poor peripheral circulation 20.96 9.98 37 172158 3712 63313115
Peritonitis bacterial 20.91 9.98 43 172152 4836 63311991
Colitis ulcerative 20.82 9.98 24 172171 26067 63290760
Metastases to central nervous system 20.74 9.98 5 172190 13100 63303727
Brain natriuretic peptide abnormal 20.73 9.98 13 172182 375 63316452
Cytomegalovirus infection 20.55 9.98 16 172179 20936 63295891
Walking distance test abnormal 20.54 9.98 15 172180 559 63316268
Bile acid malabsorption 20.53 9.98 10 172185 173 63316654
Vessel puncture site haemorrhage 20.51 9.98 9 172186 121 63316706
Dystonia 20.49 9.98 6 172189 13813 63303014
Torsade de pointes 20.43 9.98 81 172114 13270 63303557
Occult blood positive 20.24 9.98 36 172159 3634 63313193
Chronic hepatic failure 20.15 9.98 15 172180 576 63316251
Cardiac dysfunction 20.14 9.98 28 172167 2287 63314540
Catheter removal 20.08 9.98 13 172182 397 63316430
Pulmonary arterial wedge pressure increased 19.95 9.98 12 172183 321 63316506
Haemorrhoidal haemorrhage 19.88 9.98 39 172156 4240 63312587
Viral diarrhoea 19.83 9.98 10 172185 187 63316640
Myelosuppression 19.80 9.98 21 172174 23682 63293145
Pyrexia 19.74 9.98 1059 171136 469419 62847408
Pulmonary hypertensive crisis 19.58 9.98 12 172183 332 63316495
Asthenia 19.58 9.98 1248 170947 382356 62934471
Blood pressure systolic abnormal 19.51 9.98 6 172189 13380 63303447
Electrocardiogram abnormal 19.47 9.98 62 172133 9117 63307710
Joint effusion 19.47 9.98 11 172184 17049 63299778
Gastrooesophageal reflux disease 19.44 9.98 366 171829 95273 63221554
Marasmus 19.42 9.98 14 172181 511 63316316
Sputum culture 19.39 9.98 11 172184 263 63316564
Vascular access site infection 19.27 9.98 7 172188 55 63316772
Hyperuricaemia 19.21 9.98 44 172151 5326 63311501
Immunodeficiency 19.20 9.98 16 172179 20238 63296589
Multiple drug therapy 19.13 9.98 35 172160 3611 63313216
Gout 19.10 9.98 79 172116 13192 63303635
Dementia 19.05 9.98 101 172094 18693 63298134
Red cell distribution width abnormal 19.00 9.98 9 172186 146 63316681
Peripartum cardiomyopathy 19.00 9.98 9 172186 146 63316681
Gastric varices haemorrhage 18.94 9.98 9 172186 147 63316680
Cough 18.91 9.98 973 171222 291770 63025057
Right ventricular dysfunction 18.90 9.98 24 172171 1795 63315032
Device alarm issue 18.85 9.98 22 172173 1508 63315319
Electrocardiogram T wave amplitude increased 18.81 9.98 6 172189 30 63316797
Systemic infection 18.73 9.98 40 172155 4620 63312207
Neonatal respiratory failure 18.70 9.98 11 172184 282 63316545
Prerenal failure 18.62 9.98 23 172172 1673 63315154
Brain stem stroke 18.58 9.98 12 172183 365 63316462
Sciatica 18.48 9.98 41 172154 34283 63282544
Right atrial dilatation 18.34 9.98 15 172180 662 63316165
Suicidal ideation 18.29 9.98 97 172098 62324 63254503
Cardiac murmur 18.17 9.98 83 172112 14469 63302358
Adverse event 18.16 9.98 108 172087 67451 63249376
Altered state of consciousness 18.15 9.98 124 172071 25106 63291721
Diet noncompliance 18.12 9.98 12 172183 381 63316446
Nodal rhythm 18.12 9.98 23 172172 1720 63315107
Sedation 18.05 9.98 50 172145 38759 63278068
Accidental exposure to product 18.04 9.98 29 172166 27376 63289451
Vasodilatation 17.96 9.98 27 172168 2368 63314459
Oesophageal variceal ligation 17.93 9.98 5 172190 14 63316813
Anxiety 17.90 9.98 451 171744 217090 63099737
Activated partial thromboplastin time prolonged 17.89 9.98 50 172145 6843 63309984
Myocardial infarction 17.86 9.98 375 171820 99518 63217309
Pneumonia 17.82 9.98 1454 170741 455313 62861514
Foetal death 17.75 9.98 4 172191 10976 63305851
Hypercholesterolaemia 17.71 9.98 19 172176 21315 63295512
Central venous catheterisation 17.67 9.98 28 172167 2571 63314256
Chronic obstructive pulmonary disease 17.60 9.98 253 171942 62433 63254394
Back pain 17.57 9.98 564 171631 263581 63053246
Deformity 17.46 9.98 5 172190 11679 63305148
Peripheral swelling 17.41 9.98 569 171626 265373 63051454
Schizophrenia 17.40 9.98 3 172192 9949 63306878
Heart valve incompetence 17.35 9.98 29 172166 2785 63314042
Ear pain 17.20 9.98 46 172149 36072 63280755
Atrioventricular block first degree 17.17 9.98 51 172144 7222 63309605
Catheter site pain 17.17 9.98 39 172156 4696 63312131
Urine output increased 17.11 9.98 20 172175 1373 63315454
Acidosis 17.07 9.98 68 172127 11165 63305662
Aspiration pleural cavity 17.03 9.98 16 172179 851 63315976
Blood parathyroid hormone decreased 17.02 9.98 3 172192 9788 63307039
Gastric polyps 17.00 9.98 32 172163 3373 63313454
Female sexual arousal disorder 16.99 9.98 6 172189 43 63316784
Hyperglycaemia 16.95 9.98 181 172014 41686 63275141
Progressive multifocal leukoencephalopathy 16.88 9.98 7 172188 12964 63303863
Injection site swelling 16.85 9.98 69 172126 47503 63269324
Hypercapnia 16.74 9.98 42 172153 5389 63311438
Aortic stenosis 16.73 9.98 40 172155 4980 63311847
Seizure 16.68 9.98 256 171939 132378 63184449
Product odour abnormal 16.58 9.98 19 172176 1277 63315550
Leukaemic infiltration renal 16.57 9.98 5 172190 20 63316807
Oropharyngeal pain 16.52 9.98 170 172025 94317 63222510
Parkinsonism 16.51 9.98 64 172131 10375 63306452
Nodal arrhythmia 16.50 9.98 18 172177 1145 63315682
Erysipelas 16.41 9.98 53 172142 7852 63308975
Disseminated intravascular coagulation 16.41 9.98 98 172097 18953 63297874
Blood potassium abnormal 16.38 9.98 27 172168 2563 63314264
Device related sepsis 16.29 9.98 35 172160 4059 63312768
Incision site impaired healing 16.17 9.98 9 172186 207 63316620
Sinus arrest 16.11 9.98 23 172172 1926 63314901
Aortic valve incompetence 16.10 9.98 44 172151 5944 63310883
Venous pressure jugular increased 16.09 9.98 13 172182 564 63316263
Cardiac ablation 16.08 9.98 20 172175 1465 63315362
Catheter site swelling 16.08 9.98 20 172175 1465 63315362
Vascular device infection 16.07 9.98 50 172145 7262 63309565
Primary biliary cholangitis 16.05 9.98 18 172177 1181 63315646
Gouty arthritis 16.01 9.98 13 172182 568 63316259
Ventricular failure 15.97 9.98 11 172184 373 63316454
Ulcer 15.93 9.98 29 172166 26078 63290749
Blood creatine increased 15.91 9.98 42 172153 5559 63311268
Blood cholesterol decreased 15.88 9.98 16 172179 928 63315899
Cerebral infarction 15.77 9.98 115 172080 23778 63293049
Cardiac arrest 15.77 9.98 345 171850 92200 63224627
Migraine 15.68 9.98 192 172003 103154 63213673
Bleeding varicose vein 15.66 9.98 10 172185 298 63316529
Drug therapeutic incompatibility 15.52 9.98 6 172189 57 63316770
Amaurosis 15.47 9.98 13 172182 596 63316231
Akathisia 15.47 9.98 3 172192 9143 63307684
Left atrial dilatation 15.44 9.98 22 172173 1839 63314988
Blood albumin decreased 15.41 9.98 80 172115 14686 63302141
Musculoskeletal disorder 15.41 9.98 20 172175 20624 63296203
Pulmonary veno-occlusive disease 15.30 9.98 17 172178 1104 63315723
Mixed hepatocellular cholangiocarcinoma 15.28 9.98 4 172191 8 63316819
Renin decreased 15.21 9.98 7 172188 106 63316721
Malignant neoplasm progression 15.08 9.98 146 172049 81975 63234852
Low cardiac output syndrome 15.06 9.98 11 172184 410 63316417
Therapeutic embolisation 15.03 9.98 8 172187 168 63316659
Renal artery stenosis 15.01 9.98 22 172173 1887 63314940
Alanine aminotransferase increased 14.97 9.98 378 171817 103392 63213435
Splenomegaly 14.96 9.98 65 172130 11092 63305735
Hypernatraemia 14.89 9.98 50 172145 7559 63309268
Mucosal inflammation 14.85 9.98 71 172124 46857 63269970
Blood pressure systolic decreased 14.82 9.98 49 172146 7348 63309479
Gamma-glutamyltransferase abnormal 14.79 9.98 10 172185 329 63316498
Left ventricular enlargement 14.75 9.98 6 172189 66 63316761
Blood calcium decreased 14.73 9.98 31 172164 26420 63290407
Exostosis 14.72 9.98 16 172179 17846 63298981
Circulatory collapse 14.72 9.98 106 172089 21832 63294995
Embolic stroke 14.70 9.98 32 172163 3744 63313083
Product quality issue 14.68 9.98 49 172146 35816 63281011
Chronic respiratory failure 14.68 9.98 22 172173 1925 63314902
Supraventricular tachycardia 14.67 9.98 77 172118 14194 63302633
Presyncope 14.65 9.98 127 172068 27658 63289169
Tendonitis 14.64 9.98 19 172176 19596 63297231
Malignant ascites 14.59 9.98 15 172180 891 63315936
Premature baby 14.56 9.98 21 172174 20714 63296113
Suicide attempt 14.53 9.98 101 172094 60817 63256010
Pruritus 14.51 9.98 817 171378 360636 62956191
Pain in extremity 14.28 9.98 744 171451 330742 62986085
Alcoholic liver disease 14.27 9.98 7 172188 123 63316704
Upper respiratory tract inflammation 14.24 9.98 25 172170 2498 63314329
Azotaemia 14.23 9.98 35 172160 4436 63312391
Subchorionic haematoma 14.22 9.98 7 172188 124 63316703
Coagulopathy 14.21 9.98 100 172095 20444 63296383
Pericarditis constrictive 14.17 9.98 10 172185 353 63316474
Blood urea abnormal 14.17 9.98 13 172182 671 63316156
Cortisol free urine increased 14.14 9.98 5 172190 36 63316791
Pulmonary aplasia 14.14 9.98 4 172191 12 63316815
Electrocardiogram QT shortened 14.12 9.98 7 172188 126 63316701
Sepsis 14.11 9.98 528 171667 152595 63164232
Metastases to bone 14.06 9.98 22 172173 20997 63295830
Acute myocardial infarction 14.01 9.98 141 172054 31983 63284844
Hepatorenal failure 14.01 9.98 13 172182 681 63316146
Throat tightness 14.00 9.98 29 172166 24858 63291969
Blood uric acid increased 13.99 9.98 39 172156 5328 63311499
Pulmonary fibrosis 13.94 9.98 58 172137 39751 63277076
Brain natriuretic peptide 13.91 9.98 5 172190 38 63316789
Asterixis 13.82 9.98 18 172177 1381 63315446
Neuroglycopenia 13.82 9.98 11 172184 467 63316360
Urinary retention 13.70 9.98 134 172061 30167 63286660
Postpericardiotomy syndrome 13.67 9.98 4 172191 14 63316813
Blood catecholamines decreased 13.67 9.98 4 172191 14 63316813
Inferior vena cava dilatation 13.65 9.98 6 172189 81 63316746
Angina pectoris 13.60 9.98 133 172062 29945 63286882
Oligohydramnios 13.50 9.98 43 172152 6323 63310504
Panniculitis 13.49 9.98 7 172188 11378 63305449
No adverse event 13.48 9.98 62 172133 41343 63275484
Toxic epidermal necrolysis 13.47 9.98 116 172079 25218 63291609
Disability 13.46 9.98 18 172177 18329 63298498
Hypophosphataemia 13.41 9.98 64 172131 11362 63305465
Encephalopathy 13.40 9.98 162 172033 38458 63278369
Respiratory distress 13.39 9.98 146 172049 33805 63283022
Colitis 13.35 9.98 77 172118 48451 63268376
Cardiac failure high output 13.31 9.98 9 172186 296 63316531
Drug monitoring procedure not performed 13.30 9.98 12 172183 606 63316221
Blood bilirubin abnormal 13.28 9.98 15 172180 992 63315835
Catheter site pruritus 13.27 9.98 22 172173 2098 63314729
Urine potassium increased 13.26 9.98 4 172191 16 63316811
Photophobia 13.25 9.98 17 172178 17618 63299209
Haptoglobin decreased 13.16 9.98 13 172182 736 63316091
Dizziness postural 13.15 9.98 47 172148 7329 63309498
Injection site haemorrhage 13.12 9.98 29 172166 24285 63292542
Intentional product misuse 13.09 9.98 104 172091 60813 63256014
Prescribed overdose 13.08 9.98 48 172147 34105 63282722
Basal cell carcinoma 13.06 9.98 36 172159 27955 63288872
X-ray abnormal 13.02 9.98 3 172192 8107 63308720
Injection site mass 12.99 9.98 19 172176 18637 63298190
Localised oedema 12.97 9.98 38 172157 5340 63311487
Depression 12.95 9.98 420 171775 196072 63120755
Mucocutaneous haemorrhage 12.91 9.98 6 172189 93 63316734
Haemorrhage 12.91 9.98 235 171960 60787 63256040
Epstein-Barr virus infection 12.88 9.98 3 172192 8047 63308780
Electrocardiogram QT prolonged 12.85 9.98 230 171965 59300 63257527
Blood culture negative 12.74 9.98 7 172188 157 63316670
Bronchiectasis 12.72 9.98 15 172180 16127 63300700
Toxic neuropathy 12.70 9.98 10 172185 418 63316409
Haemodynamic instability 12.68 9.98 54 172141 9136 63307691
Haemodialysis 12.67 9.98 53 172142 8894 63307933
Stevens-Johnson syndrome 12.62 9.98 113 172082 24837 63291990
Blood pressure systolic increased 12.61 9.98 76 172119 47321 63269506
Scleroderma 12.61 9.98 38 172157 5424 63311403
Ear infection 12.57 9.98 57 172138 38156 63278671
Visual acuity reduced transiently 12.54 9.98 7 172188 162 63316665
Right ventricular systolic pressure increased 12.52 9.98 11 172184 536 63316291
Bone density decreased 12.48 9.98 75 172120 14537 63302290
Neonatal hyponatraemia 12.45 9.98 5 172190 53 63316774
Glaucoma 12.45 9.98 20 172175 18885 63297942
Electrocardiogram change 12.41 9.98 12 172183 662 63316165
Multiple sclerosis 12.41 9.98 30 172165 24342 63292485
Atrial septal defect repair 12.39 9.98 8 172187 243 63316584
Ventricular hypokinesia 12.36 9.98 34 172161 4610 63312217
Respiratory tract infection 12.28 9.98 169 172026 41314 63275513
Lupus-like syndrome 12.28 9.98 14 172181 15281 63301546
Psoriasis 12.28 9.98 164 172031 86793 63230034
Device difficult to use 12.26 9.98 10 172185 12786 63304041
Tachyarrhythmia 12.26 9.98 33 172162 4417 63312410
Dilatation ventricular 12.24 9.98 23 172172 2422 63314405
Right-to-left cardiac shunt 12.22 9.98 8 172187 249 63316578
Ventricular arrhythmia 12.22 9.98 30 172165 3798 63313029
Blood antidiuretic hormone increased 12.21 9.98 3 172192 4 63316823
Labelled drug-drug interaction issue 12.20 9.98 15 172180 1086 63315741
Platelet dysfunction 12.15 9.98 6 172189 107 63316720
Coma hepatic 12.13 9.98 12 172183 681 63316146
Food allergy 12.11 9.98 8 172187 11393 63305434
Neurodevelopmental disorder 12.09 9.98 7 172188 174 63316653
Diarrhoea infectious 12.09 9.98 15 172180 1096 63315731
Catastrophic reaction 12.08 9.98 4 172191 23 63316804
Walking disability 12.03 9.98 17 172178 1410 63315417
Blood pressure diastolic abnormal 12.02 9.98 13 172182 14529 63302298
Hepatitis fulminant 11.97 9.98 28 172167 3436 63313391
Vascular stenosis 11.97 9.98 9 172186 351 63316476
Glomerular filtration rate abnormal 11.93 9.98 13 172182 826 63316001
Cardiac flutter 11.92 9.98 31 172164 4065 63312762
Renal injury 11.91 9.98 54 172141 9385 63307442
Nasal congestion 11.90 9.98 247 171948 65413 63251414
Gastrointestinal angiectasia 11.83 9.98 5 172190 61 63316766
Sudden cardiac death 11.81 9.98 21 172174 2119 63314708
Chronic right ventricular failure 11.80 9.98 4 172191 25 63316802
Ventricular assist device insertion 11.80 9.98 4 172191 25 63316802
Cardiac pacemaker insertion 11.78 9.98 31 172164 4095 63312732
Gastrointestinal arteriovenous malformation 11.77 9.98 11 172184 581 63316246
Posterior reversible encephalopathy syndrome 11.75 9.98 18 172177 17327 63299500
International normalised ratio abnormal 11.74 9.98 27 172168 3277 63313550
Hypoosmolar state 11.71 9.98 7 172188 185 63316642
Urogenital haemorrhage 11.68 9.98 8 172187 269 63316558
Conduction disorder 11.67 9.98 17 172178 1450 63315377
Extensor plantar response 11.62 9.98 16 172179 1295 63315532
Catheter site inflammation 11.56 9.98 13 172182 856 63315971
Hepatitis C 11.53 9.98 36 172159 5238 63311589
Blood bilirubin unconjugated increased 11.49 9.98 9 172186 373 63316454
Fibrinous bronchitis 11.46 9.98 3 172192 6 63316821
Lower limb fracture 11.42 9.98 31 172164 24190 63292637
Human metapneumovirus test positive 11.41 9.98 5 172190 67 63316760
Lower gastrointestinal haemorrhage 11.38 9.98 47 172148 7843 63308984
Blood chloride decreased 11.36 9.98 37 172158 5505 63311322
Haematocrit abnormal 11.34 9.98 13 172182 874 63315953
Hypertonic bladder 11.32 9.98 28 172167 3560 63313267
Burning sensation 11.32 9.98 209 171986 54198 63262629
Left ventricular dilatation 11.32 9.98 10 172185 491 63316336
Neuromyelitis optica spectrum disorder 11.32 9.98 14 172181 1020 63315807
Premature delivery 11.31 9.98 43 172152 30238 63286589
Thyroxine increased 11.21 9.98 11 172184 618 63316209
Cardiac valve disease 11.19 9.98 31 172164 4221 63312606
Secretion discharge 11.18 9.98 10 172185 12221 63304606
Diabetic metabolic decompensation 11.05 9.98 18 172177 1692 63315135
Catheter site rash 11.03 9.98 12 172183 761 63316066
Duodenal ulcer 11.03 9.98 46 172149 7710 63309117
Tachycardia 11.02 9.98 408 171787 117748 63199079
White blood cell count decreased 11.00 9.98 290 171905 138814 63178013
Bradykinesia 10.97 9.98 35 172160 5153 63311674
Listeraemia 10.96 9.98 5 172190 74 63316753
Toxic skin eruption 10.91 9.98 66 172129 12819 63304008
Cardiac cirrhosis 10.86 9.98 6 172189 136 63316691
Nephrocalcinosis 10.85 9.98 14 172181 1064 63315763
Total bile acids increased 10.82 9.98 6 172189 137 63316690
Angina unstable 10.82 9.98 43 172152 7052 63309775
Erythema 10.80 9.98 379 171816 175372 63141455
Haematotoxicity 10.77 9.98 6 172189 9370 63307457
Electrocardiogram T wave peaked 10.75 9.98 7 172188 216 63316611
Volume blood decreased 10.74 9.98 6 172189 139 63316688
Ballismus 10.74 9.98 6 172189 139 63316688
Cardiac operation 10.69 9.98 26 172169 3272 63313555
Cardio-respiratory arrest 10.69 9.98 225 171970 59734 63257093
Bone marrow failure 10.68 9.98 42 172153 29248 63287579
Ventricular extrasystoles 10.63 9.98 61 172134 11626 63305201
Osteonecrosis of jaw 10.61 9.98 54 172141 35069 63281758
Pancreatic enzymes decreased 10.60 9.98 3 172192 9 63316818
CREST syndrome 10.58 9.98 10 172185 536 63316291
QRS axis abnormal 10.58 9.98 14 172181 1091 63315736
Loss of consciousness 10.56 9.98 406 171789 117715 63199112
Endocarditis 10.56 9.98 37 172158 5713 63311114
Drug withdrawal syndrome 10.56 9.98 38 172157 27156 63289671
Balloon atrial septostomy 10.56 9.98 5 172190 81 63316746
Labelled drug-disease interaction medication error 10.55 9.98 6 172189 144 63316683
Respiratory depression 10.53 9.98 13 172182 13702 63303125
Blood pressure fluctuation 10.46 9.98 78 172117 46239 63270588
Palliative care 10.41 9.98 10 172185 547 63316280
Therapy non-responder 10.41 9.98 144 172051 75757 63241070
Wound infection 10.40 9.98 27 172168 21383 63295444
Gastrointestinal toxicity 10.36 9.98 4 172191 7737 63309090
Gastritis erosive 10.36 9.98 38 172157 6001 63310826
Senile dementia 10.33 9.98 7 172188 231 63316596
Gastroenteritis 10.32 9.98 114 172081 26476 63290351
Blood pressure increased 10.30 9.98 348 171847 161714 63155113
Systemic scleroderma 10.28 9.98 13 172182 968 63315859
Breast cancer female 10.26 9.98 13 172182 13546 63303281
Synovial cyst 10.19 9.98 8 172187 10425 63306402
Right ventricular hypertrophy 10.19 9.98 11 172184 692 63316135
Gastrointestinal endoscopic therapy 10.17 9.98 4 172191 40 63316787
Dependence on oxygen therapy 10.17 9.98 9 172186 443 63316384
Strabismus 10.15 9.98 19 172176 1995 63314832
Flatulence 10.12 9.98 141 172054 34561 63282266
Blood corticotrophin decreased 10.10 9.98 8 172187 337 63316490
Pharyngitis 10.09 9.98 25 172170 20118 63296709
Hyperlipidaemia 10.08 9.98 89 172106 19482 63297345
Herpes zoster 10.08 9.98 160 172035 82302 63234525
Chronic sinusitis 10.05 9.98 12 172183 12831 63303996
Percutaneous coronary intervention 10.05 9.98 7 172188 242 63316585
Intervertebral disc degeneration 10.03 9.98 17 172178 15715 63301112
Chondrocalcinosis 10.01 9.98 12 172183 846 63315981
Hypocalvaria 10.00 9.98 4 172191 42 63316785

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 2475.73 10.86 2038 125688 67351 34761854
Acute kidney injury 940.20 10.86 2837 124889 302151 34527054
Cardiac failure 704.37 10.86 1224 126502 90024 34739181
Hepatic encephalopathy 606.47 10.86 471 127255 14214 34814991
Ascites 390.87 10.86 649 127077 45922 34783283
Cardiac failure chronic 343.39 10.86 261 127465 7618 34821587
Drug ineffective 302.58 10.86 775 126951 455976 34373229
Hypotension 292.20 10.86 1586 126140 220063 34609142
Hyponatraemia 288.97 10.86 807 126919 81884 34747321
Cardiac failure congestive 288.39 10.86 810 126916 82460 34746745
Oedema peripheral 269.24 10.86 1005 126721 118807 34710398
Hepatic cirrhosis 260.63 10.86 319 127407 16995 34812210
Drug abuse 245.72 10.86 35 127691 99061 34730144
Hepatic failure 239.95 10.86 443 127283 34088 34795117
Gynaecomastia 228.20 10.86 231 127495 9949 34819256
Dyspnoea 225.15 10.86 2230 125496 374552 34454653
Renal impairment 216.54 10.86 798 126928 93715 34735490
Completed suicide 200.92 10.86 55 127671 98113 34731092
Right ventricular failure 196.30 10.86 199 127527 8585 34820620
Off label use 191.34 10.86 837 126889 418687 34410518
Pulmonary hypertension 188.15 10.86 301 127425 20623 34808582
Blood potassium increased 171.80 10.86 254 127472 16241 34812964
Ejection fraction decreased 170.12 10.86 274 127452 18880 34810325
Dehydration 164.73 10.86 921 126805 129048 34700157
Renal failure 154.21 10.86 908 126818 129649 34699556
N-terminal prohormone brain natriuretic peptide increased 152.69 10.86 105 127621 2610 34826595
Febrile neutropenia 143.83 10.86 173 127553 136676 34692529
Blood creatinine increased 142.95 10.86 706 127020 94270 34734935
Toxicity to various agents 138.98 10.86 331 127395 200031 34629174
Pulmonary arterial hypertension 137.99 10.86 165 127561 8574 34820631
Oesophageal varices haemorrhage 136.59 10.86 104 127622 3042 34826163
Neutropenia 135.26 10.86 228 127498 156550 34672655
Congestive cardiomyopathy 134.00 10.86 151 127575 7359 34821846
Ventricular tachycardia 132.27 10.86 297 127429 26282 34802923
Hepatorenal syndrome 131.14 10.86 95 127631 2571 34826634
Brain natriuretic peptide increased 118.84 10.86 124 127602 5535 34823670
International normalised ratio increased 118.84 10.86 412 127314 46915 34782290
Bradycardia 117.29 10.86 566 127160 74852 34754353
Hepatocellular carcinoma 115.65 10.86 140 127586 7369 34821836
Orthopnoea 114.73 10.86 116 127610 4987 34824218
Arthralgia 111.54 10.86 289 127437 169752 34659453
Oedema 109.51 10.86 392 127334 45349 34783856
Blood urea increased 108.52 10.86 299 127427 30065 34799140
Mitral valve incompetence 106.64 10.86 194 127532 14749 34814456
Drug interaction 102.47 10.86 1268 126458 224678 34604527
General physical health deterioration 101.21 10.86 808 126918 127461 34701744
Hepatic cancer 100.28 10.86 137 127589 8138 34821067
Syncope 90.39 10.86 608 127118 90843 34738362
Intentional overdose 90.18 10.86 24 127702 43650 34785555
Ischaemic cardiomyopathy 90.16 10.86 114 127612 6275 34822930
Therapeutic product effect incomplete 86.68 10.86 38 127688 50503 34778702
Varices oesophageal 85.59 10.86 86 127640 3669 34825536
Orthostatic hypotension 85.54 10.86 248 127478 25671 34803534
Cardiac failure acute 82.86 10.86 143 127583 10427 34818778
Atrial fibrillation 81.76 10.86 743 126983 121650 34707555
Foetal exposure during pregnancy 78.55 10.86 21 127705 38080 34791125
Atrioventricular block complete 78.25 10.86 130 127596 9189 34820016
Fluid retention 75.40 10.86 243 127483 26644 34802561
Arrhythmia 74.16 10.86 293 127433 35515 34793690
Dyspnoea exertional 73.24 10.86 333 127393 42946 34786259
Chronic kidney disease 71.17 10.86 319 127407 40891 34788314
Suicide attempt 69.33 10.86 28 127698 39088 34790117
Tricuspid valve incompetence 68.73 10.86 126 127600 9634 34819571
Blood pressure decreased 67.07 10.86 368 127358 51147 34778058
Breast tenderness 66.31 10.86 39 127687 732 34828473
Glomerular filtration rate decreased 65.78 10.86 146 127580 12815 34816390
Pain 65.11 10.86 459 127267 204216 34624989
Melaena 64.99 10.86 279 127447 35101 34794104
Treatment failure 64.39 10.86 46 127680 46651 34782554
Pyrexia 63.12 10.86 848 126878 332165 34497040
Bundle branch block left 62.14 10.86 92 127634 5887 34823318
Electrolyte imbalance 61.83 10.86 152 127574 14260 34814945
Product dose omission issue